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The map label for this gene is yfcY [C]

Identifier: 121610789

GI number: 121610789

Start: 4265524

End: 4266678

Strand: Direct

Name: yfcY [C]

Synonym: Veis_3870

Alternate gene names: 121610789

Gene position: 4265524-4266678 (Clockwise)

Preceding gene: 121610788

Following gene: 121610790

Centisome position: 76.63

GC content: 68.31

Gene sequence:

>1155_bases
TTGAACCGGCTGCTGCGTGAACGCACCGTCTACGTCGTGGGCATCGGCATGCACGCCTATGGCTTCCCATCGGAAACACC
TTATGTGCAACTGGGCCTGCAGGCTGTCCGAGAAGCCCTGGACGATGCCGACTTGGCCTGGCCCCAGGTGCAAAGCGCCG
TGGTCGGCACGGCGGCCCTGGGCATGGCCGCTGGCCGTGTGATGCTGCGCCACCTGGGCTCGACTGGCCTGGAGGTGCTG
CAGGTCGAGAACGCCTCGGCGTCCGGCTCCACGGCTTTCCGCCTGGCCTGCCTGCAAGTCGCCAGCGGCGAGCGCGACGT
GGTGCTTGCGTTGGGCGTCGACAAGTTCGGCGATGGCCGCCGCGCGGCCCTCAAGGACGGACTGCCTCCACTGAGTCCAA
CCTCGCATGTGCCGCTGGTGAAATTCGCGCTGTTGGCGCGTCGCTGCATGCGCGAGCAAGGATTGACGTTGCACGACATG
GCCCGCGTGGCCGTCAAGAACCATGGCAACGCTGCGCGCAACCCCTATGCGCAGTTCCGCAAGCCACGCACGCTGGAGCA
AGTGCTGGCCTCGCCGCGCGTGGTCGGCGATCTCACCGCGCTGCAATGCTGCCCACGGGGAGAAGGCGCCGCCGCGGTCA
TCGTGGTGTCAGAAGACGGGCTGCGCCGCCTCGACCTGGCGCGCACGCGCGCCGTTCAGGTGCTGGCCTCCGTCGCCAGC
AGCGAGGAACTAACGCCGGAAGGCTCGCCACCGCTGGTCGAACTGGTGCGCAAATCCTCGGCGGCGGCGCTGTCGCAAGC
CGGCATCGTGCCCAAGGATCTGGACATCGTGGAACTGCACGATGCCTTCTCCATAGAGGAACTGCTCTATACCGAGGCCA
TCGGTATCTGCGAAACCGGCGAAGGCGCGGCCTACGTGGCCCGAGGCGCAGCCGACATCGACGGTGGGGCTTGCGCCATC
AATCCTTCCGGCGGCCTGATCGGCATGGGCCATCCGCTGGGACCAACCGGCGTCGGGCAGATCGCGGAGATCACGCGCCA
GTTGCGCGGCGAGGCCACGGGACGCCAGCACCCCGGTGCGCGCCTGGCCTTGGCCCACATGATCGGCCTGGGCTCGGTCG
CCGTGGCCCATGTGCTGGCTCGCGCCGGAACCTGA

Upstream 100 bases:

>100_bases
AACTGCGTCTGGGCATGGCCCTGGAGCCAGTCTGGCAGCCCGGGAAGGCTCAAAGTGACGGCACTTGGGTGTTCCGTGCA
CCTGCAGCGGAGGTGGCATC

Downstream 100 bases:

>100_bases
AGAAACATATGGATTACTCGACCCTGTTGTACGAAGTCGCCGAGGGAGTGGCGTTGATCCGGCTGAACCGCCCGGAGCGC
ATGAATGCCATCGGCGGCGC

Product: thiolase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MNRLLRERTVYVVGIGMHAYGFPSETPYVQLGLQAVREALDDADLAWPQVQSAVVGTAALGMAAGRVMLRHLGSTGLEVL
QVENASASGSTAFRLACLQVASGERDVVLALGVDKFGDGRRAALKDGLPPLSPTSHVPLVKFALLARRCMREQGLTLHDM
ARVAVKNHGNAARNPYAQFRKPRTLEQVLASPRVVGDLTALQCCPRGEGAAAVIVVSEDGLRRLDLARTRAVQVLASVAS
SEELTPEGSPPLVELVRKSSAAALSQAGIVPKDLDIVELHDAFSIEELLYTEAIGICETGEGAAYVARGAADIDGGACAI
NPSGGLIGMGHPLGPTGVGQIAEITRQLRGEATGRQHPGARLALAHMIGLGSVAVAHVLARAGT

Sequences:

>Translated_384_residues
MNRLLRERTVYVVGIGMHAYGFPSETPYVQLGLQAVREALDDADLAWPQVQSAVVGTAALGMAAGRVMLRHLGSTGLEVL
QVENASASGSTAFRLACLQVASGERDVVLALGVDKFGDGRRAALKDGLPPLSPTSHVPLVKFALLARRCMREQGLTLHDM
ARVAVKNHGNAARNPYAQFRKPRTLEQVLASPRVVGDLTALQCCPRGEGAAAVIVVSEDGLRRLDLARTRAVQVLASVAS
SEELTPEGSPPLVELVRKSSAAALSQAGIVPKDLDIVELHDAFSIEELLYTEAIGICETGEGAAYVARGAADIDGGACAI
NPSGGLIGMGHPLGPTGVGQIAEITRQLRGEATGRQHPGARLALAHMIGLGSVAVAHVLARAGT
>Mature_384_residues
MNRLLRERTVYVVGIGMHAYGFPSETPYVQLGLQAVREALDDADLAWPQVQSAVVGTAALGMAAGRVMLRHLGSTGLEVL
QVENASASGSTAFRLACLQVASGERDVVLALGVDKFGDGRRAALKDGLPPLSPTSHVPLVKFALLARRCMREQGLTLHDM
ARVAVKNHGNAARNPYAQFRKPRTLEQVLASPRVVGDLTALQCCPRGEGAAAVIVVSEDGLRRLDLARTRAVQVLASVAS
SEELTPEGSPPLVELVRKSSAAALSQAGIVPKDLDIVELHDAFSIEELLYTEAIGICETGEGAAYVARGAADIDGGACAI
NPSGGLIGMGHPLGPTGVGQIAEITRQLRGEATGRQHPGARLALAHMIGLGSVAVAHVLARAGT

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=391, Percent_Identity=36.8286445012788, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI302344760, Length=387, Percent_Identity=36.1757105943152, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI302344767, Length=320, Percent_Identity=37.8125, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI302344762, Length=376, Percent_Identity=34.3085106382979, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI55956775, Length=338, Percent_Identity=32.2485207100592, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17537653, Length=381, Percent_Identity=32.2834645669291, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI19921506, Length=388, Percent_Identity=35.8247422680412, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24585051, Length=396, Percent_Identity=36.3636363636364, Blast_Score=229, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 40092; Mature: 40092

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLLRERTVYVVGIGMHAYGFPSETPYVQLGLQAVREALDDADLAWPQVQSAVVGTAAL
CCCHHHHCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GMAAGRVMLRHLGSTGLEVLQVENASASGSTAFRLACLQVASGERDVVLALGVDKFGDGR
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
RAALKDGLPPLSPTSHVPLVKFALLARRCMREQGLTLHDMARVAVKNHGNAARNPYAQFR
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHC
KPRTLEQVLASPRVVGDLTALQCCPRGEGAAAVIVVSEDGLRRLDLARTRAVQVLASVAS
CCHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHC
SEELTPEGSPPLVELVRKSSAAALSQAGIVPKDLDIVELHDAFSIEELLYTEAIGICETG
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHCCCEECC
EGAAYVARGAADIDGGACAINPSGGLIGMGHPLGPTGVGQIAEITRQLRGEATGRQHPGA
CCCEEEECCCCCCCCCEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCH
RLALAHMIGLGSVAVAHVLARAGT
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNRLLRERTVYVVGIGMHAYGFPSETPYVQLGLQAVREALDDADLAWPQVQSAVVGTAAL
CCCHHHHCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GMAAGRVMLRHLGSTGLEVLQVENASASGSTAFRLACLQVASGERDVVLALGVDKFGDGR
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
RAALKDGLPPLSPTSHVPLVKFALLARRCMREQGLTLHDMARVAVKNHGNAARNPYAQFR
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHC
KPRTLEQVLASPRVVGDLTALQCCPRGEGAAAVIVVSEDGLRRLDLARTRAVQVLASVAS
CCHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHC
SEELTPEGSPPLVELVRKSSAAALSQAGIVPKDLDIVELHDAFSIEELLYTEAIGICETG
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHCCCEECC
EGAAYVARGAADIDGGACAINPSGGLIGMGHPLGPTGVGQIAEITRQLRGEATGRQHPGA
CCCEEEECCCCCCCCCEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCH
RLALAHMIGLGSVAVAHVLARAGT
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]