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The map label for this gene is yngF [H]

Identifier: 121610782

GI number: 121610782

Start: 4258667

End: 4259227

Strand: Direct

Name: yngF [H]

Synonym: Veis_3862

Alternate gene names: 121610782

Gene position: 4258667-4259227 (Clockwise)

Preceding gene: 121610780

Following gene: 121610783

Centisome position: 76.5

GC content: 68.98

Gene sequence:

>561_bases
ATGCCGTATGGACAGGCGGTGGATCCCACCGCGTTCTATGCGGAGGCGATGCGACTGTTCCGCAACCGCAAGCCCCTGGT
GGCGGCGGTCGAGGGGGCCGCAGTTGGCGCGGGGCTGGGCCTGGCGCTGTTGACCGATTTTCGCGTGACCTGCCCGGAGG
CCCGCTTCAGCGCAAATTTCAACCGCCTGGGCTTTCATCCTGGCTTCGGACTGAGCCTGACGCTGCCCCGCCTGGTCGGT
GCGCAGAAAGCCGCCATGCTGTTCTACACCGGCCGCCGCATCGGCGGCGAGGAGGCCGTGGCCATCGGCCTAGCCGACGA
GCTGGTGGACAAGGTACAGGTGCTCCCGCGCGCCATGGCACTGACGCAGGACATCGCAGCTTCGGCACCGCTGGCGGTGG
CCTCCACGCGCCGCAGCCTGCGCGAAGGACTGGCCGAACAGGTGGCCGAGGCCAATCAGCAGGAGTTGGCGATCCAGCGC
GAGCAGTTCCGCACCGAGGATTTCCGCGAGGGCGTGGCCGCGATGGCGGCGCGCCGCTTGCCCGTGTTCCATGGGCGTTG
A

Upstream 100 bases:

>100_bases
GCGGTAACGCGGCCAGATAGGCCAAACCGACAGCAGTTTTTTGGACAGGCACGCGTGTGCCAAGCGTGACGCGCCGCAAT
TTGGAAACACTGTCAGGACT

Downstream 100 bases:

>100_bases
CAGCAGACAAGAGTATTCGAGAGCCCATATGACAACCTCACCCACTATGCCCGACGGGCAGCGCCAGCGCGCCCCAAGCA
GTGGCCCGCTCGATGGCATT

Product: enoyl-CoA hydratase/isomerase

Products: trans-2-enoyl-CoA; trans-3-enoyl-CoA; H2O

Alternate protein names: NA

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MPYGQAVDPTAFYAEAMRLFRNRKPLVAAVEGAAVGAGLGLALLTDFRVTCPEARFSANFNRLGFHPGFGLSLTLPRLVG
AQKAAMLFYTGRRIGGEEAVAIGLADELVDKVQVLPRAMALTQDIAASAPLAVASTRRSLREGLAEQVAEANQQELAIQR
EQFRTEDFREGVAAMAARRLPVFHGR

Sequences:

>Translated_186_residues
MPYGQAVDPTAFYAEAMRLFRNRKPLVAAVEGAAVGAGLGLALLTDFRVTCPEARFSANFNRLGFHPGFGLSLTLPRLVG
AQKAAMLFYTGRRIGGEEAVAIGLADELVDKVQVLPRAMALTQDIAASAPLAVASTRRSLREGLAEQVAEANQQELAIQR
EQFRTEDFREGVAAMAARRLPVFHGR
>Mature_185_residues
PYGQAVDPTAFYAEAMRLFRNRKPLVAAVEGAAVGAGLGLALLTDFRVTCPEARFSANFNRLGFHPGFGLSLTLPRLVGA
QKAAMLFYTGRRIGGEEAVAIGLADELVDKVQVLPRAMALTQDIAASAPLAVASTRRSLREGLAEQVAEANQQELAIQRE
QFRTEDFREGVAAMAARRLPVFHGR

Specific function: Catalyzes The Reversible Dehydration Of L-Carnitinyl-CoA To Crotobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=182, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI68989263, Length=90, Percent_Identity=42.2222222222222, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI70995211, Length=175, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI221142681, Length=178, Percent_Identity=34.2696629213483, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787659, Length=173, Percent_Identity=36.9942196531792, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1790281, Length=85, Percent_Identity=40, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1787660, Length=192, Percent_Identity=30.2083333333333, Blast_Score=60, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI25145438, Length=172, Percent_Identity=30.8139534883721, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560910, Length=138, Percent_Identity=32.6086956521739, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17554946, Length=164, Percent_Identity=28.6585365853659, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17540714, Length=128, Percent_Identity=29.6875, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI20129971, Length=181, Percent_Identity=31.4917127071823, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24653477, Length=181, Percent_Identity=31.4917127071823, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24653139, Length=165, Percent_Identity=30.9090909090909, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19920382, Length=163, Percent_Identity=33.7423312883436, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: 4.2.1.17

Molecular weight: Translated: 20084; Mature: 19953

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYGQAVDPTAFYAEAMRLFRNRKPLVAAVEGAAVGAGLGLALLTDFRVTCPEARFSANF
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHCCC
NRLGFHPGFGLSLTLPRLVGAQKAAMLFYTGRRIGGEEAVAIGLADELVDKVQVLPRAMA
CCCCCCCCCCCEEHHHHHHCHHHHHHHEEECCCCCCCHHEEEHHHHHHHHHHHHHHHHHH
LTQDIAASAPLAVASTRRSLREGLAEQVAEANQQELAIQREQFRTEDFREGVAAMAARRL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PVFHGR
CCCCCC
>Mature Secondary Structure 
PYGQAVDPTAFYAEAMRLFRNRKPLVAAVEGAAVGAGLGLALLTDFRVTCPEARFSANF
CCCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHCCC
NRLGFHPGFGLSLTLPRLVGAQKAAMLFYTGRRIGGEEAVAIGLADELVDKVQVLPRAMA
CCCCCCCCCCCEEHHHHHHCHHHHHHHEEECCCCCCCHHEEEHHHHHHHHHHHHHHHHHH
LTQDIAASAPLAVASTRRSLREGLAEQVAEANQQELAIQREQFRTEDFREGVAAMAARRL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PVFHGR
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3S)-3-hydroxyacyl-CoA

Specific reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]