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The map label for this gene is tpm [H]

Identifier: 120597476

GI number: 120597476

Start: 709179

End: 709835

Strand: Direct

Name: tpm [H]

Synonym: Sputw3181_0645

Alternate gene names: 120597476

Gene position: 709179-709835 (Clockwise)

Preceding gene: 120597475

Following gene: 120597478

Centisome position: 15.06

GC content: 45.05

Gene sequence:

>657_bases
ATGGAACCCGGTTTTTGGCATGAAAAGTGGTACAAGCAGCAGATAGGCTTTCATCAACAGGATATTAATCCCTTCCTCGT
TCAGTATTGGCAACGGTTAGCATTGCCTGCCGGGGCTAAAGTGTTTGTGCCTTTGTGTGGTAAATCCTTAGATATGTGTT
TCTTGGCAGAGCAGGGGCACCAAGTTATAGGATGTGAGTTGAATGAATTAGCGGTGCAGCAGTTCTTTAGCGATAACCAA
CTCGAGATGACACAAACTGTTGAGGGTGAGCATCAACACTATCAAACCGAGCAAGTCAGTTTGTATCAGGGTGATATTTT
CACCTTACCTAAGCGCATTACCCAAGATGTGACGGCATTTTATGATCGTGCGGCGTTAATTGCTTGGCCCGAAGAGATGC
GCGCACAGTATGCTAAGCAACTGGCCAATTTATTACCTAGCGGCAGCCTTGGTTTGCTTGTTACCCTAGATTATCCACAA
GAAACCTTAAACGGCCCGCCATTTGCTGTGTCGCCCAATTGGATTGAAGCCCATTTAACCGATGATTTTGAGATCCAAGC
ACTCGCTTGCCAAGATGTATTAGCCGATAACCCTCGATTCGTTAAAAAAGAGGTTCCTTGGTTAAATGAAGCCGCCTATC
TTTTGAAACGTAAATAG

Upstream 100 bases:

>100_bases
AGTTTTTACACAGCGAGGAAGCGTTGCTTACATTAGCGGTTTTGCATCTATTTGGAAATGCCATTAGAGTAGGGCTACTT
TCGTTATTTGAGATATTCCT

Downstream 100 bases:

>100_bases
CACGATATTAGATTTTGAATACATCTCATTGAATAATAATGTTTTATTAATTAAAGCTTGAGTTTGATGAGGTGTTTTTG
ATTAAAAGTTAATGTGTTGA

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MEPGFWHEKWYKQQIGFHQQDINPFLVQYWQRLALPAGAKVFVPLCGKSLDMCFLAEQGHQVIGCELNELAVQQFFSDNQ
LEMTQTVEGEHQHYQTEQVSLYQGDIFTLPKRITQDVTAFYDRAALIAWPEEMRAQYAKQLANLLPSGSLGLLVTLDYPQ
ETLNGPPFAVSPNWIEAHLTDDFEIQALACQDVLADNPRFVKKEVPWLNEAAYLLKRK

Sequences:

>Translated_218_residues
MEPGFWHEKWYKQQIGFHQQDINPFLVQYWQRLALPAGAKVFVPLCGKSLDMCFLAEQGHQVIGCELNELAVQQFFSDNQ
LEMTQTVEGEHQHYQTEQVSLYQGDIFTLPKRITQDVTAFYDRAALIAWPEEMRAQYAKQLANLLPSGSLGLLVTLDYPQ
ETLNGPPFAVSPNWIEAHLTDDFEIQALACQDVLADNPRFVKKEVPWLNEAAYLLKRK
>Mature_218_residues
MEPGFWHEKWYKQQIGFHQQDINPFLVQYWQRLALPAGAKVFVPLCGKSLDMCFLAEQGHQVIGCELNELAVQQFFSDNQ
LEMTQTVEGEHQHYQTEQVSLYQGDIFTLPKRITQDVTAFYDRAALIAWPEEMRAQYAKQLANLLPSGSLGLLVTLDYPQ
ETLNGPPFAVSPNWIEAHLTDDFEIQALACQDVLADNPRFVKKEVPWLNEAAYLLKRK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family [H]

Homologues:

Organism=Homo sapiens, GI4507653, Length=219, Percent_Identity=31.5068493150685, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822 [H]

Pfam domain/function: PF05724 TPMT [H]

EC number: =2.1.1.67 [H]

Molecular weight: Translated: 25059; Mature: 25059

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPGFWHEKWYKQQIGFHQQDINPFLVQYWQRLALPAGAKVFVPLCGKSLDMCFLAEQGH
CCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCC
QVIGCELNELAVQQFFSDNQLEMTQTVEGEHQHYQTEQVSLYQGDIFTLPKRITQDVTAF
EEECCCHHHHHHHHHHCCCCEEEHHHHCCCHHHHCCHHEEEECCCHHHHHHHHHHHHHHH
YDRAALIAWPEEMRAQYAKQLANLLPSGSLGLLVTLDYPQETLNGPPFAVSPNWIEAHLT
HHCHHEEECCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHCCCCCEEECCCCEEEEEC
DDFEIQALACQDVLADNPRFVKKEVPWLNEAAYLLKRK
CCCEEEHHHHHHHHCCCCCCHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure
MEPGFWHEKWYKQQIGFHQQDINPFLVQYWQRLALPAGAKVFVPLCGKSLDMCFLAEQGH
CCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCC
QVIGCELNELAVQQFFSDNQLEMTQTVEGEHQHYQTEQVSLYQGDIFTLPKRITQDVTAF
EEECCCHHHHHHHHHHCCCCEEEHHHHCCCHHHHCCHHEEEECCCHHHHHHHHHHHHHHH
YDRAALIAWPEEMRAQYAKQLANLLPSGSLGLLVTLDYPQETLNGPPFAVSPNWIEAHLT
HHCHHEEECCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHCCCCCEEECCCCEEEEEC
DDFEIQALACQDVLADNPRFVKKEVPWLNEAAYLLKRK
CCCEEEHHHHHHHHCCCCCCHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA