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The map label for this gene is pcm [H]

Identifier: 120598084

GI number: 120598084

Start: 1433229

End: 1433864

Strand: Direct

Name: pcm [H]

Synonym: Sputw3181_1261

Alternate gene names: 120598084

Gene position: 1433229-1433864 (Clockwise)

Preceding gene: 120598083

Following gene: 120598085

Centisome position: 30.44

GC content: 45.91

Gene sequence:

>636_bases
ATGACTCGAGTTGCCTTAACATCGGCGGTGAATCTCGCTAAAAAGCTTTCTGATGCGGGGATCCGTAATCAAGCCGTGTT
AAAGGCGATATCGCAAACCCCGCGTGAAATGTTTCTCGATAATGCGTTAGCCCATAAAGCTTACGAAAATACCGCTTTGC
CAATTGGTCAAGGTCAAACGATTTCTCAGCCTTATATCGTTGCCAGAATGACCGAACTATTACTCAGTAATATGCCAAAA
AAGGTGCTAGAAGTCGGAACGGGGTCGGGTTATCAAGCCGCCATATTAGCCCAGTTAGTGCCAGAGCTTTGTACGATAGA
GCGTATTAAAGGCTTACAAATTCAAGCTCGGCAAAGATTAAAACGGCTCGATCTACATAATGTGTCATTCAAATATGGCG
ATGGCTGGCAAGGATGGTCTAACCGTAGCCCGTTTGATGCCATTATGGTGACCGCTGCCGCAGCGACAGTACCCGAGGCA
CTTTTATCCCAACTGGTCGATGGCGGGGTGTTAGTGTTACCAGTGGGAGAGAACACACAGCAATTGATGCGGATCACCCG
TCATCGCGAGCGTTTTAGTTCAGAAAATATTGAAACGGTAAAATTTGTGCCATTAGTTAATGGTGAATTAGCATAA

Upstream 100 bases:

>100_bases
TTCATGCAGTTGCCAATGGGTATGTGTCAATTACCCCTTTGACAGTTGATCTCACAGCCTACAGACAATTATCGGTATTG
CAGAATTGGGTAGATAAAAT

Downstream 100 bases:

>100_bases
ATTGGATTGCAACTTCATCACTTGTTAGTGATGTTTAGAGGAAGTGTGTTTCTCATCATAAACAGTAATGCAACTTAGTA
GAGGAGTTTTTATTGTTGAA

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MTRVALTSAVNLAKKLSDAGIRNQAVLKAISQTPREMFLDNALAHKAYENTALPIGQGQTISQPYIVARMTELLLSNMPK
KVLEVGTGSGYQAAILAQLVPELCTIERIKGLQIQARQRLKRLDLHNVSFKYGDGWQGWSNRSPFDAIMVTAAAATVPEA
LLSQLVDGGVLVLPVGENTQQLMRITRHRERFSSENIETVKFVPLVNGELA

Sequences:

>Translated_211_residues
MTRVALTSAVNLAKKLSDAGIRNQAVLKAISQTPREMFLDNALAHKAYENTALPIGQGQTISQPYIVARMTELLLSNMPK
KVLEVGTGSGYQAAILAQLVPELCTIERIKGLQIQARQRLKRLDLHNVSFKYGDGWQGWSNRSPFDAIMVTAAAATVPEA
LLSQLVDGGVLVLPVGENTQQLMRITRHRERFSSENIETVKFVPLVNGELA
>Mature_210_residues
TRVALTSAVNLAKKLSDAGIRNQAVLKAISQTPREMFLDNALAHKAYENTALPIGQGQTISQPYIVARMTELLLSNMPKK
VLEVGTGSGYQAAILAQLVPELCTIERIKGLQIQARQRLKRLDLHNVSFKYGDGWQGWSNRSPFDAIMVTAAAATVPEAL
LSQLVDGGVLVLPVGENTQQLMRITRHRERFSSENIETVKFVPLVNGELA

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI226530908, Length=193, Percent_Identity=33.6787564766839, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1789100, Length=200, Percent_Identity=61, Blast_Score=254, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI71983477, Length=174, Percent_Identity=32.183908045977, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193207222, Length=139, Percent_Identity=33.8129496402878, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17981723, Length=216, Percent_Identity=30.0925925925926, Blast_Score=80, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 23149; Mature: 23018

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS01279 PCMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVALTSAVNLAKKLSDAGIRNQAVLKAISQTPREMFLDNALAHKAYENTALPIGQGQT
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCC
ISQPYIVARMTELLLSNMPKKVLEVGTGSGYQAAILAQLVPELCTIERIKGLQIQARQRL
CCCCHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KRLDLHNVSFKYGDGWQGWSNRSPFDAIMVTAAAATVPEALLSQLVDGGVLVLPVGENTQ
HHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHH
QLMRITRHRERFSSENIETVKFVPLVNGELA
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
TRVALTSAVNLAKKLSDAGIRNQAVLKAISQTPREMFLDNALAHKAYENTALPIGQGQT
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCC
ISQPYIVARMTELLLSNMPKKVLEVGTGSGYQAAILAQLVPELCTIERIKGLQIQARQRL
CCCCHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KRLDLHNVSFKYGDGWQGWSNRSPFDAIMVTAAAATVPEALLSQLVDGGVLVLPVGENTQ
HHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHH
QLMRITRHRERFSSENIETVKFVPLVNGELA
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA