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The map label for this gene is apt [H]

Identifier: 120598522

GI number: 120598522

Start: 1961062

End: 1961616

Strand: Direct

Name: apt [H]

Synonym: Sputw3181_1705

Alternate gene names: 120598522

Gene position: 1961062-1961616 (Clockwise)

Preceding gene: 120598521

Following gene: 120598523

Centisome position: 41.65

GC content: 43.06

Gene sequence:

>555_bases
ATGATGGCTATGAATACAGAAACCTTATCCTTGATAAAGCAAAGCATTAAAACGATTCCGAACTATCCTAAGGAAGGGAT
CCTATTTCGCGATGTCACCAGTTTACTTGAGAATGCCGCAGCCTATAAAGCGGCCATCGATTTATTGGTTGAACATTATC
GTGGTCAAGGTTTTACCAAAATTGTCGGCACTGAAGCCCGTGGTTTCTTATTTGGTGCACCACTTGCTTTAGAATTAGGC
ATTGGTTTTGTGCCCGTTCGTAAACCCGGTAAATTACCCCGAGCGACTATCAGCCAAAGCTATGAACTTGAATATGGTCA
CGATAGCCTAGAAATTCATACTGATGCGATTAGCGCAAATGACAAAGTGCTCGTTGTTGACGATTTACTCGCAACCGGTG
GTACGATTGAAGCGACGGTAAAACTTATCCGCCAATTAGGTGGTGAAGTGAAAGATGCTGCTTTTGTGATTTCATTACCC
GATTTAGGTGGTGAGGCGCGTTTAACGGCATTAGGGCTTGAGTTGGTTAAACTTTGTGAGTTTGAAGGCGAATAA

Upstream 100 bases:

>100_bases
AGCTTTGTGCGATTTTTTGCAATTCGTCCACACTCGATGTGGACGTTTTGTTTTATACCGCCAATCTTGGCGAATTGATT
AAGTAACTTACTAAGTAAAT

Downstream 100 bases:

>100_bases
TTCTTCAGCCAAAGGCGCCTTAGGATAGTTTGATGGCATGTCACACCATGACATGTTATCTTTCAAAGTTCCCGGGGCGC
ATGCTCCCATTTTTGTATCA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MMAMNTETLSLIKQSIKTIPNYPKEGILFRDVTSLLENAAAYKAAIDLLVEHYRGQGFTKIVGTEARGFLFGAPLALELG
IGFVPVRKPGKLPRATISQSYELEYGHDSLEIHTDAISANDKVLVVDDLLATGGTIEATVKLIRQLGGEVKDAAFVISLP
DLGGEARLTALGLELVKLCEFEGE

Sequences:

>Translated_184_residues
MMAMNTETLSLIKQSIKTIPNYPKEGILFRDVTSLLENAAAYKAAIDLLVEHYRGQGFTKIVGTEARGFLFGAPLALELG
IGFVPVRKPGKLPRATISQSYELEYGHDSLEIHTDAISANDKVLVVDDLLATGGTIEATVKLIRQLGGEVKDAAFVISLP
DLGGEARLTALGLELVKLCEFEGE
>Mature_184_residues
MMAMNTETLSLIKQSIKTIPNYPKEGILFRDVTSLLENAAAYKAAIDLLVEHYRGQGFTKIVGTEARGFLFGAPLALELG
IGFVPVRKPGKLPRATISQSYELEYGHDSLEIHTDAISANDKVLVVDDLLATGGTIEATVKLIRQLGGEVKDAAFVISLP
DLGGEARLTALGLELVKLCEFEGE

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=169, Percent_Identity=43.7869822485207, Blast_Score=143, Evalue=7e-35,
Organism=Homo sapiens, GI71773201, Length=133, Percent_Identity=47.3684210526316, Blast_Score=126, Evalue=1e-29,
Organism=Escherichia coli, GI1786675, Length=183, Percent_Identity=68.8524590163934, Blast_Score=250, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI17509087, Length=164, Percent_Identity=43.2926829268293, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=164, Percent_Identity=43.2926829268293, Blast_Score=121, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6320649, Length=173, Percent_Identity=35.8381502890173, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17136334, Length=173, Percent_Identity=44.5086705202312, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19845; Mature: 19845

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAMNTETLSLIKQSIKTIPNYPKEGILFRDVTSLLENAAAYKAAIDLLVEHYRGQGFTK
CCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IVGTEARGFLFGAPLALELGIGFVPVRKPGKLPRATISQSYELEYGHDSLEIHTDAISAN
EECCCCCCEEEECCEEEECCCCEEECCCCCCCCHHHHCCCEEEEECCCCEEEEEEEECCC
DKVLVVDDLLATGGTIEATVKLIRQLGGEVKDAAFVISLPDLGGEARLTALGLELVKLCE
CCEEEEEHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHH
FEGE
CCCC
>Mature Secondary Structure
MMAMNTETLSLIKQSIKTIPNYPKEGILFRDVTSLLENAAAYKAAIDLLVEHYRGQGFTK
CCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IVGTEARGFLFGAPLALELGIGFVPVRKPGKLPRATISQSYELEYGHDSLEIHTDAISAN
EECCCCCCEEEECCEEEECCCCEEECCCCCCCCHHHHCCCEEEEECCCCEEEEEEEECCC
DKVLVVDDLLATGGTIEATVKLIRQLGGEVKDAAFVISLPDLGGEARLTALGLELVKLCE
CCEEEEEHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHH
FEGE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA