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The map label for this gene is pbpC [H]

Identifier: 120610637

GI number: 120610637

Start: 2125134

End: 2127488

Strand: Direct

Name: pbpC [H]

Synonym: Aave_1957

Alternate gene names: 120610637

Gene position: 2125134-2127488 (Clockwise)

Preceding gene: 120610636

Following gene: 120610638

Centisome position: 39.7

GC content: 74.99

Gene sequence:

>2355_bases
ATGCCTTTCCTCGCTTTCCTGCGCCACCGGGCGCGCCGTCCCGGCACTGAAGCACTGGCTGTCCTGCCGCTGTGCCTCGC
GCTCTGGGCGCCGCTGCCGGCCCGCGCCCTGCCGGCCTATGCCGAGGTGCGCGCGGACTACCGCTCGTCCGAAACCCTGG
TGCTCTCGCGCGAAGGCGAGGTGGTGCAGCGGCTGCGGACCGATGCCACCGTGCGGCGCGGCCAGTGGACGGGGCTGGAC
GACATATCGCCCGCGCTGCGGGAGGCGCTGGTGCTCAGCGAGGACCGGCGCTTCTACGAGCACAGCGGCGTGGACTGGCG
CGCCGTCTCGGCCGCCGCCTGGGGCAATCTGTGGAACCAGCGCACGCGAGGCGCTTCCACCCTGACCATGCAACTCGCCG
GCCTGCTGGACGGCGACTGGCGTCAGGGGCCCGGCGGCCGGTCGGTGGCCCAGAAGCTCGGGCAGACCGTGGCCGCGCAG
GTGCTGGAGAGGCGCTGGCGCAAGGACCAGATCCTGGAGGCCTACCTCAACCTCGTGCCCTTCCGGGGCGAACTGGTGGG
CATCGACGCACTGTCCCGCACGCTGTTCGGCAAGGCGCCGCATGGGCTGGACGACCGCGAGGCCGCGGTCGCCGCGGCGC
TGGTGCGGGCGCCGAACGCCCGGCCCGCGCTCGTGGCCCAGCGCGCCTGCGGCGTGCTGCGTTCCATGGCCGGGCAGGCC
GGCGGTGGCGGCGGCCGTCCCGCGCCATCGTCCATGGACTGCGATGCGCTGGACCTGTTCACCACCGCCGCGCTGCAGCG
CCGGGATTACGCGGCCAGCGAGGGCGTGGCTCCGCATTTCGCGCGCCAGCTGCTGGCGCGCATGGAAGGGCCGCCTCCGG
CGTCCGTCGTGTCCAGCCTCAGCGCGCCGCTGCAGCGCATGGCCGTTCAGTCGCTGCACCAGCACCTGCGCGAGCTGCAC
GGCCGCAACGTGGAGGACGGCGCCGTGGTCGTGCTCGACAACGCCACCGGCGAAGTGCTGGCGTGGGTGGGGTCGTCCGG
CCTGTTGAGCCAGGCGGGAGAGGTGGACGGGGTGCTGGCCGCGCGCCAGCCGGGCTCCACGCTCAAGCCCTTCCTCTACG
CCCAGGCGATCGCGCAGCGCCGCATCACCGCCGCGTCGCTGATCGAGGATTCGCCCGCGTACATACCCACCGCCTCGGGG
CTCTACATCCCGCAGAACTACGACCGGCAGTTCAAGGGCTGGGTGTCCGCGCGCACCGCCCTGGCCGCCTCGCTCAACGT
GCCGGCGGTGCGCACCCTCGCCATGGTCACTCCCGACGCCTTCTTCCGCCAGTTGCAGGCCCTGGGCCTGCCGCTGCGGG
AGACGGGCGACTACTACGGCTACAGCCTCGCGCTGGGCAGCGCCGAGGTGCCTCTGCTCCACCTGGCCAATGCCTACCGC
GCGCTCGCCAACGGCGGCCGGCCCGGTCCCGCCGTGTTACGTCCCGCCGCTGCGGGCACGCGGCGCACGGGCACCAGGCC
GGCCCCGGCCGCGGCGACGGAGGCACCCCCCGCGGTCGATCCGCGCGCGGCCTTCATCGTGGGCGACATCCTTTCGGACG
GCAATGCACGCGCGCGCACGTTCGGCACCGACAGCGTGCTGGCCACGCGGTTCTGGAGCGCGGTGAAGACCGGCACCAGC
AAGGACATGCGCGACAACTGGGCGCTGGGCTGGTCGCAGCGCTACACCGTGGGCGTGTGGGTGGGCAATGCGGGCGGGGC
GCCCATGCACGACGTGAGCGGCACCAGCGGCGCGGCGCCCGTGTGGGCCGAGATCATGGGCTGGCTGCACGGCCGGGGCG
TGCGCAGCCGCCCGCCCGAGCCACCGCCCGGGCTGGTCCGCGCCGCCGTGCGCTTCGGCCCCGAGCCGGGCGGCACGCGC
CTGCTGGAAAGCGCGCGCCAGGAATGGTTCCTCGCCGGCACGCAGCAGTCGCTCTTCGCCGTGGATGCGGGCCCCGGCAC
CGTCCGGCGGGGGCGCGCGGCGCCGGAGCCGGCAGCCGGCGAGGGCGGTGCGCCGGACGGCCTGCAGGCCCCGCAGCCGC
GCATCGTGTCGCCCGCCACGGGCACCATCGTGGCGCTGGACCCCGACATCCCTCCCGCCCATCAGCGCCTGCAGTTCGCC
GCCGCGGGCGGCGGCGTGCCGGGGACGCTGCGTTGGCGCATCGACGGCCGGGTGCAGGGCCGGGGGGCGGAATGGGCCTG
GCTGCCCTGGCCCGGACGCCACCGGGTGGAGCTGGTGGATGCGGGAGGGCAGGTGGTGGACGAGATCCGCATCGAGGTGC
GGGGAGCGGGCGTGGTGAAAGGGCCCCGCCCCTGA

Upstream 100 bases:

>100_bases
TTCTGAGCGCACCCCAGCGGCGGCTGGCCGCCGCTGCGCCAGAATCGGGGCCTTCCAGCCCTTTTCGCGCCGCCGTCGTG
CTTCCCCCGGCGGCTTTCCC

Downstream 100 bases:

>100_bases
AGCGACTCTTGCGGCGGTGGCCCGCGCGTGGCGAGCTGCCGCGCCCGGGCGGCCCCGGTTCCAGGGATACTGCTCCCCTT
GAGGAAGGAACCGGCATGCA

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 784; Mature: 783

Protein sequence:

>784_residues
MPFLAFLRHRARRPGTEALAVLPLCLALWAPLPARALPAYAEVRADYRSSETLVLSREGEVVQRLRTDATVRRGQWTGLD
DISPALREALVLSEDRRFYEHSGVDWRAVSAAAWGNLWNQRTRGASTLTMQLAGLLDGDWRQGPGGRSVAQKLGQTVAAQ
VLERRWRKDQILEAYLNLVPFRGELVGIDALSRTLFGKAPHGLDDREAAVAAALVRAPNARPALVAQRACGVLRSMAGQA
GGGGGRPAPSSMDCDALDLFTTAALQRRDYAASEGVAPHFARQLLARMEGPPPASVVSSLSAPLQRMAVQSLHQHLRELH
GRNVEDGAVVVLDNATGEVLAWVGSSGLLSQAGEVDGVLAARQPGSTLKPFLYAQAIAQRRITAASLIEDSPAYIPTASG
LYIPQNYDRQFKGWVSARTALAASLNVPAVRTLAMVTPDAFFRQLQALGLPLRETGDYYGYSLALGSAEVPLLHLANAYR
ALANGGRPGPAVLRPAAAGTRRTGTRPAPAAATEAPPAVDPRAAFIVGDILSDGNARARTFGTDSVLATRFWSAVKTGTS
KDMRDNWALGWSQRYTVGVWVGNAGGAPMHDVSGTSGAAPVWAEIMGWLHGRGVRSRPPEPPPGLVRAAVRFGPEPGGTR
LLESARQEWFLAGTQQSLFAVDAGPGTVRRGRAAPEPAAGEGGAPDGLQAPQPRIVSPATGTIVALDPDIPPAHQRLQFA
AAGGGVPGTLRWRIDGRVQGRGAEWAWLPWPGRHRVELVDAGGQVVDEIRIEVRGAGVVKGPRP

Sequences:

>Translated_784_residues
MPFLAFLRHRARRPGTEALAVLPLCLALWAPLPARALPAYAEVRADYRSSETLVLSREGEVVQRLRTDATVRRGQWTGLD
DISPALREALVLSEDRRFYEHSGVDWRAVSAAAWGNLWNQRTRGASTLTMQLAGLLDGDWRQGPGGRSVAQKLGQTVAAQ
VLERRWRKDQILEAYLNLVPFRGELVGIDALSRTLFGKAPHGLDDREAAVAAALVRAPNARPALVAQRACGVLRSMAGQA
GGGGGRPAPSSMDCDALDLFTTAALQRRDYAASEGVAPHFARQLLARMEGPPPASVVSSLSAPLQRMAVQSLHQHLRELH
GRNVEDGAVVVLDNATGEVLAWVGSSGLLSQAGEVDGVLAARQPGSTLKPFLYAQAIAQRRITAASLIEDSPAYIPTASG
LYIPQNYDRQFKGWVSARTALAASLNVPAVRTLAMVTPDAFFRQLQALGLPLRETGDYYGYSLALGSAEVPLLHLANAYR
ALANGGRPGPAVLRPAAAGTRRTGTRPAPAAATEAPPAVDPRAAFIVGDILSDGNARARTFGTDSVLATRFWSAVKTGTS
KDMRDNWALGWSQRYTVGVWVGNAGGAPMHDVSGTSGAAPVWAEIMGWLHGRGVRSRPPEPPPGLVRAAVRFGPEPGGTR
LLESARQEWFLAGTQQSLFAVDAGPGTVRRGRAAPEPAAGEGGAPDGLQAPQPRIVSPATGTIVALDPDIPPAHQRLQFA
AAGGGVPGTLRWRIDGRVQGRGAEWAWLPWPGRHRVELVDAGGQVVDEIRIEVRGAGVVKGPRP
>Mature_783_residues
PFLAFLRHRARRPGTEALAVLPLCLALWAPLPARALPAYAEVRADYRSSETLVLSREGEVVQRLRTDATVRRGQWTGLDD
ISPALREALVLSEDRRFYEHSGVDWRAVSAAAWGNLWNQRTRGASTLTMQLAGLLDGDWRQGPGGRSVAQKLGQTVAAQV
LERRWRKDQILEAYLNLVPFRGELVGIDALSRTLFGKAPHGLDDREAAVAAALVRAPNARPALVAQRACGVLRSMAGQAG
GGGGRPAPSSMDCDALDLFTTAALQRRDYAASEGVAPHFARQLLARMEGPPPASVVSSLSAPLQRMAVQSLHQHLRELHG
RNVEDGAVVVLDNATGEVLAWVGSSGLLSQAGEVDGVLAARQPGSTLKPFLYAQAIAQRRITAASLIEDSPAYIPTASGL
YIPQNYDRQFKGWVSARTALAASLNVPAVRTLAMVTPDAFFRQLQALGLPLRETGDYYGYSLALGSAEVPLLHLANAYRA
LANGGRPGPAVLRPAAAGTRRTGTRPAPAAATEAPPAVDPRAAFIVGDILSDGNARARTFGTDSVLATRFWSAVKTGTSK
DMRDNWALGWSQRYTVGVWVGNAGGAPMHDVSGTSGAAPVWAEIMGWLHGRGVRSRPPEPPPGLVRAAVRFGPEPGGTRL
LESARQEWFLAGTQQSLFAVDAGPGTVRRGRAAPEPAAGEGGAPDGLQAPQPRIVSPATGTIVALDPDIPPAHQRLQFAA
AGGGVPGTLRWRIDGRVQGRGAEWAWLPWPGRHRVELVDAGGQVVDEIRIEVRGAGVVKGPRP

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=593, Percent_Identity=34.9072512647555, Blast_Score=213, Evalue=4e-56,
Organism=Escherichia coli, GI1786343, Length=588, Percent_Identity=27.2108843537415, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI87082258, Length=145, Percent_Identity=36.551724137931, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1789601, Length=179, Percent_Identity=32.9608938547486, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 83392; Mature: 83260

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFLAFLRHRARRPGTEALAVLPLCLALWAPLPARALPAYAEVRADYRSSETLVLSREGE
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHCCCCCEEEEECCHH
VVQRLRTDATVRRGQWTGLDDISPALREALVLSEDRRFYEHSGVDWRAVSAAAWGNLWNQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHH
RTRGASTLTMQLAGLLDGDWRQGPGGRSVAQKLGQTVAAQVLERRWRKDQILEAYLNLVP
HCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FRGELVGIDALSRTLFGKAPHGLDDREAAVAAALVRAPNARPALVAQRACGVLRSMAGQA
CCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
GGGGGRPAPSSMDCDALDLFTTAALQRRDYAASEGVAPHFARQLLARMEGPPPASVVSSL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
SAPLQRMAVQSLHQHLRELHGRNVEDGAVVVLDNATGEVLAWVGSSGLLSQAGEVDGVLA
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEECCCCHHHCCCCCCCEEE
ARQPGSTLKPFLYAQAIAQRRITAASLIEDSPAYIPTASGLYIPQNYDRQFKGWVSARTA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHH
LAASLNVPAVRTLAMVTPDAFFRQLQALGLPLRETGDYYGYSLALGSAEVPLLHLANAYR
HHHCCCCCHHHHHHHCCHHHHHHHHHHHCCCHHHCCCCCEEEEEECCCCCHHHHHHHHHH
ALANGGRPGPAVLRPAAAGTRRTGTRPAPAAATEAPPAVDPRAAFIVGDILSDGNARART
HHHCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEHHHCCCCCCEEE
FGTDSVLATRFWSAVKTGTSKDMRDNWALGWSQRYTVGVWVGNAGGAPMHDVSGTSGAAP
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCH
VWAEIMGWLHGRGVRSRPPEPPPGLVRAAVRFGPEPGGTRLLESARQEWFLAGTQQSLFA
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHEEECCCCCEEE
VDAGPGTVRRGRAAPEPAAGEGGAPDGLQAPQPRIVSPATGTIVALDPDIPPAHQRLQFA
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCCHHHHEEEE
AAGGGVPGTLRWRIDGRVQGRGAEWAWLPWPGRHRVELVDAGGQVVDEIRIEVRGAGVVK
ECCCCCCCEEEEEECCEEECCCCCEEECCCCCCCEEEEECCCCCEEEEEEEEEECCCCCC
GPRP
CCCC
>Mature Secondary Structure 
PFLAFLRHRARRPGTEALAVLPLCLALWAPLPARALPAYAEVRADYRSSETLVLSREGE
CHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHCCCCCEEEEECCHH
VVQRLRTDATVRRGQWTGLDDISPALREALVLSEDRRFYEHSGVDWRAVSAAAWGNLWNQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHH
RTRGASTLTMQLAGLLDGDWRQGPGGRSVAQKLGQTVAAQVLERRWRKDQILEAYLNLVP
HCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FRGELVGIDALSRTLFGKAPHGLDDREAAVAAALVRAPNARPALVAQRACGVLRSMAGQA
CCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
GGGGGRPAPSSMDCDALDLFTTAALQRRDYAASEGVAPHFARQLLARMEGPPPASVVSSL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
SAPLQRMAVQSLHQHLRELHGRNVEDGAVVVLDNATGEVLAWVGSSGLLSQAGEVDGVLA
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEECCCCHHHCCCCCCCEEE
ARQPGSTLKPFLYAQAIAQRRITAASLIEDSPAYIPTASGLYIPQNYDRQFKGWVSARTA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHH
LAASLNVPAVRTLAMVTPDAFFRQLQALGLPLRETGDYYGYSLALGSAEVPLLHLANAYR
HHHCCCCCHHHHHHHCCHHHHHHHHHHHCCCHHHCCCCCEEEEEECCCCCHHHHHHHHHH
ALANGGRPGPAVLRPAAAGTRRTGTRPAPAAATEAPPAVDPRAAFIVGDILSDGNARART
HHHCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEHHHCCCCCCEEE
FGTDSVLATRFWSAVKTGTSKDMRDNWALGWSQRYTVGVWVGNAGGAPMHDVSGTSGAAP
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCH
VWAEIMGWLHGRGVRSRPPEPPPGLVRAAVRFGPEPGGTRLLESARQEWFLAGTQQSLFA
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHEEECCCCCEEE
VDAGPGTVRRGRAAPEPAAGEGGAPDGLQAPQPRIVSPATGTIVALDPDIPPAHQRLQFA
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCCHHHHEEEE
AAGGGVPGTLRWRIDGRVQGRGAEWAWLPWPGRHRVELVDAGGQVVDEIRIEVRGAGVVK
ECCCCCCCEEEEEECCEEECCCCCEEECCCCCCCEEEEECCCCCEEEEEEEEEECCCCCC
GPRP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]