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The map label for this gene is opuD [H]

Identifier: 120610705

GI number: 120610705

Start: 2207044

End: 2208645

Strand: Reverse

Name: opuD [H]

Synonym: Aave_2025

Alternate gene names: 120610705

Gene position: 2208645-2207044 (Counterclockwise)

Preceding gene: 120610706

Following gene: 120610704

Centisome position: 41.26

GC content: 69.91

Gene sequence:

>1602_bases
ATGCAAGCACCATCCGCCTCCCCTCCGCCTCCAGGGCACACCTCCCTCATCGCACGCGCCAGGAGCGCGGCGCTCGGCAA
CCTGCAGCTCACGGTCTCGGCCGGGATGATCGCCGTGGTGGTGCTCTGGGGACTGGTGTCTCCCGCCAGCCTCGGTACGT
TCTTCGGCACGCTGCTGTCGGACATCACGCGGAATTTCGGGTGGCTGTACCTGTGGGTGGTGCTGGGGCTGGTCGGGCTG
GCCCTGTTCCTGGCCCTGAGCCGCTACGGCGACCTGAAGCTGGGCGACGAGGACGAGGAACCCGAGTTCTCCGCCGCGAC
ATGGTTCGCGATGCTCTTCGCGGCGGGCATGGGCATCGGCCTGGTGTTCTGGGGCGTGGCCGAGCCGATCTCGCACTACG
GGCTGCCGCCGCCCGGCATCGTCCCGCAGACGCCCGAGGCCGCGGGCGCCGCCATGCGCTACGCCTTCTTCCACTGGGGC
CTGCATCCCTGGGCGATCTACGGCATCGTCGGGCTGACGATCGCCTTCTTCCAGTTCCGCCGGCAGGCCCCGGCCCTGGT
CAGTTCCGCGACCGAGTCGCTGCCCTGGCGCGGCATGCGCCACCTCTCGCCGCTGGTGAACGTGCTGGCGGTGGTGGCCA
CGGCCTTCGGGGTCGCCGCCTCGCTCGGCATGGGCGCCGCGCAGATCAACGGCGGGCTGCAGGCGGTGTTCGGCGTGCCG
GTGGGTCCCTGGTCGCAGGCCGTGATCATCGTGGTGACGACGGCGCTGTTCATCACCTCGGCGGTGAGCGGCGTGGAGCG
GGGCGTCAAATGGCTCTCCAGCGCCAATCTGATGCTCGCCGCCCTGCTGGCGCTGGCGGTGTTCCTGCTCGGGCCCACGG
TGTCGCTGGTGAACACCTTCACCAACACGCTGGGCGCCTACCTGAGCGAATTCGTGCGCACCAGCCTGCGCATGTCGCCC
TTCCGGGACAGCAGTTGGGTGGGCGACTGGACCATCTTCTATTGGTCGTGGTGGATCGCCTGGTCGCCGTTCGTGGGCCT
GTTCATCGCGCGCGTGTCGCGCGGGCGCACGATCCGCGAGTTCGTGCTGGGCACGGTGATCGCGCCCACGCTGGTGGGCT
TCCTGTGGTTCTCGATCTTCGGCGGCACCGCGCTGCACCTGGAGATCTTCCGGCAGGTCCCCCTGGCCGCGGCCGCGCAG
GCCGACCCGGCCACCGCGATGTTCGCCATGTTCGGCGCCATGCCGATGGGGCTGGCGATGTCCGTCGTGGCCACGATGCT
GGTGATCGTGTTCTTCATCACTTCGGGCGATTCGGCCACCCTGGTGCTCAGCACGATGAGCACGCGCGGCGACCCCAATC
CGTCCGCGCGCGTGAAGATCGTCTGGGGCCTGCTGGTGGCCGGCATCGCGCTGTCGCTGCTCTTCGCGGGGGGCCTGCAG
GCGGTGCAGACCGCCACCATCGTCTTCGCGCTGCCGTTCGCGCTGGTGCTGCTGCTGATGGCGGTGGCCCTGATGCGGGC
GGTGCGCGAGGACCACGAGGCCGAACGCAGACGCGAACGCGCCCTGCGGCGCCGGATGCGCGAAATGGCGATGCGCGAGT
GA

Upstream 100 bases:

>100_bases
CTGGGATGACCGGAACGGCGGGAACGGAAGGGGGTGGCGGCTCATCCGTTTCCGGCATCGGCTGACAGACCGGGGCTCTG
CCGTCGCCCACACTGCGCGG

Downstream 100 bases:

>100_bases
AACCGGGCAGGGCGCGGCCGCCAAAGCGGCTCCGTCCTACAGGCCCAGTCGCCGCTACCGCGCGAGCTCGACCGGCCGCT
GCGTGCGCCAATGGCTTTCA

Product: choline/carnitine/betaine transporter

Products: Proton [Cytoplasm]; choline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MQAPSASPPPPGHTSLIARARSAALGNLQLTVSAGMIAVVVLWGLVSPASLGTFFGTLLSDITRNFGWLYLWVVLGLVGL
ALFLALSRYGDLKLGDEDEEPEFSAATWFAMLFAAGMGIGLVFWGVAEPISHYGLPPPGIVPQTPEAAGAAMRYAFFHWG
LHPWAIYGIVGLTIAFFQFRRQAPALVSSATESLPWRGMRHLSPLVNVLAVVATAFGVAASLGMGAAQINGGLQAVFGVP
VGPWSQAVIIVVTTALFITSAVSGVERGVKWLSSANLMLAALLALAVFLLGPTVSLVNTFTNTLGAYLSEFVRTSLRMSP
FRDSSWVGDWTIFYWSWWIAWSPFVGLFIARVSRGRTIREFVLGTVIAPTLVGFLWFSIFGGTALHLEIFRQVPLAAAAQ
ADPATAMFAMFGAMPMGLAMSVVATMLVIVFFITSGDSATLVLSTMSTRGDPNPSARVKIVWGLLVAGIALSLLFAGGLQ
AVQTATIVFALPFALVLLLMAVALMRAVREDHEAERRRERALRRRMREMAMRE

Sequences:

>Translated_533_residues
MQAPSASPPPPGHTSLIARARSAALGNLQLTVSAGMIAVVVLWGLVSPASLGTFFGTLLSDITRNFGWLYLWVVLGLVGL
ALFLALSRYGDLKLGDEDEEPEFSAATWFAMLFAAGMGIGLVFWGVAEPISHYGLPPPGIVPQTPEAAGAAMRYAFFHWG
LHPWAIYGIVGLTIAFFQFRRQAPALVSSATESLPWRGMRHLSPLVNVLAVVATAFGVAASLGMGAAQINGGLQAVFGVP
VGPWSQAVIIVVTTALFITSAVSGVERGVKWLSSANLMLAALLALAVFLLGPTVSLVNTFTNTLGAYLSEFVRTSLRMSP
FRDSSWVGDWTIFYWSWWIAWSPFVGLFIARVSRGRTIREFVLGTVIAPTLVGFLWFSIFGGTALHLEIFRQVPLAAAAQ
ADPATAMFAMFGAMPMGLAMSVVATMLVIVFFITSGDSATLVLSTMSTRGDPNPSARVKIVWGLLVAGIALSLLFAGGLQ
AVQTATIVFALPFALVLLLMAVALMRAVREDHEAERRRERALRRRMREMAMRE
>Mature_533_residues
MQAPSASPPPPGHTSLIARARSAALGNLQLTVSAGMIAVVVLWGLVSPASLGTFFGTLLSDITRNFGWLYLWVVLGLVGL
ALFLALSRYGDLKLGDEDEEPEFSAATWFAMLFAAGMGIGLVFWGVAEPISHYGLPPPGIVPQTPEAAGAAMRYAFFHWG
LHPWAIYGIVGLTIAFFQFRRQAPALVSSATESLPWRGMRHLSPLVNVLAVVATAFGVAASLGMGAAQINGGLQAVFGVP
VGPWSQAVIIVVTTALFITSAVSGVERGVKWLSSANLMLAALLALAVFLLGPTVSLVNTFTNTLGAYLSEFVRTSLRMSP
FRDSSWVGDWTIFYWSWWIAWSPFVGLFIARVSRGRTIREFVLGTVIAPTLVGFLWFSIFGGTALHLEIFRQVPLAAAAQ
ADPATAMFAMFGAMPMGLAMSVVATMLVIVFFITSGDSATLVLSTMSTRGDPNPSARVKIVWGLLVAGIALSLLFAGGLQ
AVQTATIVFALPFALVLLLMAVALMRAVREDHEAERRRERALRRRMREMAMRE

Specific function: High-affinity uptake of glycine betaine [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family [H]

Homologues:

Organism=Escherichia coli, GI1786506, Length=518, Percent_Identity=36.1003861003861, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI1788102, Length=450, Percent_Identity=31.1111111111111, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI1786224, Length=470, Percent_Identity=28.0851063829787, Blast_Score=192, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 57239; Mature: 57239

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAPSASPPPPGHTSLIARARSAALGNLQLTVSAGMIAVVVLWGLVSPASLGTFFGTLLS
CCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHH
DITRNFGWLYLWVVLGLVGLALFLALSRYGDLKLGDEDEEPEFSAATWFAMLFAAGMGIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LVFWGVAEPISHYGLPPPGIVPQTPEAAGAAMRYAFFHWGLHPWAIYGIVGLTIAFFQFR
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RQAPALVSSATESLPWRGMRHLSPLVNVLAVVATAFGVAASLGMGAAQINGGLQAVFGVP
HHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHEEECCC
VGPWSQAVIIVVTTALFITSAVSGVERGVKWLSSANLMLAALLALAVFLLGPTVSLVNTF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHH
TNTLGAYLSEFVRTSLRMSPFRDSSWVGDWTIFYWSWWIAWSPFVGLFIARVSRGRTIRE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
FVLGTVIAPTLVGFLWFSIFGGTALHLEIFRQVPLAAAAQADPATAMFAMFGAMPMGLAM
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHH
SVVATMLVIVFFITSGDSATLVLSTMSTRGDPNPSARVKIVWGLLVAGIALSLLFAGGLQ
HHHHHHHHHHHHHCCCCCCEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHH
AVQTATIVFALPFALVLLLMAVALMRAVREDHEAERRRERALRRRMREMAMRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQAPSASPPPPGHTSLIARARSAALGNLQLTVSAGMIAVVVLWGLVSPASLGTFFGTLLS
CCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHH
DITRNFGWLYLWVVLGLVGLALFLALSRYGDLKLGDEDEEPEFSAATWFAMLFAAGMGIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LVFWGVAEPISHYGLPPPGIVPQTPEAAGAAMRYAFFHWGLHPWAIYGIVGLTIAFFQFR
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RQAPALVSSATESLPWRGMRHLSPLVNVLAVVATAFGVAASLGMGAAQINGGLQAVFGVP
HHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHEEECCC
VGPWSQAVIIVVTTALFITSAVSGVERGVKWLSSANLMLAALLALAVFLLGPTVSLVNTF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHH
TNTLGAYLSEFVRTSLRMSPFRDSSWVGDWTIFYWSWWIAWSPFVGLFIARVSRGRTIRE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
FVLGTVIAPTLVGFLWFSIFGGTALHLEIFRQVPLAAAAQADPATAMFAMFGAMPMGLAM
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHH
SVVATMLVIVFFITSGDSATLVLSTMSTRGDPNPSARVKIVWGLLVAGIALSLLFAGGLQ
HHHHHHHHHHHHHCCCCCCEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHH
AVQTATIVFALPFALVLLLMAVALMRAVREDHEAERRRERALRRRMREMAMRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; choline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + choline [Periplasm] = Proton [Cytoplasm] + choline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8752321; 9387221; 9384377 [H]