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The map label for this gene is hemN [H]

Identifier: 120610216

GI number: 120610216

Start: 1695515

End: 1696897

Strand: Direct

Name: hemN [H]

Synonym: Aave_1531

Alternate gene names: 120610216

Gene position: 1695515-1696897 (Clockwise)

Preceding gene: 120610214

Following gene: 120610217

Centisome position: 31.68

GC content: 67.97

Gene sequence:

>1383_bases
ATGAACGCTGTGACTCCCGAGCTTCTGCGCCGCTTCGACGTGCCGGGCCCCCGCTATACCTCGTACCCGACCGCGGACCG
GTTCGTGGAGGCCTTCGGCGCGGACGAGTACGTGCTGGCGCTGCAGCAGCGCCGCCTCGGCTCGGCCGCCAAGGCCGTGC
CTCTTTCGCTGTACGTGCACATCCCGTTCTGCGAATCGCTGTGCTACTACTGCGCGTGCAACAAGATCATCACGCGCCAC
CCCGAGCGCGCCGACGTGTACCTGCGCTACCTCAGCCGCGAGATCGACCTGCACATGGCGCACTGCGCGCTCGGCCATGC
GGTGAGCCAGCTGCACATCGGCGGCGGCAGCCCCACCTTCCTCGGCGACGAGGCGCTGCAGGAACTGATGAACATGCTGC
GCCGCAGCTTCACGCTCGTGCCCGGGGGCGAGTATTCCATCGAGGTCGATCCCCGCACGGTGGACGCCGGACGGCTCGCG
CGGCTGGCGGAGCTCGGCTTCAACCGGTTGAGCTTCGGCGTGCAGGATTTCGACCCGGCCGTGCAGAAGGCCGTGCACCG
CGTGCAGCCCGCCGAGCAGGTGTTCGCGCTCGTGCAGGAAGCGCGCCGGATCGGCTTCGAGTCGATCAACGTGGACCTGA
TCTACGGCCTGCCGCGGCAGACGCCCGAATCGTTCGACCGCACGCTGGCCCAGGTGTGCGAACTGCGGCCCGACCGCATC
GCGCTCTATGCCTATGCCCACCTGCCGGAGCGCTTCAAGCCGCAGCGCCGCATCGTGTCGGCCGAGCTGCCGATGGCGTC
GGCCAAGGTGTCGATGCTGTCGCGCTCGCTCAACGCCTTCCAGGATGCCGGCTACGTGTACGTGGGGATGGACCATTTCG
CGCTCCCCGAGGACGCGCTGGCCGTGGCCAAGCGGCAGGGGCGGCTGCACCGCAACTTCCAGGGCTACAGCACGCAGCCC
GACTGCGACCTCATCGCCCTGGGCGTCTCGGCCATCGGCCGCGTGGGCGCCACCTACAGCCAGAACGCCAAGACGCTCGA
CGAGTATTACGACCTGATCAACCAGGGCCGCCTTCCGGTGGTCCGCGGCCTGGCGCTCACGCGCGATGATCTCGTGCGGC
GTTCGGTCATCATGGCCCTGATGTGCCAGGGCGAAGTGCTGTTCGAGCCGATGGAGCAATCGTGGCTGATCGATTTCCGG
AGGTACTTCGCGGCGGAGCTGGAAGCGCTCGAAGGCATGGCTGGCGACGGCCTCGTCAACGTGGGCGAGGACGGCATCAC
CGTCACCGAGATGGGCTGGTTCTTCGTGCGCGGCGTGGCGATGGTGTTCGACCGCTATCTGCAGGCGGACCGCAACCGCG
CGCGGTTCTCCCGGATCATCTGA

Upstream 100 bases:

>100_bases
GTCAATTGTCGCAGCGACGCGCGTCGAAATGCTTGACCGGCGTCAAGGACATGGGCGCGGGACATGGGGCACATTGTGAA
TCGTTAAGGAATTCCGCACC

Downstream 100 bases:

>100_bases
CGATCCTTTCCTTCCCGCAGGAGCCGCATGCCCGATGCACTGATCTGGACGGCCTTCGCCATGGGCCTGGCGGGCGGGCC
CCACTGCCTGGCGATGTGCG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MNAVTPELLRRFDVPGPRYTSYPTADRFVEAFGADEYVLALQQRRLGSAAKAVPLSLYVHIPFCESLCYYCACNKIITRH
PERADVYLRYLSREIDLHMAHCALGHAVSQLHIGGGSPTFLGDEALQELMNMLRRSFTLVPGGEYSIEVDPRTVDAGRLA
RLAELGFNRLSFGVQDFDPAVQKAVHRVQPAEQVFALVQEARRIGFESINVDLIYGLPRQTPESFDRTLAQVCELRPDRI
ALYAYAHLPERFKPQRRIVSAELPMASAKVSMLSRSLNAFQDAGYVYVGMDHFALPEDALAVAKRQGRLHRNFQGYSTQP
DCDLIALGVSAIGRVGATYSQNAKTLDEYYDLINQGRLPVVRGLALTRDDLVRRSVIMALMCQGEVLFEPMEQSWLIDFR
RYFAAELEALEGMAGDGLVNVGEDGITVTEMGWFFVRGVAMVFDRYLQADRNRARFSRII

Sequences:

>Translated_460_residues
MNAVTPELLRRFDVPGPRYTSYPTADRFVEAFGADEYVLALQQRRLGSAAKAVPLSLYVHIPFCESLCYYCACNKIITRH
PERADVYLRYLSREIDLHMAHCALGHAVSQLHIGGGSPTFLGDEALQELMNMLRRSFTLVPGGEYSIEVDPRTVDAGRLA
RLAELGFNRLSFGVQDFDPAVQKAVHRVQPAEQVFALVQEARRIGFESINVDLIYGLPRQTPESFDRTLAQVCELRPDRI
ALYAYAHLPERFKPQRRIVSAELPMASAKVSMLSRSLNAFQDAGYVYVGMDHFALPEDALAVAKRQGRLHRNFQGYSTQP
DCDLIALGVSAIGRVGATYSQNAKTLDEYYDLINQGRLPVVRGLALTRDDLVRRSVIMALMCQGEVLFEPMEQSWLIDFR
RYFAAELEALEGMAGDGLVNVGEDGITVTEMGWFFVRGVAMVFDRYLQADRNRARFSRII
>Mature_460_residues
MNAVTPELLRRFDVPGPRYTSYPTADRFVEAFGADEYVLALQQRRLGSAAKAVPLSLYVHIPFCESLCYYCACNKIITRH
PERADVYLRYLSREIDLHMAHCALGHAVSQLHIGGGSPTFLGDEALQELMNMLRRSFTLVPGGEYSIEVDPRTVDAGRLA
RLAELGFNRLSFGVQDFDPAVQKAVHRVQPAEQVFALVQEARRIGFESINVDLIYGLPRQTPESFDRTLAQVCELRPDRI
ALYAYAHLPERFKPQRRIVSAELPMASAKVSMLSRSLNAFQDAGYVYVGMDHFALPEDALAVAKRQGRLHRNFQGYSTQP
DCDLIALGVSAIGRVGATYSQNAKTLDEYYDLINQGRLPVVRGLALTRDDLVRRSVIMALMCQGEVLFEPMEQSWLIDFR
RYFAAELEALEGMAGDGLVNVGEDGITVTEMGWFFVRGVAMVFDRYLQADRNRARFSRII

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=244, Percent_Identity=27.8688524590164, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87082341, Length=453, Percent_Identity=49.0066225165563, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1789325, Length=285, Percent_Identity=30.1754385964912, Blast_Score=122, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 51749; Mature: 51749

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVTPELLRRFDVPGPRYTSYPTADRFVEAFGADEYVLALQQRRLGSAAKAVPLSLYVH
CCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHHCCEEEEEEE
IPFCESLCYYCACNKIITRHPERADVYLRYLSREIDLHMAHCALGHAVSQLHIGGGSPTF
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
LGDEALQELMNMLRRSFTLVPGGEYSIEVDPRTVDAGRLARLAELGFNRLSFGVQDFDPA
CCHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCHHHHHHHHHHCCHHHHCCCHHCCHH
VQKAVHRVQPAEQVFALVQEARRIGFESINVDLIYGLPRQTPESFDRTLAQVCELRPDRI
HHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCE
ALYAYAHLPERFKPQRRIVSAELPMASAKVSMLSRSLNAFQDAGYVYVGMDHFALPEDAL
EEEEEECCCHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHH
AVAKRQGRLHRNFQGYSTQPDCDLIALGVSAIGRVGATYSQNAKTLDEYYDLINQGRLPV
HHHHHHCHHHCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHH
VRGLALTRDDLVRRSVIMALMCQGEVLFEPMEQSWLIDFRRYFAAELEALEGMAGDGLVN
HHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
VGEDGITVTEMGWFFVRGVAMVFDRYLQADRNRARFSRII
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure
MNAVTPELLRRFDVPGPRYTSYPTADRFVEAFGADEYVLALQQRRLGSAAKAVPLSLYVH
CCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHHCCEEEEEEE
IPFCESLCYYCACNKIITRHPERADVYLRYLSREIDLHMAHCALGHAVSQLHIGGGSPTF
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
LGDEALQELMNMLRRSFTLVPGGEYSIEVDPRTVDAGRLARLAELGFNRLSFGVQDFDPA
CCHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCHHHHHHHHHHCCHHHHCCCHHCCHH
VQKAVHRVQPAEQVFALVQEARRIGFESINVDLIYGLPRQTPESFDRTLAQVCELRPDRI
HHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCE
ALYAYAHLPERFKPQRRIVSAELPMASAKVSMLSRSLNAFQDAGYVYVGMDHFALPEDAL
EEEEEECCCHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHH
AVAKRQGRLHRNFQGYSTQPDCDLIALGVSAIGRVGATYSQNAKTLDEYYDLINQGRLPV
HHHHHHCHHHCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHH
VRGLALTRDDLVRRSVIMALMCQGEVLFEPMEQSWLIDFRRYFAAELEALEGMAGDGLVN
HHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
VGEDGITVTEMGWFFVRGVAMVFDRYLQADRNRARFSRII
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9396835 [H]