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The map label for this gene is hda [H]

Identifier: 120610651

GI number: 120610651

Start: 2141004

End: 2141714

Strand: Direct

Name: hda [H]

Synonym: Aave_1971

Alternate gene names: 120610651

Gene position: 2141004-2141714 (Clockwise)

Preceding gene: 120610644

Following gene: 120610652

Centisome position: 40.0

GC content: 70.6

Gene sequence:

>711_bases
ATGAAGCAGCTCGCGCTCGACATCGGCCTGTCCACCGGACCCACGCTGGCGCGGTTCTTTCCCGGCGCCAACGCCCAGGC
ATTGCAGCATCTGCGCATCGCGGTGGGGGAGGGGGACGCGGCCTCGGGCGCGGCGCCGGTGCGCTCGCCGGTTCCCACCT
ACCTCTGGGGCGAGTCGGGCAGCGGCAAAACCCACCTGCTCGAAGCCGTGCGCGAGGCGCTGCGCGAACAGGGCTGCACG
GTGGGCTGGCTCGACGCGTCGGTGATGCTGCCCACGGCCTTCGACGAGCGCTGGTCCGCCGTGCTGCTCGACGAGGTGCA
CCTGTATTCCACCGCCCAGCAGGCCGCGGCGTTCAATTGGTTCATCAACGCCATCAGCCCCGCCGTCGGCGCGCCGCGCT
GGGTGCTGGCCGCCGGCGAACTGCCGCCCGCGGACCTGCCGTTGCGCGACGACCTGCGCACGCGCCTGGGCTGGGGCCAC
ATATTCCAATTGCACCTGCTGGACGAAACCGAGCGCCGCGCGGTGCTGCGGCAGGAAGCCGACGCCCGCGGCATCGCCCT
GGGCGACGACGTGGTGAACTACATGCTGGGCCGCTTCTCGCGCGACCTGGGCAGCCTCATGCAGCTGCTCGACCAGCTCG
ACAGTTTCGCGCTGCGCACGCAGCGGGCCATCACGATCCCCCTGCTCAAGACCATGCTGGAGTCCGAATAG

Upstream 100 bases:

>100_bases
CGCTGCCGCTTTCCCCGTTCCGCGCCACCGCCGTGCACGCACCCGTGCCGCCGGCCCGCCGCGCGCCGGTGGCCGTACCC
GGCGGCCTGCAAGGGCTCCC

Downstream 100 bases:

>100_bases
CGGGCCGACGCCGCTGCCGACGACGCTTAGTTCCCCTTCGCACCGAATGCCCGCATGACCCCCGACACTCCGGCCTCCCC
AGATCGCCGCCCCCGGCTCG

Product: chromosomal replication initiator DnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MKQLALDIGLSTGPTLARFFPGANAQALQHLRIAVGEGDAASGAAPVRSPVPTYLWGESGSGKTHLLEAVREALREQGCT
VGWLDASVMLPTAFDERWSAVLLDEVHLYSTAQQAAAFNWFINAISPAVGAPRWVLAAGELPPADLPLRDDLRTRLGWGH
IFQLHLLDETERRAVLRQEADARGIALGDDVVNYMLGRFSRDLGSLMQLLDQLDSFALRTQRAITIPLLKTMLESE

Sequences:

>Translated_236_residues
MKQLALDIGLSTGPTLARFFPGANAQALQHLRIAVGEGDAASGAAPVRSPVPTYLWGESGSGKTHLLEAVREALREQGCT
VGWLDASVMLPTAFDERWSAVLLDEVHLYSTAQQAAAFNWFINAISPAVGAPRWVLAAGELPPADLPLRDDLRTRLGWGH
IFQLHLLDETERRAVLRQEADARGIALGDDVVNYMLGRFSRDLGSLMQLLDQLDSFALRTQRAITIPLLKTMLESE
>Mature_236_residues
MKQLALDIGLSTGPTLARFFPGANAQALQHLRIAVGEGDAASGAAPVRSPVPTYLWGESGSGKTHLLEAVREALREQGCT
VGWLDASVMLPTAFDERWSAVLLDEVHLYSTAQQAAAFNWFINAISPAVGAPRWVLAAGELPPADLPLRDDLRTRLGWGH
IFQLHLLDETERRAVLRQEADARGIALGDDVVNYMLGRFSRDLGSLMQLLDQLDSFALRTQRAITIPLLKTMLESE

Specific function: Mediates the interactions of dnaA with the beta subunit sliding clamp, promoting hydrolysis of dnaA-bound ATP. It is essential for the control of initiation of DNA replication by inhibiting reinitiation of replication [H]

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family. HdA subfamily [H]

Homologues:

Organism=Escherichia coli, GI226510964, Length=240, Percent_Identity=31.25, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020591
- InterPro:   IPR017788
- InterPro:   IPR013317
- InterPro:   IPR022864 [H]

Pfam domain/function: PF00308 Bac_DnaA [H]

EC number: NA

Molecular weight: Translated: 25780; Mature: 25780

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLALDIGLSTGPTLARFFPGANAQALQHLRIAVGEGDAASGAAPVRSPVPTYLWGESG
CCCEEEEECCCCCCHHHHHCCCCCHHHHHHHHHEECCCCCCCCCCCCCCCCCCEEECCCC
SGKTHLLEAVREALREQGCTVGWLDASVMLPTAFDERWSAVLLDEVHLYSTAQQAAAFNW
CCHHHHHHHHHHHHHHCCCEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FINAISPAVGAPRWVLAAGELPPADLPLRDDLRTRLGWGHIFQLHLLDETERRAVLRQEA
HHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHC
DARGIALGDDVVNYMLGRFSRDLGSLMQLLDQLDSFALRTQRAITIPLLKTMLESE
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEHHHHHHHHHCCC
>Mature Secondary Structure
MKQLALDIGLSTGPTLARFFPGANAQALQHLRIAVGEGDAASGAAPVRSPVPTYLWGESG
CCCEEEEECCCCCCHHHHHCCCCCHHHHHHHHHEECCCCCCCCCCCCCCCCCCEEECCCC
SGKTHLLEAVREALREQGCTVGWLDASVMLPTAFDERWSAVLLDEVHLYSTAQQAAAFNW
CCHHHHHHHHHHHHHHCCCEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FINAISPAVGAPRWVLAAGELPPADLPLRDDLRTRLGWGHIFQLHLLDETERRAVLRQEA
HHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHC
DARGIALGDDVVNYMLGRFSRDLGSLMQLLDQLDSFALRTQRAITIPLLKTMLESE
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA