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The map label for this gene is oprM [H]

Identifier: 120610787

GI number: 120610787

Start: 2315898

End: 2317460

Strand: Reverse

Name: oprM [H]

Synonym: Aave_2110

Alternate gene names: 120610787

Gene position: 2317460-2315898 (Counterclockwise)

Preceding gene: 120610788

Following gene: 120610785

Centisome position: 43.29

GC content: 74.73

Gene sequence:

>1563_bases
ATGACGCGCGCGCCCTTTCCCTCCCTTTTCGCCTGCCCGCGCCTCGCCAGCGGGGCGGCCCTGGCCGCCGCGCTGCTCGC
GGCGGGCTGCACCAACCTCGCGCCGCCGTTCTGGAAGCCCGCGCTGCCCGTGCCGGAGGTGGTCGGTTCCCCGTCCACCC
GCGGCACCGACAGCGTGACCTTCGGAATCGCGGTGGACATCGGCCTGAGGCCCTGGGAGTCGTTCATCACGGAGCCGCGG
CTGCGGGGCGTGATCGCGCAATCGCTCGAAGCCAACCGCGACCTGCGCGTGGCCGTGCTGGCCATCGAGCGGGCCCGGGC
CCAGTACGGCGTGAGCCGCGCGGACCTCTTCCCCACCGTGGGCGCCACGGGCGCCGGCACCCGCAGCCGCACGGCCGACG
ATCTCACCGCCGCCGGCCGCGCCAGCACGGCCAGCCAGTACAGCGCCCAGATCGGCTTCGCGAGCTACGAGATCGACTTC
TTCGGCCGGGTGCGCAACCTCAACGATGCCGCGCTGCAGGAATTCCTGCGCGTGGGCGAGAACGCGCGCAGCGTGCGCCT
GAGCCTGGTGGCCGACGTGGCCGGCGCCTGGCTCGCGCTCGACGCCGACGCGCGCCGCCTGCTGCTGGCGCGCGAAACGC
TACGCACCCGGTCGCAGTCGCTCGCCCTGGCGCGGCGCAGCTATGAACAGGGAGCCACCTCGGGCCTCACGCTCACGCAG
ACGCAGGCCACGGTCGATGCGGCGCGCGCCGACCTCGCCAGCGCCGCCACCCAGCTCGCCCGGGACCGCAACGCGCTCCA
CCTGCTGGCGGGACGCCCCGTGGACGATGCCCTGCTGCCGCCCGCGGCCGTGGAGGCGCTGGCGCCGCCGCCCGCGGAAA
CCGGGGCCTCCGCGCCGGGCGGCGACCGCGCCGGCAGTCCCGATCCGGCGCGCTCGCAGCGGCCCGCGGTGTCGGTGGCG
CAGGCCCTGGCGGTGCCCGCGGGCTCGCTGCCGTCTTCCACGCTGCTGCACCGCCCGGACGTGCAGGCGGCCGAGCGCTC
GCTGCGGGGCGCGTTCGCCAATATCGGCGCCGCGCGCGCCGCGTTCTTCCCTTCCATCACGCTCACCACCAGCGTGGGCA
CGGCGAGCAACGAACTGTCGGGACTTTTCGGCGCGGGCAACGGCACCTGGAGCTTCGCGCCGCAGATCCGCCTGCCGATC
TTCGACGGCGGGCGCAACCGGGCCAACCTGCGCGTGGCCGAGGTCGCGCGGGAAACCGCCCTGGCCCAGTACGAGAAGAC
CGTGCAGACGGCCTTTCGCGAGGCAGCGGACGCGCTGGCCGAGCGCGCCACGCTGCAGGAGCGCCTGCAGGCGCAGCAAT
CCCTCGTGGACTCCAGCCAGCGCGCGCTCGACCTGACCCTGGCCCGGTGGCGGCTGGGCGCCGACAGCTACCTGGCCGTG
CTGGATGCGCAGCGCTCGCTCTACACCGCGCAGCAGGGGCTGATCGGCGTGCAACTGGCCGACCAGTCCAACCGGGTCAC
GCTCTACAAGGTGCTCGGTGGATGGGGCGACAGCGACGGCTGA

Upstream 100 bases:

>100_bases
TCTTCGCCCGGCGCGGGGCGCGTACCGGGCCCGACGCGGCGCACCCGTCGGCGGGCATCGACGCCCCCCCGCCTTCCAGC
CCTGCCCCCGGAGCCTCCGC

Downstream 100 bases:

>100_bases
GCCGCCATCAGGCGTCCAGGGGCAGGAGCGTCACTTCCATCGCATCGTCCAGCCATGCCATGGCGGGTTCGCCGGCCTCG
TCGGCCACCCCCTGCCCGAA

Product: RND efflux system outer membrane lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MTRAPFPSLFACPRLASGAALAAALLAAGCTNLAPPFWKPALPVPEVVGSPSTRGTDSVTFGIAVDIGLRPWESFITEPR
LRGVIAQSLEANRDLRVAVLAIERARAQYGVSRADLFPTVGATGAGTRSRTADDLTAAGRASTASQYSAQIGFASYEIDF
FGRVRNLNDAALQEFLRVGENARSVRLSLVADVAGAWLALDADARRLLLARETLRTRSQSLALARRSYEQGATSGLTLTQ
TQATVDAARADLASAATQLARDRNALHLLAGRPVDDALLPPAAVEALAPPPAETGASAPGGDRAGSPDPARSQRPAVSVA
QALAVPAGSLPSSTLLHRPDVQAAERSLRGAFANIGAARAAFFPSITLTTSVGTASNELSGLFGAGNGTWSFAPQIRLPI
FDGGRNRANLRVAEVARETALAQYEKTVQTAFREAADALAERATLQERLQAQQSLVDSSQRALDLTLARWRLGADSYLAV
LDAQRSLYTAQQGLIGVQLADQSNRVTLYKVLGGWGDSDG

Sequences:

>Translated_520_residues
MTRAPFPSLFACPRLASGAALAAALLAAGCTNLAPPFWKPALPVPEVVGSPSTRGTDSVTFGIAVDIGLRPWESFITEPR
LRGVIAQSLEANRDLRVAVLAIERARAQYGVSRADLFPTVGATGAGTRSRTADDLTAAGRASTASQYSAQIGFASYEIDF
FGRVRNLNDAALQEFLRVGENARSVRLSLVADVAGAWLALDADARRLLLARETLRTRSQSLALARRSYEQGATSGLTLTQ
TQATVDAARADLASAATQLARDRNALHLLAGRPVDDALLPPAAVEALAPPPAETGASAPGGDRAGSPDPARSQRPAVSVA
QALAVPAGSLPSSTLLHRPDVQAAERSLRGAFANIGAARAAFFPSITLTTSVGTASNELSGLFGAGNGTWSFAPQIRLPI
FDGGRNRANLRVAEVARETALAQYEKTVQTAFREAADALAERATLQERLQAQQSLVDSSQRALDLTLARWRLGADSYLAV
LDAQRSLYTAQQGLIGVQLADQSNRVTLYKVLGGWGDSDG
>Mature_519_residues
TRAPFPSLFACPRLASGAALAAALLAAGCTNLAPPFWKPALPVPEVVGSPSTRGTDSVTFGIAVDIGLRPWESFITEPRL
RGVIAQSLEANRDLRVAVLAIERARAQYGVSRADLFPTVGATGAGTRSRTADDLTAAGRASTASQYSAQIGFASYEIDFF
GRVRNLNDAALQEFLRVGENARSVRLSLVADVAGAWLALDADARRLLLARETLRTRSQSLALARRSYEQGATSGLTLTQT
QATVDAARADLASAATQLARDRNALHLLAGRPVDDALLPPAAVEALAPPPAETGASAPGGDRAGSPDPARSQRPAVSVAQ
ALAVPAGSLPSSTLLHRPDVQAAERSLRGAFANIGAARAAFFPSITLTTSVGTASNELSGLFGAGNGTWSFAPQIRLPIF
DGGRNRANLRVAEVARETALAQYEKTVQTAFREAADALAERATLQERLQAQQSLVDSSQRALDLTLARWRLGADSYLAVL
DAQRSLYTAQQGLIGVQLADQSNRVTLYKVLGGWGDSDG

Specific function: The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor. Note=Attached to the outer membrane by a lipid anchor and via the transmembrane beta-barrel. The membrane anchor is not necessary for antibiotic efflux. In one report (PubMed:10889211) the Cys-18- Gly mutant is reported

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=494, Percent_Identity=37.246963562753, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI2367348, Length=456, Percent_Identity=23.9035087719298, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 54631; Mature: 54500

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.2 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRAPFPSLFACPRLASGAALAAALLAAGCTNLAPPFWKPALPVPEVVGSPSTRGTDSVT
CCCCCCCHHHHCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCCHHHHCCCCCCCCCCEE
FGIAVDIGLRPWESFITEPRLRGVIAQSLEANRDLRVAVLAIERARAQYGVSRADLFPTV
EEEEEECCCCCHHHHHCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCHHHHCCCC
GATGAGTRSRTADDLTAAGRASTASQYSAQIGFASYEIDFFGRVRNLNDAALQEFLRVGE
CCCCCCCCCCCCHHHHHCCCCCCHHHHHHHCCEEEEEEEHHHHHCCCCHHHHHHHHHHCC
NARSVRLSLVADVAGAWLALDADARRLLLARETLRTRSQSLALARRSYEQGATSGLTLTQ
CCHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
TQATVDAARADLASAATQLARDRNALHLLAGRPVDDALLPPAAVEALAPPPAETGASAPG
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCCC
GDRAGSPDPARSQRPAVSVAQALAVPAGSLPSSTLLHRPDVQAAERSLRGAFANIGAARA
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHH
AFFPSITLTTSVGTASNELSGLFGAGNGTWSFAPQIRLPIFDGGRNRANLRVAEVARETA
HHCCCEEEEEECCCCCHHCCCEEECCCCCEEECCEEEEEEECCCCCCCCCHHHHHHHHHH
LAQYEKTVQTAFREAADALAERATLQERLQAQQSLVDSSQRALDLTLARWRLGADSYLAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LDAQRSLYTAQQGLIGVQLADQSNRVTLYKVLGGWGDSDG
HHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure 
TRAPFPSLFACPRLASGAALAAALLAAGCTNLAPPFWKPALPVPEVVGSPSTRGTDSVT
CCCCCCHHHHCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCCHHHHCCCCCCCCCCEE
FGIAVDIGLRPWESFITEPRLRGVIAQSLEANRDLRVAVLAIERARAQYGVSRADLFPTV
EEEEEECCCCCHHHHHCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCHHHHCCCC
GATGAGTRSRTADDLTAAGRASTASQYSAQIGFASYEIDFFGRVRNLNDAALQEFLRVGE
CCCCCCCCCCCCHHHHHCCCCCCHHHHHHHCCEEEEEEEHHHHHCCCCHHHHHHHHHHCC
NARSVRLSLVADVAGAWLALDADARRLLLARETLRTRSQSLALARRSYEQGATSGLTLTQ
CCHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
TQATVDAARADLASAATQLARDRNALHLLAGRPVDDALLPPAAVEALAPPPAETGASAPG
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCCC
GDRAGSPDPARSQRPAVSVAQALAVPAGSLPSSTLLHRPDVQAAERSLRGAFANIGAARA
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHH
AFFPSITLTTSVGTASNELSGLFGAGNGTWSFAPQIRLPIFDGGRNRANLRVAEVARETA
HHCCCEEEEEECCCCCHHCCCEEECCCCCEEECCEEEEEEECCCCCCCCCHHHHHHHHHH
LAQYEKTVQTAFREAADALAERATLQERLQAQQSLVDSSQRALDLTLARWRLGADSYLAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LDAQRSLYTAQQGLIGVQLADQSNRVTLYKVLGGWGDSDG
HHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8226684; 10889211; 10984043; 7968531; 8540696; 9401051; 9603892; 10952562 [H]