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The map label for this gene is gdhA [H]

Identifier: 120608896

GI number: 120608896

Start: 211910

End: 213211

Strand: Reverse

Name: gdhA [H]

Synonym: Aave_0188

Alternate gene names: 120608896

Gene position: 213211-211910 (Counterclockwise)

Preceding gene: 120608897

Following gene: 120608891

Centisome position: 3.98

GC content: 68.36

Gene sequence:

>1302_bases
ATGTCGAACACCGCCGGCACCCTCGTCCAACATCCCGTGCCTTCCTATCTCCAGGCCGACCATCTCGGTCCCTGGGGCAA
CTACCTGCAACAGGTGGACCGCGTCACGCCGTACCTCGGCGGCCTCGCGCGCTGGGTGGAGACGCTCAAGCGTCCCAAGC
GCATCCTGGTCGTGGACGTGCCCATCGAGCTGGACAACGGCACCATCGCCCACTTCGAGGGCTACCGCGTGCAGCACAAC
CTGAGCCGCGGCCCCGGCAAGGGCGGCGTGCGCTTCCACCAGGACGTGACGCTGTCCGAGGTGATGGCCCTGTCGGCCTG
GATGTCGGTGAAGAACGCGGCCGTGAACGTGCCCTACGGCGGCGCCAAGGGCGGCATCCGCGTCGATCCCAAGAAGCTCT
CGCGCGGCGAGCTCGAGCGCCTCACCCGCCGCTACACCAGCGAGATCGGCCTGCTCATCGGCTCCTCCAAGGACATCCCC
GCACCTGACGTGAACACCAACGGCCAGATCATGGCCTGGATGATGGACACGTACTCGATGAACGTGGGCGCCACCGCCAC
CGGCGTGGTCACCGGCAAGCCCGTGGACCTGGGCGGCTCGCTGGGCCGCGTGGAAGCCACCGGCCGCGGCGTGTACACCG
TGGGCGTCGAAGCCGCCAAGCTCACCGGCCTGCCCGTCGAGGGCGCGCGCGTGGCCGTGCAGGGCTTCGGCAACGTGGGC
GGCATCGCCGGCAAGCTCTTCGCCGAGGCGGGCGCCAAGGTCGTGGCCGTGCAGGACCACACGGGCACCATCCTGAACAA
GAACGGCCTGGACGTGCCCGCCCTGCTGGCACACGTCAAGCAGACCGGCGGCGTGGGCGGCTTCGCCGGCGCCGAAGCGA
TGGCGAAGGAAGACTTCTGGGGCGTGGACTGCGAGATCCTCATCCCCGCCGCGCTGGAAAACCAGATCACCAAGGACAAC
GCCGGCCAGATCAAGGCCAAGCTGGTGATCGAGGGCGCCAACGGCCCCACCACCACCGAGGCCGACGACATCCTGGCCGA
CAAGGGCGTGCTGGTGCTGCCCGACGTGATCGCCAACGCCGGCGGCGTGACGGTGAGCTACTTCGAGTGGGTGCAGGACT
TCTCCAGCTTCTTCTGGAGCGAGGACGAGATCAACGCCCGCCTCGTGCGCATCATGCAGGAAGCCTTCGCCGGCATCTGG
CACGTCGCGCAGGAACACAAGGTGACACTGCGCACCGCCACCTTCATCGTGGCCTGCCAGCGCATCCTGCACGCCCGCGA
AATGCGCGGCCTGTATCCCTGA

Upstream 100 bases:

>100_bases
GCCGCATAACCCGGAAACACTCAGGCCTTGGACAGCCCGGAGGGCCGGGCATACAGTCGCTGGCCTGACCCTACCTCCTA
TACCCAAGGGAAACATCCGC

Downstream 100 bases:

>100_bases
TGCATTGACATCGGCAATACCGACGGCCCTCCCGCCGTGCACGCCCACCGAGCACGCACGGCAGAAAGAAGCCGCCAGCG
CCTTACCCGGCCTGGCGGCT

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: GDH [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MSNTAGTLVQHPVPSYLQADHLGPWGNYLQQVDRVTPYLGGLARWVETLKRPKRILVVDVPIELDNGTIAHFEGYRVQHN
LSRGPGKGGVRFHQDVTLSEVMALSAWMSVKNAAVNVPYGGAKGGIRVDPKKLSRGELERLTRRYTSEIGLLIGSSKDIP
APDVNTNGQIMAWMMDTYSMNVGATATGVVTGKPVDLGGSLGRVEATGRGVYTVGVEAAKLTGLPVEGARVAVQGFGNVG
GIAGKLFAEAGAKVVAVQDHTGTILNKNGLDVPALLAHVKQTGGVGGFAGAEAMAKEDFWGVDCEILIPAALENQITKDN
AGQIKAKLVIEGANGPTTTEADDILADKGVLVLPDVIANAGGVTVSYFEWVQDFSSFFWSEDEINARLVRIMQEAFAGIW
HVAQEHKVTLRTATFIVACQRILHAREMRGLYP

Sequences:

>Translated_433_residues
MSNTAGTLVQHPVPSYLQADHLGPWGNYLQQVDRVTPYLGGLARWVETLKRPKRILVVDVPIELDNGTIAHFEGYRVQHN
LSRGPGKGGVRFHQDVTLSEVMALSAWMSVKNAAVNVPYGGAKGGIRVDPKKLSRGELERLTRRYTSEIGLLIGSSKDIP
APDVNTNGQIMAWMMDTYSMNVGATATGVVTGKPVDLGGSLGRVEATGRGVYTVGVEAAKLTGLPVEGARVAVQGFGNVG
GIAGKLFAEAGAKVVAVQDHTGTILNKNGLDVPALLAHVKQTGGVGGFAGAEAMAKEDFWGVDCEILIPAALENQITKDN
AGQIKAKLVIEGANGPTTTEADDILADKGVLVLPDVIANAGGVTVSYFEWVQDFSSFFWSEDEINARLVRIMQEAFAGIW
HVAQEHKVTLRTATFIVACQRILHAREMRGLYP
>Mature_432_residues
SNTAGTLVQHPVPSYLQADHLGPWGNYLQQVDRVTPYLGGLARWVETLKRPKRILVVDVPIELDNGTIAHFEGYRVQHNL
SRGPGKGGVRFHQDVTLSEVMALSAWMSVKNAAVNVPYGGAKGGIRVDPKKLSRGELERLTRRYTSEIGLLIGSSKDIPA
PDVNTNGQIMAWMMDTYSMNVGATATGVVTGKPVDLGGSLGRVEATGRGVYTVGVEAAKLTGLPVEGARVAVQGFGNVGG
IAGKLFAEAGAKVVAVQDHTGTILNKNGLDVPALLAHVKQTGGVGGFAGAEAMAKEDFWGVDCEILIPAALENQITKDNA
GQIKAKLVIEGANGPTTTEADDILADKGVLVLPDVIANAGGVTVSYFEWVQDFSSFFWSEDEINARLVRIMQEAFAGIWH
VAQEHKVTLRTATFIVACQRILHAREMRGLYP

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=371, Percent_Identity=42.5876010781671, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI4885281, Length=371, Percent_Identity=41.7789757412399, Blast_Score=275, Evalue=5e-74,
Organism=Escherichia coli, GI1788059, Length=374, Percent_Identity=36.096256684492, Blast_Score=192, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17544676, Length=392, Percent_Identity=38.265306122449, Blast_Score=258, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6319256, Length=393, Percent_Identity=32.0610687022901, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6324951, Length=384, Percent_Identity=30.46875, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24649283, Length=333, Percent_Identity=46.2462462462462, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI45553475, Length=361, Percent_Identity=41.5512465373961, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI45549226, Length=364, Percent_Identity=41.2087912087912, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24649460, Length=311, Percent_Identity=40.8360128617363, Blast_Score=227, Evalue=1e-59,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.3 [H]

Molecular weight: Translated: 46274; Mature: 46143

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTAGTLVQHPVPSYLQADHLGPWGNYLQQVDRVTPYLGGLARWVETLKRPKRILVVDV
CCCCCCCHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
PIELDNGTIAHFEGYRVQHNLSRGPGKGGVRFHQDVTLSEVMALSAWMSVKNAAVNVPYG
EEEECCCEEEEEECEEEEECCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCEEECCCC
GAKGGIRVDPKKLSRGELERLTRRYTSEIGLLIGSSKDIPAPDVNTNGQIMAWMMDTYSM
CCCCCEEECHHHCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCEEEEEEEEEEC
NVGATATGVVTGKPVDLGGSLGRVEATGRGVYTVGVEAAKLTGLPVEGARVAVQGFGNVG
CCCCCEEEEEECCCCCCCCCCCEEEECCCEEEEEECCHHEECCCCCCCCEEEEECCCCCC
GIAGKLFAEAGAKVVAVQDHTGTILNKNGLDVPALLAHVKQTGGVGGFAGAEAMAKEDFW
CHHHHHHHHCCCEEEEEECCCCCEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHCCCC
GVDCEILIPAALENQITKDNAGQIKAKLVIEGANGPTTTEADDILADKGVLVLPDVIANA
CCCEEEEECHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHCCCEEEECHHHCCC
GGVTVSYFEWVQDFSSFFWSEDEINARLVRIMQEAFAGIWHVAQEHKVTLRTATFIVACQ
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEHHHHHHHHHHH
RILHAREMRGLYP
HHHHHHHHCCCCC
>Mature Secondary Structure 
SNTAGTLVQHPVPSYLQADHLGPWGNYLQQVDRVTPYLGGLARWVETLKRPKRILVVDV
CCCCCCHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
PIELDNGTIAHFEGYRVQHNLSRGPGKGGVRFHQDVTLSEVMALSAWMSVKNAAVNVPYG
EEEECCCEEEEEECEEEEECCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCEEECCCC
GAKGGIRVDPKKLSRGELERLTRRYTSEIGLLIGSSKDIPAPDVNTNGQIMAWMMDTYSM
CCCCCEEECHHHCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCEEEEEEEEEEC
NVGATATGVVTGKPVDLGGSLGRVEATGRGVYTVGVEAAKLTGLPVEGARVAVQGFGNVG
CCCCCEEEEEECCCCCCCCCCCEEEECCCEEEEEECCHHEECCCCCCCCEEEEECCCCCC
GIAGKLFAEAGAKVVAVQDHTGTILNKNGLDVPALLAHVKQTGGVGGFAGAEAMAKEDFW
CHHHHHHHHCCCEEEEEECCCCCEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHCCCC
GVDCEILIPAALENQITKDNAGQIKAKLVIEGANGPTTTEADDILADKGVLVLPDVIANA
CCCEEEEECHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHCCCEEEECHHHCCC
GGVTVSYFEWVQDFSSFFWSEDEINARLVRIMQEAFAGIWHVAQEHKVTLRTATFIVACQ
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEHHHHHHHHHHH
RILHAREMRGLYP
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9680336; 10360571; 9135121; 9654452; 10366510 [H]