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The map label for this gene is dapA [H]

Identifier: 121609692

GI number: 121609692

Start: 3084666

End: 3085604

Strand: Direct

Name: dapA [H]

Synonym: Veis_2739

Alternate gene names: 121609692

Gene position: 3084666-3085604 (Clockwise)

Preceding gene: 121609691

Following gene: 121609693

Centisome position: 55.41

GC content: 68.69

Gene sequence:

>939_bases
ATGCACCGCAACACCGTCGACTGGGCAGGCTACATCCCTGCCATCACCACCCCCTTCACCCGCAGCGGGGCGCTGGACTG
GGCGGCGCTGGACGCCCAACTGCAGTGGTATCTGCAAGAGCGCATGCACGGCGTGGTGCTGGCGGGCACTTCGGGCGAAT
GGTTCAGCCTGAGCGCGGCCGAGCGCGCCGAATTGTTTGCCCAGGCCGGCCGCATGATCGCCGGGCGCATCACCGTGCTC
GGCGGCTGCAATGCCTACACGGCGGCCGAGGCCATCGGCCACGCGCGCGCGGCCGAGCGCGCCGGGCTCGATGGCATCTT
GCTGACGCCGCCGCCCTACATCGTGCCGAGCCGGCGCGAGTTGGTGCAGTTCTACACCGACGTGTCCGATGCCACCGACA
TTCCGATCTGCATCTACAACTGGCCGCGCGGCTGCGTGGTGGACATGGATGTCGAACTGCTGGAAGAACTGGCCGAGATC
GATCATGTCGTGGCGATCAAGAACTCGACCGGAAATTTCGCACTGTTCCTGCAAGGGGCCTACGCACTGCGCGACAAGGT
GCGCTACTTCAACATGCCGACCACGGAACTCGGCGCGGACCTGGCGCGGCTGGGGGTCAGCGACGGCCTGATGGGGGCCG
GCGGCGTGCTGGGCGCAGACCATCCCGATTTCTGGCGCCTGCTGGCGGCCGGCGACAAGGCCGGCGCGCTGGTGTTGGGC
GAGCGCGACCGGGTGCTGATGAAAGCCTGGTTCAACCAGGACTTCGCCGGCCGGTTCGGCAGCGCGCAGGCCATTCTCAA
GACGGCGCTGCGCCTGCGCGGCGTGCCCGCAGGCCATGTCCGCCGGCCGCTGCTCGAACTGACGGCGGATGACATCGCGC
AGGTGCGTGCCACCCTCGAAGGACTGGGCATCGCCACCGCCGCGTTGGCCGGCGCATGA

Upstream 100 bases:

>100_bases
GCCTGCGGCCAACACCTTCATCGGCGTGCAGGCGCTGGCGCTGCCCGAGTTCCTGATCGAAATCGAAGCCGATGCGGCCT
TGGACTGAGCCTGCCGATCG

Downstream 100 bases:

>100_bases
CCGGGGTGCCGTCGGCCGTCGGGCGCCGGCCCGAGCGCATCGCCACGCTGGTGGTCGGCGGCGGCCTGCTCGGCTGTGCT
GTCAGCTACCTGCTGGCGGC

Product: dihydrodipicolinate synthetase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MHRNTVDWAGYIPAITTPFTRSGALDWAALDAQLQWYLQERMHGVVLAGTSGEWFSLSAAERAELFAQAGRMIAGRITVL
GGCNAYTAAEAIGHARAAERAGLDGILLTPPPYIVPSRRELVQFYTDVSDATDIPICIYNWPRGCVVDMDVELLEELAEI
DHVVAIKNSTGNFALFLQGAYALRDKVRYFNMPTTELGADLARLGVSDGLMGAGGVLGADHPDFWRLLAAGDKAGALVLG
ERDRVLMKAWFNQDFAGRFGSAQAILKTALRLRGVPAGHVRRPLLELTADDIAQVRATLEGLGIATAALAGA

Sequences:

>Translated_312_residues
MHRNTVDWAGYIPAITTPFTRSGALDWAALDAQLQWYLQERMHGVVLAGTSGEWFSLSAAERAELFAQAGRMIAGRITVL
GGCNAYTAAEAIGHARAAERAGLDGILLTPPPYIVPSRRELVQFYTDVSDATDIPICIYNWPRGCVVDMDVELLEELAEI
DHVVAIKNSTGNFALFLQGAYALRDKVRYFNMPTTELGADLARLGVSDGLMGAGGVLGADHPDFWRLLAAGDKAGALVLG
ERDRVLMKAWFNQDFAGRFGSAQAILKTALRLRGVPAGHVRRPLLELTADDIAQVRATLEGLGIATAALAGA
>Mature_312_residues
MHRNTVDWAGYIPAITTPFTRSGALDWAALDAQLQWYLQERMHGVVLAGTSGEWFSLSAAERAELFAQAGRMIAGRITVL
GGCNAYTAAEAIGHARAAERAGLDGILLTPPPYIVPSRRELVQFYTDVSDATDIPICIYNWPRGCVVDMDVELLEELAEI
DHVVAIKNSTGNFALFLQGAYALRDKVRYFNMPTTELGADLARLGVSDGLMGAGGVLGADHPDFWRLLAAGDKAGALVLG
ERDRVLMKAWFNQDFAGRFGSAQAILKTALRLRGVPAGHVRRPLLELTADDIAQVRATLEGLGIATAALAGA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=297, Percent_Identity=25.9259259259259, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1788823, Length=244, Percent_Identity=27.4590163934426, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87082415, Length=187, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786463, Length=264, Percent_Identity=25.7575757575758, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1789620, Length=165, Percent_Identity=27.8787878787879, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 33564; Mature: 33564

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRNTVDWAGYIPAITTPFTRSGALDWAALDAQLQWYLQERMHGVVLAGTSGEWFSLSAA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEECCCCCEEEECHH
ERAELFAQAGRMIAGRITVLGGCNAYTAAEAIGHARAAERAGLDGILLTPPPYIVPSRRE
HHHHHHHHHCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHH
LVQFYTDVSDATDIPICIYNWPRGCVVDMDVELLEELAEIDHVVAIKNSTGNFALFLQGA
HHHHHHCCCCCCCCCEEEEECCCCCEEECCHHHHHHHHHCCEEEEEECCCCCEEEEEECH
YALRDKVRYFNMPTTELGADLARLGVSDGLMGAGGVLGADHPDFWRLLAAGDKAGALVLG
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEC
ERDRVLMKAWFNQDFAGRFGSAQAILKTALRLRGVPAGHVRRPLLELTADDIAQVRATLE
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLGIATAALAGA
HCCHHHHHHCCC
>Mature Secondary Structure
MHRNTVDWAGYIPAITTPFTRSGALDWAALDAQLQWYLQERMHGVVLAGTSGEWFSLSAA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEECCCCCEEEECHH
ERAELFAQAGRMIAGRITVLGGCNAYTAAEAIGHARAAERAGLDGILLTPPPYIVPSRRE
HHHHHHHHHCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHH
LVQFYTDVSDATDIPICIYNWPRGCVVDMDVELLEELAEIDHVVAIKNSTGNFALFLQGA
HHHHHHCCCCCCCCCEEEEECCCCCEEECCHHHHHHHHHCCEEEEEECCCCCEEEEEECH
YALRDKVRYFNMPTTELGADLARLGVSDGLMGAGGVLGADHPDFWRLLAAGDKAGALVLG
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEC
ERDRVLMKAWFNQDFAGRFGSAQAILKTALRLRGVPAGHVRRPLLELTADDIAQVRATLE
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLGIATAALAGA
HCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10896225 [H]