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The map label for this gene is pdxH

Identifier: 120611467

GI number: 120611467

Start: 3076684

End: 3077361

Strand: Direct

Name: pdxH

Synonym: Aave_2803

Alternate gene names: 120611467

Gene position: 3076684-3077361 (Clockwise)

Preceding gene: 120611466

Following gene: 120611469

Centisome position: 57.48

GC content: 69.62

Gene sequence:

>678_bases
ATGCACAATCGCGGCATGTCTTCCCCCTCCTCCCCGTTGTCGTCCTCCATCGCCGACCTGCGCAAGAGCTACGAGCGCGC
CGAACTCGGCGAGGAGGCATCGCATGCCGATCCGCTGCGCCAGTTCGACCAGTGGCTGCAGGAAGCCGTGGCAGCGCAGG
TGCCCGAGCCCAATGCCATGACGCTGGCCACCGTGGGCGCGGACCTGCGCCCCAGCACCCGCGTGGTGCTCATCAAGGGC
TACGACGAGCGCGGCATCGTCTGGTACACCAACTACGGGAGCCGCAAGGGCCGGCAACTGGCGGGCAACCCGTTCGCGGC
CCTGCAGTTCCACTGGGTCGAGCTCGAACGCGTGGTGCGCATCGAAGGCCGGGTGGAGAAAGTGAGCGATGCGGAGAGCG
ACGCGTATTTCGCGAGCCGGCCGCTGGATTCGCGCATCGGCGCCTGGGCGAGCCCGCAGAGCGAGGTGATTTCCGGCCGC
GGCGTGCTCGTGGCCAATGCGGCAAAGTACGGCGCACAGTTCCTGCTGCAGCCGCTCCGCCCGCCGCACTGGGGCGGCTT
CCGCCTGAAACCCGACCGCTGGGAGTTCTGGCAGGGCCGCAAGAGCCGCCTGCACGACCGGCTCTGCTACCGGGAAGAGA
CGCCGGGCGCCTGGGTGCGCGAGCGCCTCGCTCCCTGA

Upstream 100 bases:

>100_bases
ACGTGAACGCACTGATGCAGCGCATGGCGGACCAGGGCCGCCATTCCGCGCCGGTGTGACGCCGGCGTGCGCTGCCGCGG
CACGGAGGCGGGCGGAAGGC

Downstream 100 bases:

>100_bases
CGGCCCTCTCCTGCCCCGCCGGCTCGGCGGGCCTGCGGCGACGGGGCCGTGCCGGCCGCTGCCGTCTCAGTGCCAGAGCC
GCTGGGCCAGCAGAAGCATC

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MHNRGMSSPSSPLSSSIADLRKSYERAELGEEASHADPLRQFDQWLQEAVAAQVPEPNAMTLATVGADLRPSTRVVLIKG
YDERGIVWYTNYGSRKGRQLAGNPFAALQFHWVELERVVRIEGRVEKVSDAESDAYFASRPLDSRIGAWASPQSEVISGR
GVLVANAAKYGAQFLLQPLRPPHWGGFRLKPDRWEFWQGRKSRLHDRLCYREETPGAWVRERLAP

Sequences:

>Translated_225_residues
MHNRGMSSPSSPLSSSIADLRKSYERAELGEEASHADPLRQFDQWLQEAVAAQVPEPNAMTLATVGADLRPSTRVVLIKG
YDERGIVWYTNYGSRKGRQLAGNPFAALQFHWVELERVVRIEGRVEKVSDAESDAYFASRPLDSRIGAWASPQSEVISGR
GVLVANAAKYGAQFLLQPLRPPHWGGFRLKPDRWEFWQGRKSRLHDRLCYREETPGAWVRERLAP
>Mature_225_residues
MHNRGMSSPSSPLSSSIADLRKSYERAELGEEASHADPLRQFDQWLQEAVAAQVPEPNAMTLATVGADLRPSTRVVLIKG
YDERGIVWYTNYGSRKGRQLAGNPFAALQFHWVELERVVRIEGRVEKVSDAESDAYFASRPLDSRIGAWASPQSEVISGR
GVLVANAAKYGAQFLLQPLRPPHWGGFRLKPDRWEFWQGRKSRLHDRLCYREETPGAWVRERLAP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=228, Percent_Identity=40.7894736842105, Blast_Score=163, Evalue=1e-40,
Organism=Escherichia coli, GI1787926, Length=211, Percent_Identity=46.4454976303318, Blast_Score=179, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17553712, Length=231, Percent_Identity=40.6926406926407, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319509, Length=211, Percent_Identity=42.654028436019, Blast_Score=141, Evalue=7e-35,
Organism=Drosophila melanogaster, GI45551845, Length=245, Percent_Identity=40.4081632653061, Blast_Score=151, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24644901, Length=217, Percent_Identity=41.0138248847926, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24644903, Length=174, Percent_Identity=27.5862068965517, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_ACIAC (A1TQY3)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971145.1
- ProteinModelPortal:   A1TQY3
- SMR:   A1TQY3
- STRING:   A1TQY3
- GeneID:   4666365
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_2803
- NMPDR:   fig|397945.5.peg.2381
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- PhylomeDB:   A1TQY3
- BioCyc:   AAVE397945:AAVE_2803-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 25428; Mature: 25428

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 74-74 BINDING 77-77 BINDING 79-79 BINDING 96-96 BINDING 136-136 BINDING 140-140 BINDING 144-144

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNRGMSSPSSPLSSSIADLRKSYERAELGEEASHADPLRQFDQWLQEAVAAQVPEPNAM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCE
TLATVGADLRPSTRVVLIKGYDERGIVWYTNYGSRKGRQLAGNPFAALQFHWVELERVVR
EEEEECCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHHH
IEGRVEKVSDAESDAYFASRPLDSRIGAWASPQSEVISGRGVLVANAAKYGAQFLLQPLR
HCCCHHHHCCCCCCCHHHCCCCHHHCCCCCCCHHHHHCCCCEEEECHHHHHHHHHHHCCC
PPHWGGFRLKPDRWEFWQGRKSRLHDRLCYREETPGAWVRERLAP
CCCCCCEEECCCHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHCCC
>Mature Secondary Structure
MHNRGMSSPSSPLSSSIADLRKSYERAELGEEASHADPLRQFDQWLQEAVAAQVPEPNAM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCE
TLATVGADLRPSTRVVLIKGYDERGIVWYTNYGSRKGRQLAGNPFAALQFHWVELERVVR
EEEEECCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHHH
IEGRVEKVSDAESDAYFASRPLDSRIGAWASPQSEVISGRGVLVANAAKYGAQFLLQPLR
HCCCHHHHCCCCCCCHHHCCCCHHHCCCCCCCHHHHHCCCCEEEECHHHHHHHHHHHCCC
PPHWGGFRLKPDRWEFWQGRKSRLHDRLCYREETPGAWVRERLAP
CCCCCCEEECCCHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA