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The map label for this gene is gatD [H]

Identifier: 121609636

GI number: 121609636

Start: 3026258

End: 3027301

Strand: Direct

Name: gatD [H]

Synonym: Veis_2683

Alternate gene names: 121609636

Gene position: 3026258-3027301 (Clockwise)

Preceding gene: 121609635

Following gene: 121609637

Centisome position: 54.36

GC content: 68.87

Gene sequence:

>1044_bases
ATGAACTCCAGCCATCCCACCACCATGCGCGCTGCCGTGATGCACAAGCCGGGCGACATTCGTCTGGAAGACAAACCCAA
GCCGCAAGTGCGGGCCGGCCACGCGCTGGTCAAGGTGGCGGTGTGCGGCGTGTGCGGCTCCGACATTCCGCGCATGCTCC
AGAAGGGGGCCCACGTCATGCCGCTGATCTGCGGCCATGAATTCGCCGGCTACGTCGAGGCGCTCGGCGAAGGCGTGCAG
GGCCATGCCATCGGTGACCTCGTCACCGTGCCGCCGCTGCTACCGTGCGGCACCTGCGACCAGTGCGCGCGCGGCTTCCC
GTCGCGCTGCACCGACTACGACTACTTCGGCAGCCGCCGCGATGGTGCCTATGCCGAGTACGTGAACGTGCCCGCCGCGA
ACCTGCTCACGTGCCCCGAGGGCATGGACCCCGCCGCTGCCGCCATGACCGACCCGGCCGCCGTGGCACTGCACGCCATC
TGGAAGGCGCGCTTCACGCTCGGCCACGTCGGCGCCGTGGTCGGGTGCGGCCCCATCGGCCTGTTCGCCATCCAGTGGAT
GAAGCTGCTGGGCGGCAAGGACATCATCGGCGTGGACATCGACCCCCGGAAGCTGGCGCTGGCCCGCGAGGCCGGCGCCA
CGCACACGCGCCTGGGCAGCGAGCCGATGGACGACCTGCCCGGGTGCCACCTCATCATCGAAGCTGCGGGCCACCCCACG
GCCATCAACCAGGCCATCCGGATGGCGGCACCCGGTGGCAGCGTGGTGTGCATCGGCATTCCCGCCGGCGACATCGTGCT
GGAGAGCGTCACCTTCAGCCACCTGCTGCGCCAGGAGGTCACCCTGGCCGGCGCCTGGAACTCCTTCGGCACGCCCTTCC
CCGGCGAGGAGTGGGTGGTGTCGCTGGCCAAACTGGCCAGCGGCGAGCTGAAGTGGAAGTTCATGGTCACGCACGACCTG
CCGCTGGAAGACCTGGGGGCCATGTTCGAGAACTTCGCGCAGAAAAAACAGAGCGCTGCCAAGGTTCTTTTCCGGCCCGC
CTGA

Upstream 100 bases:

>100_bases
CCTGCGGTCTTCAAGTAAAGCCGGCCTGTTTTCTCCCTGTTTTTCTCCCTCCTTGCCGGGCAGGCAGGGGGCCTGCCTTC
ATCCATCGTCCGCACATTCC

Downstream 100 bases:

>100_bases
CCCGGGGCGCAGCGCAGCGCGGCGTGGCGTGGCGAGTGGCCGCGCGGCAAACACACAAAAATGAAGCGCACACCCGGGGC
CTTCATGCGCGGGGCAAAGG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MNSSHPTTMRAAVMHKPGDIRLEDKPKPQVRAGHALVKVAVCGVCGSDIPRMLQKGAHVMPLICGHEFAGYVEALGEGVQ
GHAIGDLVTVPPLLPCGTCDQCARGFPSRCTDYDYFGSRRDGAYAEYVNVPAANLLTCPEGMDPAAAAMTDPAAVALHAI
WKARFTLGHVGAVVGCGPIGLFAIQWMKLLGGKDIIGVDIDPRKLALAREAGATHTRLGSEPMDDLPGCHLIIEAAGHPT
AINQAIRMAAPGGSVVCIGIPAGDIVLESVTFSHLLRQEVTLAGAWNSFGTPFPGEEWVVSLAKLASGELKWKFMVTHDL
PLEDLGAMFENFAQKKQSAAKVLFRPA

Sequences:

>Translated_347_residues
MNSSHPTTMRAAVMHKPGDIRLEDKPKPQVRAGHALVKVAVCGVCGSDIPRMLQKGAHVMPLICGHEFAGYVEALGEGVQ
GHAIGDLVTVPPLLPCGTCDQCARGFPSRCTDYDYFGSRRDGAYAEYVNVPAANLLTCPEGMDPAAAAMTDPAAVALHAI
WKARFTLGHVGAVVGCGPIGLFAIQWMKLLGGKDIIGVDIDPRKLALAREAGATHTRLGSEPMDDLPGCHLIIEAAGHPT
AINQAIRMAAPGGSVVCIGIPAGDIVLESVTFSHLLRQEVTLAGAWNSFGTPFPGEEWVVSLAKLASGELKWKFMVTHDL
PLEDLGAMFENFAQKKQSAAKVLFRPA
>Mature_347_residues
MNSSHPTTMRAAVMHKPGDIRLEDKPKPQVRAGHALVKVAVCGVCGSDIPRMLQKGAHVMPLICGHEFAGYVEALGEGVQ
GHAIGDLVTVPPLLPCGTCDQCARGFPSRCTDYDYFGSRRDGAYAEYVNVPAANLLTCPEGMDPAAAAMTDPAAVALHAI
WKARFTLGHVGAVVGCGPIGLFAIQWMKLLGGKDIIGVDIDPRKLALAREAGATHTRLGSEPMDDLPGCHLIIEAAGHPT
AINQAIRMAAPGGSVVCIGIPAGDIVLESVTFSHLLRQEVTLAGAWNSFGTPFPGEEWVVSLAKLASGELKWKFMVTHDL
PLEDLGAMFENFAQKKQSAAKVLFRPA

Specific function: Converts galactitol 1-phosphate to tagatose 6-phosphate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=348, Percent_Identity=27.8735632183908, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI4501933, Length=358, Percent_Identity=26.536312849162, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788407, Length=342, Percent_Identity=36.5497076023392, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI1787863, Length=346, Percent_Identity=29.1907514450867, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1788073, Length=351, Percent_Identity=29.0598290598291, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI226510992, Length=337, Percent_Identity=28.1899109792285, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790045, Length=338, Percent_Identity=27.5147928994083, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1790718, Length=324, Percent_Identity=28.3950617283951, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1788075, Length=355, Percent_Identity=27.887323943662, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI87082125, Length=363, Percent_Identity=27.5482093663912, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786825, Length=398, Percent_Identity=26.6331658291457, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI87081918, Length=261, Percent_Identity=30.2681992337165, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17562876, Length=361, Percent_Identity=27.1468144044321, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17562878, Length=211, Percent_Identity=31.2796208530806, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71988145, Length=273, Percent_Identity=27.8388278388278, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=166, Percent_Identity=30.1204819277108, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=313, Percent_Identity=27.4760383386581, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319955, Length=359, Percent_Identity=27.5766016713092, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6322619, Length=359, Percent_Identity=27.5766016713092, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6323099, Length=357, Percent_Identity=24.9299719887955, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323961, Length=311, Percent_Identity=29.2604501607717, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6323729, Length=300, Percent_Identity=27.6666666666667, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6324486, Length=302, Percent_Identity=27.4834437086093, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319258, Length=234, Percent_Identity=29.4871794871795, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319621, Length=276, Percent_Identity=29.3478260869565, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=383, Percent_Identity=24.5430809399478, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17137530, Length=349, Percent_Identity=29.2263610315186, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17737897, Length=351, Percent_Identity=28.4900284900285, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI221457811, Length=329, Percent_Identity=23.7082066869301, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45551930, Length=329, Percent_Identity=23.7082066869301, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI45550770, Length=329, Percent_Identity=23.7082066869301, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.251 [H]

Molecular weight: Translated: 36758; Mature: 36758

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSHPTTMRAAVMHKPGDIRLEDKPKPQVRAGHALVKVAVCGVCGSDIPRMLQKGAHVM
CCCCCCCHHHHHHEECCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEE
PLICGHEFAGYVEALGEGVQGHAIGDLVTVPPLLPCGTCDQCARGFPSRCTDYDYFGSRR
EEECCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCC
DGAYAEYVNVPAANLLTCPEGMDPAAAAMTDPAAVALHAIWKARFTLGHVGAVVGCGPIG
CCCHHHHCCCCCHHEEECCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LFAIQWMKLLGGKDIIGVDIDPRKLALAREAGATHTRLGSEPMDDLPGCHLIIEAAGHPT
HHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCHHHCCCCCHHHCCCCEEEEEECCCCH
AINQAIRMAAPGGSVVCIGIPAGDIVLESVTFSHLLRQEVTLAGAWNSFGTPFPGEEWVV
HHHHHHHEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHH
SLAKLASGELKWKFMVTHDLPLEDLGAMFENFAQKKQSAAKVLFRPA
HHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCC
>Mature Secondary Structure
MNSSHPTTMRAAVMHKPGDIRLEDKPKPQVRAGHALVKVAVCGVCGSDIPRMLQKGAHVM
CCCCCCCHHHHHHEECCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEE
PLICGHEFAGYVEALGEGVQGHAIGDLVTVPPLLPCGTCDQCARGFPSRCTDYDYFGSRR
EEECCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCC
DGAYAEYVNVPAANLLTCPEGMDPAAAAMTDPAAVALHAIWKARFTLGHVGAVVGCGPIG
CCCHHHHCCCCCHHEEECCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LFAIQWMKLLGGKDIIGVDIDPRKLALAREAGATHTRLGSEPMDDLPGCHLIIEAAGHPT
HHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCHHHCCCCCHHHCCCCEEEEEECCCCH
AINQAIRMAAPGGSVVCIGIPAGDIVLESVTFSHLLRQEVTLAGAWNSFGTPFPGEEWVV
HHHHHHHEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHH
SLAKLASGELKWKFMVTHDLPLEDLGAMFENFAQKKQSAAKVLFRPA
HHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]