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The map label for this gene is cbl [H]

Identifier: 120611825

GI number: 120611825

Start: 3495236

End: 3496177

Strand: Direct

Name: cbl [H]

Synonym: Aave_3166

Alternate gene names: 120611825

Gene position: 3495236-3496177 (Clockwise)

Preceding gene: 120611824

Following gene: 120611826

Centisome position: 65.3

GC content: 67.2

Gene sequence:

>942_bases
ATGAACCTGCACCAGTTCCGCTTCGTCCAGGAAGCCGCCCGCCGCAACCTCAACCTGACGGAGGCCGCCAAGGCGCTCCA
CACCTCGCAGCCCGGGGTGTCCAAGGCCATCATCGAACTGGAAGACGAGCTGGGCGTGGACATCTTCGCGCGCCACGGCA
AGCGGCTCAAGCGCATCACCGAGCCGGGGCAGCACGTGCTCAAGAGCATCGAGCTGATCATGCGCGAGGTGGGCAACCTC
AAGCGCATCGGCGAGCAGTTCAGCGCGCAGGACAGCGGCACGCTGAGCATCGCCACCACCCACACGCAGGCGCGCTACGT
GCTGCCGGTGCCGGTGGCGAAGCTGCGCGAGGCCTATCCCAAGGTGAACGTGAGCCTGCACCAGGCCACGCCGCACGAGG
TGGCGCGCATGGTGATCGACGAGGTGGCGGAAATCGGCATGGCCACCGAATCGCTCGCGGACTACCCGGACCTCGTCACC
CTGCCCTGCTACGAATGGCAGCACGTGCTGGTGATGCCCTCGGGCCATCCGCTGGCGCAGCAGGAGCGCATCAGCGTGGA
CGACATCGCCCACGAAGCCCTCATCACCTACCACCCCTCGTTCACGGGGCGCGGCAAGATCGACCAGGCCTTCGCCGCGC
GCAAGCTGCAGCCGCGCATCGTGCTGGAGGCCATCGACTCCGACGTGATCAAGACCTACGTGCGCCTGGGCCTGGGCGTG
GGCATCGTGGCCGAGATGGCCATGCGCGACGATCCGCTGGGTGACCTGGTGGTGCGCCCCGTGGGCCACCTGTTCGGACA
GAGCGTGGCGCGCGTGGCCTTCAAGCGCGGCGCCTACCTGCGCAACTTCGTCTATAAATTCGCGGAACTGCTCAGCGACC
GGCTGAACCGCGAACTCGTGGCCCGCGCGATGACCGGGCACGTGAACGACTACGAGCTTTGA

Upstream 100 bases:

>100_bases
CCGCCATGGCGGGCGGCGGTGCATTATTTTTGCGACCGGGTGACGCCGGTGGCTTAGACGATTGCCGCATAATCAAAAGA
ATCCTTAGCAGCAATCAGAT

Downstream 100 bases:

>100_bases
TTTCCTGCCTCCCACGCCCATGACCACCACCGCTGCCGCGCGCACGCCGGCCCTCCCCAGCAAGCTGCCCCAGGTGGGCA
CGACCATCTTTGCCGTGATG

Product: transcriptional regulator CysB-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MNLHQFRFVQEAARRNLNLTEAAKALHTSQPGVSKAIIELEDELGVDIFARHGKRLKRITEPGQHVLKSIELIMREVGNL
KRIGEQFSAQDSGTLSIATTHTQARYVLPVPVAKLREAYPKVNVSLHQATPHEVARMVIDEVAEIGMATESLADYPDLVT
LPCYEWQHVLVMPSGHPLAQQERISVDDIAHEALITYHPSFTGRGKIDQAFAARKLQPRIVLEAIDSDVIKTYVRLGLGV
GIVAEMAMRDDPLGDLVVRPVGHLFGQSVARVAFKRGAYLRNFVYKFAELLSDRLNRELVARAMTGHVNDYEL

Sequences:

>Translated_313_residues
MNLHQFRFVQEAARRNLNLTEAAKALHTSQPGVSKAIIELEDELGVDIFARHGKRLKRITEPGQHVLKSIELIMREVGNL
KRIGEQFSAQDSGTLSIATTHTQARYVLPVPVAKLREAYPKVNVSLHQATPHEVARMVIDEVAEIGMATESLADYPDLVT
LPCYEWQHVLVMPSGHPLAQQERISVDDIAHEALITYHPSFTGRGKIDQAFAARKLQPRIVLEAIDSDVIKTYVRLGLGV
GIVAEMAMRDDPLGDLVVRPVGHLFGQSVARVAFKRGAYLRNFVYKFAELLSDRLNRELVARAMTGHVNDYEL
>Mature_313_residues
MNLHQFRFVQEAARRNLNLTEAAKALHTSQPGVSKAIIELEDELGVDIFARHGKRLKRITEPGQHVLKSIELIMREVGNL
KRIGEQFSAQDSGTLSIATTHTQARYVLPVPVAKLREAYPKVNVSLHQATPHEVARMVIDEVAEIGMATESLADYPDLVT
LPCYEWQHVLVMPSGHPLAQQERISVDDIAHEALITYHPSFTGRGKIDQAFAARKLQPRIVLEAIDSDVIKTYVRLGLGV
GIVAEMAMRDDPLGDLVVRPVGHLFGQSVARVAFKRGAYLRNFVYKFAELLSDRLNRELVARAMTGHVNDYEL

Specific function: May be an accessory regulatory protein within the cys regulon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788296, Length=302, Percent_Identity=46.3576158940397, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI1787530, Length=312, Percent_Identity=42.3076923076923, Blast_Score=265, Evalue=2e-72,
Organism=Escherichia coli, GI157672245, Length=244, Percent_Identity=28.6885245901639, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789204, Length=245, Percent_Identity=28.1632653061224, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788887, Length=300, Percent_Identity=26.3333333333333, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790399, Length=305, Percent_Identity=25.2459016393443, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788481, Length=231, Percent_Identity=26.4069264069264, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI145693105, Length=249, Percent_Identity=24.4979919678715, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI2367136, Length=238, Percent_Identity=23.5294117647059, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34982; Mature: 34982

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLHQFRFVQEAARRNLNLTEAAKALHTSQPGVSKAIIELEDELGVDIFARHGKRLKRIT
CCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHCCHHHHHHC
EPGQHVLKSIELIMREVGNLKRIGEQFSAQDSGTLSIATTHTQARYVLPVPVAKLREAYP
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEECCCHHHHHHHCC
KVNVSLHQATPHEVARMVIDEVAEIGMATESLADYPDLVTLPCYEWQHVLVMPSGHPLAQ
CCCEEEECCCHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEECCCCCCEEEEECCCCCCCH
QERISVDDIAHEALITYHPSFTGRGKIDQAFAARKLQPRIVLEAIDSDVIKTYVRLGLGV
HHCCCHHHHHHHHHEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCH
GIVAEMAMRDDPLGDLVVRPVGHLFGQSVARVAFKRGAYLRNFVYKFAELLSDRLNRELV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARAMTGHVNDYEL
HHHHHCCCCCCCC
>Mature Secondary Structure
MNLHQFRFVQEAARRNLNLTEAAKALHTSQPGVSKAIIELEDELGVDIFARHGKRLKRIT
CCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHCCHHHHHHC
EPGQHVLKSIELIMREVGNLKRIGEQFSAQDSGTLSIATTHTQARYVLPVPVAKLREAYP
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEECCCHHHHHHHCC
KVNVSLHQATPHEVARMVIDEVAEIGMATESLADYPDLVTLPCYEWQHVLVMPSGHPLAQ
CCCEEEECCCHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEECCCCCCEEEEECCCCCCCH
QERISVDDIAHEALITYHPSFTGRGKIDQAFAARKLQPRIVLEAIDSDVIKTYVRLGLGV
HHCCCHHHHHHHHHEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCH
GIVAEMAMRDDPLGDLVVRPVGHLFGQSVARVAFKRGAYLRNFVYKFAELLSDRLNRELV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARAMTGHVNDYEL
HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8529872; 9097040; 9278503 [H]