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The map label for this gene is ilvD [H]

Identifier: 120609448

GI number: 120609448

Start: 808085

End: 809866

Strand: Reverse

Name: ilvD [H]

Synonym: Aave_0754

Alternate gene names: 120609448

Gene position: 809866-808085 (Counterclockwise)

Preceding gene: 120609449

Following gene: 120609447

Centisome position: 15.13

GC content: 71.44

Gene sequence:

>1782_bases
ATGACCCCACCCGAAGGCCGCCGCTTCCGCTCGCGCGACTGGTTCGCCGACCCGGCGCGCTCCGACATGACCGCGCTCTA
CCTCGAGCGCTTCATGAACTACGGGCTCACGCCCGAGGAGCTGCGCTCGGGCCGGCCCATCATCGGCATCGCCCAGACCG
GCAGCGATCTTTCCCCCTGCAACCGCATCCACCTCGAACTGGCCCGCCGCGTGCGCGACGGCATCCGCGATGCGGGTGGC
ATCCCGATCGAATTTCCCGTCCACCCGATCTTCGAGAACTGCCGCCGCCCCTCCGCCGCGCTGGACCGCAACCTCGCCTA
CCTGGGCCTGGTCGAGATCCTCTACGGCTACCCCATCGACGCCGTGGTGCTGACCACCGGCTGCGACAAGACCACGCCGG
CCGGCATCATGGCCGCTTCCACCGTCGATATCCCCGCCATCGTGCTCTCGGGCGGGCCGATGCTCGATGGCTGGCACGAG
GGCGAACTGGTCGGCTCGGGCACCGTCATCTGGCGCAGCCGCCGCATGCTGGCGGCCGGCGAGATCGACGAGGAAGAATT
CCTGCAGCGCGCCTGCGACAGCGCGCCCTCGGCCGGCCACTGCAACACCATGGGCACGGCCTCCACCATGAACGCGGTGG
CCGAGGCCCTGGGCCTCTCGCTGCCCGGCTGCGCCGCCATCCCCGCGCCCTACCGCGAGCGCGGCCAGATGGCCTATGCC
ACCGGCCGGCGCATCGTCGAGATGGCGCACGAAGACCTGCGCCCCTCGCGCGTGCTCACCCGCGAGAGCTTCCTCAACGC
GCTGGCGGTGGTCAGCTGCGCGGGCGGCTCCAGCAACGCGCAGGTGCACATCCAGGCCATGGCGCGCCATGCCGGCGTCG
AACTGCACCCGCGCGACTGGACCGACCATGCCTACGGCCTGCCCCTGCTGGTCAACATGCAGCCCGCCGGCAAATACCTG
GGCGAGCGCTTCTTCCGTGCCGGCGGCGTGCCCGCGGTGATGTGGGAGCTGCTGCAGGCCGGCCGGCTGCACGGCGACTG
CGCCAGCGTCACGGGCCGCAGCATCGCCGAGAACCTGCAGGGCCGCGAAGCGACGGACCGCGAGGTGATCCGCACCTTCG
CCGACCCGCTGATGGACAAGGCCGGCTTCCTGGTGCTCTCGGGCAACCTGTTCGATTTCGGCATCATGAAAACCTCGGTG
ATCTCCGAGGCCTTCCGCGCGCGCTACCTCTGCCGGCCGGGCCATGAAGACGTGTTCACGGCCCGGGCCATCGTTTTCGA
CGGCGCCGAGGACTACCACGCGCGCATCAACGACCCTGCCCTCGGCATCGACGAGGACTGCATCCTGGTGATGCGCGGCG
CCGGCCCGCTGGGCTGGCCCGGCTCGGCCGAGGTGGTCAACATGCAGCCGCCCGATGCGCTGATCCGGCGCGGCATCCGG
GCGCTGCCCACGCTGGGCGACGGCCGGCAATCCGGCACCGCCGACAGCCCCTCCATCCTCAACGCCTCGCCCGAGAGCGC
GGCGGGCGGGGGCCTCGCCTGGCTGCAGACCGGCGACCTGATCCTGATCGACCTGCAGCGCGGCCACTGCAACGCGCTGG
TGCCCGACGATGAGATCGCCCGCCGCCGCCGCGAACTGCCGCCGCCGCCCGTGCCTGCGAGCCGCTCGCCCTGGGAAGCG
CTCTACCGCGAGAAAACCGGCCAGCTCGCCGACGGCGCCACGCTGGATTTCGCGCTGCAGTTCCGCCGCATCGCCGAGCA
GACACCCCGCCACAACCACTGA

Upstream 100 bases:

>100_bases
AGCCCGTGGTCGCCAGGTACAGCAAGGAATTCGGCGAGGACACCACCCGCGAAATGATGGCCGAGCTGGAAAAGGCCCGC
CGCAAGTAACCGAAAACGAC

Downstream 100 bases:

>100_bases
CGCCCGAGGACGAGAACCATGAACGACGAACGCACGGGCCTGCTGCCCGACGACGGACTGGCCGGCACGCTGGTGGCCCG
GGCCTGGACACCCGGCCCGC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MTPPEGRRFRSRDWFADPARSDMTALYLERFMNYGLTPEELRSGRPIIGIAQTGSDLSPCNRIHLELARRVRDGIRDAGG
IPIEFPVHPIFENCRRPSAALDRNLAYLGLVEILYGYPIDAVVLTTGCDKTTPAGIMAASTVDIPAIVLSGGPMLDGWHE
GELVGSGTVIWRSRRMLAAGEIDEEEFLQRACDSAPSAGHCNTMGTASTMNAVAEALGLSLPGCAAIPAPYRERGQMAYA
TGRRIVEMAHEDLRPSRVLTRESFLNALAVVSCAGGSSNAQVHIQAMARHAGVELHPRDWTDHAYGLPLLVNMQPAGKYL
GERFFRAGGVPAVMWELLQAGRLHGDCASVTGRSIAENLQGREATDREVIRTFADPLMDKAGFLVLSGNLFDFGIMKTSV
ISEAFRARYLCRPGHEDVFTARAIVFDGAEDYHARINDPALGIDEDCILVMRGAGPLGWPGSAEVVNMQPPDALIRRGIR
ALPTLGDGRQSGTADSPSILNASPESAAGGGLAWLQTGDLILIDLQRGHCNALVPDDEIARRRRELPPPPVPASRSPWEA
LYREKTGQLADGATLDFALQFRRIAEQTPRHNH

Sequences:

>Translated_593_residues
MTPPEGRRFRSRDWFADPARSDMTALYLERFMNYGLTPEELRSGRPIIGIAQTGSDLSPCNRIHLELARRVRDGIRDAGG
IPIEFPVHPIFENCRRPSAALDRNLAYLGLVEILYGYPIDAVVLTTGCDKTTPAGIMAASTVDIPAIVLSGGPMLDGWHE
GELVGSGTVIWRSRRMLAAGEIDEEEFLQRACDSAPSAGHCNTMGTASTMNAVAEALGLSLPGCAAIPAPYRERGQMAYA
TGRRIVEMAHEDLRPSRVLTRESFLNALAVVSCAGGSSNAQVHIQAMARHAGVELHPRDWTDHAYGLPLLVNMQPAGKYL
GERFFRAGGVPAVMWELLQAGRLHGDCASVTGRSIAENLQGREATDREVIRTFADPLMDKAGFLVLSGNLFDFGIMKTSV
ISEAFRARYLCRPGHEDVFTARAIVFDGAEDYHARINDPALGIDEDCILVMRGAGPLGWPGSAEVVNMQPPDALIRRGIR
ALPTLGDGRQSGTADSPSILNASPESAAGGGLAWLQTGDLILIDLQRGHCNALVPDDEIARRRRELPPPPVPASRSPWEA
LYREKTGQLADGATLDFALQFRRIAEQTPRHNH
>Mature_592_residues
TPPEGRRFRSRDWFADPARSDMTALYLERFMNYGLTPEELRSGRPIIGIAQTGSDLSPCNRIHLELARRVRDGIRDAGGI
PIEFPVHPIFENCRRPSAALDRNLAYLGLVEILYGYPIDAVVLTTGCDKTTPAGIMAASTVDIPAIVLSGGPMLDGWHEG
ELVGSGTVIWRSRRMLAAGEIDEEEFLQRACDSAPSAGHCNTMGTASTMNAVAEALGLSLPGCAAIPAPYRERGQMAYAT
GRRIVEMAHEDLRPSRVLTRESFLNALAVVSCAGGSSNAQVHIQAMARHAGVELHPRDWTDHAYGLPLLVNMQPAGKYLG
ERFFRAGGVPAVMWELLQAGRLHGDCASVTGRSIAENLQGREATDREVIRTFADPLMDKAGFLVLSGNLFDFGIMKTSVI
SEAFRARYLCRPGHEDVFTARAIVFDGAEDYHARINDPALGIDEDCILVMRGAGPLGWPGSAEVVNMQPPDALIRRGIRA
LPTLGDGRQSGTADSPSILNASPESAAGGGLAWLQTGDLILIDLQRGHCNALVPDDEIARRRRELPPPPVPASRSPWEAL
YREKTGQLADGATLDFALQFRRIAEQTPRHNH

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=478, Percent_Identity=30.7531380753138, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI48994964, Length=569, Percent_Identity=27.9437609841828, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI2367371, Length=512, Percent_Identity=27.734375, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1786464, Length=434, Percent_Identity=29.7235023041475, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322476, Length=561, Percent_Identity=27.2727272727273, Blast_Score=193, Evalue=6e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 64405; Mature: 64274

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPPEGRRFRSRDWFADPARSDMTALYLERFMNYGLTPEELRSGRPIIGIAQTGSDLSPC
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCCHH
NRIHLELARRVRDGIRDAGGIPIEFPVHPIFENCRRPSAALDRNLAYLGLVEILYGYPID
HHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCCCHHHHHCCHHHHHHHHHHHCCCCC
AVVLTTGCDKTTPAGIMAASTVDIPAIVLSGGPMLDGWHEGELVGSGTVIWRSRRMLAAG
EEEEECCCCCCCCCCEEEECCCCCCEEEEECCCCCCCCCCCCEEECCEEEEECCCEEECC
EIDEEEFLQRACDSAPSAGHCNTMGTASTMNAVAEALGLSLPGCAAIPAPYRERGQMAYA
CCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCEEHH
TGRRIVEMAHEDLRPSRVLTRESFLNALAVVSCAGGSSNAQVHIQAMARHAGVELHPRDW
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEEHHHHCCCEECCCCC
TDHAYGLPLLVNMQPAGKYLGERFFRAGGVPAVMWELLQAGRLHGDCASVTGRSIAENLQ
CCCCCCCEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
GREATDREVIRTFADPLMDKAGFLVLSGNLFDFGIMKTSVISEAFRARYLCRPGHEDVFT
CCCCHHHHHHHHHHHHHHHCCCEEEEECCEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHE
ARAIVFDGAEDYHARINDPALGIDEDCILVMRGAGPLGWPGSAEVVNMQPPDALIRRGIR
EEEEEECCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEECCCCHHHHHHHHH
ALPTLGDGRQSGTADSPSILNASPESAAGGGLAWLQTGDLILIDLQRGHCNALVPDDEIA
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCHHHH
RRRRELPPPPVPASRSPWEALYREKTGQLADGATLDFALQFRRIAEQTPRHNH
HHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TPPEGRRFRSRDWFADPARSDMTALYLERFMNYGLTPEELRSGRPIIGIAQTGSDLSPC
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCCHH
NRIHLELARRVRDGIRDAGGIPIEFPVHPIFENCRRPSAALDRNLAYLGLVEILYGYPID
HHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCCCHHHHHCCHHHHHHHHHHHCCCCC
AVVLTTGCDKTTPAGIMAASTVDIPAIVLSGGPMLDGWHEGELVGSGTVIWRSRRMLAAG
EEEEECCCCCCCCCCEEEECCCCCCEEEEECCCCCCCCCCCCEEECCEEEEECCCEEECC
EIDEEEFLQRACDSAPSAGHCNTMGTASTMNAVAEALGLSLPGCAAIPAPYRERGQMAYA
CCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCEEHH
TGRRIVEMAHEDLRPSRVLTRESFLNALAVVSCAGGSSNAQVHIQAMARHAGVELHPRDW
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEEHHHHCCCEECCCCC
TDHAYGLPLLVNMQPAGKYLGERFFRAGGVPAVMWELLQAGRLHGDCASVTGRSIAENLQ
CCCCCCCEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
GREATDREVIRTFADPLMDKAGFLVLSGNLFDFGIMKTSVISEAFRARYLCRPGHEDVFT
CCCCHHHHHHHHHHHHHHHCCCEEEEECCEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHE
ARAIVFDGAEDYHARINDPALGIDEDCILVMRGAGPLGWPGSAEVVNMQPPDALIRRGIR
EEEEEECCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEECCCCHHHHHHHHH
ALPTLGDGRQSGTADSPSILNASPESAAGGGLAWLQTGDLILIDLQRGHCNALVPDDEIA
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCHHHH
RRRRELPPPPVPASRSPWEALYREKTGQLADGATLDFALQFRRIAEQTPRHNH
HHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]