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The map label for this gene is hutI

Identifier: 120611624

GI number: 120611624

Start: 3250673

End: 3251923

Strand: Reverse

Name: hutI

Synonym: Aave_2961

Alternate gene names: 120611624

Gene position: 3251923-3250673 (Counterclockwise)

Preceding gene: 120611625

Following gene: 120611623

Centisome position: 60.75

GC content: 72.02

Gene sequence:

>1251_bases
ATGCAGCCTACACCTTTTTCTTCCCTGTCCAGCGCCGACGGCTGCTGGACCGGCCTGCGGCTGGCGCAAGGCCTTTTCAT
CCCTGACGTGGCCGTGCCCGACGATGCCCTGTCCTGCGTCGTGGTGCAGGGCGGCACCGTGCGCTGGGTCGGACCCGTGG
CCGCCGTGCCGCCGGCCTTCGCCGCGCTGCCCCGCCATGCGGGTGGGGGCGCCCTGGCCACGCCCGGCCTTGTGGATTGC
CACACCCACCTCGTCTATGGCGGCCACCGCGCCAACGAATTCGCCATGCGGCTGGCCGGAGCCAGCTACGAAGAGGTCGC
CCGGGCCGGCGGAGGCATCGTCTCCTCCGTGAAAGCCACGCGCGCCGCTTCGGAAGACGAACTGTTCGCGCAGGCCCTGC
CGCGGCTTCAGGCGCTGCTGGACGAGGGCGTGTGCGCCATCGAGATCAAATCCGGCTACGGCCTGGCGCTGGAGCACGAG
CGCAAGCAGCTGCGCGCCGCGCGGCGGCTGGGCGAGGCCTGCGGCGTCACCGTGCGCACCACCTTCCTGGGCGCGCATGC
GCTGCCACCGGAATACGCCGGCCGCAGCCAGGACTACATCGATCTGGTCTGCCGCGAGATGCTTCCCGCGCTGGCCGAAG
AAGGCCTGGTGGACGCGGTGGACGTGTTCTGCGAGCGCATCGCCTTCAGCCTGGCCGAGACCGAGCAGGTCTTCCAGGCC
GCCCAGGCGCTGGGCCTGCCCGTCAAGCTGCATGCCGAGCAGCTCTCCGACATGGATGGCGCCCGGCTCGCTGCGCGCTA
CGGCGCGCTGTCGTGCGACCACATCGAGCACCTGTCCGCCGAAGGCATCGCCGCGATGAAGGCAGCCGGCACGGTGGCCG
TGCTGCTGCCCGGCGCCTACTACACATTGCGCGACACCCACCTGCCGCCCATCCAGGCGCTGCGCGAGGCGGGCGTGCCC
ATGGCCGTCTCCACCGACCACAACCCCGGCACCTCGCCCGCCCTGAGCCTGCGGCTCATGGCCAACATGGCCTGCACGCT
GTTCCGGCTGACGGTGCCCGAGGCCCTGGCCGGCATCACCACCCATGCCGCGCGCGCCCTGGGCCTGCAGGACACGCACG
GCCTCATCGCCGCCGGCCGGCCGGCCGACTTCGTGCTCTGGCCCTTCGCCGAAGCGGCCGAGCTGGCCTACTGGTTCGGC
CACCAGCCGCCGCAGGCGATCGTCCGGCAGGGCAGGGTGGTGCAGCGATGA

Upstream 100 bases:

>100_bases
TGGCCTGGATCGGCCTGGCGCCGGACGCCGGAGCGGCCCCCGCGCCGGCCCTGCAGCACTCTTGATGGAACGGAGCGCCG
CGCGCTCCAGAGGGAATCCC

Downstream 100 bases:

>100_bases
CCGGCCAGACTTTCCACTCCGGCGGCGGCGCGCTCTTCGCCGCACAGGCGCTGCTGCCCGGCGGCTGGGCAAGGGACGTG
CTGCTGCGCTGGAACGAACA

Product: imidazolonepropionase

Products: NA

Alternate protein names: Imidazolone-5-propionate hydrolase

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MQPTPFSSLSSADGCWTGLRLAQGLFIPDVAVPDDALSCVVVQGGTVRWVGPVAAVPPAFAALPRHAGGGALATPGLVDC
HTHLVYGGHRANEFAMRLAGASYEEVARAGGGIVSSVKATRAASEDELFAQALPRLQALLDEGVCAIEIKSGYGLALEHE
RKQLRAARRLGEACGVTVRTTFLGAHALPPEYAGRSQDYIDLVCREMLPALAEEGLVDAVDVFCERIAFSLAETEQVFQA
AQALGLPVKLHAEQLSDMDGARLAARYGALSCDHIEHLSAEGIAAMKAAGTVAVLLPGAYYTLRDTHLPPIQALREAGVP
MAVSTDHNPGTSPALSLRLMANMACTLFRLTVPEALAGITTHAARALGLQDTHGLIAAGRPADFVLWPFAEAAELAYWFG
HQPPQAIVRQGRVVQR

Sequences:

>Translated_416_residues
MQPTPFSSLSSADGCWTGLRLAQGLFIPDVAVPDDALSCVVVQGGTVRWVGPVAAVPPAFAALPRHAGGGALATPGLVDC
HTHLVYGGHRANEFAMRLAGASYEEVARAGGGIVSSVKATRAASEDELFAQALPRLQALLDEGVCAIEIKSGYGLALEHE
RKQLRAARRLGEACGVTVRTTFLGAHALPPEYAGRSQDYIDLVCREMLPALAEEGLVDAVDVFCERIAFSLAETEQVFQA
AQALGLPVKLHAEQLSDMDGARLAARYGALSCDHIEHLSAEGIAAMKAAGTVAVLLPGAYYTLRDTHLPPIQALREAGVP
MAVSTDHNPGTSPALSLRLMANMACTLFRLTVPEALAGITTHAARALGLQDTHGLIAAGRPADFVLWPFAEAAELAYWFG
HQPPQAIVRQGRVVQR
>Mature_416_residues
MQPTPFSSLSSADGCWTGLRLAQGLFIPDVAVPDDALSCVVVQGGTVRWVGPVAAVPPAFAALPRHAGGGALATPGLVDC
HTHLVYGGHRANEFAMRLAGASYEEVARAGGGIVSSVKATRAASEDELFAQALPRLQALLDEGVCAIEIKSGYGLALEHE
RKQLRAARRLGEACGVTVRTTFLGAHALPPEYAGRSQDYIDLVCREMLPALAEEGLVDAVDVFCERIAFSLAETEQVFQA
AQALGLPVKLHAEQLSDMDGARLAARYGALSCDHIEHLSAEGIAAMKAAGTVAVLLPGAYYTLRDTHLPPIQALREAGVP
MAVSTDHNPGTSPALSLRLMANMACTLFRLTVPEALAGITTHAARALGLQDTHGLIAAGRPADFVLWPFAEAAELAYWFG
HQPPQAIVRQGRVVQR

Specific function: Unknown

COG id: COG1228

COG function: function code Q; Imidazolonepropionase and related amidohydrolases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hutI family

Homologues:

Organism=Homo sapiens, GI223972677, Length=412, Percent_Identity=35.6796116504854, Blast_Score=229, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17555004, Length=419, Percent_Identity=32.9355608591885, Blast_Score=224, Evalue=6e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTI_ACIAC (A1TRE0)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971302.1
- ProteinModelPortal:   A1TRE0
- SMR:   A1TRE0
- STRING:   A1TRE0
- GeneID:   4668440
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_2961
- NMPDR:   fig|397945.5.peg.2520
- eggNOG:   COG1228
- HOGENOM:   HBG686142
- OMA:   MNMACTL
- ProtClustDB:   PRK09356
- BioCyc:   AAVE397945:AAVE_2961-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00372
- InterPro:   IPR013108
- InterPro:   IPR005920
- InterPro:   IPR011059
- TIGRFAMs:   TIGR01224

Pfam domain/function: PF07969 Amidohydro_3; SSF51338 Metalo_hydrolase

EC number: =3.5.2.7

Molecular weight: Translated: 43899; Mature: 43899

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00449 ATPASE_A

Important sites: BINDING 90-90 BINDING 103-103 BINDING 153-153 BINDING 186-186 BINDING 254-254

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPTPFSSLSSADGCWTGLRLAQGLFIPDVAVPDDALSCVVVQGGTVRWVGPVAAVPPAF
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCEEEEECCHHHCCHHH
AALPRHAGGGALATPGLVDCHTHLVYGGHRANEFAMRLAGASYEEVARAGGGIVSSVKAT
HHCCCCCCCCCCCCCCHHHHHHHEEECCCCHHHHHHHHCCCCHHHHHHHCCCHHHHHHHH
RAASEDELFAQALPRLQALLDEGVCAIEIKSGYGLALEHERKQLRAARRLGEACGVTVRT
HCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHCCEEEH
TFLGAHALPPEYAGRSQDYIDLVCREMLPALAEEGLVDAVDVFCERIAFSLAETEQVFQA
HHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
AQALGLPVKLHAEQLSDMDGARLAARYGALSCDHIEHLSAEGIAAMKAAGTVAVLLPGAY
HHHHCCCEEEEHHHHCCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHCCEEEEEECCCE
YTLRDTHLPPIQALREAGVPMAVSTDHNPGTSPALSLRLMANMACTLFRLTVPEALAGIT
EEECCCCCCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
THAARALGLQDTHGLIAAGRPADFVLWPFAEAAELAYWFGHQPPQAIVRQGRVVQR
HHHHHHCCCCCCCCEEECCCCCCEEEECCHHHHHHHHHHCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MQPTPFSSLSSADGCWTGLRLAQGLFIPDVAVPDDALSCVVVQGGTVRWVGPVAAVPPAF
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCEEEEECCHHHCCHHH
AALPRHAGGGALATPGLVDCHTHLVYGGHRANEFAMRLAGASYEEVARAGGGIVSSVKAT
HHCCCCCCCCCCCCCCHHHHHHHEEECCCCHHHHHHHHCCCCHHHHHHHCCCHHHHHHHH
RAASEDELFAQALPRLQALLDEGVCAIEIKSGYGLALEHERKQLRAARRLGEACGVTVRT
HCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHCCEEEH
TFLGAHALPPEYAGRSQDYIDLVCREMLPALAEEGLVDAVDVFCERIAFSLAETEQVFQA
HHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
AQALGLPVKLHAEQLSDMDGARLAARYGALSCDHIEHLSAEGIAAMKAAGTVAVLLPGAY
HHHHCCCEEEEHHHHCCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHCCEEEEEECCCE
YTLRDTHLPPIQALREAGVPMAVSTDHNPGTSPALSLRLMANMACTLFRLTVPEALAGIT
EEECCCCCCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
THAARALGLQDTHGLIAAGRPADFVLWPFAEAAELAYWFGHQPPQAIVRQGRVVQR
HHHHHHCCCCCCCCEEECCCCCCEEEECCHHHHHHHHHHCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA