Click here to switch to the map view.

The map label for this gene is lip2 [H]

Identifier: 121609777

GI number: 121609777

Start: 3179001

End: 3179921

Strand: Direct

Name: lip2 [H]

Synonym: Veis_2828

Alternate gene names: 121609777

Gene position: 3179001-3179921 (Clockwise)

Preceding gene: 121609776

Following gene: 121609778

Centisome position: 57.11

GC content: 70.9

Gene sequence:

>921_bases
ATGCGCGCTGTGCTCGAACGCATGGCCCGCGCCGGCCGGCCGTCGCTGCACCTGCTCCTGCCCCGGGATGCACGCCTGGC
CTACGAGGCCAGATCGGGCGTGCTGGAACTGCCCCGGGCGGACTTGGCACGGGTGCAAGACCTGAGCATCCCGGCCCGCG
ATGGCCATGCGCTGCCTGCGCGGCTTTATGCGCCGTCCACGGCGGCTGGGCTGGCGCTGCTGCTGTACATGCATGGCGGC
GGCTTCACCATTGGCAGCATCGCCACGCACGACACGCTGTGCCGCGAACTGGCGCGCCTGGCCGGGTGCATGGTGGTGGC
GCTGGATTACCGGTTGGCGCCGGAGCATCGCTTTCCCACGGCCAGCAACGACGCCTGGGATGCCTTGGTCTGGCTCGCTG
CGAACGCGCCGCTGCTGGGGGCCGACCGCGCCCGCCTGGCCGTCGGCGGCGACAGCGCAGGCGGCACCCTGGCGGCCGTG
AACGCCATCCTGGCGCGCGATGCGGGCTTGCCGCTGGCATTGCAACTGCTGTTTTATCCGGGCTGCGCGGCCCATCAGGA
GCACCCGTCCCACGCCCGCTTTGCCCGGGGCCTGGTGCTGGAGGCGCCCGCCATCCGCTGGTTTTTCGACCACTATGCCG
GCAACCGCGAGGAGCGCGAGGACTGGCGCTTCGCCCCCTTGCTCGCGCCGGATGTCGACGGCGTGGCGCCGGCGTGGATC
GGCCTGGCCGAGTACGATCCGCTGGTCGATGAGGGCGTGGCTTACGCCGACAAACTGCGCCTGGCCGGGGTGGCGGTGGA
ACTGGATATCTACCGTGGGGTGACCCACGAATTCATCAAGATGGGCCGCGCCATCCCTGAGGCGCGCCAGGCCCATGCCG
ACGCAGCCCGGGCCTTGCGTCGCGCTTTCGTACAGGAGTGA

Upstream 100 bases:

>100_bases
CCATTCCTGAATCATCCGTGCACTTTGTCGGCGTCGCTTGCCGCATATTCGTACTGCGTGACCGTTGACTGATTTGCCCC
ACGCCCGCCTGACCCCGCAG

Downstream 100 bases:

>100_bases
TCGAAGTGAACGGAGTCAAACCGACCATGCAACGCAGCGACTTTCGCTGTTTTCACCGCCTGCGCGTGCGCTGGGCCGAG
GTGGACATGCAAAAAATCGT

Product: alpha/beta hydrolase domain-containing protein

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MRAVLERMARAGRPSLHLLLPRDARLAYEARSGVLELPRADLARVQDLSIPARDGHALPARLYAPSTAAGLALLLYMHGG
GFTIGSIATHDTLCRELARLAGCMVVALDYRLAPEHRFPTASNDAWDALVWLAANAPLLGADRARLAVGGDSAGGTLAAV
NAILARDAGLPLALQLLFYPGCAAHQEHPSHARFARGLVLEAPAIRWFFDHYAGNREEREDWRFAPLLAPDVDGVAPAWI
GLAEYDPLVDEGVAYADKLRLAGVAVELDIYRGVTHEFIKMGRAIPEARQAHADAARALRRAFVQE

Sequences:

>Translated_306_residues
MRAVLERMARAGRPSLHLLLPRDARLAYEARSGVLELPRADLARVQDLSIPARDGHALPARLYAPSTAAGLALLLYMHGG
GFTIGSIATHDTLCRELARLAGCMVVALDYRLAPEHRFPTASNDAWDALVWLAANAPLLGADRARLAVGGDSAGGTLAAV
NAILARDAGLPLALQLLFYPGCAAHQEHPSHARFARGLVLEAPAIRWFFDHYAGNREEREDWRFAPLLAPDVDGVAPAWI
GLAEYDPLVDEGVAYADKLRLAGVAVELDIYRGVTHEFIKMGRAIPEARQAHADAARALRRAFVQE
>Mature_306_residues
MRAVLERMARAGRPSLHLLLPRDARLAYEARSGVLELPRADLARVQDLSIPARDGHALPARLYAPSTAAGLALLLYMHGG
GFTIGSIATHDTLCRELARLAGCMVVALDYRLAPEHRFPTASNDAWDALVWLAANAPLLGADRARLAVGGDSAGGTLAAV
NAILARDAGLPLALQLLFYPGCAAHQEHPSHARFARGLVLEAPAIRWFFDHYAGNREEREDWRFAPLLAPDVDGVAPAWI
GLAEYDPLVDEGVAYADKLRLAGVAVELDIYRGVTHEFIKMGRAIPEARQAHADAARALRRAFVQE

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI206597554, Length=153, Percent_Identity=36.6013071895425, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI68299767, Length=295, Percent_Identity=25.0847457627119, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI157041239, Length=107, Percent_Identity=37.3831775700935, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI21328446, Length=94, Percent_Identity=35.1063829787234, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786682, Length=254, Percent_Identity=30.3149606299213, Blast_Score=104, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17567059, Length=288, Percent_Identity=28.4722222222222, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17540028, Length=312, Percent_Identity=24.0384615384615, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71996133, Length=217, Percent_Identity=26.7281105990783, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI72001146, Length=151, Percent_Identity=34.4370860927152, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115533412, Length=85, Percent_Identity=36.4705882352941, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI115533410, Length=85, Percent_Identity=36.4705882352941, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24656084, Length=140, Percent_Identity=33.5714285714286, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24656076, Length=140, Percent_Identity=33.5714285714286, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI20130169, Length=140, Percent_Identity=33.5714285714286, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 33135; Mature: 33135

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS01173 LIPASE_GDXG_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVLERMARAGRPSLHLLLPRDARLAYEARSGVLELPRADLARVQDLSIPARDGHALPA
CHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCEECCCHHHHHHHHCCCCCCCCCCCCC
RLYAPSTAAGLALLLYMHGGGFTIGSIATHDTLCRELARLAGCMVVALDYRLAPEHRFPT
EEECCCHHHHHHHHEEECCCCEEECCHHHHHHHHHHHHHHHHHHHEEEECEECCCCCCCC
ASNDAWDALVWLAANAPLLGADRARLAVGGDSAGGTLAAVNAILARDAGLPLALQLLFYP
CCCCHHHHHEEEECCCCEECCCCCEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCC
GCAAHQEHPSHARFARGLVLEAPAIRWFFDHYAGNREEREDWRFAPLLAPDVDGVAPAWI
CCCCCCCCCCHHHHHHCEEECCCHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCHHHH
GLAEYDPLVDEGVAYADKLRLAGVAVELDIYRGVTHEFIKMGRAIPEARQAHADAARALR
HHHHCCCHHHHHHHHHHHHHHHEEEEEEHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHH
RAFVQE
HHHHCC
>Mature Secondary Structure
MRAVLERMARAGRPSLHLLLPRDARLAYEARSGVLELPRADLARVQDLSIPARDGHALPA
CHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCEECCCHHHHHHHHCCCCCCCCCCCCC
RLYAPSTAAGLALLLYMHGGGFTIGSIATHDTLCRELARLAGCMVVALDYRLAPEHRFPT
EEECCCHHHHHHHHEEECCCCEEECCHHHHHHHHHHHHHHHHHHHEEEECEECCCCCCCC
ASNDAWDALVWLAANAPLLGADRARLAVGGDSAGGTLAAVNAILARDAGLPLALQLLFYP
CCCCHHHHHEEEECCCCEECCCCCEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCC
GCAAHQEHPSHARFARGLVLEAPAIRWFFDHYAGNREEREDWRFAPLLAPDVDGVAPAWI
CCCCCCCCCCHHHHHHCEEECCCHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCHHHH
GLAEYDPLVDEGVAYADKLRLAGVAVELDIYRGVTHEFIKMGRAIPEARQAHADAARALR
HHHHCCCHHHHHHHHHHHHHHHEEEEEEHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHH
RAFVQE
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]