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The map label for this gene is zitB [H]

Identifier: 120598727

GI number: 120598727

Start: 2204182

End: 2205375

Strand: Direct

Name: zitB [H]

Synonym: Sputw3181_1912

Alternate gene names: 120598727

Gene position: 2204182-2205375 (Clockwise)

Preceding gene: 120598725

Following gene: 120598728

Centisome position: 46.81

GC content: 45.56

Gene sequence:

>1194_bases
ATGAAATCAGAACATTCAGAACAACCAGCCAGTGGTCTAGATGCCGCAAACACCACTACAGGGCACGCAATTACAAAGTG
GCAGCATTCCCATGGCTTTTCGAGCCAAAATATCGCTGGCGAGAAAAATACACGCTATGTTCTCTATTTAACGCTGATCA
CTATGGTGGCAGAGATTGTCGCTGGTACGATTTACGGCTCAATGGCACTGTTAGTCGATGGTTGGCATATGGGCACCCAT
GCTGCGGCTTTTATGATCACCTTGTTTGCCTATTCCTATGCCCGTAAACATGCCAATGATCCTACTTTTGCGTTTGGTAC
AGGAAAGGTGAGTGTGCTCGGTGGTTACACTAGCGCGATCGCCCTAGGTTTAGTGGCATTAATCATGCTGGTTGAATCTG
GGATACGACTTATCAATCCTGAGCAAATTCATTTTAATGAAGCGATTTTTGTGGCTGTGATAGGGTTAAGTGTAAATGTG
CTGAGTGTCTTTTTGCTCAAAGATCATCATAGCCATGATCATGGTCATCATCACGGTCATGACCACTCCCATATGCATTC
TGAACATGAGCATGTTCATCACGATGATGGACACCATGACCATACACATTGCCACCATAATGCTGAGCATGAGCATGAGC
ATGAGCATGAGCATGAGCATGAGCATGAGCATGAGCATGAGCATGAGCATGAGCATGAGCATGAGCATGAGCATGAGCAC
AAGAGTCAGAAGGCACATGGTGGCCATGACCACAACCTACGCGCCGCCTATTTTCATGTTTTAGCCGATGCGTTAACCTC
AGTGCTCGCTATTGTGGCATTGCTATTTGGTAAATATATGGGCTTAACTTGGCTCGATCCTATTATGGGAATTGTCGGCG
CCGTCATTATTAGCCGCTGGTCTTGGGGGCTTATTCAGCAAACCAGCCCCATTTTACTCGATGGCGGTGTGAAGGAATCA
TTGCAGCATAGGGTTAAACAAACAATCGAAGCTGTGCCGGATCATCAAGTCGCCGATTTACATATATGGCGTCTGAGTGC
AGATCATCATGCTATGATGGTGTCAATCGTGTCTCACTCACCGAAAGAAGCCAGCTATTTTAATCAGTTACTGACTCAAT
TTCCTGAGTTATCACATATCACTATTGAATTACATACGTGTCGCCAAAGCGAGTGTTTGGCTAAGGAAGTTTAA

Upstream 100 bases:

>100_bases
AATAACTAATTTGATATTCATATATTTTGATTTTCAAACTATAATCCCGAGCCAGTGAGTATCACTTATCAAGCCTTATG
TGGCGTAGGGAATTTATATA

Downstream 100 bases:

>100_bases
TGACAGCGGGGCATCCCAATACCACTCAACATCATTCGACTGATCACAGCTTGAACCATGTGATTATTGAGTTTTACGAA
AAGCTGTCGTCTTGGGAACA

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MKSEHSEQPASGLDAANTTTGHAITKWQHSHGFSSQNIAGEKNTRYVLYLTLITMVAEIVAGTIYGSMALLVDGWHMGTH
AAAFMITLFAYSYARKHANDPTFAFGTGKVSVLGGYTSAIALGLVALIMLVESGIRLINPEQIHFNEAIFVAVIGLSVNV
LSVFLLKDHHSHDHGHHHGHDHSHMHSEHEHVHHDDGHHDHTHCHHNAEHEHEHEHEHEHEHEHEHEHEHEHEHEHEHEH
KSQKAHGGHDHNLRAAYFHVLADALTSVLAIVALLFGKYMGLTWLDPIMGIVGAVIISRWSWGLIQQTSPILLDGGVKES
LQHRVKQTIEAVPDHQVADLHIWRLSADHHAMMVSIVSHSPKEASYFNQLLTQFPELSHITIELHTCRQSECLAKEV

Sequences:

>Translated_397_residues
MKSEHSEQPASGLDAANTTTGHAITKWQHSHGFSSQNIAGEKNTRYVLYLTLITMVAEIVAGTIYGSMALLVDGWHMGTH
AAAFMITLFAYSYARKHANDPTFAFGTGKVSVLGGYTSAIALGLVALIMLVESGIRLINPEQIHFNEAIFVAVIGLSVNV
LSVFLLKDHHSHDHGHHHGHDHSHMHSEHEHVHHDDGHHDHTHCHHNAEHEHEHEHEHEHEHEHEHEHEHEHEHEHEHEH
KSQKAHGGHDHNLRAAYFHVLADALTSVLAIVALLFGKYMGLTWLDPIMGIVGAVIISRWSWGLIQQTSPILLDGGVKES
LQHRVKQTIEAVPDHQVADLHIWRLSADHHAMMVSIVSHSPKEASYFNQLLTQFPELSHITIELHTCRQSECLAKEV
>Mature_397_residues
MKSEHSEQPASGLDAANTTTGHAITKWQHSHGFSSQNIAGEKNTRYVLYLTLITMVAEIVAGTIYGSMALLVDGWHMGTH
AAAFMITLFAYSYARKHANDPTFAFGTGKVSVLGGYTSAIALGLVALIMLVESGIRLINPEQIHFNEAIFVAVIGLSVNV
LSVFLLKDHHSHDHGHHHGHDHSHMHSEHEHVHHDDGHHDHTHCHHNAEHEHEHEHEHEHEHEHEHEHEHEHEHEHEHEH
KSQKAHGGHDHNLRAAYFHVLADALTSVLAIVALLFGKYMGLTWLDPIMGIVGAVIISRWSWGLIQQTSPILLDGGVKES
LQHRVKQTIEAVPDHQVADLHIWRLSADHHAMMVSIVSHSPKEASYFNQLLTQFPELSHITIELHTCRQSECLAKEV

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI222080086, Length=336, Percent_Identity=25, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI40255009, Length=336, Percent_Identity=25, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI20070323, Length=145, Percent_Identity=31.0344827586207, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1786966, Length=158, Percent_Identity=30.379746835443, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32564488, Length=114, Percent_Identity=35.0877192982456, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323899, Length=332, Percent_Identity=27.4096385542169, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324892, Length=335, Percent_Identity=25.0746268656716, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24656728, Length=316, Percent_Identity=26.5822784810127, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24656724, Length=316, Percent_Identity=26.5822784810127, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24656720, Length=316, Percent_Identity=26.5822784810127, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24656715, Length=316, Percent_Identity=26.5822784810127, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357035, Length=316, Percent_Identity=26.5822784810127, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24645863, Length=298, Percent_Identity=23.489932885906, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24585900, Length=386, Percent_Identity=20.4663212435233, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24585898, Length=386, Percent_Identity=20.4663212435233, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24585896, Length=386, Percent_Identity=20.4663212435233, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921672, Length=386, Percent_Identity=20.4663212435233, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 44570; Mature: 44570

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSEHSEQPASGLDAANTTTGHAITKWQHSHGFSSQNIAGEKNTRYVLYLTLITMVAEIV
CCCCCCCCCCCCCCCCCCCCCCHHEEEHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHH
AGTIYGSMALLVDGWHMGTHAAAFMITLFAYSYARKHANDPTFAFGTGKVSVLGGYTSAI
HHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCHHHHH
ALGLVALIMLVESGIRLINPEQIHFNEAIFVAVIGLSVNVLSVFLLKDHHSHDHGHHHGH
HHHHHHHHHHHHCCCCCCCCCCEECCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DHSHMHSEHEHVHHDDGHHDHTHCHHNAEHEHEHEHEHEHEHEHEHEHEHEHEHEHEHEH
CCHHHCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSQKAHGGHDHNLRAAYFHVLADALTSVLAIVALLFGKYMGLTWLDPIMGIVGAVIISRW
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
SWGLIQQTSPILLDGGVKESLQHRVKQTIEAVPDHQVADLHIWRLSADHHAMMVSIVSHS
CCCHHHCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCC
PKEASYFNQLLTQFPELSHITIELHTCRQSECLAKEV
CHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHCC
>Mature Secondary Structure
MKSEHSEQPASGLDAANTTTGHAITKWQHSHGFSSQNIAGEKNTRYVLYLTLITMVAEIV
CCCCCCCCCCCCCCCCCCCCCCHHEEEHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHH
AGTIYGSMALLVDGWHMGTHAAAFMITLFAYSYARKHANDPTFAFGTGKVSVLGGYTSAI
HHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCHHHHH
ALGLVALIMLVESGIRLINPEQIHFNEAIFVAVIGLSVNVLSVFLLKDHHSHDHGHHHGH
HHHHHHHHHHHHCCCCCCCCCCEECCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DHSHMHSEHEHVHHDDGHHDHTHCHHNAEHEHEHEHEHEHEHEHEHEHEHEHEHEHEHEH
CCHHHCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSQKAHGGHDHNLRAAYFHVLADALTSVLAIVALLFGKYMGLTWLDPIMGIVGAVIISRW
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
SWGLIQQTSPILLDGGVKESLQHRVKQTIEAVPDHQVADLHIWRLSADHHAMMVSIVSHS
CCCHHHCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCC
PKEASYFNQLLTQFPELSHITIELHTCRQSECLAKEV
CHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]