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The map label for this gene is lpxC

Identifier: 120597226

GI number: 120597226

Start: 428063

End: 428983

Strand: Direct

Name: lpxC

Synonym: Sputw3181_0395

Alternate gene names: 120597226

Gene position: 428063-428983 (Clockwise)

Preceding gene: 120597225

Following gene: 120597228

Centisome position: 9.09

GC content: 44.63

Gene sequence:

>921_bases
ATGATATTTCAAAGAACTGTTCAAAAAATGGTGAAAGCTACCGGGGTCGGATTACACTCTGGCAACAAGGTCACCTTGAG
CATTATGCCCGCACCAGTTAATACAGGGATCGTACTTGTGCGTACCGACTTGAGTCCTGCTGTTGCTATTCCAGCGAAGG
CAGAACAAGTTCGCGAAACCACGATGTGCACGGCTCTTGTTAATGACGAAGGTATTCGAATTTCAACTATTGAACATTTA
TTTGCAGCACTCGCGGGTTTAGGCATAGATAACGCCGTAATCGAAGTGGACGCGCCTGAAATTCCTATTATGGATGGCAG
TGCGAGCCCATTTGTCTTCTTATTGCAGTCTGCTGGCATTAAAGAGCAGGCAGCACCTAAGAAGTACTTAAAGATTAAAC
GCCCTGTGCGCGTTGAAGATGGTGATAAATGGGCTGAGTTAAAACCGTTTAAAGGTTTTAGAGTTAATTTTAAAATTGAC
TTTGCTCATCCAGAGATCGCTCGTAGTCAACAGCATGTGGTGATGGACTTCTCAACCTCTGCATTTGTAAAAGAAATCAG
TCGAGCCCGTACTTTTGGTTTTATGCGCGATATTGAGTATCTGCGTGCGAACAACCTTGCTTTAGGTGGCAGCATGGAAA
ATGCGGTTGTGCTTGATGAATACCGCGTCCTCAACCCCGATGGCCTGCGTTATGAGGATGAGTTTGTTAAGCACAAGATT
TTAGATGCATTTGGTGATCTCTATGTCGCAGGACACGCGATTTTAGGTGAGTTCACGGCCTATAAAACGGGTCATGCGTT
AAATAACCAATTAGTACGAGCATTGCTGGCACAACAAGATGCATGGGAATTGGTTAGCTTTGAAAAAGAAGCTGATGTTC
CCGTCAGCTTTAGTGTACCTAGTGGCGCAGTATTTGCCTAA

Upstream 100 bases:

>100_bases
TGGTTAAGTTATGTTACCATGTCATACCAGTGTGGCCGTTTCGCCACTGCTGAGTGTGTAAATATTAAGCGCTATAATAG
AAATTTAAACGGGTAACTGA

Downstream 100 bases:

>100_bases
AAAGGGTTGATTTATTTATTACGGCTGGCCAATGAGGCCAGCCGTTTTAGTTTTTCACCCAGCGTTCCACTAATATTTTC
CGCAAGTGCAGCAATATGTT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MIFQRTVQKMVKATGVGLHSGNKVTLSIMPAPVNTGIVLVRTDLSPAVAIPAKAEQVRETTMCTALVNDEGIRISTIEHL
FAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSAGIKEQAAPKKYLKIKRPVRVEDGDKWAELKPFKGFRVNFKID
FAHPEIARSQQHVVMDFSTSAFVKEISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
LDAFGDLYVAGHAILGEFTAYKTGHALNNQLVRALLAQQDAWELVSFEKEADVPVSFSVPSGAVFA

Sequences:

>Translated_306_residues
MIFQRTVQKMVKATGVGLHSGNKVTLSIMPAPVNTGIVLVRTDLSPAVAIPAKAEQVRETTMCTALVNDEGIRISTIEHL
FAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSAGIKEQAAPKKYLKIKRPVRVEDGDKWAELKPFKGFRVNFKID
FAHPEIARSQQHVVMDFSTSAFVKEISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
LDAFGDLYVAGHAILGEFTAYKTGHALNNQLVRALLAQQDAWELVSFEKEADVPVSFSVPSGAVFA
>Mature_306_residues
MIFQRTVQKMVKATGVGLHSGNKVTLSIMPAPVNTGIVLVRTDLSPAVAIPAKAEQVRETTMCTALVNDEGIRISTIEHL
FAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSAGIKEQAAPKKYLKIKRPVRVEDGDKWAELKPFKGFRVNFKID
FAHPEIARSQQHVVMDFSTSAFVKEISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
LDAFGDLYVAGHAILGEFTAYKTGHALNNQLVRALLAQQDAWELVSFEKEADVPVSFSVPSGAVFA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=304, Percent_Identity=62.828947368421, Blast_Score=423, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 33619; Mature: 33619

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFQRTVQKMVKATGVGLHSGNKVTLSIMPAPVNTGIVLVRTDLSPAVAIPAKAEQVRET
CCHHHHHHHHHHHHCCCEECCCEEEEEEECCCCCCCEEEEEECCCCCEECCCCHHHHHHH
TMCTALVNDEGIRISTIEHLFAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSAGI
HHEEEEECCCCCEEHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCEEEEEECCCC
KEQAAPKKYLKIKRPVRVEDGDKWAELKPFKGFRVNFKIDFAHPEIARSQQHVVMDFSTS
CHHCCCHHHHEECCCEEECCCCCCCCCCCCCCEEEEEEEEECCCHHHCCCCEEEEEECHH
AFVKEISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECEEEECCCCCCCHHHHHHHHH
LDAFGDLYVAGHAILGEFTAYKTGHALNNQLVRALLAQQDAWELVSFEKEADVPVSFSVP
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEECC
SGAVFA
CCCCCC
>Mature Secondary Structure
MIFQRTVQKMVKATGVGLHSGNKVTLSIMPAPVNTGIVLVRTDLSPAVAIPAKAEQVRET
CCHHHHHHHHHHHHCCCEECCCEEEEEEECCCCCCCEEEEEECCCCCEECCCCHHHHHHH
TMCTALVNDEGIRISTIEHLFAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSAGI
HHEEEEECCCCCEEHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCEEEEEECCCC
KEQAAPKKYLKIKRPVRVEDGDKWAELKPFKGFRVNFKIDFAHPEIARSQQHVVMDFSTS
CHHCCCHHHHEECCCEEECCCCCCCCCCCCCCEEEEEEEEECCCHHHCCCCEEEEEECHH
AFVKEISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECEEEECCCCCCCHHHHHHHHH
LDAFGDLYVAGHAILGEFTAYKTGHALNNQLVRALLAQQDAWELVSFEKEADVPVSFSVP
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEECC
SGAVFA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA