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The map label for this gene is yfcY [C]

Identifier: 121610777

GI number: 121610777

Start: 4254506

End: 4255657

Strand: Direct

Name: yfcY [C]

Synonym: Veis_3857

Alternate gene names: 121610777

Gene position: 4254506-4255657 (Clockwise)

Preceding gene: 121610776

Following gene: 121610779

Centisome position: 76.43

GC content: 66.32

Gene sequence:

>1152_bases
ATGCCTGTCACCCTTGGTTCCCTACGCCCCGTCTACGTGGTGGGCGTGGGATTGCACCCCTACCAGCCGCTGAGCGAGAC
GCCTTATGTACAACTCGGCCTCTCTGCAGCCCGCGACGCCCTGACCGACGCACGCGTGCCGTGGGAGTTCGTGGATTCGG
CCTACGTGGCCAAGGCCTTGCTGCCCATGGCCGTCGGCCGCCCGATGCTGCGGCACCTGGGGGCCACCGGGCTGCCTATC
ACCCATGTCGAAAACGCATCGGCCTCCGGATCCGCCGCTTTCCGCCAGGCCTGCATGGAAGTCGCTTGCGCGATGAGCGA
CATCTCCTTCGTCATCGGCGTCGACAAGCCGACCGCGCTGGGGTCGCGAGCGGAAATGCTGACCGGCATTCCTAACTTGG
CCGACGACGCCATCGTCCCATTCACGCATTTCGCGCTGCTGGCCGATGCGTACGCGCAGCGAACCGGCTGTTCGTTCGAA
GACATCGCGCGCGTCGCCGGCAAGAACCTGCGCAATGCCAGCCTGAACCCGTTCGCCCAACGCCGGCAGGCCAAGACGCT
GGATGAAATCCTGGGCGGCAAGAAAGTCTCCGGCCAGTTCACGACCCTGCAATGCACCCCCGTGGGCGAAGGCGCAGCCG
CCGTGGTGGTTGCCTCCGAAGAGGGTCTGCGCCGTGCCGGCCTGGGATTGGAGCGCGCCGTGCGCATCACGGCTTCGGCG
GCCCGCAGCCAGCGCGTCTACACCGACCCCACGCGCTACGACGAAATGCTGACCAAGGAAACCGTCGAGGCGGCACTGGC
ACAGGCGGGTGTCTCCGCTGGTGGCCTGGATGTAATCGAACTTCACGACGCCTTCACGGTCGAGGAACTCGAGTACCTGG
AAGCCATCGGCGTATGCGGTCACGGCCAGGCGGCAGGCCTTCTAAAAGAAGGTGCCTTCGACATCGGCGGACGCTGTGCC
GTGAGTCCTTCAGGGGGCCTGATCGGCATGGGACACCCGATTGGCCCCACGGGCATTGGGCAGATCGTGGAGATCACCCG
GCAGTTGCGCGGCGAAGCTGGCGTGCGACAGCACCCCGATGCGCAGATCGGCCCGGCACACATGGTCGGACTCGGCGCGG
TGTGCTTCGCCCACGTGCTGCAGAGCCTCTAG

Upstream 100 bases:

>100_bases
CATGGTCGCCGTTCTATCGCCGGTGGCATCCGAGGAAGGCTCCCGCGTGCACGACTTGCGCTTCTCACTCGCGCAACCTG
CCCCACTTCAGGAGTAAGTC

Downstream 100 bases:

>100_bases
TCCACTGCATCATTGAACAAGCACCTGCCGAATGCGCCGTGATGGATCGTCGTACTTCCACTTGATGGGCTTGGGATTCT
TGTTGTGTTCGCGGATGTAG

Product: thiolase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MPVTLGSLRPVYVVGVGLHPYQPLSETPYVQLGLSAARDALTDARVPWEFVDSAYVAKALLPMAVGRPMLRHLGATGLPI
THVENASASGSAAFRQACMEVACAMSDISFVIGVDKPTALGSRAEMLTGIPNLADDAIVPFTHFALLADAYAQRTGCSFE
DIARVAGKNLRNASLNPFAQRRQAKTLDEILGGKKVSGQFTTLQCTPVGEGAAAVVVASEEGLRRAGLGLERAVRITASA
ARSQRVYTDPTRYDEMLTKETVEAALAQAGVSAGGLDVIELHDAFTVEELEYLEAIGVCGHGQAAGLLKEGAFDIGGRCA
VSPSGGLIGMGHPIGPTGIGQIVEITRQLRGEAGVRQHPDAQIGPAHMVGLGAVCFAHVLQSL

Sequences:

>Translated_383_residues
MPVTLGSLRPVYVVGVGLHPYQPLSETPYVQLGLSAARDALTDARVPWEFVDSAYVAKALLPMAVGRPMLRHLGATGLPI
THVENASASGSAAFRQACMEVACAMSDISFVIGVDKPTALGSRAEMLTGIPNLADDAIVPFTHFALLADAYAQRTGCSFE
DIARVAGKNLRNASLNPFAQRRQAKTLDEILGGKKVSGQFTTLQCTPVGEGAAAVVVASEEGLRRAGLGLERAVRITASA
ARSQRVYTDPTRYDEMLTKETVEAALAQAGVSAGGLDVIELHDAFTVEELEYLEAIGVCGHGQAAGLLKEGAFDIGGRCA
VSPSGGLIGMGHPIGPTGIGQIVEITRQLRGEAGVRQHPDAQIGPAHMVGLGAVCFAHVLQSL
>Mature_382_residues
PVTLGSLRPVYVVGVGLHPYQPLSETPYVQLGLSAARDALTDARVPWEFVDSAYVAKALLPMAVGRPMLRHLGATGLPIT
HVENASASGSAAFRQACMEVACAMSDISFVIGVDKPTALGSRAEMLTGIPNLADDAIVPFTHFALLADAYAQRTGCSFED
IARVAGKNLRNASLNPFAQRRQAKTLDEILGGKKVSGQFTTLQCTPVGEGAAAVVVASEEGLRRAGLGLERAVRITASAA
RSQRVYTDPTRYDEMLTKETVEAALAQAGVSAGGLDVIELHDAFTVEELEYLEAIGVCGHGQAAGLLKEGAFDIGGRCAV
SPSGGLIGMGHPIGPTGIGQIVEITRQLRGEAGVRQHPDAQIGPAHMVGLGAVCFAHVLQSL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=398, Percent_Identity=33.6683417085427, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI302344760, Length=394, Percent_Identity=32.48730964467, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI302344762, Length=388, Percent_Identity=30.9278350515464, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI302344767, Length=320, Percent_Identity=33.4375, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI55956775, Length=354, Percent_Identity=29.3785310734463, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17537653, Length=384, Percent_Identity=28.6458333333333, Blast_Score=157, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24585051, Length=383, Percent_Identity=31.5926892950392, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI19921506, Length=388, Percent_Identity=31.701030927835, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 40016; Mature: 39885

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVTLGSLRPVYVVGVGLHPYQPLSETPYVQLGLSAARDALTDARVPWEFVDSAYVAKAL
CCCCCCCCCCEEEEEECCCCCCCCCCCCEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHH
LPMAVGRPMLRHLGATGLPITHVENASASGSAAFRQACMEVACAMSDISFVIGVDKPTAL
HHHHHCCHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCC
GSRAEMLTGIPNLADDAIVPFTHFALLADAYAQRTGCSFEDIARVAGKNLRNASLNPFAQ
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHH
RRQAKTLDEILGGKKVSGQFTTLQCTPVGEGAAAVVVASEEGLRRAGLGLERAVRITASA
HHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEEEEECCCCHHHHCCCHHHHHHHHHHH
ARSQRVYTDPTRYDEMLTKETVEAALAQAGVSAGGLDVIELHDAFTVEELEYLEAIGVCG
HHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCC
HGQAAGLLKEGAFDIGGRCAVSPSGGLIGMGHPIGPTGIGQIVEITRQLRGEAGVRQHPD
CCHHHHHHHCCCCCCCCEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
AQIGPAHMVGLGAVCFAHVLQSL
CCCCCHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
PVTLGSLRPVYVVGVGLHPYQPLSETPYVQLGLSAARDALTDARVPWEFVDSAYVAKAL
CCCCCCCCCEEEEEECCCCCCCCCCCCEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHH
LPMAVGRPMLRHLGATGLPITHVENASASGSAAFRQACMEVACAMSDISFVIGVDKPTAL
HHHHHCCHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCC
GSRAEMLTGIPNLADDAIVPFTHFALLADAYAQRTGCSFEDIARVAGKNLRNASLNPFAQ
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHH
RRQAKTLDEILGGKKVSGQFTTLQCTPVGEGAAAVVVASEEGLRRAGLGLERAVRITASA
HHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEEEEECCCCHHHHCCCHHHHHHHHHHH
ARSQRVYTDPTRYDEMLTKETVEAALAQAGVSAGGLDVIELHDAFTVEELEYLEAIGVCG
HHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCC
HGQAAGLLKEGAFDIGGRCAVSPSGGLIGMGHPIGPTGIGQIVEITRQLRGEAGVRQHPD
CCHHHHHHHCCCCCCCCEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
AQIGPAHMVGLGAVCFAHVLQSL
CCCCCHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]