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The map label for this gene is 120610528

Identifier: 120610528

GI number: 120610528

Start: 2004921

End: 2005685

Strand: Reverse

Name: 120610528

Synonym: Aave_1848

Alternate gene names: NA

Gene position: 2005685-2004921 (Counterclockwise)

Preceding gene: 120610532

Following gene: 120610527

Centisome position: 37.47

GC content: 69.54

Gene sequence:

>765_bases
ATGCCCGAAGGCCCATCCCTCGTCCTGCTCAAGGAAGCCGCCCGTCCGCTGGCCGAGGGCCGCAGGATCGAGCGGGCGTC
GGGCAACACCACCGCCATCGATACCGCTGCCCTGCCCGGCCGCCGCGTCGTCTCGGTGCGCACCTGGGGAAAGCACTTCC
TGCTCGAGCTGGACAGCGGCTGCACGGTGCGCGTGCATTTCCTCCTCTTCGGCTCCTTCCGCATCGATGACCCGAAGGAC
GCACCCGCCCGGCTCAGCCTGGGCTTCGAGGGCGGGCATGCGATCGATTTCTATGCCTGCTCGGTCCGGCCGGTCGAGGG
GCCGCTGGACGGGGCCTATGACTGGCGCGCGGACGTCATGTCCGATGCCTGGGACGCCGCGCTCGCCCGCAGGCGCCTGC
GGGCCCACCCGGAAGTCCTCGCCTGCGACGCGCTGCTCGACCAGGACGTGTTCGCGGGCGTGGGCAACATCATCAAGAAC
GAGGTGCTCTTCCGCATCCGCGTGCATCCGCTCTCGCCCGTGGGCGCCCTGCCCGCCACGCGCCTGCGCGAGCTCGTGGC
GCAGGCGCGGGAATATGCGTTCGAGTTCCTGGAGTGGAAACGCCAGGGCGTGCTGCGGCGCCACTGGCTGGCCCACCGGC
AGTCCGAATGCCCGCGCTGCCATATCCCCTTCGAAAAGCGCAAACTGGGGCGCACCGCACGCATCGCTTACTACTGCGAA
CGCTGCCAGGAACTTTTCGGCGCTGCCGCCTTGTCCCAGCCTTGA

Upstream 100 bases:

>100_bases
CGCTCGCGCCCAACGTGACTTTTTGCATGGAATAAGGCCTACAAGCTGCGAAAGTGGCTGGGGAGAATAATGGATTTTCA
CGAACGCCGCAGACCGCCCC

Downstream 100 bases:

>100_bases
CTGCCGGGCCTGCTCCGCATGCCAATAATCGGCGCACGTACCAGCCCCTCCGAACCTCGCGCAGCGAACGGTTGCCCATC
CGCACCCTCCAGTACCACGT

Product: formamidopyrimidine-DNA glycolase

Products: NA

Alternate protein names: Putative DNA-(apurinic or apyrimidinic site) lyase SCO5760; Putative AP lyase SCO5760 [H]

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MPEGPSLVLLKEAARPLAEGRRIERASGNTTAIDTAALPGRRVVSVRTWGKHFLLELDSGCTVRVHFLLFGSFRIDDPKD
APARLSLGFEGGHAIDFYACSVRPVEGPLDGAYDWRADVMSDAWDAALARRRLRAHPEVLACDALLDQDVFAGVGNIIKN
EVLFRIRVHPLSPVGALPATRLRELVAQAREYAFEFLEWKRQGVLRRHWLAHRQSECPRCHIPFEKRKLGRTARIAYYCE
RCQELFGAAALSQP

Sequences:

>Translated_254_residues
MPEGPSLVLLKEAARPLAEGRRIERASGNTTAIDTAALPGRRVVSVRTWGKHFLLELDSGCTVRVHFLLFGSFRIDDPKD
APARLSLGFEGGHAIDFYACSVRPVEGPLDGAYDWRADVMSDAWDAALARRRLRAHPEVLACDALLDQDVFAGVGNIIKN
EVLFRIRVHPLSPVGALPATRLRELVAQAREYAFEFLEWKRQGVLRRHWLAHRQSECPRCHIPFEKRKLGRTARIAYYCE
RCQELFGAAALSQP
>Mature_253_residues
PEGPSLVLLKEAARPLAEGRRIERASGNTTAIDTAALPGRRVVSVRTWGKHFLLELDSGCTVRVHFLLFGSFRIDDPKDA
PARLSLGFEGGHAIDFYACSVRPVEGPLDGAYDWRADVMSDAWDAALARRRLRAHPEVLACDALLDQDVFAGVGNIIKNE
VLFRIRVHPLSPVGALPATRLRELVAQAREYAFEFLEWKRQGVLRRHWLAHRQSECPRCHIPFEKRKLGRTARIAYYCER
CQELFGAAALSQP

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA b

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Homo sapiens, GI209364526, Length=266, Percent_Identity=30.8270676691729, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI21450800, Length=266, Percent_Identity=30.8270676691729, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI209364528, Length=266, Percent_Identity=30.8270676691729, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI209364530, Length=169, Percent_Identity=33.7278106508876, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI157388969, Length=128, Percent_Identity=30.46875, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR012319
- InterPro:   IPR010979
- InterPro:   IPR000214 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 28522; Mature: 28391

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEGPSLVLLKEAARPLAEGRRIERASGNTTAIDTAALPGRRVVSVRTWGKHFLLELDSG
CCCCCCEEEEHHHCCHHHCCCEEECCCCCCCEEECCCCCCCEEEEEEECCCEEEEEECCC
CTVRVHFLLFGSFRIDDPKDAPARLSLGFEGGHAIDFYACSVRPVEGPLDGAYDWRADVM
CEEEEEEEEEEEEECCCCCCCCCEEEECCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHH
SDAWDAALARRRLRAHPEVLACDALLDQDVFAGVGNIIKNEVLFRIRVHPLSPVGALPAT
HHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCHH
RLRELVAQAREYAFEFLEWKRQGVLRRHWLAHRQSECPRCHIPFEKRKLGRTARIAYYCE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHH
RCQELFGAAALSQP
HHHHHHHHHHCCCC
>Mature Secondary Structure 
PEGPSLVLLKEAARPLAEGRRIERASGNTTAIDTAALPGRRVVSVRTWGKHFLLELDSG
CCCCCEEEEHHHCCHHHCCCEEECCCCCCCEEECCCCCCCEEEEEEECCCEEEEEECCC
CTVRVHFLLFGSFRIDDPKDAPARLSLGFEGGHAIDFYACSVRPVEGPLDGAYDWRADVM
CEEEEEEEEEEEEECCCCCCCCCEEEECCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHH
SDAWDAALARRRLRAHPEVLACDALLDQDVFAGVGNIIKNEVLFRIRVHPLSPVGALPAT
HHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCHH
RLRELVAQAREYAFEFLEWKRQGVLRRHWLAHRQSECPRCHIPFEKRKLGRTARIAYYCE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHH
RCQELFGAAALSQP
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]