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The map label for this gene is folC [H]

Identifier: 120610540

GI number: 120610540

Start: 2014623

End: 2015948

Strand: Direct

Name: folC [H]

Synonym: Aave_1860

Alternate gene names: 120610540

Gene position: 2014623-2015948 (Clockwise)

Preceding gene: 120610535

Following gene: 120610541

Centisome position: 37.64

GC content: 69.98

Gene sequence:

>1326_bases
ATGCACACCACTTTCGACACCCTGGACGGCTGGCTGGCCCATTGCGAACGCATCCACCCGAAAACCATCGACATGGGCCT
GGAGCGGGTGGGCGAGGTGGCGCGCCGGCTCGGGCTGCGTTTCACCTGCCCCGTCATCACGGTGGCCGGCACGAACGGCA
AGGGTTCCACCTGCGCCATGCTGGAGGCGGTGGCGCTGCAGTCGGGCTACCGCACCGGCGTCTATACCTCGCCGCACCTC
GTGAAGTTCGAGGAGCGCTGCCGCATCCGGGGCGAGAGTGTCGGGGCGGACGATCTGGTCCCGCACTTCGCGGCCGTGGA
GGCGGCGAGAACGCATGGCGGCGCGGAGGTGTCCCTGTCCTACTTCGAGTTCACCACGCTCGCCATCCTGCGCCTCATGA
GCCAGGCGGGCCTGGATGTCGCCATCCTGGAGGTGGGCCTGGGCGGCCGCCTCGACGCGACCAATGTCGTGGATACCGAC
TGCGCGGTCATCACCAGCATCGACATCGACCACACGGAGTTCCTGGGACCGGACCGCGAATCCATCGGCCGGGAGAAGGC
CGGCATCATGCGGCCGGGCCGTCCCGCCATCGTCAGCGACCCCATGGCACCGCAGAGCGTGCTGGACCACGCGCGCGCCC
TCGGAGCCGACCTGTGGCAGTTCGGCCAGGACTTCAATTTTTCCGGCGACAAGCAGCAGTGGGCCTGGGCGGGGCGGGGT
CGCCGCTATGCCGGGCTGGCCTACCCGGCACTGCGGGGGGCCAACCAGCTGGTCAACGCCTCCGGCGTGCTGGCCGCCCT
GGAGGCGCTGCGCGACCGGCTGCCGATCACGGCCCAGGCCGTGCGCACCGGCCTGGCCATGGTGGAGCTGCCGGGGCGCT
TCCAGATCGTCCCGGGCCAGCCCACCCTGGTACTGGACGTGGCCCACAACCCGCATTCGGTGGCGGCGCTCACCGCCAAC
CTGGACGCCATGGGCTTTTTCCCGACCACCCATGCGGTGTTCGGCGCCATGGCCGACAAGGACCTCGCTCCCATGCTGGC
CCGCATCGGCCCGCTGGTGGACCGCTGGTACTTCACCGACCTGCCGACGCCGCGTGCCGAAACCGCCGCCGCCCTGCAGC
AGAAGTGGAACGCCCTGCAGATCGTCGCCGGCGGACGCCGCGAAGTGCGCACCAGCCTGCACCCGGACCCATGGCAGGCG
CTGCAGGCGGCCGTGGCCGCTGCAGAGCCGACTGATAGAATCGTGGTCTTTGGCTCCTTCTATACGGTCGGCGGTGTGCT
GCACCACGGAACGCCCCGCCTGCAGGCCAAGCACCTGGGCACTTGA

Upstream 100 bases:

>100_bases
TTGACCGTGTCGCAGTTGGGAATGCCATAGACGATGGGGGTGGGGGTACTCATGCGCCCGATCATCCTGCAACGCCGCCT
CGGCGACAATCGCCGGCTCT

Downstream 100 bases:

>100_bases
GCATCCGACAGCGCACTCCCCGCACTGCATCCATGGCATTTTTCAAGTTTCGTTGGCCCGGCCGCAAGGAGCAGCCCGAG
CAGCCCGCAAAGCCCGCCAA

Product: FolC bifunctional protein

Products: NA

Alternate protein names: Folylpolyglutamate synthase; Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase; Dihydrofolate synthase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MHTTFDTLDGWLAHCERIHPKTIDMGLERVGEVARRLGLRFTCPVITVAGTNGKGSTCAMLEAVALQSGYRTGVYTSPHL
VKFEERCRIRGESVGADDLVPHFAAVEAARTHGGAEVSLSYFEFTTLAILRLMSQAGLDVAILEVGLGGRLDATNVVDTD
CAVITSIDIDHTEFLGPDRESIGREKAGIMRPGRPAIVSDPMAPQSVLDHARALGADLWQFGQDFNFSGDKQQWAWAGRG
RRYAGLAYPALRGANQLVNASGVLAALEALRDRLPITAQAVRTGLAMVELPGRFQIVPGQPTLVLDVAHNPHSVAALTAN
LDAMGFFPTTHAVFGAMADKDLAPMLARIGPLVDRWYFTDLPTPRAETAAALQQKWNALQIVAGGRREVRTSLHPDPWQA
LQAAVAAAEPTDRIVVFGSFYTVGGVLHHGTPRLQAKHLGT

Sequences:

>Translated_441_residues
MHTTFDTLDGWLAHCERIHPKTIDMGLERVGEVARRLGLRFTCPVITVAGTNGKGSTCAMLEAVALQSGYRTGVYTSPHL
VKFEERCRIRGESVGADDLVPHFAAVEAARTHGGAEVSLSYFEFTTLAILRLMSQAGLDVAILEVGLGGRLDATNVVDTD
CAVITSIDIDHTEFLGPDRESIGREKAGIMRPGRPAIVSDPMAPQSVLDHARALGADLWQFGQDFNFSGDKQQWAWAGRG
RRYAGLAYPALRGANQLVNASGVLAALEALRDRLPITAQAVRTGLAMVELPGRFQIVPGQPTLVLDVAHNPHSVAALTAN
LDAMGFFPTTHAVFGAMADKDLAPMLARIGPLVDRWYFTDLPTPRAETAAALQQKWNALQIVAGGRREVRTSLHPDPWQA
LQAAVAAAEPTDRIVVFGSFYTVGGVLHHGTPRLQAKHLGT
>Mature_441_residues
MHTTFDTLDGWLAHCERIHPKTIDMGLERVGEVARRLGLRFTCPVITVAGTNGKGSTCAMLEAVALQSGYRTGVYTSPHL
VKFEERCRIRGESVGADDLVPHFAAVEAARTHGGAEVSLSYFEFTTLAILRLMSQAGLDVAILEVGLGGRLDATNVVDTD
CAVITSIDIDHTEFLGPDRESIGREKAGIMRPGRPAIVSDPMAPQSVLDHARALGADLWQFGQDFNFSGDKQQWAWAGRG
RRYAGLAYPALRGANQLVNASGVLAALEALRDRLPITAQAVRTGLAMVELPGRFQIVPGQPTLVLDVAHNPHSVAALTAN
LDAMGFFPTTHAVFGAMADKDLAPMLARIGPLVDRWYFTDLPTPRAETAAALQQKWNALQIVAGGRREVRTSLHPDPWQA
LQAAVAAAEPTDRIVVFGSFYTVGGVLHHGTPRLQAKHLGT

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=410, Percent_Identity=30.7317073170732, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI66932990, Length=410, Percent_Identity=30.7317073170732, Blast_Score=123, Evalue=4e-28,
Organism=Escherichia coli, GI1788654, Length=422, Percent_Identity=44.3127962085308, Blast_Score=326, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17553150, Length=303, Percent_Identity=30.6930693069307, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71984923, Length=303, Percent_Identity=30.6930693069307, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17553148, Length=303, Percent_Identity=30.6930693069307, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323760, Length=442, Percent_Identity=29.4117647058824, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324815, Length=199, Percent_Identity=31.6582914572864, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24641571, Length=295, Percent_Identity=30.5084745762712, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24581568, Length=167, Percent_Identity=35.9281437125749, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17; =6.3.2.12 [H]

Molecular weight: Translated: 47501; Mature: 47501

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS01012 FOLYLPOLYGLU_SYNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTTFDTLDGWLAHCERIHPKTIDMGLERVGEVARRLGLRFTCPVITVAGTNGKGSTCAM
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEECCEEEEECCCCCCCHHHH
LEAVALQSGYRTGVYTSPHLVKFEERCRIRGESVGADDLVPHFAAVEAARTHGGAEVSLS
HHHHHHHCCCCCCCCCCCCCEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEH
YFEFTTLAILRLMSQAGLDVAILEVGLGGRLDATNVVDTDCAVITSIDIDHTEFLGPDRE
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCHHHHCCCCHH
SIGREKAGIMRPGRPAIVSDPMAPQSVLDHARALGADLWQFGQDFNFSGDKQQWAWAGRG
HHCCHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCC
RRYAGLAYPALRGANQLVNASGVLAALEALRDRLPITAQAVRTGLAMVELPGRFQIVPGQ
CEEECCCCHHHHCHHHHHCHHHHHHHHHHHHHCCCCCHHHHHCCEEEEECCCCEEEECCC
PTLVLDVAHNPHSVAALTANLDAMGFFPTTHAVFGAMADKDLAPMLARIGPLVDRWYFTD
CEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHEECC
LPTPRAETAAALQQKWNALQIVAGGRREVRTSLHPDPWQALQAAVAAAEPTDRIVVFGSF
CCCCCHHHHHHHHHCCCEEEEEECCHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECH
YTVGGVLHHGTPRLQAKHLGT
HHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHTTFDTLDGWLAHCERIHPKTIDMGLERVGEVARRLGLRFTCPVITVAGTNGKGSTCAM
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEECCEEEEECCCCCCCHHHH
LEAVALQSGYRTGVYTSPHLVKFEERCRIRGESVGADDLVPHFAAVEAARTHGGAEVSLS
HHHHHHHCCCCCCCCCCCCCEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEH
YFEFTTLAILRLMSQAGLDVAILEVGLGGRLDATNVVDTDCAVITSIDIDHTEFLGPDRE
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCHHHHCCCCHH
SIGREKAGIMRPGRPAIVSDPMAPQSVLDHARALGADLWQFGQDFNFSGDKQQWAWAGRG
HHCCHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCC
RRYAGLAYPALRGANQLVNASGVLAALEALRDRLPITAQAVRTGLAMVELPGRFQIVPGQ
CEEECCCCHHHHCHHHHHCHHHHHHHHHHHHHCCCCCHHHHHCCEEEEECCCCEEEECCC
PTLVLDVAHNPHSVAALTANLDAMGFFPTTHAVFGAMADKDLAPMLARIGPLVDRWYFTD
CEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHEECC
LPTPRAETAAALQQKWNALQIVAGGRREVRTSLHPDPWQALQAAVAAAEPTDRIVVFGSF
CCCCCHHHHHHHHHCCCEEEEEECCHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECH
YTVGGVLHHGTPRLQAKHLGT
HHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3040739; 3040734; 9205837; 9278503; 1989505 [H]