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The map label for this gene is mlaD [H]

Identifier: 121609356

GI number: 121609356

Start: 2717245

End: 2717715

Strand: Direct

Name: mlaD [H]

Synonym: Veis_2399

Alternate gene names: 121609356

Gene position: 2717245-2717715 (Clockwise)

Preceding gene: 121609355

Following gene: 121609357

Centisome position: 48.81

GC content: 60.08

Gene sequence:

>471_bases
ATGCAACGCTCGAAAAATGATCTGTGGGTAGGCCTGTTCGTACTTCTGGGGGTGCTGGCGCTGGTATTTCTGGCGCTGCA
ATCGGCCAATTTGCTGAGCCTGCAATGGCAATCGGGCTACCGCATCACGGCCCGCTTCGACAACATCGGCGGGCTCAAGC
CCCAGGCGGCAGTGCGCAGCGCCGGTGTGCTGGTCGGGCGCGTGCAAGACATTGCCTTCGATGACAAAAGCTACCAGGCC
CGGGTCACGCTGGAAATGCAAAAGCGCTACATGTTCCCCAAGGACAGCTCGCTGAAAATCCTCACCAGCGGCCTGCTCGG
CGAGCAATACATCGGCATCGAAGCCGGGGCGCACGAGCAGAACCTGGCGGCAGGCGACACGGTCACCGCAACCCAGTCCG
CCGTGGTGCTGGAAAACCTGATCGGACAATTTCTTTACGGCAAAGCCGCTGGAACGGGCGACAAAAAATGA

Upstream 100 bases:

>100_bases
GGTGGTGCTGGCCTCGCTGGCCGTGCTGGCGCTGGACTTCATCCTCACGGCCCTGATGTTCAGTTGGTGAGACACTGGCA
AGTGCAGAAAGCAACGACAA

Downstream 100 bases:

>100_bases
CGCACTCAAACCTCGCGGCACATGGGGGTTGCACAGCACGGCAGACCGCGCTGTCAGATGCCTTGCGGCAGACCGTGCCG
TCCGGCGCCCCACGGTGGAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MQRSKNDLWVGLFVLLGVLALVFLALQSANLLSLQWQSGYRITARFDNIGGLKPQAAVRSAGVLVGRVQDIAFDDKSYQA
RVTLEMQKRYMFPKDSSLKILTSGLLGEQYIGIEAGAHEQNLAAGDTVTATQSAVVLENLIGQFLYGKAAGTGDKK

Sequences:

>Translated_156_residues
MQRSKNDLWVGLFVLLGVLALVFLALQSANLLSLQWQSGYRITARFDNIGGLKPQAAVRSAGVLVGRVQDIAFDDKSYQA
RVTLEMQKRYMFPKDSSLKILTSGLLGEQYIGIEAGAHEQNLAAGDTVTATQSAVVLENLIGQFLYGKAAGTGDKK
>Mature_156_residues
MQRSKNDLWVGLFVLLGVLALVFLALQSANLLSLQWQSGYRITARFDNIGGLKPQAAVRSAGVLVGRVQDIAFDDKSYQA
RVTLEMQKRYMFPKDSSLKILTSGLLGEQYIGIEAGAHEQNLAAGDTVTATQSAVVLENLIGQFLYGKAAGTGDKK

Specific function: Part of the ABC transporter complex mlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner memb

COG id: COG1463

COG function: function code Q; ABC-type transport system involved in resistance to organic solvents, periplasmic component

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mlaD family [H]

Homologues:

Organism=Escherichia coli, GI1789584, Length=153, Percent_Identity=50.9803921568627, Blast_Score=147, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003399 [H]

Pfam domain/function: PF02470 MCE [H]

EC number: NA

Molecular weight: Translated: 16907; Mature: 16907

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRSKNDLWVGLFVLLGVLALVFLALQSANLLSLQWQSGYRITARFDNIGGLKPQAAVRS
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHH
AGVLVGRVQDIAFDDKSYQARVTLEMQKRYMFPKDSSLKILTSGLLGEQYIGIEAGAHEQ
CCEEEEEHHHEEECCCCCEEEEEEEEHHHCCCCCCCCHHEEECCCCCCEEEEEECCCCCC
NLAAGDTVTATQSAVVLENLIGQFLYGKAAGTGDKK
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MQRSKNDLWVGLFVLLGVLALVFLALQSANLLSLQWQSGYRITARFDNIGGLKPQAAVRS
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHH
AGVLVGRVQDIAFDDKSYQARVTLEMQKRYMFPKDSSLKILTSGLLGEQYIGIEAGAHEQ
CCEEEEEHHHEEECCCCCEEEEEEEEHHHCCCCCCCCHHEEECCCCCCEEEEEECCCCCC
NLAAGDTVTATQSAVVLENLIGQFLYGKAAGTGDKK
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]