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The map label for this gene is liaR [H]

Identifier: 120609353

GI number: 120609353

Start: 707237

End: 708007

Strand: Direct

Name: liaR [H]

Synonym: Aave_0654

Alternate gene names: 120609353

Gene position: 707237-708007 (Clockwise)

Preceding gene: 120609351

Following gene: 120609357

Centisome position: 13.21

GC content: 73.54

Gene sequence:

>771_bases
ATGGTTTCCGACCCCCTGCCGCACCGCAGCCCATCCCTGGCGCCGGACGCCGCGCTCCTGCGGGTGTTCGTGGTGGACGA
CCATACGCTGTTCCGGCGTGGCCTGATCGCCCTGCTGTCGCAGTATCCGTCGCTGCGCGTGGCGGGGGAGGCCGGCGACG
CCGGCGAGGCCCTGCGGCTGGCGCCGCCGCTCGCGCCGCAGGTGTTGCTGCTGGACAACCACCTGCCGGGGGTGCGCGGC
ATCGATGCCATCCGCGGCCTGCGCGAGGCCATGCCGGACGTGCGGGTGCTGATGCTGACGGTGAGCGAGGATGGCGAGGA
CCTCGCCCAGGCGCTGCGCCACGGGGCCCAGGGCTACCTGCTCAAGACCATCGAAGGCGACCTGCTGGCCGATGCCATCG
GACGCGCCGCGCGGGGCGAGCCGGTGGTGAGCATGGAGCTGATGGGCAAGCTGGTGGCGGCCTTCCAGGCGCAGGGCGGC
CCGCCGGCGCGGGAGCCGCGGGCCGATGCCGGGGCGGCCGCCGTTGCCGTTACCCAAGCCCCCGCGGAGGGGACCGGCCC
GGGGGCTGCCGGTTCCGCTTCCCCGCTGTCGGCGCGCGAGGAAGACGTGCTGCGCGAGATCGCGCGCGGCGCGAGCAACA
AGGAGATCGCCCGTGCGCTGGACATCGCCGAGACCACGGTGAAGATCCATGTGCAGCACATCCTGCGCAAGCTGGGGCTG
AGTTCGCGCGTGCAGGCGGCGGTTTACGCGTCGGAACGCCAGCGCGAGTAG

Upstream 100 bases:

>100_bases
CGACCTGCCGACGACCGGGGAGCCGCACGTCCCGGCCGCCGAGACGGCGGGTTTTTCCATTTCCGATTTCGCGCCGCTGG
CGTCCTGAGCACCACCTCCC

Downstream 100 bases:

>100_bases
GCGGGCGGCGCGCAGGCGCCTTCGGCCCATGCGTGCGCCGCACAGCGCCGCGCCCACCACCAGGCCAGGCCGGCGGCCAG
CGCCAGGCCCGCGAGCATGG

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MVSDPLPHRSPSLAPDAALLRVFVVDDHTLFRRGLIALLSQYPSLRVAGEAGDAGEALRLAPPLAPQVLLLDNHLPGVRG
IDAIRGLREAMPDVRVLMLTVSEDGEDLAQALRHGAQGYLLKTIEGDLLADAIGRAARGEPVVSMELMGKLVAAFQAQGG
PPAREPRADAGAAAVAVTQAPAEGTGPGAAGSASPLSAREEDVLREIARGASNKEIARALDIAETTVKIHVQHILRKLGL
SSRVQAAVYASERQRE

Sequences:

>Translated_256_residues
MVSDPLPHRSPSLAPDAALLRVFVVDDHTLFRRGLIALLSQYPSLRVAGEAGDAGEALRLAPPLAPQVLLLDNHLPGVRG
IDAIRGLREAMPDVRVLMLTVSEDGEDLAQALRHGAQGYLLKTIEGDLLADAIGRAARGEPVVSMELMGKLVAAFQAQGG
PPAREPRADAGAAAVAVTQAPAEGTGPGAAGSASPLSAREEDVLREIARGASNKEIARALDIAETTVKIHVQHILRKLGL
SSRVQAAVYASERQRE
>Mature_256_residues
MVSDPLPHRSPSLAPDAALLRVFVVDDHTLFRRGLIALLSQYPSLRVAGEAGDAGEALRLAPPLAPQVLLLDNHLPGVRG
IDAIRGLREAMPDVRVLMLTVSEDGEDLAQALRHGAQGYLLKTIEGDLLADAIGRAARGEPVVSMELMGKLVAAFQAQGG
PPAREPRADAGAAAVAVTQAPAEGTGPGAAGSASPLSAREEDVLREIARGASNKEIARALDIAETTVKIHVQHILRKLGL
SSRVQAAVYASERQRE

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=235, Percent_Identity=36.5957446808511, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1787473, Length=233, Percent_Identity=36.480686695279, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1790102, Length=229, Percent_Identity=28.3842794759825, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1788222, Length=228, Percent_Identity=26.3157894736842, Blast_Score=78, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 26887; Mature: 26887

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSDPLPHRSPSLAPDAALLRVFVVDDHTLFRRGLIALLSQYPSLRVAGEAGDAGEALRL
CCCCCCCCCCCCCCCCHHEEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEC
APPLAPQVLLLDNHLPGVRGIDAIRGLREAMPDVRVLMLTVSEDGEDLAQALRHGAQGYL
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHCCCCCEE
LKTIEGDLLADAIGRAARGEPVVSMELMGKLVAAFQAQGGPPAREPRADAGAAAVAVTQA
EEHHCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECC
PAEGTGPGAAGSASPLSAREEDVLREIARGASNKEIARALDIAETTVKIHVQHILRKLGL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
SSRVQAAVYASERQRE
CHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVSDPLPHRSPSLAPDAALLRVFVVDDHTLFRRGLIALLSQYPSLRVAGEAGDAGEALRL
CCCCCCCCCCCCCCCCHHEEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEC
APPLAPQVLLLDNHLPGVRGIDAIRGLREAMPDVRVLMLTVSEDGEDLAQALRHGAQGYL
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHCCCCCEE
LKTIEGDLLADAIGRAARGEPVVSMELMGKLVAAFQAQGGPPAREPRADAGAAAVAVTQA
EEHHCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECC
PAEGTGPGAAGSASPLSAREEDVLREIARGASNKEIARALDIAETTVKIHVQHILRKLGL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
SSRVQAAVYASERQRE
CHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]