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The map label for this gene is dhlA [H]

Identifier: 120611742

GI number: 120611742

Start: 3397881

End: 3399335

Strand: Reverse

Name: dhlA [H]

Synonym: Aave_3082

Alternate gene names: 120611742

Gene position: 3399335-3397881 (Counterclockwise)

Preceding gene: 120611743

Following gene: 120611741

Centisome position: 63.51

GC content: 76.63

Gene sequence:

>1455_bases
ATGGGCCCGCTAGCAGGCCTGGGCGCCGCTCCCGGCGGAGCGGACCGCCAGGCCGACGAGGCCTGGATGCGGATCGCGCT
GCAGGAGGCGGCGGAGGCCGCCGCGCGGGGGGAGATTCCCGTGGGCGCGGTGGTGGTGCGCGATGGCGAATTGGTCGCAC
GGGGGAGCAATGCACCCATTGCCGGCCACGATCCCACGGCGCACGCGGAGATCGTGGCGCTGCGGGCCGCGGCCGGGCGC
CTGGGCAACTACCGGCTCGACGGCTGCACGCTCTATGTGACGCTGGAACCCTGCGCCATGTGCAGCGGCGCCATGCTGCA
CGCCCGGCTGGACCGGGTGGTGTACGGCGCCCCCGACGCCAAGACCGGGGCGGCGGGTTCGGTGGTGGACCTGTTCGCGC
AGCCGGCACTGAACCACCACACGCGCATCGAGGGCGGCGTGCTGGCGCAGGAATGCGGCGCCCTGCTGAGCGGTTTCTTC
CAGTCGCGGCGCGAAGCCCGGCGCGCCCATGCGCGCGCCGCCCTTCCCCTGCGGGACGACGCGCTGCGCACGCCGGACGC
GCGCTTCGCCGGCCTGCCGGACTGGCCCTGGGACCCGCGCTATGTCAGCGACCTGCCGGCCCTGGCGGGCCTGCGCATGC
ACTACCTGGACGAGGGGCCGCGCGATGCGCCCCGCACCTGGCTGTGCGTGCACGGCACCGGCGGCTGGAGCTACCTGTTC
CGCCACATGCTGCCGGTCTGGCTGGCTGCCGGCGACCGCGTGGTGGCGCCCGACCTGATCGGGTTCGGCCGCAGCGACAA
GCCCAAGAAGGAAGCTGCGCACACGCTGCCCTGGCACCACCGCACGCTGGCCGAACTGGTGGAGCGGCTCGACCTGCGCC
GCACCGTGCTGGTCGCCCAGGGGGAGGGCGGCCTGCCGGGCATGGCACTGCCGGCCGCACCACCCGATGCCCTGCCGGAT
GCCGCCGGCCGGTTCACCGGGCTGCTGGCGATCAGTGCCTGGCTCCCCCCTGGCGACGGCGCGCCGCTGCCGCCGGGCCT
GGCCGCCTGGCGCAAAGCACTGGCCGCACGGCAGGCGGCGGTGCTGCGCCCGGGAGCCGCGCCGGGCCTGGATGCCGCTG
CCGCCGCGGCCTGCGAAGCGCCATTTCCCGATGCGGGCTACCGCGCCGCCCTGCGCGCCGGCCTCCGTTGGTTGCCCGCC
GTGCCGGATGCCGGATCGGCCGCCATCGTGCGCGCCGGCCGCGCCTTCTGGTCGGCGCCCGGGCGCCGCAGCGCGGTCGC
GGTGGGCGCGCGCGACGCGGCCTGGGGCGCTGCGGCCCTGATGGACGCGCGGGCGGTGCCGCCGTGGCCCGCGGGCGGGG
GGGAACCCTGGGTCTGGCCCGATGCCGGCCACCTGCTGCCGGAGCGCCACGGCGCGGAACTGGCGCGCCGCGCTGTGGAA
TACTTCCATCCATGA

Upstream 100 bases:

>100_bases
TCGCTCATGCAGCAGCCGCGGCCCATGCCGGACGACGAGGCGAAGTGAAGACATCCCCGCGCACCGGGTGCGGCCCTTCG
CTGGCCTGCGCCGGCCTCCC

Downstream 100 bases:

>100_bases
GCGGCGCACTGCAGACGCCGCCGGCAACGACCCTTTCCGCCCCCTTTTTTCCTGCCTTTGCCGGAGCGGGCCTGACGGCC
CGACGAGCCTTGTCCGAACA

Product: CMP/dCMP deaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MGPLAGLGAAPGGADRQADEAWMRIALQEAAEAAARGEIPVGAVVVRDGELVARGSNAPIAGHDPTAHAEIVALRAAAGR
LGNYRLDGCTLYVTLEPCAMCSGAMLHARLDRVVYGAPDAKTGAAGSVVDLFAQPALNHHTRIEGGVLAQECGALLSGFF
QSRREARRAHARAALPLRDDALRTPDARFAGLPDWPWDPRYVSDLPALAGLRMHYLDEGPRDAPRTWLCVHGTGGWSYLF
RHMLPVWLAAGDRVVAPDLIGFGRSDKPKKEAAHTLPWHHRTLAELVERLDLRRTVLVAQGEGGLPGMALPAAPPDALPD
AAGRFTGLLAISAWLPPGDGAPLPPGLAAWRKALAARQAAVLRPGAAPGLDAAAAAACEAPFPDAGYRAALRAGLRWLPA
VPDAGSAAIVRAGRAFWSAPGRRSAVAVGARDAAWGAAALMDARAVPPWPAGGGEPWVWPDAGHLLPERHGAELARRAVE
YFHP

Sequences:

>Translated_484_residues
MGPLAGLGAAPGGADRQADEAWMRIALQEAAEAAARGEIPVGAVVVRDGELVARGSNAPIAGHDPTAHAEIVALRAAAGR
LGNYRLDGCTLYVTLEPCAMCSGAMLHARLDRVVYGAPDAKTGAAGSVVDLFAQPALNHHTRIEGGVLAQECGALLSGFF
QSRREARRAHARAALPLRDDALRTPDARFAGLPDWPWDPRYVSDLPALAGLRMHYLDEGPRDAPRTWLCVHGTGGWSYLF
RHMLPVWLAAGDRVVAPDLIGFGRSDKPKKEAAHTLPWHHRTLAELVERLDLRRTVLVAQGEGGLPGMALPAAPPDALPD
AAGRFTGLLAISAWLPPGDGAPLPPGLAAWRKALAARQAAVLRPGAAPGLDAAAAAACEAPFPDAGYRAALRAGLRWLPA
VPDAGSAAIVRAGRAFWSAPGRRSAVAVGARDAAWGAAALMDARAVPPWPAGGGEPWVWPDAGHLLPERHGAELARRAVE
YFHP
>Mature_483_residues
GPLAGLGAAPGGADRQADEAWMRIALQEAAEAAARGEIPVGAVVVRDGELVARGSNAPIAGHDPTAHAEIVALRAAAGRL
GNYRLDGCTLYVTLEPCAMCSGAMLHARLDRVVYGAPDAKTGAAGSVVDLFAQPALNHHTRIEGGVLAQECGALLSGFFQ
SRREARRAHARAALPLRDDALRTPDARFAGLPDWPWDPRYVSDLPALAGLRMHYLDEGPRDAPRTWLCVHGTGGWSYLFR
HMLPVWLAAGDRVVAPDLIGFGRSDKPKKEAAHTLPWHHRTLAELVERLDLRRTVLVAQGEGGLPGMALPAAPPDALPDA
AGRFTGLLAISAWLPPGDGAPLPPGLAAWRKALAARQAAVLRPGAAPGLDAAAAAACEAPFPDAGYRAALRAGLRWLPAV
PDAGSAAIVRAGRAFWSAPGRRSAVAVGARDAAWGAAALMDARAVPPWPAGGGEPWVWPDAGHLLPERHGAELARRAVEY
FHP

Specific function: Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. Has a broad substrate specificity, which includes terminally mono- and di- c

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the haloalkane dehalogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=121, Percent_Identity=33.8842975206612, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI19923945, Length=69, Percent_Identity=49.2753623188406, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI145693172, Length=156, Percent_Identity=54.4871794871795, Blast_Score=171, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17554608, Length=97, Percent_Identity=42.2680412371134, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17541138, Length=151, Percent_Identity=34.4370860927152, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17555996, Length=79, Percent_Identity=46.8354430379747, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325319, Length=107, Percent_Identity=36.4485981308411, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355527, Length=147, Percent_Identity=36.734693877551, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.8.1.5 [H]

Molecular weight: Translated: 50782; Mature: 50651

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPLAGLGAAPGGADRQADEAWMRIALQEAAEAAARGEIPVGAVVVRDGELVARGSNAPI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCC
AGHDPTAHAEIVALRAAAGRLGNYRLDGCTLYVTLEPCAMCSGAMLHARLDRVVYGAPDA
CCCCCCCCHHHHHHHHHHCCCCCEEECCEEEEEEECHHHHHHHHHHHHHHHHHEECCCCC
KTGAAGSVVDLFAQPALNHHTRIEGGVLAQECGALLSGFFQSRREARRAHARAALPLRDD
CCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ALRTPDARFAGLPDWPWDPRYVSDLPALAGLRMHYLDEGPRDAPRTWLCVHGTGGWSYLF
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHH
RHMLPVWLAAGDRVVAPDLIGFGRSDKPKKEAAHTLPWHHRTLAELVERLDLRRTVLVAQ
HHHHHHHHHCCCCEECCHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEE
GEGGLPGMALPAAPPDALPDAAGRFTGLLAISAWLPPGDGAPLPPGLAAWRKALAARQAA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
VLRPGAAPGLDAAAAAACEAPFPDAGYRAALRAGLRWLPAVPDAGSAAIVRAGRAFWSAP
HCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHCCHHCCCCCCCCCHHHHHHCHHHHCCC
GRRSAVAVGARDAAWGAAALMDARAVPPWPAGGGEPWVWPDAGHLLPERHGAELARRAVE
CCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
YFHP
HCCC
>Mature Secondary Structure 
GPLAGLGAAPGGADRQADEAWMRIALQEAAEAAARGEIPVGAVVVRDGELVARGSNAPI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCC
AGHDPTAHAEIVALRAAAGRLGNYRLDGCTLYVTLEPCAMCSGAMLHARLDRVVYGAPDA
CCCCCCCCHHHHHHHHHHCCCCCEEECCEEEEEEECHHHHHHHHHHHHHHHHHEECCCCC
KTGAAGSVVDLFAQPALNHHTRIEGGVLAQECGALLSGFFQSRREARRAHARAALPLRDD
CCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ALRTPDARFAGLPDWPWDPRYVSDLPALAGLRMHYLDEGPRDAPRTWLCVHGTGGWSYLF
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHH
RHMLPVWLAAGDRVVAPDLIGFGRSDKPKKEAAHTLPWHHRTLAELVERLDLRRTVLVAQ
HHHHHHHHHCCCCEECCHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEE
GEGGLPGMALPAAPPDALPDAAGRFTGLLAISAWLPPGDGAPLPPGLAAWRKALAARQAA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
VLRPGAAPGLDAAAAAACEAPFPDAGYRAALRAGLRWLPAVPDAGSAAIVRAGRAFWSAP
HCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHCCHHCCCCCCCCCHHHHHHCHHHHCCC
GRRSAVAVGARDAAWGAAALMDARAVPPWPAGGGEPWVWPDAGHLLPERHGAELARRAVE
CCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
YFHP
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2687254; 4019411; 3398051; 2026135; 8355275; 8515812; 9790663; 10508409; 10393294 [H]