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The map label for this gene is cobQ

Identifier: 120610237

GI number: 120610237

Start: 1718594

End: 1720072

Strand: Direct

Name: cobQ

Synonym: Aave_1552

Alternate gene names: 120610237

Gene position: 1718594-1720072 (Clockwise)

Preceding gene: 120610236

Following gene: 120610238

Centisome position: 32.11

GC content: 74.78

Gene sequence:

>1479_bases
ATGATCGCCCGCTGCATCATGGTCCTCGGCACCTCCAGCGGCGCCGGCAAGAGCTGGCTCGCCACGGCGCTGTGCCGCTG
GTTCAGCGACCAGGGTCTGCGCGTCGCGCCGTTCAAGGCGCAGAACATGAGCAACAACGCGCGCGTGGTGGCGGCGCCGG
GCGGCGGGCAGGGGGAGATCGGCAGCGCGCAGTACTTCCAGGCGCTGGCGGCACGCACCGAGCCCGAGGTGCGCATGAAC
CCGGTGCTGCTCAAGCCCGAGGCGGACACGCGCAGCCAGGTGGTCCTGATGGGGCAGGTGAGCGAAGAACTCACGCGCAT
GCCCTGGCGCGGGCGCAGCGTGCACGTCTGGCCGCACGTGGCCGCGGCGCTCGACGCGCTGCGGGCCGAGAACGACGTCG
TGGTGATCGAAGGCGCGGGCTCGCCGGCCGAGATCAACCTGCACGCGAACGACATCGTCAACATGCGCGTGGCGCGGCAC
GCGGGCGCGCACGGGCTGCTGGTGACCGACATCGACCGCGGCGGCGCCTTCGCCCACCTCTACGGCACCTGGGCGCTGCT
GCCCGAGGACGAGCGCGCGCTGATCCAGGGCTTCGTGCTCAACAAGTTCCGCGGCGACGCCGCGCTGCTCGCGCCCGCGC
CGGACATGCTGCGCGAGCGCACGGGCGTGCCCACGGTGGCCACCATTCCCATGCAGTGGCGCCACGGCCTGCCGGAGGAA
GACGGCGTGTTCGACGATGCCGGCCACGTGCGCGCGGGCGCCGGCGGCGCGGTGCACACCACGGTGGCGGTGGTGGCGTA
CCCGCGCATCAGCAACCTCGACGAGTTCCAGCCGCTCAAGGGCGTGCCGGGCCTGCGGCTCGTCTGGGCACGCAGCCCGG
CCGAGGTGGCCGGCGCCGACTGGATCGTGCTGCCCGGCTCCAAGGCGACCGCGGCCGACCTGGCCTGGCTGCGCGCCCAG
GGCCTGGATGCCGCCATCGCCGCCCACGCCGCGCGCGGCGGCCGCGTGCTGGGCATCTGCGGCGGCCTGCAGATGCTGGG
CGAGGCGCTGATCGACACCCACGGCGTGGACGGCAACGCGCCCGGCCTGGGCCTGCTGCCGCTGGTCACCGCGTTCGATC
CGGCCAAGACCGTGCGCCGCACGCGCACCGCCTTCGGCGCGCTGCGGGGCGCATGGAGCGCGCTCTCGGGCGTGGCGGTG
CAGGGCTACGAGATCCGCCACGGCCGCACGGCGCAGCATCCGGCCATGGCCGCGGCCGGCGACGTGGCGCACCCAGCCAT
CCCCGGCCTGGCATGGCAGAACGCGCGCGGCAACGTGCTGGGCCTGTACCTGCACGGCCTGTTCGAGGATGCGGTCGCGC
TGCGCGCGCTCTTCGGCGCGGACGTGCCGACGCTGGACGCGGTGTTCGACCGGCTGGCGCGCGGCGTGGACGAATGGTTC
GACCCCGCCTGGCGCGCGGCGCGGCGCGCGGGCCGATGA

Upstream 100 bases:

>100_bases
ACCATCCCCGTACCGCATCCGAACGGCTCCCCCGGTCCGCGAACGCTGCGCGCCGTCCATCCTCCGGCGAAGGGGCCGCC
TGCACGGCACCGGAGGCCGC

Downstream 100 bases:

>100_bases
TGATCGCGGCACCGTGCCCTGCCGCGGTGCGTTTCCTGGACTCCGAAAACCATCATGACCACGAATGACCCCACCCCGGC
CGGCGCCACGGTGCGCCCGC

Product: adenosylcobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MIARCIMVLGTSSGAGKSWLATALCRWFSDQGLRVAPFKAQNMSNNARVVAAPGGGQGEIGSAQYFQALAARTEPEVRMN
PVLLKPEADTRSQVVLMGQVSEELTRMPWRGRSVHVWPHVAAALDALRAENDVVVIEGAGSPAEINLHANDIVNMRVARH
AGAHGLLVTDIDRGGAFAHLYGTWALLPEDERALIQGFVLNKFRGDAALLAPAPDMLRERTGVPTVATIPMQWRHGLPEE
DGVFDDAGHVRAGAGGAVHTTVAVVAYPRISNLDEFQPLKGVPGLRLVWARSPAEVAGADWIVLPGSKATAADLAWLRAQ
GLDAAIAAHAARGGRVLGICGGLQMLGEALIDTHGVDGNAPGLGLLPLVTAFDPAKTVRRTRTAFGALRGAWSALSGVAV
QGYEIRHGRTAQHPAMAAAGDVAHPAIPGLAWQNARGNVLGLYLHGLFEDAVALRALFGADVPTLDAVFDRLARGVDEWF
DPAWRAARRAGR

Sequences:

>Translated_492_residues
MIARCIMVLGTSSGAGKSWLATALCRWFSDQGLRVAPFKAQNMSNNARVVAAPGGGQGEIGSAQYFQALAARTEPEVRMN
PVLLKPEADTRSQVVLMGQVSEELTRMPWRGRSVHVWPHVAAALDALRAENDVVVIEGAGSPAEINLHANDIVNMRVARH
AGAHGLLVTDIDRGGAFAHLYGTWALLPEDERALIQGFVLNKFRGDAALLAPAPDMLRERTGVPTVATIPMQWRHGLPEE
DGVFDDAGHVRAGAGGAVHTTVAVVAYPRISNLDEFQPLKGVPGLRLVWARSPAEVAGADWIVLPGSKATAADLAWLRAQ
GLDAAIAAHAARGGRVLGICGGLQMLGEALIDTHGVDGNAPGLGLLPLVTAFDPAKTVRRTRTAFGALRGAWSALSGVAV
QGYEIRHGRTAQHPAMAAAGDVAHPAIPGLAWQNARGNVLGLYLHGLFEDAVALRALFGADVPTLDAVFDRLARGVDEWF
DPAWRAARRAGR
>Mature_492_residues
MIARCIMVLGTSSGAGKSWLATALCRWFSDQGLRVAPFKAQNMSNNARVVAAPGGGQGEIGSAQYFQALAARTEPEVRMN
PVLLKPEADTRSQVVLMGQVSEELTRMPWRGRSVHVWPHVAAALDALRAENDVVVIEGAGSPAEINLHANDIVNMRVARH
AGAHGLLVTDIDRGGAFAHLYGTWALLPEDERALIQGFVLNKFRGDAALLAPAPDMLRERTGVPTVATIPMQWRHGLPEE
DGVFDDAGHVRAGAGGAVHTTVAVVAYPRISNLDEFQPLKGVPGLRLVWARSPAEVAGADWIVLPGSKATAADLAWLRAQ
GLDAAIAAHAARGGRVLGICGGLQMLGEALIDTHGVDGNAPGLGLLPLVTAFDPAKTVRRTRTAFGALRGAWSALSGVAV
QGYEIRHGRTAQHPAMAAAGDVAHPAIPGLAWQNARGNVLGLYLHGLFEDAVALRALFGADVPTLDAVFDRLARGVDEWF
DPAWRAARRAGR

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_ACIAC (A1TMF3)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969915.1
- ProteinModelPortal:   A1TMF3
- SMR:   A1TMF3
- STRING:   A1TMF3
- GeneID:   4668022
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1552
- NMPDR:   fig|397945.5.peg.1364
- eggNOG:   COG1492
- HOGENOM:   HBG302271
- OMA:   RGDIANM
- ProtClustDB:   CLSK951555
- BioCyc:   AAVE397945:AAVE_1552-MONOMER
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 52084; Mature: 52084

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 340-340 ACT_SITE 445-445

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIARCIMVLGTSSGAGKSWLATALCRWFSDQGLRVAPFKAQNMSNNARVVAAPGGGQGEI
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEECEECCCCCCCCEEEECCCCCCCCC
GSAQYFQALAARTEPEVRMNPVLLKPEADTRSQVVLMGQVSEELTRMPWRGRSVHVWPHV
CHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCEEEEEEHHHHHHHHCCCCCCEEEECHHH
AAALDALRAENDVVVIEGAGSPAEINLHANDIVNMRVARHAGAHGLLVTDIDRGGAFAHL
HHHHHHHHCCCCEEEEECCCCCEEEEEECCHHHHHHHHHHCCCCCEEEEEECCCCCEEEE
YGTWALLPEDERALIQGFVLNKFRGDAALLAPAPDMLRERTGVPTVATIPMQWRHGLPEE
EEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCEEEECCHHHHCCCCCC
DGVFDDAGHVRAGAGGAVHTTVAVVAYPRISNLDEFQPLKGVPGLRLVWARSPAEVAGAD
CCCCCCCCCEECCCCCCHHHEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCHHHCCCC
WIVLPGSKATAADLAWLRAQGLDAAIAAHAARGGRVLGICGGLQMLGEALIDTHGVDGNA
EEEECCCCCCHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCCCC
PGLGLLPLVTAFDPAKTVRRTRTAFGALRGAWSALSGVAVQGYEIRHGRTAQHPAMAAAG
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHCC
DVAHPAIPGLAWQNARGNVLGLYLHGLFEDAVALRALFGADVPTLDAVFDRLARGVDEWF
CCCCCCCCCCEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
DPAWRAARRAGR
CHHHHHHHHCCC
>Mature Secondary Structure
MIARCIMVLGTSSGAGKSWLATALCRWFSDQGLRVAPFKAQNMSNNARVVAAPGGGQGEI
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEECEECCCCCCCCEEEECCCCCCCCC
GSAQYFQALAARTEPEVRMNPVLLKPEADTRSQVVLMGQVSEELTRMPWRGRSVHVWPHV
CHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCEEEEEEHHHHHHHHCCCCCCEEEECHHH
AAALDALRAENDVVVIEGAGSPAEINLHANDIVNMRVARHAGAHGLLVTDIDRGGAFAHL
HHHHHHHHCCCCEEEEECCCCCEEEEEECCHHHHHHHHHHCCCCCEEEEEECCCCCEEEE
YGTWALLPEDERALIQGFVLNKFRGDAALLAPAPDMLRERTGVPTVATIPMQWRHGLPEE
EEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCEEEECCHHHHCCCCCC
DGVFDDAGHVRAGAGGAVHTTVAVVAYPRISNLDEFQPLKGVPGLRLVWARSPAEVAGAD
CCCCCCCCCEECCCCCCHHHEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCHHHCCCC
WIVLPGSKATAADLAWLRAQGLDAAIAAHAARGGRVLGICGGLQMLGEALIDTHGVDGNA
EEEECCCCCCHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCCCC
PGLGLLPLVTAFDPAKTVRRTRTAFGALRGAWSALSGVAVQGYEIRHGRTAQHPAMAAAG
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHCC
DVAHPAIPGLAWQNARGNVLGLYLHGLFEDAVALRALFGADVPTLDAVFDRLARGVDEWF
CCCCCCCCCCEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
DPAWRAARRAGR
CHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA