Click here to switch to the map view.

The map label for this gene is mlaA [H]

Identifier: 121609357

GI number: 121609357

Start: 2717712

End: 2718557

Strand: Direct

Name: mlaA [H]

Synonym: Veis_2400

Alternate gene names: 121609357

Gene position: 2717712-2718557 (Clockwise)

Preceding gene: 121609356

Following gene: 121609358

Centisome position: 48.82

GC content: 67.02

Gene sequence:

>846_bases
ATGACGCACTCAAACCTCGCGGCACATGGGGGTTGCACAGCACGGCAGACCGCGCTGTCAGATGCCTTGCGGCAGACCGT
GCCGTCCGGCGCCCCACGGTGGACGGCGCTGCCCGGCATATCCCGCTGGGTCGTGCTGCTCGGCGCAGCAGTGCTGGCCG
GCTGCGCCACCGTTGCCCAGCCGGACCCGCGCGATCCGCTGCAGGGCTACAACCGCAGCATGGCCCAGTTCAACGAGCAT
CTCGATACGATGGTCCTCAAGCCGGTGGCAACGGCCTACCGCGAGGTCACGCCGGCGCCGGTGCGCACCGGCGTGAGCAA
CTTCTTTGCAAACATCGGCGACATCTGGTCGTTCGTGAACAACCTGCTGCAACTGCGCGGCGAGGCAGCGGCAGCCAGTT
TCATGCGGGTCAATGTGAACACCTTCCTGGGCCTGGGCGGGCTGCTGGACATTGCCAGCGAACTGAACATCGAGCGCCAC
AAGCAGGACTTTGGCCTGACGCTGGGGCATTGGGGCGTGGGTACGGGGCCGTATCTGGTGCTGCCGCTTCTGGGGCCGTC
GACGCTGCGCGACAGCCTGGCGCTGTCGGTGGACATCAGGGGCAATGCGCTGCACCACCTGGAGTCGGCCTCGGCGCGCC
AATCGCTGTACCTGCTGCGCACGGTGGAAATGCGCGCCAACCTGTTGCGCGCGGGCGCCGTGCTCGACAGCGCCGCGCTC
GACAAGTACAGTTTCACGCGCGATGTGTTCCTGCAGGTGCGCGGCCAAGCCGCCGAGGCCAACGGCATGGATGACGAGGA
CGCCGACAACCCATCCAGCGAGGGCATGTTGCCCGAAGAGCCTTGA

Upstream 100 bases:

>100_bases
CGGCAGGCGACACGGTCACCGCAACCCAGTCCGCCGTGGTGCTGGAAAACCTGATCGGACAATTTCTTTACGGCAAAGCC
GCTGGAACGGGCGACAAAAA

Downstream 100 bases:

>100_bases
AGGCCAAAACCATGAGACCCGTGACCATGATGAACCGACGTTTCCCGGGGCCTGTGGCTCTTGGCCTGACCCTTTCCTGG
GTCTTTTCCTGGGCCCTTTT

Product: VacJ family lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MTHSNLAAHGGCTARQTALSDALRQTVPSGAPRWTALPGISRWVVLLGAAVLAGCATVAQPDPRDPLQGYNRSMAQFNEH
LDTMVLKPVATAYREVTPAPVRTGVSNFFANIGDIWSFVNNLLQLRGEAAAASFMRVNVNTFLGLGGLLDIASELNIERH
KQDFGLTLGHWGVGTGPYLVLPLLGPSTLRDSLALSVDIRGNALHHLESASARQSLYLLRTVEMRANLLRAGAVLDSAAL
DKYSFTRDVFLQVRGQAAEANGMDDEDADNPSSEGMLPEEP

Sequences:

>Translated_281_residues
MTHSNLAAHGGCTARQTALSDALRQTVPSGAPRWTALPGISRWVVLLGAAVLAGCATVAQPDPRDPLQGYNRSMAQFNEH
LDTMVLKPVATAYREVTPAPVRTGVSNFFANIGDIWSFVNNLLQLRGEAAAASFMRVNVNTFLGLGGLLDIASELNIERH
KQDFGLTLGHWGVGTGPYLVLPLLGPSTLRDSLALSVDIRGNALHHLESASARQSLYLLRTVEMRANLLRAGAVLDSAAL
DKYSFTRDVFLQVRGQAAEANGMDDEDADNPSSEGMLPEEP
>Mature_280_residues
THSNLAAHGGCTARQTALSDALRQTVPSGAPRWTALPGISRWVVLLGAAVLAGCATVAQPDPRDPLQGYNRSMAQFNEHL
DTMVLKPVATAYREVTPAPVRTGVSNFFANIGDIWSFVNNLLQLRGEAAAASFMRVNVNTFLGLGGLLDIASELNIERHK
QDFGLTLGHWGVGTGPYLVLPLLGPSTLRDSLALSVDIRGNALHHLESASARQSLYLLRTVEMRANLLRAGAVLDSAALD
KYSFTRDVFLQVRGQAAEANGMDDEDADNPSSEGMLPEEP

Specific function: Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane [H]

COG id: COG2853

COG function: function code M; Surface lipoprotein

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mlaA family [H]

Homologues:

Organism=Escherichia coli, GI1788688, Length=236, Percent_Identity=35.5932203389831, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007428 [H]

Pfam domain/function: PF04333 VacJ [H]

EC number: NA

Molecular weight: Translated: 30158; Mature: 30026

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHSNLAAHGGCTARQTALSDALRQTVPSGAPRWTALPGISRWVVLLGAAVLAGCATVAQ
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
PDPRDPLQGYNRSMAQFNEHLDTMVLKPVATAYREVTPAPVRTGVSNFFANIGDIWSFVN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
NLLQLRGEAAAASFMRVNVNTFLGLGGLLDIASELNIERHKQDFGLTLGHWGVGTGPYLV
HHHHHCCHHHHHHHHEEEHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEECCCCCCCCEEE
LPLLGPSTLRDSLALSVDIRGNALHHLESASARQSLYLLRTVEMRANLLRAGAVLDSAAL
EECCCCHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKYSFTRDVFLQVRGQAAEANGMDDEDADNPSSEGMLPEEP
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
THSNLAAHGGCTARQTALSDALRQTVPSGAPRWTALPGISRWVVLLGAAVLAGCATVAQ
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
PDPRDPLQGYNRSMAQFNEHLDTMVLKPVATAYREVTPAPVRTGVSNFFANIGDIWSFVN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
NLLQLRGEAAAASFMRVNVNTFLGLGGLLDIASELNIERHKQDFGLTLGHWGVGTGPYLV
HHHHHCCHHHHHHHHEEEHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEECCCCCCCCEEE
LPLLGPSTLRDSLALSVDIRGNALHHLESASARQSLYLLRTVEMRANLLRAGAVLDSAAL
EECCCCHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKYSFTRDVFLQVRGQAAEANGMDDEDADNPSSEGMLPEEP
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]