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The map label for this gene is hslU [H]

Identifier: 120609505

GI number: 120609505

Start: 876627

End: 877943

Strand: Direct

Name: hslU [H]

Synonym: Aave_0811

Alternate gene names: 120609505

Gene position: 876627-877943 (Clockwise)

Preceding gene: 120609504

Following gene: 120609506

Centisome position: 16.38

GC content: 67.5

Gene sequence:

>1317_bases
ATGTCTTCCATGACCCCCCAGGAAATCGTCTCCGAGCTCGACCGCCACATCGTGGGCCAGTCGGGCGCCAAGCGCGCCGT
CGCCATCGCGCTGCGCAACCGCTGGCGCCGCCAGCAGGTCGATCCCGCACTGCGCCAGGAGATCACCCCCAAGAACATCC
TCATGATCGGCCCCACCGGCGTGGGCAAGACGGAAATCGCCCGCCGCCTCGCCCGCCTGGCGGATGCGCCGTTCATCAAG
GTCGAGGCCACCAAGTTCACCGAGGTGGGCTACGTCGGCAAGGACGTGGACTCCATCGTGCGCGACCTCGTCGAGGTGGC
CGTCAAGCAGACCCGCGAGGCCGACGTGAAGAAAGTGCGCGCCCGGGCCGAGGATGCCGCCGAGGACCGCATCCTCGACG
TGCTCATCCCCACGGCGCGCACGGGCGAGCAGCCCGCGGACAGCACCGCGCGCCAGGTGTTCCGCAAGAAGCTGCGCGAG
GGCCAGCTGGACGACAAGGAGATCGAGATCGACGTCGCCGACGCCCGGCCCCAGCTCGAGATCATGGGTCCCCAGGGCAT
GGAGGAAATGGCCGAGCAGCTGCGCGGCATGTTCAGCCAGATGGGCCACGAGCGCCGCAAGGCGCGCAAGCTGCGGATCG
CCGAGGCGCTGAAGCTGCTCACCGACGAAGAGGCGGGCAAGCTGGTCAACGAGGAGGAAGTCAAGACGCGCGCCCTGCAG
AACGCCGAGCAGAACGGCATCGTGTTCATCGACGAGATCGACAAGGTCGCCACGCGCCAGGAGGCCGGCGGCTCCGACGT
CTCCCGCCAGGGCGTGCAGCGCGACCTGCTGCCCTTGGTGGAAGGCACCACCGTGAGCACCAAGTACGGCATGGTGAAGA
CCGACCACATCCTCTTCATCACCTCCGGGGCCTTCCACCTGGCCAAGCCGAGCGACCTGATCCCCGAACTGCAGGGGCGC
TTTCCCATCCGCGTCGAGCTGGAGTCGCTCTCCGTGGGCGATTTCGAGGCCATCCTCACCCAGACGCATGCCTCCCTGGT
GAAGCAGTACCAAGCGCTGCTGGCCACCGAAGGGGTCACGCTGGAGTTCGTTCCGGAGGGCATCACCCGGCTCGCCCACA
TCGCCTTCGAGGTGAACGAGCGCACCGAGAACATCGGCGCGCGCCGGCTGTCCACGGTCATGGAGCGGCTGCTGGACGAG
GTGAGCTTCGACGCCGCGAAACTCTCCGGCCAGACCGTGCGCGTCGATGCCGCCTACGTGGATGGACGCCTCGCGAGCCT
GAGCCAGAACGAGGATCTTTCGCGCTACATCCTGTAA

Upstream 100 bases:

>100_bases
CCCGCGTCGTCCTTCCGCCGAGAGCGGCGGGCTGCCCGTGGGCCGCCCGCCGTGTCCCCTTCCTGCCGGTTCCCGGCCCG
TTCCGTCCCGAGTGAACACC

Downstream 100 bases:

>100_bases
GAAGCGAACTTTTCCTACAGACTTGTGGATGTTTCCACAGGTTTTTCCCAATTCGCACCGCCGCCCGGACGCCAGCCGCC
GGGCGGCGGTTTCGCTTGGG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSSMTPQEIVSELDRHIVGQSGAKRAVAIALRNRWRRQQVDPALRQEITPKNILMIGPTGVGKTEIARRLARLADAPFIK
VEATKFTEVGYVGKDVDSIVRDLVEVAVKQTREADVKKVRARAEDAAEDRILDVLIPTARTGEQPADSTARQVFRKKLRE
GQLDDKEIEIDVADARPQLEIMGPQGMEEMAEQLRGMFSQMGHERRKARKLRIAEALKLLTDEEAGKLVNEEEVKTRALQ
NAEQNGIVFIDEIDKVATRQEAGGSDVSRQGVQRDLLPLVEGTTVSTKYGMVKTDHILFITSGAFHLAKPSDLIPELQGR
FPIRVELESLSVGDFEAILTQTHASLVKQYQALLATEGVTLEFVPEGITRLAHIAFEVNERTENIGARRLSTVMERLLDE
VSFDAAKLSGQTVRVDAAYVDGRLASLSQNEDLSRYIL

Sequences:

>Translated_438_residues
MSSMTPQEIVSELDRHIVGQSGAKRAVAIALRNRWRRQQVDPALRQEITPKNILMIGPTGVGKTEIARRLARLADAPFIK
VEATKFTEVGYVGKDVDSIVRDLVEVAVKQTREADVKKVRARAEDAAEDRILDVLIPTARTGEQPADSTARQVFRKKLRE
GQLDDKEIEIDVADARPQLEIMGPQGMEEMAEQLRGMFSQMGHERRKARKLRIAEALKLLTDEEAGKLVNEEEVKTRALQ
NAEQNGIVFIDEIDKVATRQEAGGSDVSRQGVQRDLLPLVEGTTVSTKYGMVKTDHILFITSGAFHLAKPSDLIPELQGR
FPIRVELESLSVGDFEAILTQTHASLVKQYQALLATEGVTLEFVPEGITRLAHIAFEVNERTENIGARRLSTVMERLLDE
VSFDAAKLSGQTVRVDAAYVDGRLASLSQNEDLSRYIL
>Mature_437_residues
SSMTPQEIVSELDRHIVGQSGAKRAVAIALRNRWRRQQVDPALRQEITPKNILMIGPTGVGKTEIARRLARLADAPFIKV
EATKFTEVGYVGKDVDSIVRDLVEVAVKQTREADVKKVRARAEDAAEDRILDVLIPTARTGEQPADSTARQVFRKKLREG
QLDDKEIEIDVADARPQLEIMGPQGMEEMAEQLRGMFSQMGHERRKARKLRIAEALKLLTDEEAGKLVNEEEVKTRALQN
AEQNGIVFIDEIDKVATRQEAGGSDVSRQGVQRDLLPLVEGTTVSTKYGMVKTDHILFITSGAFHLAKPSDLIPELQGRF
PIRVELESLSVGDFEAILTQTHASLVKQYQALLATEGVTLEFVPEGITRLAHIAFEVNERTENIGARRLSTVMERLLDEV
SFDAAKLSGQTVRVDAAYVDGRLASLSQNEDLSRYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=443, Percent_Identity=67.4943566591422, Blast_Score=604, Evalue=1e-174,
Organism=Escherichia coli, GI1786642, Length=117, Percent_Identity=43.5897435897436, Blast_Score=98, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24648291, Length=263, Percent_Identity=29.277566539924, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24648289, Length=263, Percent_Identity=29.277566539924, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 48711; Mature: 48580

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSMTPQEIVSELDRHIVGQSGAKRAVAIALRNRWRRQQVDPALRQEITPKNILMIGPTG
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEECCCC
VGKTEIARRLARLADAPFIKVEATKFTEVGYVGKDVDSIVRDLVEVAVKQTREADVKKVR
CCHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ARAEDAAEDRILDVLIPTARTGEQPADSTARQVFRKKLREGQLDDKEIEIDVADARPQLE
HHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEE
IMGPQGMEEMAEQLRGMFSQMGHERRKARKLRIAEALKLLTDEEAGKLVNEEEVKTRALQ
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHH
NAEQNGIVFIDEIDKVATRQEAGGSDVSRQGVQRDLLPLVEGTTVSTKYGMVKTDHILFI
CCCCCCEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEECCCCCEEECEEEEE
TSGAFHLAKPSDLIPELQGRFPIRVELESLSVGDFEAILTQTHASLVKQYQALLATEGVT
ECCCEECCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
LEFVPEGITRLAHIAFEVNERTENIGARRLSTVMERLLDEVSFDAAKLSGQTVRVDAAYV
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEEHHH
DGRLASLSQNEDLSRYIL
CCHHHCCCCCCCHHHHCC
>Mature Secondary Structure 
SSMTPQEIVSELDRHIVGQSGAKRAVAIALRNRWRRQQVDPALRQEITPKNILMIGPTG
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEECCCC
VGKTEIARRLARLADAPFIKVEATKFTEVGYVGKDVDSIVRDLVEVAVKQTREADVKKVR
CCHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ARAEDAAEDRILDVLIPTARTGEQPADSTARQVFRKKLREGQLDDKEIEIDVADARPQLE
HHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEE
IMGPQGMEEMAEQLRGMFSQMGHERRKARKLRIAEALKLLTDEEAGKLVNEEEVKTRALQ
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHH
NAEQNGIVFIDEIDKVATRQEAGGSDVSRQGVQRDLLPLVEGTTVSTKYGMVKTDHILFI
CCCCCCEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEECCCCCEEECEEEEE
TSGAFHLAKPSDLIPELQGRFPIRVELESLSVGDFEAILTQTHASLVKQYQALLATEGVT
ECCCEECCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
LEFVPEGITRLAHIAFEVNERTENIGARRLSTVMERLLDEVSFDAAKLSGQTVRVDAAYV
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEEHHH
DGRLASLSQNEDLSRYIL
CCHHHCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA