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The map label for this gene is hutC [H]

Identifier: 120611629

GI number: 120611629

Start: 3256841

End: 3257623

Strand: Reverse

Name: hutC [H]

Synonym: Aave_2966

Alternate gene names: 120611629

Gene position: 3257623-3256841 (Counterclockwise)

Preceding gene: 120611630

Following gene: 120611628

Centisome position: 60.86

GC content: 72.54

Gene sequence:

>783_bases
ATGAAGACGACCGCCCGCAAGCGCCCCTCCCGACCCGCCGGCCCGCCGGCCGCCGCCGAACCGGCGCTCGCCCTCTACCA
GCAGATCAAGGACCACATCGTGCGCAGGATCCAGGACGGATCGTGGCGCGCGGGCGACCGGCTTCCGTCGGAGAGCGAAC
TGGTGCAGCAGTTCGGCATGTCGCGCATGACCGTGAACCGCGCGCTGCGCGAGCTGGCGGAGCAGGGCCGCATCGTGCGC
GTGGCCGGCGTGGGCAGCTTCGTGGCGGAGGACAAGCCGCAGTCCACGCTGCTGCAGATCGCCAACCTCGCCAGCGAGAT
CCGGCAGCGCGGCCACGATTACCGCTGCGACGTGCTCGCGGTGGAGCGTGTCTCCGCGCCGCTGGACATCGCGGCCGCGC
TGGACCTGCGCACGGGCGAGTCGGTCTTCCACGCGGTCTGCGTGCACCGCGAGGACGGCGTCCCGGTGCAACTGGAAGAC
CGCTACGTGAACCCGCGCGCGGTGCCGCAGTTCGGCGCGCAGGACTTCACGCGGCTGCAGCCCTCCGAGTACCTGGTGCG
CAATGTGCCGTTCGACCAGATGGAGCACGTGGTGGATGCCGTGCTGCCCACGCCCGAGCAGGCGCGCCTGCTGGACATGG
CGGGAGGCGACCCGTGCCTGCTGCTCACGCGCCGGACCTGGACGCGGGGCATGCCGGTCACGCTGGTGCGCTGCCTGCAC
CCGGGCTCGCGCTACCGGCTCGGCAGCCGCATCCGGGCCGACGGCCATCCGCTCGTCGGGTGA

Upstream 100 bases:

>100_bases
AAGGCGCGGCTGACCGAGGAAATCCGGGCCGAATCCACGGCGGCCGAGGCGCATTGATGGGTGGCCGGCCATCGCGCGAT
GCGCTGCTAGAGTCCCGCGC

Downstream 100 bases:

>100_bases
GACACGTGAAAACCAGCCTGTATATACAAGTTGGTGATTCCGTGGTTCAATGCGCCCGCCGCCGAGAAAAACCGTCGGCC
CAGTTGTAGATTGACTTGTA

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MKTTARKRPSRPAGPPAAAEPALALYQQIKDHIVRRIQDGSWRAGDRLPSESELVQQFGMSRMTVNRALRELAEQGRIVR
VAGVGSFVAEDKPQSTLLQIANLASEIRQRGHDYRCDVLAVERVSAPLDIAAALDLRTGESVFHAVCVHREDGVPVQLED
RYVNPRAVPQFGAQDFTRLQPSEYLVRNVPFDQMEHVVDAVLPTPEQARLLDMAGGDPCLLLTRRTWTRGMPVTLVRCLH
PGSRYRLGSRIRADGHPLVG

Sequences:

>Translated_260_residues
MKTTARKRPSRPAGPPAAAEPALALYQQIKDHIVRRIQDGSWRAGDRLPSESELVQQFGMSRMTVNRALRELAEQGRIVR
VAGVGSFVAEDKPQSTLLQIANLASEIRQRGHDYRCDVLAVERVSAPLDIAAALDLRTGESVFHAVCVHREDGVPVQLED
RYVNPRAVPQFGAQDFTRLQPSEYLVRNVPFDQMEHVVDAVLPTPEQARLLDMAGGDPCLLLTRRTWTRGMPVTLVRCLH
PGSRYRLGSRIRADGHPLVG
>Mature_260_residues
MKTTARKRPSRPAGPPAAAEPALALYQQIKDHIVRRIQDGSWRAGDRLPSESELVQQFGMSRMTVNRALRELAEQGRIVR
VAGVGSFVAEDKPQSTLLQIANLASEIRQRGHDYRCDVLAVERVSAPLDIAAALDLRTGESVFHAVCVHREDGVPVQLED
RYVNPRAVPQFGAQDFTRLQPSEYLVRNVPFDQMEHVVDAVLPTPEQARLLDMAGGDPCLLLTRRTWTRGMPVTLVRCLH
PGSRYRLGSRIRADGHPLVG

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=200, Percent_Identity=30, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI87082252, Length=204, Percent_Identity=25.4901960784314, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1790118, Length=139, Percent_Identity=26.6187050359712, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 28922; Mature: 28922

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTARKRPSRPAGPPAAAEPALALYQQIKDHIVRRIQDGSWRAGDRLPSESELVQQFGM
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCC
SRMTVNRALRELAEQGRIVRVAGVGSFVAEDKPQSTLLQIANLASEIRQRGHDYRCDVLA
HHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
VERVSAPLDIAAALDLRTGESVFHAVCVHREDGVPVQLEDRYVNPRAVPQFGAQDFTRLQ
HHHHCCCHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCC
PSEYLVRNVPFDQMEHVVDAVLPTPEQARLLDMAGGDPCLLLTRRTWTRGMPVTLVRCLH
HHHHHHHCCCHHHHHHHHHHHCCCCCHHHEEECCCCCCEEEEEECCCCCCCHHHHHHHHC
PGSRYRLGSRIRADGHPLVG
CCCCCCCCCEECCCCCCCCC
>Mature Secondary Structure
MKTTARKRPSRPAGPPAAAEPALALYQQIKDHIVRRIQDGSWRAGDRLPSESELVQQFGM
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCC
SRMTVNRALRELAEQGRIVRVAGVGSFVAEDKPQSTLLQIANLASEIRQRGHDYRCDVLA
HHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
VERVSAPLDIAAALDLRTGESVFHAVCVHREDGVPVQLEDRYVNPRAVPQFGAQDFTRLQ
HHHHCCCHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCC
PSEYLVRNVPFDQMEHVVDAVLPTPEQARLLDMAGGDPCLLLTRRTWTRGMPVTLVRCLH
HHHHHHHCCCHHHHHHHHHHHCCCCCHHHEEECCCCCCEEEEEECCCCCCCHHHHHHHHC
PGSRYRLGSRIRADGHPLVG
CCCCCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]