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The map label for this gene is lysR [H]

Identifier: 120610615

GI number: 120610615

Start: 2097901

End: 2098824

Strand: Direct

Name: lysR [H]

Synonym: Aave_1935

Alternate gene names: 120610615

Gene position: 2097901-2098824 (Clockwise)

Preceding gene: 120610612

Following gene: 120610617

Centisome position: 39.19

GC content: 71.86

Gene sequence:

>924_bases
ATGCGCCTGCGCCACATCGAAGTCTTCAACGCCGTGATGCTCACGGGCAGCGTGAGCGCGGCCGCGCGGCTCATCAACGT
CACGCAGCCCGCGGTGAGCCGCATCCTCGCGCATGCGGAGCTGCAGCTGGGCTTCGCGCTGTTCCACCGGCACAAGGGGC
GCCTCGTGCCGACGCGCGAGGCGCAGACGCTCTATCCGCACATCGAGCGGCTGTTCACGCAGCTCGACGAGGTACAGCGT
CTGGCCGGCAGCCTGCGCGGGCAGCAGCGCGAGGGCGAGCTGCATGTGCTGAGCGTGCTCGCCTTGAGCCACGAGGTGAT
GCCGCGGGCGCTGCGGGCCTTCCATGCGCTGCATCCCGGCGTGCACGTCACCATCGACGCGCTGCATTCCCCGCAGATCG
TCTCGGCCCTGGTGCTGCAGGAGGCCGACGTGGGCTTCGTGTTCTCGGCGCTGTCGCACCCGTCGCTGGAGCAGGAGACG
CTCGCCGAAGGCGCCATGGTCTGCGTGGCGCCGCGCGGCCTGCTGGATGCCCAGGTGGTGAGCGCGGACGCGGTGCACCT
GGCCGATCTGGCCGGCGTGCCGGTGGTGCGGCTGGGGCTGAACGATCCGCTCGGCACCATGGTGAACCATGCCTGCCGCG
AGGCCGAGGTCGGGCTGCAATCGGCGATCACGGTGCAGACCTACCATGCCGCGCTGGCGCTCGCGCACCACGGGCTGGGC
GTGGCGCTGGTCGATGCCTGCACGGCCGCATCCGCGGACCGGCGGCAGGTGGACGTGCTGGAGCTGCTGCCGCGCATCGC
CGTGCCGGTGAGGGCGCTGCGCATGCCGCACCGCCCGGCATCGCTGCTCGCCGATGCGATGGTGCGCTGCATGCGCGAGG
CCGTGCTGCAGACCGTGCAGAAGGGGCCGGCTCAGGCGGCGTGA

Upstream 100 bases:

>100_bases
TGGCCGGCGATTGTGCAGGGAAGCTCCGGCACTGGAAGATAGGAAACGCTTTGATGCAATATCCCACCCTGTCCTCACCA
CTGCACCGTCTCGCCGTTCC

Downstream 100 bases:

>100_bases
ACGGCGCCCGGTACGGCGGTGGCCTGCGGCGCCTGCGCCATCGCCTCCGCCAATTGCTCCGCGGTGCCGAACGAGAGCGT
GAACCCCAGGGCGCCGTGGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MRLRHIEVFNAVMLTGSVSAAARLINVTQPAVSRILAHAELQLGFALFHRHKGRLVPTREAQTLYPHIERLFTQLDEVQR
LAGSLRGQQREGELHVLSVLALSHEVMPRALRAFHALHPGVHVTIDALHSPQIVSALVLQEADVGFVFSALSHPSLEQET
LAEGAMVCVAPRGLLDAQVVSADAVHLADLAGVPVVRLGLNDPLGTMVNHACREAEVGLQSAITVQTYHAALALAHHGLG
VALVDACTAASADRRQVDVLELLPRIAVPVRALRMPHRPASLLADAMVRCMREAVLQTVQKGPAQAA

Sequences:

>Translated_307_residues
MRLRHIEVFNAVMLTGSVSAAARLINVTQPAVSRILAHAELQLGFALFHRHKGRLVPTREAQTLYPHIERLFTQLDEVQR
LAGSLRGQQREGELHVLSVLALSHEVMPRALRAFHALHPGVHVTIDALHSPQIVSALVLQEADVGFVFSALSHPSLEQET
LAEGAMVCVAPRGLLDAQVVSADAVHLADLAGVPVVRLGLNDPLGTMVNHACREAEVGLQSAITVQTYHAALALAHHGLG
VALVDACTAASADRRQVDVLELLPRIAVPVRALRMPHRPASLLADAMVRCMREAVLQTVQKGPAQAA
>Mature_307_residues
MRLRHIEVFNAVMLTGSVSAAARLINVTQPAVSRILAHAELQLGFALFHRHKGRLVPTREAQTLYPHIERLFTQLDEVQR
LAGSLRGQQREGELHVLSVLALSHEVMPRALRAFHALHPGVHVTIDALHSPQIVSALVLQEADVGFVFSALSHPSLEQET
LAEGAMVCVAPRGLLDAQVVSADAVHLADLAGVPVVRLGLNDPLGTMVNHACREAEVGLQSAITVQTYHAALALAHHGLG
VALVDACTAASADRRQVDVLELLPRIAVPVRALRMPHRPASLLADAMVRCMREAVLQTVQKGPAQAA

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=291, Percent_Identity=31.6151202749141, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI87082132, Length=176, Percent_Identity=29.5454545454545, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788481, Length=177, Percent_Identity=26.5536723163842, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33017; Mature: 33017

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRHIEVFNAVMLTGSVSAAARLINVTQPAVSRILAHAELQLGFALFHRHKGRLVPTRE
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
AQTLYPHIERLFTQLDEVQRLAGSLRGQQREGELHVLSVLALSHEVMPRALRAFHALHPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
VHVTIDALHSPQIVSALVLQEADVGFVFSALSHPSLEQETLAEGAMVCVAPRGLLDAQVV
CEEEEECCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHCCCEEEEECCCCHHHHHH
SADAVHLADLAGVPVVRLGLNDPLGTMVNHACREAEVGLQSAITVQTYHAALALAHHGLG
HHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCC
VALVDACTAASADRRQVDVLELLPRIAVPVRALRMPHRPASLLADAMVRCMREAVLQTVQ
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
KGPAQAA
CCCCCCC
>Mature Secondary Structure
MRLRHIEVFNAVMLTGSVSAAARLINVTQPAVSRILAHAELQLGFALFHRHKGRLVPTRE
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
AQTLYPHIERLFTQLDEVQRLAGSLRGQQREGELHVLSVLALSHEVMPRALRAFHALHPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
VHVTIDALHSPQIVSALVLQEADVGFVFSALSHPSLEQETLAEGAMVCVAPRGLLDAQVV
CEEEEECCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHCCCEEEEECCCCHHHHHH
SADAVHLADLAGVPVVRLGLNDPLGTMVNHACREAEVGLQSAITVQTYHAALALAHHGLG
HHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCC
VALVDACTAASADRRQVDVLELLPRIAVPVRALRMPHRPASLLADAMVRCMREAVLQTVQ
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
KGPAQAA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]