Click here to switch to the map view.

The map label for this gene is lrp [H]

Identifier: 120613125

GI number: 120613125

Start: 4989964

End: 4990500

Strand: Reverse

Name: lrp [H]

Synonym: Aave_4492

Alternate gene names: 120613125

Gene position: 4990500-4989964 (Counterclockwise)

Preceding gene: 120613129

Following gene: 120613123

Centisome position: 93.23

GC content: 70.58

Gene sequence:

>537_bases
ATGTGCGCAACAAAATTACGAAGGTCGAGTGCCGCCGCCGGGCTGCCTGCCGCTCCCCCGGCCCCGCCGCCAGCGGACAT
CGACCGCACGGACCGCGCCATCCTGCGGGCGCTGCAGCGCGACGCGTCCGTGTCGAACGTGGCGCTGGCCGCCAAGGTGC
ATCTCAGCCCGCCCGCCTGCCTGCGCCGCGTGGAGCGCCTGAAACGCCTGGGCCTGATCGAACGCACGGTCGCGCTGCTG
CATCCGCGCGCGGTGGGCGCGGGCATGCTGGTGATGATCGGCGTGGTGCTGGACCGCTCCACGCCCGAGTCCTTCGCGGC
GTTCGAGAAGGCCGCCGCGCAGATCTCGGGCTGCATGGAGTGCCACCTCGTGACGGGCGAGTTCGACTACTTCATGCTGG
TGCGCACGCGCGACAGCGACAGCTTCAACCGCCTGCACGCGGAGCAGCTGCTCTACCTGCCGGGCGTGCGGCAGGTGCGT
TCGTTCATGGCGCTGCGCAACGTGGTGTCCACCACGGAGCTGCCGCTGGCCATCTGA

Upstream 100 bases:

>100_bases
GAAAATGCGCGGGAAACAGGGTTGCAAATACGAGTGCCGAAGCATCCGTGGAATGCATGGATGGCTTCGGATTGTGGTTT
TTAATTTTGTGGAAATGATC

Downstream 100 bases:

>100_bases
CGGCAGCGGCGGGCCGCCGCCGCGCCGTCAGGGCTGGCGGACCATGTGCGGGTAGATCAGGCCGTAGCGGCCCGCCAGGC
CCGCCGCGACGCCGGGATTG

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MCATKLRRSSAAAGLPAAPPAPPPADIDRTDRAILRALQRDASVSNVALAAKVHLSPPACLRRVERLKRLGLIERTVALL
HPRAVGAGMLVMIGVVLDRSTPESFAAFEKAAAQISGCMECHLVTGEFDYFMLVRTRDSDSFNRLHAEQLLYLPGVRQVR
SFMALRNVVSTTELPLAI

Sequences:

>Translated_178_residues
MCATKLRRSSAAAGLPAAPPAPPPADIDRTDRAILRALQRDASVSNVALAAKVHLSPPACLRRVERLKRLGLIERTVALL
HPRAVGAGMLVMIGVVLDRSTPESFAAFEKAAAQISGCMECHLVTGEFDYFMLVRTRDSDSFNRLHAEQLLYLPGVRQVR
SFMALRNVVSTTELPLAI
>Mature_178_residues
MCATKLRRSSAAAGLPAAPPAPPPADIDRTDRAILRALQRDASVSNVALAAKVHLSPPACLRRVERLKRLGLIERTVALL
HPRAVGAGMLVMIGVVLDRSTPESFAAFEKAAAQISGCMECHLVTGEFDYFMLVRTRDSDSFNRLHAEQLLYLPGVRQVR
SFMALRNVVSTTELPLAI

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=152, Percent_Identity=41.4473684210526, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=28.6666666666667, Blast_Score=83, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 19357; Mature: 19357

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCATKLRRSSAAAGLPAAPPAPPPADIDRTDRAILRALQRDASVSNVALAAKVHLSPPAC
CCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHH
LRRVERLKRLGLIERTVALLHPRAVGAGMLVMIGVVLDRSTPESFAAFEKAAAQISGCME
HHHHHHHHHHHHHHHHHHHHCCHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHE
CHLVTGEFDYFMLVRTRDSDSFNRLHAEQLLYLPGVRQVRSFMALRNVVSTTELPLAI
EEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MCATKLRRSSAAAGLPAAPPAPPPADIDRTDRAILRALQRDASVSNVALAAKVHLSPPAC
CCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHH
LRRVERLKRLGLIERTVALLHPRAVGAGMLVMIGVVLDRSTPESFAAFEKAAAQISGCME
HHHHHHHHHHHHHHHHHHHHCCHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHE
CHLVTGEFDYFMLVRTRDSDSFNRLHAEQLLYLPGVRQVRSFMALRNVVSTTELPLAI
EEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]