Click here to switch to the map view.

The map label for this gene is ghrA [H]

Identifier: 120610856

GI number: 120610856

Start: 2399640

End: 2400566

Strand: Reverse

Name: ghrA [H]

Synonym: Aave_2182

Alternate gene names: 120610856

Gene position: 2400566-2399640 (Counterclockwise)

Preceding gene: 120610857

Following gene: 120610855

Centisome position: 44.85

GC content: 70.98

Gene sequence:

>927_bases
ATGAGCTTTCTCTACAAGTCCGACCCCGTGCGCGGCGCGGTGTGGGCGGAGCGCTTCGCGCTGGCGATGCCGGACCTGCC
GTTCCGCATCTGGCCCGACGTGGGAGATGCACGCGACGTGCGCTACCTCGCCGCCTGGGAACCGCCCCAGGATCTGGCCG
CACGGTTCCCGAACCTCGAAGTGCTGTTCTCGACCGGTGCCGGCGTCGATCAGTTCGACTTCTCCGCCCTGCCCCCGGGC
CTGCCCATCGTGCGCATGGTGGAGCCGGGCATCGTGCAGGGAATGGTCGAGTACGTGACGATGGCCGTGCTGTCCGTCCA
CCGCGACCTGCACACGTACCTCGGCCAGCAACGCGCGAAGAGCTGGCAGCCGCATCGCGTCCATCCCGCGTCCTCGCGGC
GCGTCGGCGTGCTGGGCCTGGGCACGCTGGGCCGCGCCGTACTGGAACGCCTGCACGGTTTCGGTTTCGCATGCGCGGGC
TGGAGCCGGTCGCCGCAGCGCATCGAGGGCATCGCATGCCACGCCGGCCCCGACGGACTGCGCGGCTTCCTCGCACGCAC
CGACATCCTCGTCTGCCTGCTGCCACTCACCGGCGACACCCGGGGCATCCTCTGCAGGCAGGTGTTCGACCAGCTGCCGC
GCGGCGCCACCGTGATCAACGTGGGGCGCGGCGGCCACCTCGTGCAGGACGACCTGCTCCACGCGCTCGATGCCGGCCAG
TTGGCCGGGGCCATCCTGGACGTGTGCGAGCCCGAGCCGCTGCCGCCGCAACACCCGTTCTGGACACACCCCAAGGTGGT
GCTGACGCCGCACATCGCGAGCATGACCCAGCCGGAAACGGCCGTGGACGCGCTCATCGACAACCTGCGGCGGCACCGCG
AGGGCCTGCCGATGGTCGGCCTCGTCGACCGGAGCCGGGGCTACTGA

Upstream 100 bases:

>100_bases
GCCAGCTGCAGCTGGGACAGCCGCGACCACGTGGCCAAGCTCTACGTGATCTATCGACCCAAGTGACACGCGCCACCCAG
CGCCCAAGCCGCGAGTCACC

Downstream 100 bases:

>100_bases
CCCATGCCGGGCCCGTGCCGGCCCGCGAAACGATGTGCTGTCCAAACCCCAACAACCGCAGCCTGCTGTAAGCAGCGCCC
CCAAACCAGCACCACGCGAT

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSFLYKSDPVRGAVWAERFALAMPDLPFRIWPDVGDARDVRYLAAWEPPQDLAARFPNLEVLFSTGAGVDQFDFSALPPG
LPIVRMVEPGIVQGMVEYVTMAVLSVHRDLHTYLGQQRAKSWQPHRVHPASSRRVGVLGLGTLGRAVLERLHGFGFACAG
WSRSPQRIEGIACHAGPDGLRGFLARTDILVCLLPLTGDTRGILCRQVFDQLPRGATVINVGRGGHLVQDDLLHALDAGQ
LAGAILDVCEPEPLPPQHPFWTHPKVVLTPHIASMTQPETAVDALIDNLRRHREGLPMVGLVDRSRGY

Sequences:

>Translated_308_residues
MSFLYKSDPVRGAVWAERFALAMPDLPFRIWPDVGDARDVRYLAAWEPPQDLAARFPNLEVLFSTGAGVDQFDFSALPPG
LPIVRMVEPGIVQGMVEYVTMAVLSVHRDLHTYLGQQRAKSWQPHRVHPASSRRVGVLGLGTLGRAVLERLHGFGFACAG
WSRSPQRIEGIACHAGPDGLRGFLARTDILVCLLPLTGDTRGILCRQVFDQLPRGATVINVGRGGHLVQDDLLHALDAGQ
LAGAILDVCEPEPLPPQHPFWTHPKVVLTPHIASMTQPETAVDALIDNLRRHREGLPMVGLVDRSRGY
>Mature_307_residues
SFLYKSDPVRGAVWAERFALAMPDLPFRIWPDVGDARDVRYLAAWEPPQDLAARFPNLEVLFSTGAGVDQFDFSALPPGL
PIVRMVEPGIVQGMVEYVTMAVLSVHRDLHTYLGQQRAKSWQPHRVHPASSRRVGVLGLGTLGRAVLERLHGFGFACAGW
SRSPQRIEGIACHAGPDGLRGFLARTDILVCLLPLTGDTRGILCRQVFDQLPRGATVINVGRGGHLVQDDLLHALDAGQL
AGAILDVCEPEPLPPQHPFWTHPKVVLTPHIASMTQPETAVDALIDNLRRHREGLPMVGLVDRSRGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=255, Percent_Identity=29.4117647058824, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI23308577, Length=249, Percent_Identity=26.5060240963855, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI145580578, Length=233, Percent_Identity=27.0386266094421, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4557499, Length=233, Percent_Identity=27.0386266094421, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI61743967, Length=233, Percent_Identity=27.4678111587983, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4557497, Length=233, Percent_Identity=27.4678111587983, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI145580575, Length=233, Percent_Identity=27.0386266094421, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081824, Length=301, Percent_Identity=38.2059800664452, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI87082289, Length=261, Percent_Identity=29.8850574712644, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=256, Percent_Identity=27.734375, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25147481, Length=241, Percent_Identity=28.6307053941909, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6324055, Length=260, Percent_Identity=26.5384615384615, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574286, Length=243, Percent_Identity=30.4526748971193, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45552429, Length=261, Percent_Identity=28.735632183908, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585514, Length=261, Percent_Identity=28.735632183908, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28574282, Length=261, Percent_Identity=28.735632183908, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28574284, Length=260, Percent_Identity=28.8461538461538, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45551003, Length=261, Percent_Identity=28.735632183908, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24585516, Length=272, Percent_Identity=26.1029411764706, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921140, Length=231, Percent_Identity=27.7056277056277, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28571528, Length=158, Percent_Identity=32.2784810126582, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33821; Mature: 33690

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLYKSDPVRGAVWAERFALAMPDLPFRIWPDVGDARDVRYLAAWEPPQDLAARFPNLE
CCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEECCCHHHHHHHCCCEE
VLFSTGAGVDQFDFSALPPGLPIVRMVEPGIVQGMVEYVTMAVLSVHRDLHTYLGQQRAK
EEEECCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SWQPHRVHPASSRRVGVLGLGTLGRAVLERLHGFGFACAGWSRSPQRIEGIACHAGPDGL
CCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHCCCEEECCCCCCHHHHCCEEECCCCHHH
RGFLARTDILVCLLPLTGDTRGILCRQVFDQLPRGATVINVGRGGHLVQDDLLHALDAGQ
HHHHHHHCEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHH
LAGAILDVCEPEPLPPQHPFWTHPKVVLTPHIASMTQPETAVDALIDNLRRHREGLPMVG
HHHHHHHHCCCCCCCCCCCCCCCCEEEECCCHHHCCCCHHHHHHHHHHHHHHHCCCCEEE
LVDRSRGY
ECCCCCCC
>Mature Secondary Structure 
SFLYKSDPVRGAVWAERFALAMPDLPFRIWPDVGDARDVRYLAAWEPPQDLAARFPNLE
CCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEECCCHHHHHHHCCCEE
VLFSTGAGVDQFDFSALPPGLPIVRMVEPGIVQGMVEYVTMAVLSVHRDLHTYLGQQRAK
EEEECCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SWQPHRVHPASSRRVGVLGLGTLGRAVLERLHGFGFACAGWSRSPQRIEGIACHAGPDGL
CCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHCCCEEECCCCCCHHHHCCEEECCCCHHH
RGFLARTDILVCLLPLTGDTRGILCRQVFDQLPRGATVINVGRGGHLVQDDLLHALDAGQ
HHHHHHHCEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHH
LAGAILDVCEPEPLPPQHPFWTHPKVVLTPHIASMTQPETAVDALIDNLRRHREGLPMVG
HHHHHHHHCCCCCCCCCCCCCCCCEEEECCCHHHCCCCHHHHHHHHHHHHHHHCCCCEEE
LVDRSRGY
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA