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The map label for this gene is yngE [H]

Identifier: 120599111

GI number: 120599111

Start: 2660070

End: 2661677

Strand: Direct

Name: yngE [H]

Synonym: Sputw3181_2307

Alternate gene names: 120599111

Gene position: 2660070-2661677 (Clockwise)

Preceding gene: 120599110

Following gene: 120599112

Centisome position: 56.5

GC content: 53.23

Gene sequence:

>1608_bases
GTGACGCAATTAAGCAGTCGTATCAACGCCCGTAGCGATGAATTTAAAGCCAAATCCGACGATATGGCCGCTCTCGTGGC
CGATCTTAAAACCAAACTCGCCAGAATCGAACTCGGCGGCGGCCCTGTGGCGCTGGAGCGTCATTTATCCCGCGGGAAAT
TACTCCCACGTCAACGGGTTGAAAAGCTGCTCGATGCAGGTTCGCCCTTTTTAGAGCTATCGCAATTTGCGGCGTTTGAA
GTCTATGACGAAGAAGTGCCCGCTGCGGGCATTATCGCTGGTATCGGCCGTGTGAGCGGTGTCGAGTGCATGATTATCGC
CAACGACGCTACAGTTAAAGGCGGCACTTACTACCCGATTACCGTTAAAAAACACCTCCGCGCCCAAGATATTGCCAGTC
GTTGTCACTTGCCTTGTATCTATTTAGTCGACTCAGGCGGCGCCAACCTGCCCCGCCAAGATGAAGTCTTCCCAGACCGC
GACCATTTTGGCCGTATCTTTTATAACCAAGCGCAAATGTCCGCTAAAGGTATCCCCCAAATTGCGGTGGTGATGGGCTT
ATGTACCGCAGGCGGCGCTTATGTGCCGGCCATGGCGGATGAATCGATTATCGTAAAAGATCAAGGCACTATCTTCTTAG
CTGGGCCGCCGTTAGTAAAAGCCGCGACCGGTGAAGAAGTCAGCGCCGAAGAACTCGGCGGCGCCGAAGTGCACACTAAA
ATTTCAGGTGTCGCGGACCACTTAGCCCAAAACGATGAGCATGCCTTAGAGCTTGCCCGCCGTGCAGTGCTGCGTCTGAA
TCATCAAAAAGAAATCAAATCACTCCTAAGCCCTGTCAAACCGCCAAAGTTCGACATTAGCGAACTGTATGGCATTGTCG
GCACCGACTTGAAAAAGCCATTCGATGTCAAAGAAGTTATCGCCCGCATCGTCGACGACTCGGATTTCGATGAGTTTAAA
GCCAACTATGGCGCGACTTTGGTCTGCGGTTTTGCCCGTATTCACGGCTATCCAGTTGGGATTGTCGCCAACAACGGCAT
TTTATTCTCAGAATCGGCGCAAAAAGGCGCGCACTTTATCGAGCTGTGTTGCCAGCGTAAGATCCCGCTACTGTTCCTGC
AAAACATCACCGGCTTTATGGTGGGTAAAAAGTACGAACACGAAGGTATCGCCAAGCACGGCGCCAAGATGGTGACCGCA
GTGTCCTGCGCCAATGTACCTAAATTTACCGTGATTATTGGTGGCAGCTATGGCGCAGGTAACTACGGTATGTGTGGCCG
CGCCTTCGAGCCAACCATGATGTGGATGTGGCCCAATGCGCGTATCTCTGTAATGGGTGGCGAGCAAGCCGCTGGCGTAT
TAGCGACTGTACGCCGCGACGGTTTAGCCCGTAAGGGCGAAGCATGGTCAGTTGAGGATGAAAAAGCCTTCAAGGCACCG
ATTATTGCCCAGTACGATAAAGAGGGTCATCCCTACCATGCCAGTGCCCGCCTGTGGGATGACGGCATTATCGACCCGGC
GCAAACCCGTGATGTGGTGGGCCTCGCCCTGTCAGCCGCATTAAATGCCCCTATCGAAGACACCCGCTTCGGCGTCTTCC
GTATGTAA

Upstream 100 bases:

>100_bases
GCCCAGGGCGAACGATGCATAACTCGGCTTAAGTCCTTCATGCTCCCTCGCCCAACTAAGCCAACGGATACTGAGTTACC
GCTTTATAAGGACAATCAAA

Downstream 100 bases:

>100_bases
CGCATCTTGCGATGCCTTACGTATCACTCATAGAGGGAATAACGATGACGGGAATAAAATAATGACTGACACACAACACC
AGAACACTAGCACTCAATCC

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTQLSSRINARSDEFKAKSDDMAALVADLKTKLARIELGGGPVALERHLSRGKLLPRQRVEKLLDAGSPFLELSQFAAFE
VYDEEVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPITVKKHLRAQDIASRCHLPCIYLVDSGGANLPRQDEVFPDR
DHFGRIFYNQAQMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVKDQGTIFLAGPPLVKAATGEEVSAEELGGAEVHTK
ISGVADHLAQNDEHALELARRAVLRLNHQKEIKSLLSPVKPPKFDISELYGIVGTDLKKPFDVKEVIARIVDDSDFDEFK
ANYGATLVCGFARIHGYPVGIVANNGILFSESAQKGAHFIELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTA
VSCANVPKFTVIIGGSYGAGNYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVRRDGLARKGEAWSVEDEKAFKAP
IIAQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTRFGVFRM

Sequences:

>Translated_535_residues
MTQLSSRINARSDEFKAKSDDMAALVADLKTKLARIELGGGPVALERHLSRGKLLPRQRVEKLLDAGSPFLELSQFAAFE
VYDEEVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPITVKKHLRAQDIASRCHLPCIYLVDSGGANLPRQDEVFPDR
DHFGRIFYNQAQMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVKDQGTIFLAGPPLVKAATGEEVSAEELGGAEVHTK
ISGVADHLAQNDEHALELARRAVLRLNHQKEIKSLLSPVKPPKFDISELYGIVGTDLKKPFDVKEVIARIVDDSDFDEFK
ANYGATLVCGFARIHGYPVGIVANNGILFSESAQKGAHFIELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTA
VSCANVPKFTVIIGGSYGAGNYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVRRDGLARKGEAWSVEDEKAFKAP
IIAQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTRFGVFRM
>Mature_534_residues
TQLSSRINARSDEFKAKSDDMAALVADLKTKLARIELGGGPVALERHLSRGKLLPRQRVEKLLDAGSPFLELSQFAAFEV
YDEEVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPITVKKHLRAQDIASRCHLPCIYLVDSGGANLPRQDEVFPDRD
HFGRIFYNQAQMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVKDQGTIFLAGPPLVKAATGEEVSAEELGGAEVHTKI
SGVADHLAQNDEHALELARRAVLRLNHQKEIKSLLSPVKPPKFDISELYGIVGTDLKKPFDVKEVIARIVDDSDFDEFKA
NYGATLVCGFARIHGYPVGIVANNGILFSESAQKGAHFIELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTAV
SCANVPKFTVIIGGSYGAGNYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVRRDGLARKGEAWSVEDEKAFKAPI
IAQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTRFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=536, Percent_Identity=68.6567164179104, Blast_Score=746, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=491, Percent_Identity=34.0122199592668, Blast_Score=239, Evalue=6e-63,
Organism=Homo sapiens, GI295821216, Length=511, Percent_Identity=32.8767123287671, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI310133460, Length=132, Percent_Identity=64.3939393939394, Blast_Score=158, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=63.2270168855535, Blast_Score=708, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=490, Percent_Identity=32.8571428571429, Blast_Score=242, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI25147362, Length=490, Percent_Identity=32.8571428571429, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24586065, Length=549, Percent_Identity=65.5737704918033, Blast_Score=741, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 57925; Mature: 57794

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLSSRINARSDEFKAKSDDMAALVADLKTKLARIELGGGPVALERHLSRGKLLPRQRV
CCCCHHHHCCCCHHCCCCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCCCCCHHHH
EKLLDAGSPFLELSQFAAFEVYDEEVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPI
HHHHHCCCCHHHHHHHHHEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCEECCCEEEEE
TVKKHLRAQDIASRCHLPCIYLVDSGGANLPRQDEVFPDRDHFGRIFYNQAQMSAKGIPQ
EHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCEEEEHHHHCCCCCCH
IAVVMGLCTAGGAYVPAMADESIIVKDQGTIFLAGPPLVKAATGEEVSAEELGGAEVHTK
HHHHHHHHHCCCEEEECCCCCEEEEECCCEEEEECCCEEEECCCCCCCHHHCCCCHHHHH
ISGVADHLAQNDEHALELARRAVLRLNHQKEIKSLLSPVKPPKFDISELYGIVGTDLKKP
HHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCC
FDVKEVIARIVDDSDFDEFKANYGATLVCGFARIHGYPVGIVANNGILFSESAQKGAHFI
CCHHHHHHHHHCCCCHHHHHHCCCCEEEEEHHHHCCEEEEEEECCCEEEECCHHHHHHHH
ELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTAVSCANVPKFTVIIGGSYGAG
HHHHHCCCCEEEHHCCHHHHCCCCCCCCCHHHHCCCEEEEEHHCCCCEEEEEEECCCCCC
NYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVRRDGLARKGEAWSVEDEKAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCC
IIAQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTRFGVFRM
EEEEECCCCCCEECCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEECC
>Mature Secondary Structure 
TQLSSRINARSDEFKAKSDDMAALVADLKTKLARIELGGGPVALERHLSRGKLLPRQRV
CCCHHHHCCCCHHCCCCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCCCCCHHHH
EKLLDAGSPFLELSQFAAFEVYDEEVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPI
HHHHHCCCCHHHHHHHHHEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCEECCCEEEEE
TVKKHLRAQDIASRCHLPCIYLVDSGGANLPRQDEVFPDRDHFGRIFYNQAQMSAKGIPQ
EHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCEEEEHHHHCCCCCCH
IAVVMGLCTAGGAYVPAMADESIIVKDQGTIFLAGPPLVKAATGEEVSAEELGGAEVHTK
HHHHHHHHHCCCEEEECCCCCEEEEECCCEEEEECCCEEEECCCCCCCHHHCCCCHHHHH
ISGVADHLAQNDEHALELARRAVLRLNHQKEIKSLLSPVKPPKFDISELYGIVGTDLKKP
HHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCC
FDVKEVIARIVDDSDFDEFKANYGATLVCGFARIHGYPVGIVANNGILFSESAQKGAHFI
CCHHHHHHHHHCCCCHHHHHHCCCCEEEEEHHHHCCEEEEEEECCCEEEECCHHHHHHHH
ELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTAVSCANVPKFTVIIGGSYGAG
HHHHHCCCCEEEHHCCHHHHCCCCCCCCCHHHHCCCEEEEEHHCCCCEEEEEEECCCCCC
NYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVRRDGLARKGEAWSVEDEKAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCC
IIAQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTRFGVFRM
EEEEECCCCCCEECCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]