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The map label for this gene is gppA [H]

Identifier: 120597339

GI number: 120597339

Start: 546503

End: 547429

Strand: Direct

Name: gppA [H]

Synonym: Sputw3181_0508

Alternate gene names: 120597339

Gene position: 546503-547429 (Clockwise)

Preceding gene: 120597338

Following gene: 120597352

Centisome position: 11.61

GC content: 45.74

Gene sequence:

>927_bases
ATGCCAACACCCGCTTATGCCGCAATTACGTTAGGCTCTAATAGCTTTAATATGCTGATCGCCAAGACAAAAGGCGGTCA
GCCACATATTATTGCAAAATATAAGCGTAAGGTAAGATTAGCTGAAGGTATTGGTGAGGATGGCAAGTTAAATCCAGAGG
TTATGCAACGTGGTCTCGATTGTCTTGCCATGTTTGCGCAGATGCTGACACAGCATAAAATTCATCAAGATCATGTCGCA
GTCATCGCCACCGCCACTCTTCGTAGTATCAGTAATGCCGATGAGTTTAATGAGCGTGCATTGCCTTTACTTGGGCATTC
CATTGAGATTATCTCTGGGATGCGCGAAGCCGAGCTTATCTACCAAGGTATGGTGGCTACCACCTGTGGGCAAGGGCGGC
GTTTAGTGATCGATATTGGCGGTGCCAGTACTGAGTTTATTATTGGCGATGGTCATCAAGTGTTGTTTAAAACCAGCTTG
CCTATGGGAAGCGTGACTTATAATCGCCAATTTTTCAGTAATATGCCTTTTCAACAGTTAGATTTTGATGATGCGAAACA
GCAGGTTTTAGTCACTCTGGCTGAGCATAGGAAGACACTGCGTGACTTAGGTTGGCATTGTGTAGTGGGAGCCTCTGGCG
CGGTGCAATCTGTGGTTGAAGTACTATTACATCGAGAGCAATCTGAAACCATCACCCTTGAAGTGCTTAATCAGCTAAAG
GCTGAAATTCTCGTTCAAGAGGATAGGCAGCTTTTGGGGATCCATGGTTTAAGTAGCGAACGTGCTCCGACCTTTGCCGC
GGGTGTTGCGATCCTATTAGCACTATTTGAGCTATTGGGTATTGAGCATCTAAGCCTATCGGGTGGCGCATTACGTGAGG
GTGTATTAATAATGTTAGCGCAGCGGATCCTTGAAGAAGCAATTTAG

Upstream 100 bases:

>100_bases
GCGTAACCTACGCGAGCGTGCAGGAGCTGGTCGTCCACAGGGCGCCCATCGTAGTGGTGGACGTCCACCTCGCCATGACA
GGACACGTAGACACTCGTAA

Downstream 100 bases:

>100_bases
TACTCATGGCCTAGAACGCTTCGCTGCTAGAGCCTCGCATCGATAACTGCTCCTGCGTTATTCTACCTTCTGCATCCATG
CAGTCGTTCGCGAGGATGAC

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MPTPAYAAITLGSNSFNMLIAKTKGGQPHIIAKYKRKVRLAEGIGEDGKLNPEVMQRGLDCLAMFAQMLTQHKIHQDHVA
VIATATLRSISNADEFNERALPLLGHSIEIISGMREAELIYQGMVATTCGQGRRLVIDIGGASTEFIIGDGHQVLFKTSL
PMGSVTYNRQFFSNMPFQQLDFDDAKQQVLVTLAEHRKTLRDLGWHCVVGASGAVQSVVEVLLHREQSETITLEVLNQLK
AEILVQEDRQLLGIHGLSSERAPTFAAGVAILLALFELLGIEHLSLSGGALREGVLIMLAQRILEEAI

Sequences:

>Translated_308_residues
MPTPAYAAITLGSNSFNMLIAKTKGGQPHIIAKYKRKVRLAEGIGEDGKLNPEVMQRGLDCLAMFAQMLTQHKIHQDHVA
VIATATLRSISNADEFNERALPLLGHSIEIISGMREAELIYQGMVATTCGQGRRLVIDIGGASTEFIIGDGHQVLFKTSL
PMGSVTYNRQFFSNMPFQQLDFDDAKQQVLVTLAEHRKTLRDLGWHCVVGASGAVQSVVEVLLHREQSETITLEVLNQLK
AEILVQEDRQLLGIHGLSSERAPTFAAGVAILLALFELLGIEHLSLSGGALREGVLIMLAQRILEEAI
>Mature_307_residues
PTPAYAAITLGSNSFNMLIAKTKGGQPHIIAKYKRKVRLAEGIGEDGKLNPEVMQRGLDCLAMFAQMLTQHKIHQDHVAV
IATATLRSISNADEFNERALPLLGHSIEIISGMREAELIYQGMVATTCGQGRRLVIDIGGASTEFIIGDGHQVLFKTSLP
MGSVTYNRQFFSNMPFQQLDFDDAKQQVLVTLAEHRKTLRDLGWHCVVGASGAVQSVVEVLLHREQSETITLEVLNQLKA
EILVQEDRQLLGIHGLSSERAPTFAAGVAILLALFELLGIEHLSLSGGALREGVLIMLAQRILEEAI

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=303, Percent_Identity=43.2343234323432, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1788848, Length=304, Percent_Identity=40.1315789473684, Blast_Score=203, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 33671; Mature: 33539

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTPAYAAITLGSNSFNMLIAKTKGGQPHIIAKYKRKVRLAEGIGEDGKLNPEVMQRGLD
CCCCCEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
CLAMFAQMLTQHKIHQDHVAVIATATLRSISNADEFNERALPLLGHSIEIISGMREAELI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHCCHHHHHHCCHHHHHH
YQGMVATTCGQGRRLVIDIGGASTEFIIGDGHQVLFKTSLPMGSVTYNRQFFSNMPFQQL
HHHHHHHHCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCCCEEECHHHHHCCCHHHC
DFDDAKQQVLVTLAEHRKTLRDLGWHCVVGASGAVQSVVEVLLHREQSETITLEVLNQLK
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCCCCEEHHHHHHHHH
AEILVQEDRQLLGIHGLSSERAPTFAAGVAILLALFELLGIEHLSLSGGALREGVLIMLA
HHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHH
QRILEEAI
HHHHHHCC
>Mature Secondary Structure 
PTPAYAAITLGSNSFNMLIAKTKGGQPHIIAKYKRKVRLAEGIGEDGKLNPEVMQRGLD
CCCCEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
CLAMFAQMLTQHKIHQDHVAVIATATLRSISNADEFNERALPLLGHSIEIISGMREAELI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHCCHHHHHHCCHHHHHH
YQGMVATTCGQGRRLVIDIGGASTEFIIGDGHQVLFKTSLPMGSVTYNRQFFSNMPFQQL
HHHHHHHHCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCCCEEECHHHHHCCCHHHC
DFDDAKQQVLVTLAEHRKTLRDLGWHCVVGASGAVQSVVEVLLHREQSETITLEVLNQLK
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCCCCEEHHHHHHHHH
AEILVQEDRQLLGIHGLSSERAPTFAAGVAILLALFELLGIEHLSLSGGALREGVLIMLA
HHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHH
QRILEEAI
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA