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The map label for this gene is cvrA [H]

Identifier: 120597704

GI number: 120597704

Start: 990187

End: 991911

Strand: Direct

Name: cvrA [H]

Synonym: Sputw3181_0874

Alternate gene names: 120597704

Gene position: 990187-991911 (Clockwise)

Preceding gene: 120597700

Following gene: 120597706

Centisome position: 21.03

GC content: 45.74

Gene sequence:

>1725_bases
GTGGATGCAGATTCCATCAATAGTTTTTTTCTGATCGGTGCCTTGCTTGCAGCAGTGAGTGTTTTGCTTAGTCCTATGTC
TTCCCGTTTAGGCATTCCAATTTTATTGATTTTCCTTGCTGTAGGTATTTTGGCTGGTGAAGATGGTCTTGGTGGTATCC
AATTTGATGATTACTCCACAGCTTATTTAGTCAGTAACTTAGCCTTAGCGATTATTTTGCTCGACGGCGGTATGCGCACG
CGCGTAGCCAGTTTTAGGGTGGCGCTATGGCCTGCATTATCCTTGGCGACTTTTGGCGTTGCGATTACCACCAGTATTAC
TGGCTTGATGGCCGCATGGTTGTTTGATTTGCATTGGCTGCAGGGGTTACTGGTTGGGGCTATTGTGGGCTCGACTGATG
CGGCAGCGGTATTTTCCTTACTTAAAGGACGAAGTCTTAATGAGCGGGTTGGGGCAACCTTGGAAATTGAGTCCGGTAGT
AACGATCCTATGGCGGTATTTTTAACCGTCACATTAATTGCTATTTTGGCTAATGTTGATACTGAGCTTTCGGTTAGTTT
TATGCTGGTAAGCTTTATTAAACAGTTTGGTTTGGGAATTTGTTTAGGTTTAGGCGGTGGTTGGCTGCTATGGAAACTGG
TTAATTTAAGTAAGCTTGCAGAGGGGCTTTACTCAATTTTAGTCTTAAGTGGCGGACTGATTATCTATGCTGTATCTAAC
AAGTTGGGTGGAAGTGGCATTTTATCCATTTACTTAGTCGGATTATTCCTCGGTAATAAACCCACTCGTGGTCGTCATTC
TATTTTAAACGTACTCGATGGTATGACTTGGGTCAGCCAAATCGGTATGTTCCTTGTCTTAGGCTTGCTACTTACCCCTT
CTGATTTATTTGATATTTTGCTGCCTGGTTTTGCCTTGGCATTTGGGATGATCTTATTCGCCCGTCCTCTGGCTGTGTGG
CTGAGCTTATTGCCCTTTAAAAGCTTTAGTAGCCGGGATCGTTGGTTTATTTCTTGGGTGGGGTTACGCGGCGCTGTACC
GATCATCTTAGCAGTATTTCCTATGATGGCGGGCCTGCCAGGGGCTCAGTTATATTTCAACTTAGCTTTCTTCGTCGTGC
TAGTCTCGCTGCTGATCCAAGGAGCTTCGTTAACCACGGCAGCGCGCTTGGCAAAGGTGGAACTGCCCCCAAAGCCGCTC
CCCATTTCACGCTCGGGTGTTGAAATTTATCCGAGTAGTGAATGGGAGGTCTTTGTTTACTGTTTGAGCGAAAATAAATG
GTGTGTTGGTGAGCCCTTAAAACGGTTATCGATGCCTGATGGTACGCGTATTGCGGCTGTTTTTAGGGGAGACAAACTAT
TGCATCCCTCTGGTAGTACTTGCTTAGAGGCGGGAGATATACTCTGTGTTCTAGGTCAGGAGCGAAGTTTAGATGCATTA
AGCCATCTTTTTAGCCAAGCACCTGAAACTAAGGAAGTTCCACGTTTCTTCGGTGATTTCTTTATTGAGACTGATGTCAA
GTTAGCTGATCTGGCCCCTATCTATGGTTTGGACTTAGATGAGGAGGCGAGTGAGATGACTGTGGCTGATCTTGTGGCAT
CTGAGCTTGGTGCACATCCGGTCATAGGGGATCATTTCCAATGGCAATCTTTACACTGGGTTGTTGCAGGATTGCATGAA
GGCAAAGTGACGAATATCGGGATTCGCTTACCGCCAGAAACCTAG

Upstream 100 bases:

>100_bases
TGTGCTAATATAAAATCATAAAAATTGTAAGTTGAGTCATTTTTAACCTCGGTGATTTGTCTATCGTTTAACTAAACAAC
CTGTATTTAAGGAGGCATGT

Downstream 100 bases:

>100_bases
CATTCTAGGGCCTATAAAAAATGCCAGCTTAATTGCTGGCATTTTTGTGTTAAAAAGTGTGTTAGGTTACTGATATACAG
ATTTATCAGTGGGATCAGGA

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MDADSINSFFLIGALLAAVSVLLSPMSSRLGIPILLIFLAVGILAGEDGLGGIQFDDYSTAYLVSNLALAIILLDGGMRT
RVASFRVALWPALSLATFGVAITTSITGLMAAWLFDLHWLQGLLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGS
NDPMAVFLTVTLIAILANVDTELSVSFMLVSFIKQFGLGICLGLGGGWLLWKLVNLSKLAEGLYSILVLSGGLIIYAVSN
KLGGSGILSIYLVGLFLGNKPTRGRHSILNVLDGMTWVSQIGMFLVLGLLLTPSDLFDILLPGFALAFGMILFARPLAVW
LSLLPFKSFSSRDRWFISWVGLRGAVPIILAVFPMMAGLPGAQLYFNLAFFVVLVSLLIQGASLTTAARLAKVELPPKPL
PISRSGVEIYPSSEWEVFVYCLSENKWCVGEPLKRLSMPDGTRIAAVFRGDKLLHPSGSTCLEAGDILCVLGQERSLDAL
SHLFSQAPETKEVPRFFGDFFIETDVKLADLAPIYGLDLDEEASEMTVADLVASELGAHPVIGDHFQWQSLHWVVAGLHE
GKVTNIGIRLPPET

Sequences:

>Translated_574_residues
MDADSINSFFLIGALLAAVSVLLSPMSSRLGIPILLIFLAVGILAGEDGLGGIQFDDYSTAYLVSNLALAIILLDGGMRT
RVASFRVALWPALSLATFGVAITTSITGLMAAWLFDLHWLQGLLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGS
NDPMAVFLTVTLIAILANVDTELSVSFMLVSFIKQFGLGICLGLGGGWLLWKLVNLSKLAEGLYSILVLSGGLIIYAVSN
KLGGSGILSIYLVGLFLGNKPTRGRHSILNVLDGMTWVSQIGMFLVLGLLLTPSDLFDILLPGFALAFGMILFARPLAVW
LSLLPFKSFSSRDRWFISWVGLRGAVPIILAVFPMMAGLPGAQLYFNLAFFVVLVSLLIQGASLTTAARLAKVELPPKPL
PISRSGVEIYPSSEWEVFVYCLSENKWCVGEPLKRLSMPDGTRIAAVFRGDKLLHPSGSTCLEAGDILCVLGQERSLDAL
SHLFSQAPETKEVPRFFGDFFIETDVKLADLAPIYGLDLDEEASEMTVADLVASELGAHPVIGDHFQWQSLHWVVAGLHE
GKVTNIGIRLPPET
>Mature_574_residues
MDADSINSFFLIGALLAAVSVLLSPMSSRLGIPILLIFLAVGILAGEDGLGGIQFDDYSTAYLVSNLALAIILLDGGMRT
RVASFRVALWPALSLATFGVAITTSITGLMAAWLFDLHWLQGLLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGS
NDPMAVFLTVTLIAILANVDTELSVSFMLVSFIKQFGLGICLGLGGGWLLWKLVNLSKLAEGLYSILVLSGGLIIYAVSN
KLGGSGILSIYLVGLFLGNKPTRGRHSILNVLDGMTWVSQIGMFLVLGLLLTPSDLFDILLPGFALAFGMILFARPLAVW
LSLLPFKSFSSRDRWFISWVGLRGAVPIILAVFPMMAGLPGAQLYFNLAFFVVLVSLLIQGASLTTAARLAKVELPPKPL
PISRSGVEIYPSSEWEVFVYCLSENKWCVGEPLKRLSMPDGTRIAAVFRGDKLLHPSGSTCLEAGDILCVLGQERSLDAL
SHLFSQAPETKEVPRFFGDFFIETDVKLADLAPIYGLDLDEEASEMTVADLVASELGAHPVIGDHFQWQSLHWVVAGLHE
GKVTNIGIRLPPET

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=575, Percent_Identity=59.6521739130435, Blast_Score=610, Evalue=1e-176,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 61641; Mature: 61641

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDADSINSFFLIGALLAAVSVLLSPMSSRLGIPILLIFLAVGILAGEDGLGGIQFDDYST
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEECCCCH
AYLVSNLALAIILLDGGMRTRVASFRVALWPALSLATFGVAITTSITGLMAAWLFDLHWL
HHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGSNDPMAVFLTVTLIAILANVD
HHHHHHHHHCCCHHHHHHHHHHCCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCCC
TELSVSFMLVSFIKQFGLGICLGLGGGWLLWKLVNLSKLAEGLYSILVLSGGLIIYAVSN
CHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECC
KLGGSGILSIYLVGLFLGNKPTRGRHSILNVLDGMTWVSQIGMFLVLGLLLTPSDLFDIL
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LPGFALAFGMILFARPLAVWLSLLPFKSFSSRDRWFISWVGLRGAVPIILAVFPMMAGLP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCC
GAQLYFNLAFFVVLVSLLIQGASLTTAARLAKVELPPKPLPISRSGVEIYPSSEWEVFVY
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCCCEEEEECCCCEEEEE
CLSENKWCVGEPLKRLSMPDGTRIAAVFRGDKLLHPSGSTCLEAGDILCVLGQERSLDAL
EECCCCCCCCCHHHHCCCCCCCEEEEEEECCEEECCCCCCCCCCCCEEEEECCCCCHHHH
SHLFSQAPETKEVPRFFGDFFIETDVKLADLAPIYGLDLDEEASEMTVADLVASELGAHP
HHHHHCCCCCHHHHHHHHHHHEECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
VIGDHFQWQSLHWVVAGLHEGKVTNIGIRLPPET
CCCCCCCCCHHHEEEEECCCCCEEEEEEECCCCC
>Mature Secondary Structure
MDADSINSFFLIGALLAAVSVLLSPMSSRLGIPILLIFLAVGILAGEDGLGGIQFDDYST
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEECCCCH
AYLVSNLALAIILLDGGMRTRVASFRVALWPALSLATFGVAITTSITGLMAAWLFDLHWL
HHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGSNDPMAVFLTVTLIAILANVD
HHHHHHHHHCCCHHHHHHHHHHCCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCCC
TELSVSFMLVSFIKQFGLGICLGLGGGWLLWKLVNLSKLAEGLYSILVLSGGLIIYAVSN
CHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECC
KLGGSGILSIYLVGLFLGNKPTRGRHSILNVLDGMTWVSQIGMFLVLGLLLTPSDLFDIL
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LPGFALAFGMILFARPLAVWLSLLPFKSFSSRDRWFISWVGLRGAVPIILAVFPMMAGLP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCC
GAQLYFNLAFFVVLVSLLIQGASLTTAARLAKVELPPKPLPISRSGVEIYPSSEWEVFVY
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCCCEEEEECCCCEEEEE
CLSENKWCVGEPLKRLSMPDGTRIAAVFRGDKLLHPSGSTCLEAGDILCVLGQERSLDAL
EECCCCCCCCCHHHHCCCCCCCEEEEEEECCEEECCCCCCCCCCCCEEEEECCCCCHHHH
SHLFSQAPETKEVPRFFGDFFIETDVKLADLAPIYGLDLDEEASEMTVADLVASELGAHP
HHHHHCCCCCHHHHHHHHHHHEECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
VIGDHFQWQSLHWVVAGLHEGKVTNIGIRLPPET
CCCCCCCCCHHHEEEEECCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA