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The map label for this gene is icfA [H]

Identifier: 120609365

GI number: 120609365

Start: 724440

End: 725153

Strand: Direct

Name: icfA [H]

Synonym: Aave_0666

Alternate gene names: 120609365

Gene position: 724440-725153 (Clockwise)

Preceding gene: 120609364

Following gene: 120609366

Centisome position: 13.53

GC content: 70.73

Gene sequence:

>714_bases
ATGCCCGACGAGCTGCTGCAGCGCCTGCGCCGTTTCCACGACGATGCGTTCCCGCGCTACCGCCAGCGCTTCCAGGACCT
GGTGGCGCAGGGCCAGCGGCCCACCACGCTCTTCATCGGCTGCTCCGATTCGCGCCTGGTGCCGCACCTGCTCACCGGCA
CGGGGCCGGGCGAACTCTTCCTGGTGCGCAACGTGGGCGCCTTCGTTCCGCCCTGCGACGGCTCGCACGGCCACCACGGC
ACGGCCGCCGCGATCGAATTCGCGGTGCTCAGCCTGCAGGTGCGGCGCATCGTCGTCTGCGGGCACAGCCACTGCGGCGC
GGTGAAGGCGCTCTACGGCGAGGTGCCGGCCGAAGCCCTCAACCTGCAGCGCTGGCTGGAGCTCGGCCGCGAAGCCGTGC
TGCCCGTGCAGGCCACGCCCGAGGCGCTGCGGCGTACCGAACAGCGTGCCGTGGTGCTGCAGCTCGAACGCCTCATGGAC
TACCCCATGGTGCGGCGCCGCGTGCAGGCGGGCGAACTCACGCTGCATGGCTGGCACTACGTGATCGAGGAAGGCGAGGT
GCATGTCTTCGACCTGGAGCAGGCCGGTTTCGTGGCCGCATCCAGTGCCGACCACAGCGGCACCGGGCCCTATGCGCCCT
ACGTCGAGCACGACGGGCAAGTCCTTTGCGCCGACGTTGACATAGCCCAGTGCGGCGCGCCGGCGCAGGAGTAG

Upstream 100 bases:

>100_bases
TACCTGCAGGTGCTCGCGGGCGAAGCCGCGCTGCAGGGCGTGGACCTGGACGGCGCCGACACGCCGCTCGTGCAGTAGCG
TTCCCGGGCTCCGCCACGCC

Downstream 100 bases:

>100_bases
AAAGACGGCTTGGCCGTGTTCAGGAACTGGAACCCATGCAACGCGATCCGATCGACTCCCTCGCGCCCGACGCGGCGCCC
CGCCTGCCCGAGCAGCCCAT

Product: carbonate dehydratase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MPDELLQRLRRFHDDAFPRYRQRFQDLVAQGQRPTTLFIGCSDSRLVPHLLTGTGPGELFLVRNVGAFVPPCDGSHGHHG
TAAAIEFAVLSLQVRRIVVCGHSHCGAVKALYGEVPAEALNLQRWLELGREAVLPVQATPEALRRTEQRAVVLQLERLMD
YPMVRRRVQAGELTLHGWHYVIEEGEVHVFDLEQAGFVAASSADHSGTGPYAPYVEHDGQVLCADVDIAQCGAPAQE

Sequences:

>Translated_237_residues
MPDELLQRLRRFHDDAFPRYRQRFQDLVAQGQRPTTLFIGCSDSRLVPHLLTGTGPGELFLVRNVGAFVPPCDGSHGHHG
TAAAIEFAVLSLQVRRIVVCGHSHCGAVKALYGEVPAEALNLQRWLELGREAVLPVQATPEALRRTEQRAVVLQLERLMD
YPMVRRRVQAGELTLHGWHYVIEEGEVHVFDLEQAGFVAASSADHSGTGPYAPYVEHDGQVLCADVDIAQCGAPAQE
>Mature_236_residues
PDELLQRLRRFHDDAFPRYRQRFQDLVAQGQRPTTLFIGCSDSRLVPHLLTGTGPGELFLVRNVGAFVPPCDGSHGHHGT
AAAIEFAVLSLQVRRIVVCGHSHCGAVKALYGEVPAEALNLQRWLELGREAVLPVQATPEALRRTEQRAVVLQLERLMDY
PMVRRRVQAGELTLHGWHYVIEEGEVHVFDLEQAGFVAASSADHSGTGPYAPYVEHDGQVLCADVDIAQCGAPAQE

Specific function: Reversible hydration of carbon dioxide. Essential to photosynthetic carbon dioxide fixation [H]

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786534, Length=205, Percent_Identity=38.5365853658537, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786318, Length=176, Percent_Identity=32.9545454545455, Blast_Score=78, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI115532990, Length=234, Percent_Identity=26.9230769230769, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25147564, Length=222, Percent_Identity=27.027027027027, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324292, Length=175, Percent_Identity=32.5714285714286, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24645213, Length=230, Percent_Identity=23.9130434782609, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 26159; Mature: 26028

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00704 PROK_CO2_ANHYDRASE_1 ; PS00705 PROK_CO2_ANHYDRASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDELLQRLRRFHDDAFPRYRQRFQDLVAQGQRPTTLFIGCSDSRLVPHLLTGTGPGELF
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHCCCCCCCEE
LVRNVGAFVPPCDGSHGHHGTAAAIEFAVLSLQVRRIVVCGHSHCGAVKALYGEVPAEAL
EEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCCCHHHH
NLQRWLELGREAVLPVQATPEALRRTEQRAVVLQLERLMDYPMVRRRVQAGELTLHGWHY
HHHHHHHCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEECEEE
VIEEGEVHVFDLEQAGFVAASSADHSGTGPYAPYVEHDGQVLCADVDIAQCGAPAQE
EEECCCEEEEEECCCCEEEECCCCCCCCCCCCCCEECCCCEEEEECCHHHCCCCCCC
>Mature Secondary Structure 
PDELLQRLRRFHDDAFPRYRQRFQDLVAQGQRPTTLFIGCSDSRLVPHLLTGTGPGELF
CHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHCCCCCCCEE
LVRNVGAFVPPCDGSHGHHGTAAAIEFAVLSLQVRRIVVCGHSHCGAVKALYGEVPAEAL
EEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCCCHHHH
NLQRWLELGREAVLPVQATPEALRRTEQRAVVLQLERLMDYPMVRRRVQAGELTLHGWHY
HHHHHHHCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEECEEE
VIEEGEVHVFDLEQAGFVAASSADHSGTGPYAPYVEHDGQVLCADVDIAQCGAPAQE
EEECCCEEEEEECCCCEEEECCCCCCCCCCCCCCEECCCCEEEEECCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1584776 [H]