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The map label for this gene is ruvC

Identifier: 120609527

GI number: 120609527

Start: 904262

End: 904810

Strand: Reverse

Name: ruvC

Synonym: Aave_0833

Alternate gene names: 120609527

Gene position: 904810-904262 (Counterclockwise)

Preceding gene: 120609528

Following gene: 120609524

Centisome position: 16.9

GC content: 71.77

Gene sequence:

>549_bases
ATGAGAATCCTGGGCATCGATCCCGGCCTGCAGACCACCGGCTTCGGCGTGGTGGACGTGGACGGCCACCATTTGAGCTA
CGTGGCCAGCGGCACCATCCGCACCACGGGCGCGGCCCTGGGCGACCTGCCGGGCCGCCTGAAGATCCTGTTCGACGGCA
TCACCGAGGTGGCCGCGCGCTACCAGCCGGACGTGGCCACGGTCGAGATCGTCTTCGTGAACGTGAACCCCCAGTCCACC
CTGCTGCTCGGCCAGGCGCGCGGCGCCTGCGTCACCGCCCTGGTGGCCAGCCGGTTGCCCGTGGCCGAATACACCGCGCT
GCAGATGAAGAAGGCCGTCGTGGGCCATGGCCGCGCGGCCAAGTCCCAGGTGCAGGAGATGGTGCGCCGGCTGCTGCAGC
TGCCCGGCCTGCCGGGCACCGATGCCGCCGACGCGCTGGGCCTGGCCATCACCCATGCCCACGCGGGCGCGGCGATGGCA
CGGCTGGGGGAAGCGACCTCGCTCAACCGCCGCCAGCACGCCATGTACCGGAGCGGACGGGCGCTCTGA

Upstream 100 bases:

>100_bases
GGGGCGGGCGGCCTGCTGGACCGCGTGGACGCGCTGTGCTTCGCGGGCCCCGTGTTCTTTCATTCGGCCCGCTGGTACTT
CGGCCTGTGAACGGCATCCC

Downstream 100 bases:

>100_bases
TGCCCTCCGGCTACCGGAAGACGATCTGCGCGATGACGCCGGAGCCCACCGAGATCAGCAGGTAGTCGGGACCGTTCTGT
ACCCAGTGATACCCATGGGG

Product: Holliday junction resolvase

Products: NA

Alternate protein names: Holliday junction nuclease ruvC; Holliday junction resolvase ruvC

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MRILGIDPGLQTTGFGVVDVDGHHLSYVASGTIRTTGAALGDLPGRLKILFDGITEVAARYQPDVATVEIVFVNVNPQST
LLLGQARGACVTALVASRLPVAEYTALQMKKAVVGHGRAAKSQVQEMVRRLLQLPGLPGTDAADALGLAITHAHAGAAMA
RLGEATSLNRRQHAMYRSGRAL

Sequences:

>Translated_182_residues
MRILGIDPGLQTTGFGVVDVDGHHLSYVASGTIRTTGAALGDLPGRLKILFDGITEVAARYQPDVATVEIVFVNVNPQST
LLLGQARGACVTALVASRLPVAEYTALQMKKAVVGHGRAAKSQVQEMVRRLLQLPGLPGTDAADALGLAITHAHAGAAMA
RLGEATSLNRRQHAMYRSGRAL
>Mature_182_residues
MRILGIDPGLQTTGFGVVDVDGHHLSYVASGTIRTTGAALGDLPGRLKILFDGITEVAARYQPDVATVEIVFVNVNPQST
LLLGQARGACVTALVASRLPVAEYTALQMKKAVVGHGRAAKSQVQEMVRRLLQLPGLPGTDAADALGLAITHAHAGAAMA
RLGEATSLNRRQHAMYRSGRAL

Specific function: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leav

COG id: COG0817

COG function: function code L; Holliday junction resolvasome, endonuclease subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvC family

Homologues:

Organism=Escherichia coli, GI1788170, Length=163, Percent_Identity=51.5337423312883, Blast_Score=144, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVC_ACIAC (A1TKE3)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969205.1
- ProteinModelPortal:   A1TKE3
- SMR:   A1TKE3
- STRING:   A1TKE3
- GeneID:   4668165
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_0833
- NMPDR:   fig|397945.5.peg.724
- eggNOG:   COG0817
- HOGENOM:   HBG437552
- OMA:   RTGWGVI
- PhylomeDB:   A1TKE3
- ProtClustDB:   PRK00039
- BioCyc:   AAVE397945:AAVE_0833-MONOMER
- HAMAP:   MF_00034
- InterPro:   IPR012337
- InterPro:   IPR020563
- InterPro:   IPR002176
- PRINTS:   PR00696
- TIGRFAMs:   TIGR00228

Pfam domain/function: PF02075 RuvC; SSF53098 RNaseH_fold

EC number: =3.1.22.4

Molecular weight: Translated: 19086; Mature: 19086

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS01321 RUVC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILGIDPGLQTTGFGVVDVDGHHLSYVASGTIRTTGAALGDLPGRLKILFDGITEVAAR
CEEEECCCCCCCCCCEEEEECCCEEEEEECCCEEECCCHHCCCCCEEEEEHHHHHHHHHH
YQPDVATVEIVFVNVNPQSTLLLGQARGACVTALVASRLPVAEYTALQMKKAVVGHGRAA
CCCCCEEEEEEEEEECCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHH
KSQVQEMVRRLLQLPGLPGTDAADALGLAITHAHAGAAMARLGEATSLNRRQHAMYRSGR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
AL
CC
>Mature Secondary Structure
MRILGIDPGLQTTGFGVVDVDGHHLSYVASGTIRTTGAALGDLPGRLKILFDGITEVAAR
CEEEECCCCCCCCCCEEEEECCCEEEEEECCCEEECCCHHCCCCCEEEEEHHHHHHHHHH
YQPDVATVEIVFVNVNPQSTLLLGQARGACVTALVASRLPVAEYTALQMKKAVVGHGRAA
CCCCCEEEEEEEEEECCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHH
KSQVQEMVRRLLQLPGLPGTDAADALGLAITHAHAGAAMARLGEATSLNRRQHAMYRSGR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
AL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA