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The map label for this gene is gntR [H]

Identifier: 120611462

GI number: 120611462

Start: 3071423

End: 3072463

Strand: Direct

Name: gntR [H]

Synonym: Aave_2798

Alternate gene names: 120611462

Gene position: 3071423-3072463 (Clockwise)

Preceding gene: 120611455

Following gene: 120611465

Centisome position: 57.38

GC content: 73.87

Gene sequence:

>1041_bases
TTGAACGATTCCGCCCTGCCCCGCCCCCGACGGGCCCGCCGCGCCAGCGGCCGCGTCACCCTGGACGACGTGGCCCGGCT
CGCGGGCGTGAGCCCGATCACCGTCTCGCGCGCGCTGCGTCGCGAGCGCAGCGTGGACCCGGCCCTGGCCGAGCGCGTGC
AGGCCGCCGCGCAGCAACTGGGCTACGTGCCCGATCCGGCAGCGCGCGCCCTTGCCTCGCAGCGCAGCACCCAGGTGCTC
GTGCTGGTGCCCATGCTGTCGAACACGCTGTTCGTGGACCTGCTCGAGGCCGTGCACCGCACGCTGTTCCCGCAGGGCTT
CCTGCCGCTGATCGGCGTGACCCACTACGATGCGGCCGAGGAAGAGGTGCTGCTGCGCACCTACCTGCCCCACCGGCCCG
CCGGCCTGCTCGTGACCGGCTTCGACCGCAGCGAGGCCGCCCGCCAGCTGATCGCGCGCAGCGGCGTGCCGTGCGTGCAC
CTGATGGAGACCAGCGAAGCGCCGGGCGTGTACTGCGTGGGGTTTTCGCAGCTGGAGGCGGGCGCCGCCATCACGCGCCA
CCTGCTCGAGCGCGGCCGGCGGCGCATCGCGTTCTGCGCCGCCCAGCTCGACCCGCGCACGCTGCAGCGCGCCGAGGGCT
ACCGCCGCACGCTGCGCGAGGCCGGGGTGTACGACCCGCAACTGGAAATGCTGAGCCCCGAAGGCTCCTCCATCGCGCTG
GGCGCGCGCCTCTTCGAGGAAACGTTGCGGCGCGCGCCGGACGTGGATGCGATCTTCTTCTGCAACGACGACATCGCGCA
GGGCGGCCTGCTGGCCGCGAGCCGCTGTGGCGTGCCGGTGCCGGAACGGGTGGCCGTGGCCGGCTTCAACGACCTGGCCG
GCAGCGACCAGATGGTGCCGCCCCTCACCACCGTGCGCACCCCGCGCGGCGAGGTCGGCCGCGCCGGCGCCGCGATGCTG
CTGGGACTGATGCACGGGACACCGCCCGCACGGCACTGCGTGTCGCTGGACTTCGAACTGGTCGTGCGTGGCAGCACCTG
A

Upstream 100 bases:

>100_bases
GTCGAATGAATGAGGTCAATCGCCTTGCCCTGTCGTTAACCCTGAGCAAGATAGCGCTATCCTAGAACACAATGGCGGCC
AGACCGATCCGGATTAACCC

Downstream 100 bases:

>100_bases
CGGCGCGGTCCGTGCTGCCTGAGACAAAGCCCGGCGAACCGGGCGGGGATGGGCAGGATTTCGCCGGGGCCGCGGAGCGG
CTGGCTAGCCGTTCTCGTTC

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Gluconate utilization system GNT-I transcriptional repressor [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MNDSALPRPRRARRASGRVTLDDVARLAGVSPITVSRALRRERSVDPALAERVQAAAQQLGYVPDPAARALASQRSTQVL
VLVPMLSNTLFVDLLEAVHRTLFPQGFLPLIGVTHYDAAEEEVLLRTYLPHRPAGLLVTGFDRSEAARQLIARSGVPCVH
LMETSEAPGVYCVGFSQLEAGAAITRHLLERGRRRIAFCAAQLDPRTLQRAEGYRRTLREAGVYDPQLEMLSPEGSSIAL
GARLFEETLRRAPDVDAIFFCNDDIAQGGLLAASRCGVPVPERVAVAGFNDLAGSDQMVPPLTTVRTPRGEVGRAGAAML
LGLMHGTPPARHCVSLDFELVVRGST

Sequences:

>Translated_346_residues
MNDSALPRPRRARRASGRVTLDDVARLAGVSPITVSRALRRERSVDPALAERVQAAAQQLGYVPDPAARALASQRSTQVL
VLVPMLSNTLFVDLLEAVHRTLFPQGFLPLIGVTHYDAAEEEVLLRTYLPHRPAGLLVTGFDRSEAARQLIARSGVPCVH
LMETSEAPGVYCVGFSQLEAGAAITRHLLERGRRRIAFCAAQLDPRTLQRAEGYRRTLREAGVYDPQLEMLSPEGSSIAL
GARLFEETLRRAPDVDAIFFCNDDIAQGGLLAASRCGVPVPERVAVAGFNDLAGSDQMVPPLTTVRTPRGEVGRAGAAML
LGLMHGTPPARHCVSLDFELVVRGST
>Mature_346_residues
MNDSALPRPRRARRASGRVTLDDVARLAGVSPITVSRALRRERSVDPALAERVQAAAQQLGYVPDPAARALASQRSTQVL
VLVPMLSNTLFVDLLEAVHRTLFPQGFLPLIGVTHYDAAEEEVLLRTYLPHRPAGLLVTGFDRSEAARQLIARSGVPCVH
LMETSEAPGVYCVGFSQLEAGAAITRHLLERGRRRIAFCAAQLDPRTLQRAEGYRRTLREAGVYDPQLEMLSPEGSSIAL
GARLFEETLRRAPDVDAIFFCNDDIAQGGLLAASRCGVPVPERVAVAGFNDLAGSDQMVPPLTTVRTPRGEVGRAGAAML
LGLMHGTPPARHCVSLDFELVVRGST

Specific function: Negative regulator for the gluconate utilization system GNT-I, the gntUKR operon [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI48994940, Length=330, Percent_Identity=32.4242424242424, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1790715, Length=338, Percent_Identity=30.4733727810651, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1790369, Length=343, Percent_Identity=30.9037900874636, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1790194, Length=306, Percent_Identity=30.0653594771242, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787948, Length=310, Percent_Identity=27.4193548387097, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1789202, Length=296, Percent_Identity=29.3918918918919, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788474, Length=323, Percent_Identity=28.7925696594427, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789068, Length=323, Percent_Identity=29.4117647058824, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1787580, Length=318, Percent_Identity=24.5283018867925, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787906, Length=334, Percent_Identity=28.1437125748503, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786540, Length=314, Percent_Identity=26.4331210191083, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37411; Mature: 37411

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDSALPRPRRARRASGRVTLDDVARLAGVSPITVSRALRRERSVDPALAERVQAAAQQL
CCCCCCCCCHHHHHCCCCEEHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
GYVPDPAARALASQRSTQVLVLVPMLSNTLFVDLLEAVHRTLFPQGFLPLIGVTHYDAAE
CCCCCHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCH
EEVLLRTYLPHRPAGLLVTGFDRSEAARQLIARSGVPCVHLMETSEAPGVYCVGFSQLEA
HHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEHHHHHH
GAAITRHLLERGRRRIAFCAAQLDPRTLQRAEGYRRTLREAGVYDPQLEMLSPEGSSIAL
HHHHHHHHHHHCCCEEEHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHEECCCCCEEHH
GARLFEETLRRAPDVDAIFFCNDDIAQGGLLAASRCGVPVPERVAVAGFNDLAGSDQMVP
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEHHCCCCCCCCCEEEECCHHCCCCCCCCC
PLTTVRTPRGEVGRAGAAMLLGLMHGTPPARHCVSLDFELVVRGST
CHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHEECCEEEEEECCC
>Mature Secondary Structure
MNDSALPRPRRARRASGRVTLDDVARLAGVSPITVSRALRRERSVDPALAERVQAAAQQL
CCCCCCCCCHHHHHCCCCEEHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
GYVPDPAARALASQRSTQVLVLVPMLSNTLFVDLLEAVHRTLFPQGFLPLIGVTHYDAAE
CCCCCHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCH
EEVLLRTYLPHRPAGLLVTGFDRSEAARQLIARSGVPCVHLMETSEAPGVYCVGFSQLEA
HHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEHHHHHH
GAAITRHLLERGRRRIAFCAAQLDPRTLQRAEGYRRTLREAGVYDPQLEMLSPEGSSIAL
HHHHHHHHHHHCCCEEEHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHEECCCCCEEHH
GARLFEETLRRAPDVDAIFFCNDDIAQGGLLAASRCGVPVPERVAVAGFNDLAGSDQMVP
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEHHCCCCCCCCCEEEECCHHCCCCCCCCC
PLTTVRTPRGEVGRAGAAMLLGLMHGTPPARHCVSLDFELVVRGST
CHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHEECCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]