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The map label for this gene is uvrC [H]

Identifier: 120610347

GI number: 120610347

Start: 1825283

End: 1827295

Strand: Direct

Name: uvrC [H]

Synonym: Aave_1664

Alternate gene names: 120610347

Gene position: 1825283-1827295 (Clockwise)

Preceding gene: 120610346

Following gene: 120610348

Centisome position: 34.1

GC content: 70.54

Gene sequence:

>2013_bases
ATGTCCGACGTGCACTCCGATGAACTGCTCGCGCAGGTGGCCTCGCTGCCACCGCTGCCGGGCGTGTACCGCTACTTCGA
TGCCCAGGGCGGGCTGCTCTACGTGGGCAAGGCCCGCAACCTGAAAAAGCGCGTCTCCAGCTATTTCACCAAGACCCATG
GCGGCACGCGCATCGGCCACATGGTGGGCAAGATCGCCCGGCTGGAGACCACCGTGGTGCGCTCCGAGGCCGAGGCGCTG
CTGCTGGAAAACAACCTCATCAAGTCGCTGAACCCGCGCTACAACATCCTGTTCCGCGACGACAAGAGCTATCCCTACCT
GAAGATCACGGGCGTGGCCGCGCGCGACGGCACCGGCGAGCAGCCCGGCCAGCGGTTTCCGCGGGTGGCCTACTACCGCG
GCGCCGTGGACAAGCGGCACCGGTACTTCGGCCCCTATCCCGGTGCCTGGGCGGTGAAGGAAACCATCCTGCTGCTGCAG
AAGGTGTTCCGGCTGCGCACCTGCGAGGACACCGTCTTCGCCAACCGCACGCGGCCCTGCCTGCTCTACCAGATCAAGCG
CTGCTCCGGCCCGTGCGTGGACCTCATCTCTCCCGAGGCCTATGCGCTGGACGTGCGCAACGCCGACGCCATGCTGCGCG
GCGAGACCAGGGAACTGCTGGAAGCGCTGGAGGCGCGCATGATGGCGCACTCCGAACGGCTGGAGTTCGAGCAGGCGGCG
GACATCCGCAACCAGATCACGGCGCTGTCGCGCGTGCTGCACCAGCAGGCCATCGAGACGGTTTCCGACAAGGACGTGGA
CATCCTGGCCGTGAAGGTGCTGGGGGGGCGCGCCTGCGTCAACCTCGCCATGGTGCGCGGCGGCCGCCACCTGGGCGACC
GGCCGTACTTTCCCGTCCACGTGGAAGACGCGGCCGCGGTGTACCAGCTGGAAGAGTGGGGCGACGGGGGCGACGGCCCC
GATGGCGCGGCCGAAGCGGCAGGCGCGGCGGAGGCGCCCCCCGCCGCACCCCGTGCCCCGCAGCGCTCGCTCGAAGTGCA
GGTGCTGGAGGCCTTCATCGCCCAGCACTACATCGGCGTGCCCGTGCCGCCCGTGCTCGTCACCAGCGAGCCGGTGGACC
GCGCGTTGCTGGAGGCGCTCTCGCAGCAGGCCGGCATCCGCGTGGGCGCGGTGCACCAGCCGCGCGAGCAGCGCCGCGCC
TGGCTGGAGATGGCGCAGAAGAATGCCGACATCCAGCTCGCGCGGCTGCTCTCCGAAGAGGGCTCCCAGCAGGCCCGCAC
GCGCGCATTGGCCGAGGCGCTGGACCTGCCCATGGACGACCTGGAGTCGCTCACCATCGAGTGCTTCGACATTTCCCACA
CGGCGGGCGAGGCTACGCAGGCGTCGTGCGTGGTCTTCCACCACCACCGCATGCAGAGCAGCGAGTACCGCCGCTACAAG
ATCGAGGGCATCACCGGCGGTGACGATTACGCCGCCATGCGGCAGGTGCTCACGCGGCGCTACAGCAAGGTCGCGGAGGC
GCAGCGCGAGGCCGGCGGCGCCGAGCCGGCACCCGGGCAGGCGCGCCTGCCGGACCTCGTTCTGATCGACGGCGGCAAGG
GGCAGGTCAGCATGGCGCGCGAAGTGTTCACCGAGCTGGGCCTGGAGCTGTCCCGCATCGTCGGCGTGGAGAAAGGCGAG
GGCCGCAAGGTCGGGCTGGAGGAACTCGTCTTCGCCGACGGCCGCGAGAAGATCTACCTCGGCCGCGACTCCGCCGCGCT
CATGCTGGTGGCCCAGATCCGCGACGAGGCCCACCGCTTCGCCATCACCGGCATGCGCGCCGCGCGCGCCAGGGTGCGCG
TGGGCGGCGGGCAGCTGGAGGAGATCCCCGGCGTGGGCCCCAAGAAGCGCGCGCGCCTGCTGCAGCGCTTCGGCGGGGTG
CGGGGCGTGGCGGCGGCCAGCGTGGAGGATCTGGCCACGGTGGACGGCATCTCGCTGGAGCTCGCGCAGGAGATATACCG
GGCGCTGCGCTGA

Upstream 100 bases:

>100_bases
GTGCGCCGCGCGTACGGCGGCCGCTGACAAGGCCCGGGCGGGCGGGGGCCTTCGCAGCCCTCCGGCCGGCGCGGCCGTGC
GCGCCGGCCACAATACGCCC

Downstream 100 bases:

>100_bases
GCCGGCGGCGGCCATGGTGGCATGACACAATCGACCCATGTTCCTGACCATTCCCACCATCATGACCTGGACGCGCATCG
TCGCGATACCCTTGATCGTG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 670; Mature: 669

Protein sequence:

>670_residues
MSDVHSDELLAQVASLPPLPGVYRYFDAQGGLLYVGKARNLKKRVSSYFTKTHGGTRIGHMVGKIARLETTVVRSEAEAL
LLENNLIKSLNPRYNILFRDDKSYPYLKITGVAARDGTGEQPGQRFPRVAYYRGAVDKRHRYFGPYPGAWAVKETILLLQ
KVFRLRTCEDTVFANRTRPCLLYQIKRCSGPCVDLISPEAYALDVRNADAMLRGETRELLEALEARMMAHSERLEFEQAA
DIRNQITALSRVLHQQAIETVSDKDVDILAVKVLGGRACVNLAMVRGGRHLGDRPYFPVHVEDAAAVYQLEEWGDGGDGP
DGAAEAAGAAEAPPAAPRAPQRSLEVQVLEAFIAQHYIGVPVPPVLVTSEPVDRALLEALSQQAGIRVGAVHQPREQRRA
WLEMAQKNADIQLARLLSEEGSQQARTRALAEALDLPMDDLESLTIECFDISHTAGEATQASCVVFHHHRMQSSEYRRYK
IEGITGGDDYAAMRQVLTRRYSKVAEAQREAGGAEPAPGQARLPDLVLIDGGKGQVSMAREVFTELGLELSRIVGVEKGE
GRKVGLEELVFADGREKIYLGRDSAALMLVAQIRDEAHRFAITGMRAARARVRVGGGQLEEIPGVGPKKRARLLQRFGGV
RGVAAASVEDLATVDGISLELAQEIYRALR

Sequences:

>Translated_670_residues
MSDVHSDELLAQVASLPPLPGVYRYFDAQGGLLYVGKARNLKKRVSSYFTKTHGGTRIGHMVGKIARLETTVVRSEAEAL
LLENNLIKSLNPRYNILFRDDKSYPYLKITGVAARDGTGEQPGQRFPRVAYYRGAVDKRHRYFGPYPGAWAVKETILLLQ
KVFRLRTCEDTVFANRTRPCLLYQIKRCSGPCVDLISPEAYALDVRNADAMLRGETRELLEALEARMMAHSERLEFEQAA
DIRNQITALSRVLHQQAIETVSDKDVDILAVKVLGGRACVNLAMVRGGRHLGDRPYFPVHVEDAAAVYQLEEWGDGGDGP
DGAAEAAGAAEAPPAAPRAPQRSLEVQVLEAFIAQHYIGVPVPPVLVTSEPVDRALLEALSQQAGIRVGAVHQPREQRRA
WLEMAQKNADIQLARLLSEEGSQQARTRALAEALDLPMDDLESLTIECFDISHTAGEATQASCVVFHHHRMQSSEYRRYK
IEGITGGDDYAAMRQVLTRRYSKVAEAQREAGGAEPAPGQARLPDLVLIDGGKGQVSMAREVFTELGLELSRIVGVEKGE
GRKVGLEELVFADGREKIYLGRDSAALMLVAQIRDEAHRFAITGMRAARARVRVGGGQLEEIPGVGPKKRARLLQRFGGV
RGVAAASVEDLATVDGISLELAQEIYRALR
>Mature_669_residues
SDVHSDELLAQVASLPPLPGVYRYFDAQGGLLYVGKARNLKKRVSSYFTKTHGGTRIGHMVGKIARLETTVVRSEAEALL
LENNLIKSLNPRYNILFRDDKSYPYLKITGVAARDGTGEQPGQRFPRVAYYRGAVDKRHRYFGPYPGAWAVKETILLLQK
VFRLRTCEDTVFANRTRPCLLYQIKRCSGPCVDLISPEAYALDVRNADAMLRGETRELLEALEARMMAHSERLEFEQAAD
IRNQITALSRVLHQQAIETVSDKDVDILAVKVLGGRACVNLAMVRGGRHLGDRPYFPVHVEDAAAVYQLEEWGDGGDGPD
GAAEAAGAAEAPPAAPRAPQRSLEVQVLEAFIAQHYIGVPVPPVLVTSEPVDRALLEALSQQAGIRVGAVHQPREQRRAW
LEMAQKNADIQLARLLSEEGSQQARTRALAEALDLPMDDLESLTIECFDISHTAGEATQASCVVFHHHRMQSSEYRRYKI
EGITGGDDYAAMRQVLTRRYSKVAEAQREAGGAEPAPGQARLPDLVLIDGGKGQVSMAREVFTELGLELSRIVGVEKGEG
RKVGLEELVFADGREKIYLGRDSAALMLVAQIRDEAHRFAITGMRAARARVRVGGGQLEEIPGVGPKKRARLLQRFGGVR
GVAAASVEDLATVDGISLELAQEIYRALR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=679, Percent_Identity=40.9425625920471, Blast_Score=471, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 73680; Mature: 73549

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVHSDELLAQVASLPPLPGVYRYFDAQGGLLYVGKARNLKKRVSSYFTKTHGGTRIGH
CCCCCHHHHHHHHHCCCCCCCHHHHEECCCCEEEEECCHHHHHHHHHHHHHCCCCCHHHH
MVGKIARLETTVVRSEAEALLLENNLIKSLNPRYNILFRDDKSYPYLKITGVAARDGTGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEEECCCCCC
QPGQRFPRVAYYRGAVDKRHRYFGPYPGAWAVKETILLLQKVFRLRTCEDTVFANRTRPC
CCHHHCCCHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCH
LLYQIKRCSGPCVDLISPEAYALDVRNADAMLRGETRELLEALEARMMAHSERLEFEQAA
HHHHHHHCCCCCEECCCCCEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DIRNQITALSRVLHQQAIETVSDKDVDILAVKVLGGRACVNLAMVRGGRHLGDRPYFPVH
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEE
VEDAAAVYQLEEWGDGGDGPDGAAEAAGAAEAPPAAPRAPQRSLEVQVLEAFIAQHYIGV
ECCHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
PVPPVLVTSEPVDRALLEALSQQAGIRVGAVHQPREQRRAWLEMAQKNADIQLARLLSEE
CCCCEEECCCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHC
GSQQARTRALAEALDLPMDDLESLTIECFDISHTAGEATQASCVVFHHHRMQSSEYRRYK
CHHHHHHHHHHHHHCCCHHHHHCCEEEEEECCCCCCCCCCCEEEEEEHHHCCCCCCCEEE
IEGITGGDDYAAMRQVLTRRYSKVAEAQREAGGAEPAPGQARLPDLVLIDGGKGQVSMAR
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHH
EVFTELGLELSRIVGVEKGEGRKVGLEELVFADGREKIYLGRDSAALMLVAQIRDEAHRF
HHHHHHCHHHHHHHCCCCCCCCCCCHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHH
AITGMRAARARVRVGGGQLEEIPGVGPKKRARLLQRFGGVRGVAAASVEDLATVDGISLE
HHHHHHHHHHEEEECCCCHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHH
LAQEIYRALR
HHHHHHHHHC
>Mature Secondary Structure 
SDVHSDELLAQVASLPPLPGVYRYFDAQGGLLYVGKARNLKKRVSSYFTKTHGGTRIGH
CCCCHHHHHHHHHCCCCCCCHHHHEECCCCEEEEECCHHHHHHHHHHHHHCCCCCHHHH
MVGKIARLETTVVRSEAEALLLENNLIKSLNPRYNILFRDDKSYPYLKITGVAARDGTGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEEECCCCCC
QPGQRFPRVAYYRGAVDKRHRYFGPYPGAWAVKETILLLQKVFRLRTCEDTVFANRTRPC
CCHHHCCCHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCH
LLYQIKRCSGPCVDLISPEAYALDVRNADAMLRGETRELLEALEARMMAHSERLEFEQAA
HHHHHHHCCCCCEECCCCCEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DIRNQITALSRVLHQQAIETVSDKDVDILAVKVLGGRACVNLAMVRGGRHLGDRPYFPVH
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEE
VEDAAAVYQLEEWGDGGDGPDGAAEAAGAAEAPPAAPRAPQRSLEVQVLEAFIAQHYIGV
ECCHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
PVPPVLVTSEPVDRALLEALSQQAGIRVGAVHQPREQRRAWLEMAQKNADIQLARLLSEE
CCCCEEECCCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHC
GSQQARTRALAEALDLPMDDLESLTIECFDISHTAGEATQASCVVFHHHRMQSSEYRRYK
CHHHHHHHHHHHHHCCCHHHHHCCEEEEEECCCCCCCCCCCEEEEEEHHHCCCCCCCEEE
IEGITGGDDYAAMRQVLTRRYSKVAEAQREAGGAEPAPGQARLPDLVLIDGGKGQVSMAR
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHH
EVFTELGLELSRIVGVEKGEGRKVGLEELVFADGREKIYLGRDSAALMLVAQIRDEAHRF
HHHHHHCHHHHHHHCCCCCCCCCCCHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHH
AITGMRAARARVRVGGGQLEEIPGVGPKKRARLLQRFGGVRGVAAASVEDLATVDGISLE
HHHHHHHHHHEEEECCCCHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHH
LAQEIYRALR
HHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA