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The map label for this gene is pdxH

Identifier: 121609520

GI number: 121609520

Start: 2895508

End: 2896146

Strand: Direct

Name: pdxH

Synonym: Veis_2564

Alternate gene names: 121609520

Gene position: 2895508-2896146 (Clockwise)

Preceding gene: 121609518

Following gene: 121609521

Centisome position: 52.01

GC content: 65.1

Gene sequence:

>639_bases
ATGAACCTCTCCATCGCCGAGCTGCGCAAAAGCTACGGGCGCGCCGAACTCAACGAAGACGCGGCGCATGCCGATCCCCT
GCAGCAGTTTGACCAGTGGCTCGGGCAAGCCATTGCGGCGCAGTTGCCCGAGCCCAATGCGATGACGCTGGCCACCGTGG
GCAGTGACCTGCGCCCCAGCACGCGCATCGTGCTCATCAAGGGCTATGACGAGCGCGGCATCGTCTGGTTTACCAATTAC
GACAGCCGCAAGGGGCGTCAAATCGCGGGCAACCCTTGTGCGGCCTTGCAGTTCCATTGGGTGGAGTTGGAGCGTGTGGT
GCGCATCGAAGGTCTGGTGCAAAAGGTCAGCGATCAGGAAAGCGATGCGTACTTCGACAGCCGCCCGCTCGATTCGCGCA
TCGGCGCCTGGGCCAGCCCGCAAAGCCAGGTGATTGCAGGCCGTGGTGTGCTGCTGGCCAATGCCGCCAGGTACGGCGCG
CAGTTCATGCTCAAGCCACCCCGGCCACAGCATTGGGGCGGGTACCGGCTCGAACCGGACCTGTGGGAGTTCTGGCAGGG
GCGCAAGAGCCGCTTGCATGACCGGTTGCGCTATCGGATGGCCGGGGGGCAGTGGGTGCGGGAGCGGCTGGCGCCTTGA

Upstream 100 bases:

>100_bases
TCATCGCCGCGCCAATATATGCGGATCAGCGCCTGGCCGGCTTTCGGGTGTGCTGCGCGACCGCGCAGGCCCTGCCGTCA
CGGGGTGCACAATCGTGCCC

Downstream 100 bases:

>100_bases
CCTTTGCCGCCGCCGATCAGGGGCTTACACTGGGCGGCGCGGCGTAAATCCCCGGCGCCGCCCTGACTTTGCCGGCGCCG
CCGCGCCCGCCTCGGCTGCG

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MNLSIAELRKSYGRAELNEDAAHADPLQQFDQWLGQAIAAQLPEPNAMTLATVGSDLRPSTRIVLIKGYDERGIVWFTNY
DSRKGRQIAGNPCAALQFHWVELERVVRIEGLVQKVSDQESDAYFDSRPLDSRIGAWASPQSQVIAGRGVLLANAARYGA
QFMLKPPRPQHWGGYRLEPDLWEFWQGRKSRLHDRLRYRMAGGQWVRERLAP

Sequences:

>Translated_212_residues
MNLSIAELRKSYGRAELNEDAAHADPLQQFDQWLGQAIAAQLPEPNAMTLATVGSDLRPSTRIVLIKGYDERGIVWFTNY
DSRKGRQIAGNPCAALQFHWVELERVVRIEGLVQKVSDQESDAYFDSRPLDSRIGAWASPQSQVIAGRGVLLANAARYGA
QFMLKPPRPQHWGGYRLEPDLWEFWQGRKSRLHDRLRYRMAGGQWVRERLAP
>Mature_212_residues
MNLSIAELRKSYGRAELNEDAAHADPLQQFDQWLGQAIAAQLPEPNAMTLATVGSDLRPSTRIVLIKGYDERGIVWFTNY
DSRKGRQIAGNPCAALQFHWVELERVVRIEGLVQKVSDQESDAYFDSRPLDSRIGAWASPQSQVIAGRGVLLANAARYGA
QFMLKPPRPQHWGGYRLEPDLWEFWQGRKSRLHDRLRYRMAGGQWVRERLAP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=230, Percent_Identity=40, Blast_Score=160, Evalue=8e-40,
Organism=Escherichia coli, GI1787926, Length=209, Percent_Identity=44.9760765550239, Blast_Score=176, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17553712, Length=226, Percent_Identity=39.8230088495575, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6319509, Length=209, Percent_Identity=41.6267942583732, Blast_Score=141, Evalue=7e-35,
Organism=Drosophila melanogaster, GI45551845, Length=218, Percent_Identity=43.5779816513761, Blast_Score=160, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24644901, Length=218, Percent_Identity=43.5779816513761, Blast_Score=160, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24644903, Length=174, Percent_Identity=29.3103448275862, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_VEREI (A1WL02)

Other databases:

- EMBL:   CP000542
- RefSeq:   YP_997327.1
- ProteinModelPortal:   A1WL02
- SMR:   A1WL02
- STRING:   A1WL02
- GeneID:   4691480
- GenomeReviews:   CP000542_GR
- KEGG:   vei:Veis_2564
- NMPDR:   fig|391735.5.peg.2412
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- PhylomeDB:   A1WL02
- BioCyc:   VEIS391735:VEIS_2564-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24157; Mature: 24157

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 62-62 BINDING 65-65 BINDING 67-67 BINDING 84-84 BINDING 124-124 BINDING 128-128 BINDING 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSIAELRKSYGRAELNEDAAHADPLQQFDQWLGQAIAAQLPEPNAMTLATVGSDLRPS
CCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
TRIVLIKGYDERGIVWFTNYDSRKGRQIAGNPCAALQFHWVELERVVRIEGLVQKVSDQE
EEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCC
SDAYFDSRPLDSRIGAWASPQSQVIAGRGVLLANAARYGAQFMLKPPRPQHWGGYRLEPD
CCCCCCCCCCHHHHCCCCCCCCCEEECCCEEEEHHHHHCCEEEECCCCCCCCCCCCCCCH
LWEFWQGRKSRLHDRLRYRMAGGQWVRERLAP
HHHHHCCHHHHHHHHHHHHHCCCHHHHHHCCC
>Mature Secondary Structure
MNLSIAELRKSYGRAELNEDAAHADPLQQFDQWLGQAIAAQLPEPNAMTLATVGSDLRPS
CCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
TRIVLIKGYDERGIVWFTNYDSRKGRQIAGNPCAALQFHWVELERVVRIEGLVQKVSDQE
EEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCC
SDAYFDSRPLDSRIGAWASPQSQVIAGRGVLLANAARYGAQFMLKPPRPQHWGGYRLEPD
CCCCCCCCCCHHHHCCCCCCCCCEEECCCEEEEHHHHHCCEEEECCCCCCCCCCCCCCCH
LWEFWQGRKSRLHDRLRYRMAGGQWVRERLAP
HHHHHCCHHHHHHHHHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA