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The map label for this gene is maeB [H]

Identifier: 120613386

GI number: 120613386

Start: 5306928

End: 5309240

Strand: Direct

Name: maeB [H]

Synonym: Aave_4759

Alternate gene names: 120613386

Gene position: 5306928-5309240 (Clockwise)

Preceding gene: 120613383

Following gene: 120613387

Centisome position: 99.14

GC content: 67.62

Gene sequence:

>2313_bases
ATGTCCGATACCCCCCCGGTCAACACCACGCCTGACAAACGCGCCCTGCTGCGCCAAGCGGCCCTCGAATACCACGAGTT
TCCGAAACCGGGAAAGATCGCCATCGCCGCCACCAAGCAGATGGTCAACCAGCACGATCTGGCGCTGGCCTACTCGCCGG
GCGTGGCAGCGCCCTGCGAGGAGATCGTCAAGGACCCCGCCGCCGCCTTCCGCTACACGTCGCGCGGCAACCTCGTGGGC
GTGATCTCCAACGGCACGGCGGTGCTGGGCCTGGGCGACATCGGCGCACTGGCCTCCAAGCCCGTCATGGAAGGCAAGGC
CGTCCTGTTCAAGAAGTTCGCCGGCGTCGATGTCTTCGACATCGAGATCAACGAGAAGGACCCGGCCAAGCTCGTCGAGG
TCATCGCCGCCCTGGAACCCACCTTCGGCGCCATCAACCTCGAGGACATCAAGGCCCCCGACTGCTTCTACGTCGAGCGC
GAACTGCGCAAGCGCCTGAACATCCCCGTCTTCCATGACGACCAGCACGGCACGGCCATCACCGTGGCGGCGGCCATGCT
CAACGCCCTGAAGGTGGTGGGCAAGGACATCGGCGAGGTGCGCCTGGTCACCTCCGGCGCGGGCGCCGCCGCGCTCGCCT
GCCTGAACCTGCTGCTGAAGGTGGGTCTCAAGCGCGAGAACGTGTTCGTCACCGACCTGGCCGGCGTGGTCTATGAAGGC
CGCACCGAGCTGATGGACGAGGACAAGATCCAGTTCGCCCAGAAGACCGACGCCCGCACCCTGGCCGAAGTCATCGAAGG
CGCCGACGTGTTCCTGGGCCTGTCGGCCGGCGGCGTGCTCAAGCCCGCCATGGTGGCGAAGATGGCGGCGCGCCCGGTCA
TCTTCGCGCTGGCCAACCCCAACCCGGAAATCACGCCCGAGGACGCCCACGCCGTGCGCGGCGACGTGGTGATGGCCACC
GGCCGCACCGACTACCCGAACCAGGTCAACAACGTCCTGTGCTTCCCCTACATTTTCCGCGGTGCGCTCGACTGCGGCGC
CACGACCATCACGCTGGAGATGGAGATCGCCGCGGTGCATGCCATCGCCGAGCTGGCCCAGGCCGAGCAGAGCGAGGTGG
TGGCCGCGGCCTACGTGGGCGAGCCCCTGGCCTTCGGTCCCGAATACCTGATCCCGAAGCCGTTCGATCCGCGGCTGATG
ATCAAGATCGCGCCGGCCGTGGCCCAGGCCGCCGCCGACAGCGGCGTGGCCCAGCGCCCCATCGCCGACATGGACGCCTA
CCGCGACCACCTGCAGACCTTCGTCTATGCCTCCGGCACGATGATGAAGCCCATCGTCAATGCCGCCAAGCTGGCCGCCA
GGAAGCGGGTGGCCTACGCCGAGGGCGAGGAAGAGCGCGTGCTGCGCGCCGCCCAGATCGTGGTGGACGAGAAGATCGCC
CGCCCCACCCTGATCGGCCGCCCGGCCATCATCGCCCAGCGCGTCGAGAAGTTCGGCCTGCGCCTGAAGGAAGGCGTGGA
CTACGACGTGGTCAACGTCGAGAACGACCACCGCTACCGCGACTTCTGGCAGACCTACCACCGCATGACCGAGCGCAAGG
GCATCACCGTGCCCATCGCCAAGATCGAGATGCGCCGCCGCCTGGCGCTGATCGCCTCCATGCTGCTGCACAAGGGCGAG
GTGGACGGCATGATCTGCGGCACCTGGGGGCACACCGCGCACCACCTGAACTACATCGACCAGGTGATCGGCAAGCGCGC
CGGCGTGAACACCTACGCCTGCATGAACGGCCTGTTGCTGCCCGACCGCCAGGTGTTCCTGGTGGACACGCACGTCAACT
ACGACCCCACGGCCGAACAGCTGGCGGAGATCACCGTGATGGCGGCCGAGGAAATGATGCGCTTCGGCATCAAGCCCAAG
GCGGCATTGCTGTCGCACTCCAACTTCGGCTCCAGCACCCAGCCCAGCGCGGTGAAGATGCGGCAGACGCTGGAACTGCT
GCGGGTGCAGGCTCCCTGGCTCGAAGTGGACGGCGAGATGCACGGCGACGTGGCGCTGGACGCCGCGCTGCGCACCCAGG
TCATGCCGCACAGCACGCTGGCCGGAAGCGCCAACCTGCTGGTGCTGCCCAACATCGATGCGGCCAACATCTCCTACAAC
CTGCTCAAGACGGCGGCCGGCGGCGGCATCGCCATCGGCCCCGTGCTGCTCGGCGCGTCCGAGCCGGTGCACATCCTCAC
GGCCAGCGCGACCGTACGGCGCATCGTCAATATGACAGCGCTCACGGTGGCGGACGCCAACGCCGCTCGCTGA

Upstream 100 bases:

>100_bases
CAGGCTGACTACAATCTCACACCCTAAAACGCCGGCCCGCCCTGGAGCGCCCGCTTCCTGGCGAGGTCCGGCAGCCCTTC
ACAGAGCTGGAGACCCCTTG

Downstream 100 bases:

>100_bases
CCGGCTCGGCCATAGCGAGCGCTAACTTTAAGAGGCTCCGAACCCCTCCGGCGCCTGCTCAATTATTGAGCAGGCGCTTG
CTTTTTGGGGGTCTTTACGT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 770; Mature: 769

Protein sequence:

>770_residues
MSDTPPVNTTPDKRALLRQAALEYHEFPKPGKIAIAATKQMVNQHDLALAYSPGVAAPCEEIVKDPAAAFRYTSRGNLVG
VISNGTAVLGLGDIGALASKPVMEGKAVLFKKFAGVDVFDIEINEKDPAKLVEVIAALEPTFGAINLEDIKAPDCFYVER
ELRKRLNIPVFHDDQHGTAITVAAAMLNALKVVGKDIGEVRLVTSGAGAAALACLNLLLKVGLKRENVFVTDLAGVVYEG
RTELMDEDKIQFAQKTDARTLAEVIEGADVFLGLSAGGVLKPAMVAKMAARPVIFALANPNPEITPEDAHAVRGDVVMAT
GRTDYPNQVNNVLCFPYIFRGALDCGATTITLEMEIAAVHAIAELAQAEQSEVVAAAYVGEPLAFGPEYLIPKPFDPRLM
IKIAPAVAQAAADSGVAQRPIADMDAYRDHLQTFVYASGTMMKPIVNAAKLAARKRVAYAEGEEERVLRAAQIVVDEKIA
RPTLIGRPAIIAQRVEKFGLRLKEGVDYDVVNVENDHRYRDFWQTYHRMTERKGITVPIAKIEMRRRLALIASMLLHKGE
VDGMICGTWGHTAHHLNYIDQVIGKRAGVNTYACMNGLLLPDRQVFLVDTHVNYDPTAEQLAEITVMAAEEMMRFGIKPK
AALLSHSNFGSSTQPSAVKMRQTLELLRVQAPWLEVDGEMHGDVALDAALRTQVMPHSTLAGSANLLVLPNIDAANISYN
LLKTAAGGGIAIGPVLLGASEPVHILTASATVRRIVNMTALTVADANAAR

Sequences:

>Translated_770_residues
MSDTPPVNTTPDKRALLRQAALEYHEFPKPGKIAIAATKQMVNQHDLALAYSPGVAAPCEEIVKDPAAAFRYTSRGNLVG
VISNGTAVLGLGDIGALASKPVMEGKAVLFKKFAGVDVFDIEINEKDPAKLVEVIAALEPTFGAINLEDIKAPDCFYVER
ELRKRLNIPVFHDDQHGTAITVAAAMLNALKVVGKDIGEVRLVTSGAGAAALACLNLLLKVGLKRENVFVTDLAGVVYEG
RTELMDEDKIQFAQKTDARTLAEVIEGADVFLGLSAGGVLKPAMVAKMAARPVIFALANPNPEITPEDAHAVRGDVVMAT
GRTDYPNQVNNVLCFPYIFRGALDCGATTITLEMEIAAVHAIAELAQAEQSEVVAAAYVGEPLAFGPEYLIPKPFDPRLM
IKIAPAVAQAAADSGVAQRPIADMDAYRDHLQTFVYASGTMMKPIVNAAKLAARKRVAYAEGEEERVLRAAQIVVDEKIA
RPTLIGRPAIIAQRVEKFGLRLKEGVDYDVVNVENDHRYRDFWQTYHRMTERKGITVPIAKIEMRRRLALIASMLLHKGE
VDGMICGTWGHTAHHLNYIDQVIGKRAGVNTYACMNGLLLPDRQVFLVDTHVNYDPTAEQLAEITVMAAEEMMRFGIKPK
AALLSHSNFGSSTQPSAVKMRQTLELLRVQAPWLEVDGEMHGDVALDAALRTQVMPHSTLAGSANLLVLPNIDAANISYN
LLKTAAGGGIAIGPVLLGASEPVHILTASATVRRIVNMTALTVADANAAR
>Mature_769_residues
SDTPPVNTTPDKRALLRQAALEYHEFPKPGKIAIAATKQMVNQHDLALAYSPGVAAPCEEIVKDPAAAFRYTSRGNLVGV
ISNGTAVLGLGDIGALASKPVMEGKAVLFKKFAGVDVFDIEINEKDPAKLVEVIAALEPTFGAINLEDIKAPDCFYVERE
LRKRLNIPVFHDDQHGTAITVAAAMLNALKVVGKDIGEVRLVTSGAGAAALACLNLLLKVGLKRENVFVTDLAGVVYEGR
TELMDEDKIQFAQKTDARTLAEVIEGADVFLGLSAGGVLKPAMVAKMAARPVIFALANPNPEITPEDAHAVRGDVVMATG
RTDYPNQVNNVLCFPYIFRGALDCGATTITLEMEIAAVHAIAELAQAEQSEVVAAAYVGEPLAFGPEYLIPKPFDPRLMI
KIAPAVAQAAADSGVAQRPIADMDAYRDHLQTFVYASGTMMKPIVNAAKLAARKRVAYAEGEEERVLRAAQIVVDEKIAR
PTLIGRPAIIAQRVEKFGLRLKEGVDYDVVNVENDHRYRDFWQTYHRMTERKGITVPIAKIEMRRRLALIASMLLHKGEV
DGMICGTWGHTAHHLNYIDQVIGKRAGVNTYACMNGLLLPDRQVFLVDTHVNYDPTAEQLAEITVMAAEEMMRFGIKPKA
ALLSHSNFGSSTQPSAVKMRQTLELLRVQAPWLEVDGEMHGDVALDAALRTQVMPHSTLAGSANLLVLPNIDAANISYNL
LKTAAGGGIAIGPVLLGASEPVHILTASATVRRIVNMTALTVADANAAR

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=395, Percent_Identity=26.0759493670886, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI62420882, Length=345, Percent_Identity=27.8260869565217, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI62420880, Length=345, Percent_Identity=27.8260869565217, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI239049447, Length=345, Percent_Identity=27.8260869565217, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI4505145, Length=408, Percent_Identity=26.2254901960784, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI270265879, Length=370, Percent_Identity=26.7567567567568, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1788806, Length=752, Percent_Identity=60.5053191489362, Blast_Score=935, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=310, Percent_Identity=31.2903225806452, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788800, Length=313, Percent_Identity=31.3099041533546, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081919, Length=494, Percent_Identity=24.4939271255061, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17537199, Length=352, Percent_Identity=26.1363636363636, Blast_Score=75, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322823, Length=347, Percent_Identity=26.5129682997118, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281362672, Length=404, Percent_Identity=26.7326732673267, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281362674, Length=404, Percent_Identity=26.7326732673267, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21356279, Length=404, Percent_Identity=26.7326732673267, Blast_Score=97, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24646388, Length=349, Percent_Identity=29.512893982808, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24646386, Length=349, Percent_Identity=29.512893982808, Blast_Score=90, Evalue=7e-18,
Organism=Drosophila melanogaster, GI78707242, Length=350, Percent_Identity=25.7142857142857, Blast_Score=81, Evalue=3e-15,
Organism=Drosophila melanogaster, GI78707238, Length=350, Percent_Identity=25.7142857142857, Blast_Score=81, Evalue=3e-15,
Organism=Drosophila melanogaster, GI78707240, Length=350, Percent_Identity=25.7142857142857, Blast_Score=80, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 83024; Mature: 82893

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTPPVNTTPDKRALLRQAALEYHEFPKPGKIAIAATKQMVNQHDLALAYSPGVAAPCE
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCCEEEEECCCCCCCHH
EIVKDPAAAFRYTSRGNLVGVISNGTAVLGLGDIGALASKPVMEGKAVLFKKFAGVDVFD
HHHCCCHHHEEECCCCCEEEEEECCEEEEEECCHHHHHCCCCCCCHHHHHHHHCCCEEEE
IEINEKDPAKLVEVIAALEPTFGAINLEDIKAPDCFYVERELRKRLNIPVFHDDQHGTAI
EEECCCCHHHHHHHHHHHCCCCCCEEHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCHH
TVAAAMLNALKVVGKDIGEVRLVTSGAGAAALACLNLLLKVGLKRENVFVTDLAGVVYEG
HHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEHHHHHCCC
RTELMDEDKIQFAQKTDARTLAEVIEGADVFLGLSAGGVLKPAMVAKMAARPVIFALANP
CHHHCCCHHHHHHHHCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECC
NPEITPEDAHAVRGDVVMATGRTDYPNQVNNVLCFPYIFRGALDCGATTITLEMEIAAVH
CCCCCCCHHHHCCCCEEEEECCCCCCHHHCCEEEHHHHHHHHHHCCCEEEEEEEHHHHHH
AIAELAQAEQSEVVAAAYVGEPLAFGPEYLIPKPFDPRLMIKIAPAVAQAAADSGVAQRP
HHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHCCCCCCCC
IADMDAYRDHLQTFVYASGTMMKPIVNAAKLAARKRVAYAEGEEERVLRAAQIVVDEKIA
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
RPTLIGRPAIIAQRVEKFGLRLKEGVDYDVVNVENDHRYRDFWQTYHRMTERKGITVPIA
CCCCCCCHHHHHHHHHHHCCCHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEHH
KIEMRRRLALIASMLLHKGEVDGMICGTWGHTAHHLNYIDQVIGKRAGVNTYACMNGLLL
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCC
PDRQVFLVDTHVNYDPTAEQLAEITVMAAEEMMRFGIKPKAALLSHSNFGSSTQPSAVKM
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHHH
RQTLELLRVQAPWLEVDGEMHGDVALDAALRTQVMPHSTLAGSANLLVLPNIDAANISYN
HHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHH
LLKTAAGGGIAIGPVLLGASEPVHILTASATVRRIVNMTALTVADANAAR
HHHHCCCCCEEEEHEEECCCCCEEEEECHHHHHHHHHHHHEEEECCCCCC
>Mature Secondary Structure 
SDTPPVNTTPDKRALLRQAALEYHEFPKPGKIAIAATKQMVNQHDLALAYSPGVAAPCE
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCCEEEEECCCCCCCHH
EIVKDPAAAFRYTSRGNLVGVISNGTAVLGLGDIGALASKPVMEGKAVLFKKFAGVDVFD
HHHCCCHHHEEECCCCCEEEEEECCEEEEEECCHHHHHCCCCCCCHHHHHHHHCCCEEEE
IEINEKDPAKLVEVIAALEPTFGAINLEDIKAPDCFYVERELRKRLNIPVFHDDQHGTAI
EEECCCCHHHHHHHHHHHCCCCCCEEHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCHH
TVAAAMLNALKVVGKDIGEVRLVTSGAGAAALACLNLLLKVGLKRENVFVTDLAGVVYEG
HHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEHHHHHCCC
RTELMDEDKIQFAQKTDARTLAEVIEGADVFLGLSAGGVLKPAMVAKMAARPVIFALANP
CHHHCCCHHHHHHHHCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECC
NPEITPEDAHAVRGDVVMATGRTDYPNQVNNVLCFPYIFRGALDCGATTITLEMEIAAVH
CCCCCCCHHHHCCCCEEEEECCCCCCHHHCCEEEHHHHHHHHHHCCCEEEEEEEHHHHHH
AIAELAQAEQSEVVAAAYVGEPLAFGPEYLIPKPFDPRLMIKIAPAVAQAAADSGVAQRP
HHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHCCCCCCCC
IADMDAYRDHLQTFVYASGTMMKPIVNAAKLAARKRVAYAEGEEERVLRAAQIVVDEKIA
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
RPTLIGRPAIIAQRVEKFGLRLKEGVDYDVVNVENDHRYRDFWQTYHRMTERKGITVPIA
CCCCCCCHHHHHHHHHHHCCCHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEHH
KIEMRRRLALIASMLLHKGEVDGMICGTWGHTAHHLNYIDQVIGKRAGVNTYACMNGLLL
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCC
PDRQVFLVDTHVNYDPTAEQLAEITVMAAEEMMRFGIKPKAALLSHSNFGSSTQPSAVKM
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHHH
RQTLELLRVQAPWLEVDGEMHGDVALDAALRTQVMPHSTLAGSANLLVLPNIDAANISYN
HHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHH
LLKTAAGGGIAIGPVLLGASEPVHILTASATVRRIVNMTALTVADANAAR
HHHHCCCCCEEEEHEEECCCCCEEEEECHHHHHHHHHHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]