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The map label for this gene is ydhC [H]

Identifier: 120598827

GI number: 120598827

Start: 2327075

End: 2328349

Strand: Direct

Name: ydhC [H]

Synonym: Sputw3181_2013

Alternate gene names: 120598827

Gene position: 2327075-2328349 (Clockwise)

Preceding gene: 120598820

Following gene: 120598828

Centisome position: 49.42

GC content: 42.35

Gene sequence:

>1275_bases
ATGAAAACGTCTAGTAACACCTTTGTAAACATAAAGTTCTTTATGTTTTTATTCTATTTGGCCATGTTGAGCATGCTCGG
TTTTATTGCCACTGACATGTACTTGCCTGCTTTCAAAGCAATTGAAGGCTCATTGGGCAGCACACCATCGCAGGTGGCAA
TGTCGTTAACCTGTTTCCTAGCAGGTCTAGCACTGGGTCAACTGCTTTACGGGCCCTTAGTCAATAAAATTGGCAAGCGT
TGGGCACTGATCTTTGGCCTTGTTTTATTTGCCATTGCTAGCGTGTTTATTGCCAACAGTGATTCTATCCTAATGCTCAA
TATCGCGCGCTTCTTCCAAGCCATTGGTGCCTGTAGTGCAGGGGTTATATGGCAAGCCATTGTCGTTGAACAATATGATG
CCGATAAAGCCCAAGGTATTTTTAGTAACATTATGCCACTGGTTGCATTATCGCCTGCATTAGCACCGATCCTTGGCGCT
TATATTCTGAACGAATTAGGCTGGCGTGCAATCTTTATCTCCTTGTGTGTTATCGCTTTTATGCTTGTGTTAATGACTTT
GTACTTTGTACCTAGCAACAAGCATCAGCATAAACATAGTGAGCATGCCGCTGTATCTTATGGGCAAATTTTGAAAAATA
CCCGCTATTTAGGCAACGTAGTGATCTTCGGCGCTTGTTCTGGTGCTTTCTTTGCCTATTTAACTGTGTGGCCGATTGTG
ATGGAAATGCATGGTTATCAAGCGACTGAAATAGGACTAAGCTTCATTCCACAAACTATCATGTTTATTTTCGGTGGTTA
TGCAAGTAAGTTACTGATAAAACGTATTGGCGCAACTCAAACACTGAACATTCTATTATCGATTTTTGCGGTCTGTGTTA
TTTCCATTATCATGTTTACGCTGATTTATCCCGCAGGCTCCATTTTCCCACTGCTGATTTCTTTCTCTATTTTAGCGGCC
GCTAATGGTGCAATTTACCCAATAGTCGTTAATAGTGCGCTACAGCAGTTTAGTCAAAATGCAGCTAAGGCCGCAGGATT
ACAGAATTTCTTACAGATCAGTATTGCCTTTGGTGCATCAAGCTTAGTCGCTATGTGGGCAAGCCTTGGTGAAGTAGCAA
TTGGTTGGGGGATCCTATGTTGCGCCATCTTAGTTGTAGTCGGCTATATACTTAAGAGTCAGAAAGAGTGGGGCGATGTT
GCTAAACATTTTACTAAGCCAGATCCTGCTCGTGTAGGTATTATGTCTGATGTGAAGCAAAATCCAGCGGATTGA

Upstream 100 bases:

>100_bases
CGATGAAAATAATTGATAACACAAGTCAAAAATAAACGTTTCCAATAGATTTAACAAGTCATTAGACTGCACACTTTAGT
CAATCCGACCCGATTATTTT

Downstream 100 bases:

>100_bases
GTGGAATAACAACAATTGGCACATAATTAAGAGTTAGCGCTTTACAGCCAATAGACTTACTTATATTATGCGCGTCGTTC
GGAGGGGTGGCAGAGTGGTT

Product: inner membrane transport protein YdhC

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MKTSSNTFVNIKFFMFLFYLAMLSMLGFIATDMYLPAFKAIEGSLGSTPSQVAMSLTCFLAGLALGQLLYGPLVNKIGKR
WALIFGLVLFAIASVFIANSDSILMLNIARFFQAIGACSAGVIWQAIVVEQYDADKAQGIFSNIMPLVALSPALAPILGA
YILNELGWRAIFISLCVIAFMLVLMTLYFVPSNKHQHKHSEHAAVSYGQILKNTRYLGNVVIFGACSGAFFAYLTVWPIV
MEMHGYQATEIGLSFIPQTIMFIFGGYASKLLIKRIGATQTLNILLSIFAVCVISIIMFTLIYPAGSIFPLLISFSILAA
ANGAIYPIVVNSALQQFSQNAAKAAGLQNFLQISIAFGASSLVAMWASLGEVAIGWGILCCAILVVVGYILKSQKEWGDV
AKHFTKPDPARVGIMSDVKQNPAD

Sequences:

>Translated_424_residues
MKTSSNTFVNIKFFMFLFYLAMLSMLGFIATDMYLPAFKAIEGSLGSTPSQVAMSLTCFLAGLALGQLLYGPLVNKIGKR
WALIFGLVLFAIASVFIANSDSILMLNIARFFQAIGACSAGVIWQAIVVEQYDADKAQGIFSNIMPLVALSPALAPILGA
YILNELGWRAIFISLCVIAFMLVLMTLYFVPSNKHQHKHSEHAAVSYGQILKNTRYLGNVVIFGACSGAFFAYLTVWPIV
MEMHGYQATEIGLSFIPQTIMFIFGGYASKLLIKRIGATQTLNILLSIFAVCVISIIMFTLIYPAGSIFPLLISFSILAA
ANGAIYPIVVNSALQQFSQNAAKAAGLQNFLQISIAFGASSLVAMWASLGEVAIGWGILCCAILVVVGYILKSQKEWGDV
AKHFTKPDPARVGIMSDVKQNPAD
>Mature_424_residues
MKTSSNTFVNIKFFMFLFYLAMLSMLGFIATDMYLPAFKAIEGSLGSTPSQVAMSLTCFLAGLALGQLLYGPLVNKIGKR
WALIFGLVLFAIASVFIANSDSILMLNIARFFQAIGACSAGVIWQAIVVEQYDADKAQGIFSNIMPLVALSPALAPILGA
YILNELGWRAIFISLCVIAFMLVLMTLYFVPSNKHQHKHSEHAAVSYGQILKNTRYLGNVVIFGACSGAFFAYLTVWPIV
MEMHGYQATEIGLSFIPQTIMFIFGGYASKLLIKRIGATQTLNILLSIFAVCVISIIMFTLIYPAGSIFPLLISFSILAA
ANGAIYPIVVNSALQQFSQNAAKAAGLQNFLQISIAFGASSLVAMWASLGEVAIGWGILCCAILVVVGYILKSQKEWGDV
AKHFTKPDPARVGIMSDVKQNPAD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=388, Percent_Identity=42.2680412371134, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI1788509, Length=271, Percent_Identity=28.0442804428044, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790146, Length=240, Percent_Identity=24.5833333333333, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1787065, Length=291, Percent_Identity=25.085910652921, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082312, Length=363, Percent_Identity=21.4876033057851, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790794, Length=202, Percent_Identity=23.2673267326733, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45907; Mature: 45907

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCC
>Mature Secondary Structure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CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]