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The map label for this gene is pcoA [H]

Identifier: 120610491

GI number: 120610491

Start: 1963801

End: 1965267

Strand: Reverse

Name: pcoA [H]

Synonym: Aave_1810

Alternate gene names: 120610491

Gene position: 1965267-1963801 (Counterclockwise)

Preceding gene: 120610492

Following gene: 120610490

Centisome position: 36.71

GC content: 70.55

Gene sequence:

>1467_bases
ATGCAACGCAGACACTTCTTCGGCGGCGCCGCCACGGCCGTGGCCGCCCTCTCCGCCGCCTCGGTGGGCCGCGCGGCCCT
CGCGGCATTGCCCGAGGCCGCCGCGCCCACGGGCGCCGGCACCCAGGTGCCACCGCTCCCGCCCACGGGCCTGCCCTTCC
ACCCGGTCGTCACCCTCAACGGCTGGAGCCTGCCCTGGCGCATGGACGCCGGCGTCAAGGAATTCCACCTCGTCGCCGAA
CCCGTGGTGCGGGAGTTCGCGCCCGGCTTCCACGTCAACCTCTGGGGCTACAACGGCCAGAGCCCCGGCCCCACCATCGA
GGTGGTCGAAGGCGACCGGGTGCGCATCTTCGTCACCAACCGCCTGCCCGAGCACACCAGCGTGCACTGGCACGGCCAGC
GGCTGCCCAACGGCATGGACGGCGTCTCCGGCCTCAACCAGCCGGCGATTCCCGCGGGCAAGACCTTCGTGTACGAGTTC
ACCGCGCGCCGCCCGGGCACCTTCATGTACCACCCGCATGCCGACGAGATGGTGCAGATGGCCATGGGCCTCATGGGCCT
GTGGATCACGCACCCGCGCCTGGACGCGCGCGGCCGGCACCCGCGCATCGCCACCGCCGACCGCGACTACGCCTTCCTGC
TCGGTTCCTTCGCGGTGGAACCGGGCAGCCGCACGCCGCGCATCAACGAGATGACGGACTTCAACATCTGGTCGTGGAAC
AGCCGCGTGTTCCCGGGCATAGACCCCTTCGTCGCACGGCGCGGCGACCGCATGCGCCTGCGCATCGGCAACCTCACCAT
GACCAACCACCCCATCCACGTGCACGGCCACGAGTTCGAGGTGACGGGCACCGACGGCGGCATCGTGCCCCCCTCCGCGC
GCTGGCCCGAAGTGACCACCGACGTCGCCGTGGGACAGATGCGGCAGATCGAATTCATCGCCGACGAACCCGGCGACTGG
GCCGTGCACTGCCACAAGAGCCACCACACCATGGGCGCCATGGGCCACGACGTGCCCACCATGATCGGCGTGGACCACCG
CGGCCTGGTGGGCAAGATCCAGAAGATCGTGCCCGACTACATGGTGATGGGCGAGCGCGGCATGGCCGACATGGGCGCCA
TGGAAATGCCCCTGCCCGACAACACCCTGCCCATGATGACCGGCACCGGCCCTTTCGGTGCGCTGGAGATGGGCGGCATG
TTCAGCGTGCTCAAGGTGCGCGAAGGCCTCGCGGCGAGGGATTTCCGCGACCCGGGCGACTACGTGCAGCCGCCCGGCAC
GCGCGCGCACGAGTGGACGGGCGATGCCGACGCGCTGCCGCCCGCGCCGCGTGCTGCGAATGCGGCGCCCGCTGGTGCAA
TTGCCGACGATGGCACGGCTCGGGTGCGCAAGCCGGGGAGTGGGCACTCCGGCCATCAGGACCATCATGACCATCAGGGC
CTCATGGGCCATGGACACGGCCACTGA

Upstream 100 bases:

>100_bases
CCCGGCGCGCAGCCCGCCGCATCCGCGGCGGCCACCTCCTCCGCCCTGTCCTCCCCCACTCCGTCCAGCGCGGCCCCGGC
CGGCGCGGGCCACTGAACCC

Downstream 100 bases:

>100_bases
CCGCGCTGCTTCCCTCCCGCCACGACAGCGCGTCACACCTTCATCGTCATCACCATCACACACATGCTTCGCACGGAAAG
GAAACCCGCCATGAACGAAA

Product: multicopper oxidase, type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MQRRHFFGGAATAVAALSAASVGRAALAALPEAAAPTGAGTQVPPLPPTGLPFHPVVTLNGWSLPWRMDAGVKEFHLVAE
PVVREFAPGFHVNLWGYNGQSPGPTIEVVEGDRVRIFVTNRLPEHTSVHWHGQRLPNGMDGVSGLNQPAIPAGKTFVYEF
TARRPGTFMYHPHADEMVQMAMGLMGLWITHPRLDARGRHPRIATADRDYAFLLGSFAVEPGSRTPRINEMTDFNIWSWN
SRVFPGIDPFVARRGDRMRLRIGNLTMTNHPIHVHGHEFEVTGTDGGIVPPSARWPEVTTDVAVGQMRQIEFIADEPGDW
AVHCHKSHHTMGAMGHDVPTMIGVDHRGLVGKIQKIVPDYMVMGERGMADMGAMEMPLPDNTLPMMTGTGPFGALEMGGM
FSVLKVREGLAARDFRDPGDYVQPPGTRAHEWTGDADALPPAPRAANAAPAGAIADDGTARVRKPGSGHSGHQDHHDHQG
LMGHGHGH

Sequences:

>Translated_488_residues
MQRRHFFGGAATAVAALSAASVGRAALAALPEAAAPTGAGTQVPPLPPTGLPFHPVVTLNGWSLPWRMDAGVKEFHLVAE
PVVREFAPGFHVNLWGYNGQSPGPTIEVVEGDRVRIFVTNRLPEHTSVHWHGQRLPNGMDGVSGLNQPAIPAGKTFVYEF
TARRPGTFMYHPHADEMVQMAMGLMGLWITHPRLDARGRHPRIATADRDYAFLLGSFAVEPGSRTPRINEMTDFNIWSWN
SRVFPGIDPFVARRGDRMRLRIGNLTMTNHPIHVHGHEFEVTGTDGGIVPPSARWPEVTTDVAVGQMRQIEFIADEPGDW
AVHCHKSHHTMGAMGHDVPTMIGVDHRGLVGKIQKIVPDYMVMGERGMADMGAMEMPLPDNTLPMMTGTGPFGALEMGGM
FSVLKVREGLAARDFRDPGDYVQPPGTRAHEWTGDADALPPAPRAANAAPAGAIADDGTARVRKPGSGHSGHQDHHDHQG
LMGHGHGH
>Mature_488_residues
MQRRHFFGGAATAVAALSAASVGRAALAALPEAAAPTGAGTQVPPLPPTGLPFHPVVTLNGWSLPWRMDAGVKEFHLVAE
PVVREFAPGFHVNLWGYNGQSPGPTIEVVEGDRVRIFVTNRLPEHTSVHWHGQRLPNGMDGVSGLNQPAIPAGKTFVYEF
TARRPGTFMYHPHADEMVQMAMGLMGLWITHPRLDARGRHPRIATADRDYAFLLGSFAVEPGSRTPRINEMTDFNIWSWN
SRVFPGIDPFVARRGDRMRLRIGNLTMTNHPIHVHGHEFEVTGTDGGIVPPSARWPEVTTDVAVGQMRQIEFIADEPGDW
AVHCHKSHHTMGAMGHDVPTMIGVDHRGLVGKIQKIVPDYMVMGERGMADMGAMEMPLPDNTLPMMTGTGPFGALEMGGM
FSVLKVREGLAARDFRDPGDYVQPPGTRAHEWTGDADALPPAPRAANAAPAGAIADDGTARVRKPGSGHSGHQDHHDHQG
LMGHGHGH

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=216, Percent_Identity=27.3148148148148, Blast_Score=63, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323703, Length=96, Percent_Identity=44.7916666666667, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321067, Length=209, Percent_Identity=31.5789473684211, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI18859919, Length=218, Percent_Identity=31.1926605504587, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 52900; Mature: 52900

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRRHFFGGAATAVAALSAASVGRAALAALPEAAAPTGAGTQVPPLPPTGLPFHPVVTLN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEC
GWSLPWRMDAGVKEFHLVAEPVVREFAPGFHVNLWGYNGQSPGPTIEVVEGDRVRIFVTN
CCCCCEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCEEEEEEEC
RLPEHTSVHWHGQRLPNGMDGVSGLNQPAIPAGKTFVYEFTARRPGTFMYHPHADEMVQM
CCCCCCEEEECCCCCCCCCCHHCCCCCCCCCCCCEEEEEEECCCCCEEEECCCHHHHHHH
AMGLMGLWITHPRLDARGRHPRIATADRDYAFLLGSFAVEPGSRTPRINEMTDFNIWSWN
HHHHHHHEEECCCCCCCCCCCEEEECCCCEEEEEEHEEECCCCCCCCCCCCCCCEEEECC
SRVFPGIDPFVARRGDRMRLRIGNLTMTNHPIHVHGHEFEVTGTDGGIVPPSARWPEVTT
CEECCCCCHHHHCCCCEEEEEECCEEEECCCEEECCCEEEEECCCCCCCCCCCCCCCCHH
DVAVGQMRQIEFIADEPGDWAVHCHKSHHTMGAMGHDVPTMIGVDHRGLVGKIQKIVPDY
HHHHCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCHHHHHHHHCCHH
MVMGERGMADMGAMEMPLPDNTLPMMTGTGPFGALEMGGMFSVLKVREGLAARDFRDPGD
EEECCCCCCCCCCEECCCCCCCCCEEECCCCCCCHHHCCHHHHHHHHHCCHHCCCCCCCC
YVQPPGTRAHEWTGDADALPPAPRAANAAPAGAIADDGTARVRKPGSGHSGHQDHHDHQG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCC
LMGHGHGH
CCCCCCCC
>Mature Secondary Structure
MQRRHFFGGAATAVAALSAASVGRAALAALPEAAAPTGAGTQVPPLPPTGLPFHPVVTLN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEC
GWSLPWRMDAGVKEFHLVAEPVVREFAPGFHVNLWGYNGQSPGPTIEVVEGDRVRIFVTN
CCCCCEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCEEEEEEEC
RLPEHTSVHWHGQRLPNGMDGVSGLNQPAIPAGKTFVYEFTARRPGTFMYHPHADEMVQM
CCCCCCEEEECCCCCCCCCCHHCCCCCCCCCCCCEEEEEEECCCCCEEEECCCHHHHHHH
AMGLMGLWITHPRLDARGRHPRIATADRDYAFLLGSFAVEPGSRTPRINEMTDFNIWSWN
HHHHHHHEEECCCCCCCCCCCEEEECCCCEEEEEEHEEECCCCCCCCCCCCCCCEEEECC
SRVFPGIDPFVARRGDRMRLRIGNLTMTNHPIHVHGHEFEVTGTDGGIVPPSARWPEVTT
CEECCCCCHHHHCCCCEEEEEECCEEEECCCEEECCCEEEEECCCCCCCCCCCCCCCCHH
DVAVGQMRQIEFIADEPGDWAVHCHKSHHTMGAMGHDVPTMIGVDHRGLVGKIQKIVPDY
HHHHCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCHHHHHHHHCCHH
MVMGERGMADMGAMEMPLPDNTLPMMTGTGPFGALEMGGMFSVLKVREGLAARDFRDPGD
EEECCCCCCCCCCEECCCCCCCCCEEECCCCCCCHHHCCHHHHHHHHHCCHHCCCCCCCC
YVQPPGTRAHEWTGDADALPPAPRAANAAPAGAIADDGTARVRKPGSGHSGHQDHHDHQG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCC
LMGHGHGH
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]