Click here to switch to the map view.

The map label for this gene is pepQ [H]

Identifier: 120596847

GI number: 120596847

Start: 19738

End: 21060

Strand: Direct

Name: pepQ [H]

Synonym: Sputw3181_0014

Alternate gene names: 120596847

Gene position: 19738-21060 (Clockwise)

Preceding gene: 120596841

Following gene: 120596848

Centisome position: 0.42

GC content: 47.47

Gene sequence:

>1323_bases
ATGGATCAGTTGGCTCATCACTATCGTGCCCATATTGCCGAGTTAAACCGCCGAGTCGCAGAGATTTTGTCTCGAGAAGC
CTTGTCTGGTTTAGTGATCCATTCGGGTCAGCCGCATCGGATGTTTTTGGATGATATCAATTATCCCTTTAAAGCAAACC
CGCACTTCAAGGCATGGTTGCCAGTGTTGGATAATCCGAATTGCTGGTTAGTCGTCAATGGTCGCGATAAGCCGCAGCTG
ATTTTTTATCGTCCTGTGGATTTTTGGCACAAAGTATCCGATGTGCCGGATATGTTCTGGACCGAGCATTTTGATATTAA
GTTGTTAACTAAGGCTGATAAGGTCGCTGAACTGTTGCCCAAAGACACTGTTAATTGGGCTTATTTGGGCGAGCATTTAG
ATGTAGCCGAAGTGCTGGGTTTTACCAGTCGCAATCCCGATGCTGTGATGAGCTATTTGCATTACCACAGAACCACTAAA
ACTGAATATGAGCTGGAATGTATGCGCCGCGCCAACCAAATTGCGGTGCAGGGACATTTGGCGGCTAAAAATGCGTTTTA
TAACGGTGCGAGTGAGTTCGAGATCCAACAGCACTATTTATCTGCCGTGGGCCAGAGCGAAAATGAAGTGCCCTACGGCA
ATATTATCGCTCTTAATCAAAATGCGGCGATTTTGCATTACACCGCGCTTGAGCATCAAAGCCCCGCGAAACGTTTGTCT
TTTCTTATCGATGCGGGCGCGAGTTACTTTGGCTATGCGTCTGATATTACTAGAACCTATGCCTTCGAGAAGAATCGTTT
CGATGAGTTGATCGCTGCGATGAATAAGGCGCAGCTTGAGCTCATCGACATGATGCGTCCCGGTGTGCGTTATCCTGATT
TACACTTAGCTACTCACGCTAAAGTCGCGCAAATGCTATTGGATTTTGATTTAGCCACGGGGGATGCCCAAGGTTTGGTT
GATCAAGGCATTACCAGTGCTTTCTTCCCCCATGGTTTAGGCCACATGTTAGGTTTACAAGTGCATGATGTGGGTGGCTT
CTCCCACGATGAGCGCGGTACCCATATCGCGGCGCCCGAGGCCCACCCATTTTTGCGCTGCACCCGCATTTTAGCGCCAA
ACCAAGTACTGACTATGGAACCTGGGTTATACATCATAGATACTTTGCTTAATGAGCTTAAACAAGATAGTCGTGGCCTG
CAGATCAACTGGCAAACCGTTGATGAGTTAAGGCCTTTTGGCGGTATTCGTATCGAAGATAACGTCATAGTGCATCAAGA
TAGAAACGAGAATATGACCCGCGAGCTCGGCTTAGCCGATTGA

Upstream 100 bases:

>100_bases
TTTAACGTTTTGATTGAATCTGTTGTTCATGATCAGATTAAGATTATGTGGGCAAATTTGGCTCATAATATTAACTTTTA
TTCATTGCAGGAGATGACAA

Downstream 100 bases:

>100_bases
TCATAGGGCAAAGTTTAGGACGATCTTGTGCTCGACAGTTACCTTATCCCGAGTGAAAATATTCAGATTGAAGAAGAGAT
AAAGCATAGCCGCTTTATCT

Product: proline dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MDQLAHHYRAHIAELNRRVAEILSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWLPVLDNPNCWLVVNGRDKPQL
IFYRPVDFWHKVSDVPDMFWTEHFDIKLLTKADKVAELLPKDTVNWAYLGEHLDVAEVLGFTSRNPDAVMSYLHYHRTTK
TEYELECMRRANQIAVQGHLAAKNAFYNGASEFEIQQHYLSAVGQSENEVPYGNIIALNQNAAILHYTALEHQSPAKRLS
FLIDAGASYFGYASDITRTYAFEKNRFDELIAAMNKAQLELIDMMRPGVRYPDLHLATHAKVAQMLLDFDLATGDAQGLV
DQGITSAFFPHGLGHMLGLQVHDVGGFSHDERGTHIAAPEAHPFLRCTRILAPNQVLTMEPGLYIIDTLLNELKQDSRGL
QINWQTVDELRPFGGIRIEDNVIVHQDRNENMTRELGLAD

Sequences:

>Translated_440_residues
MDQLAHHYRAHIAELNRRVAEILSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWLPVLDNPNCWLVVNGRDKPQL
IFYRPVDFWHKVSDVPDMFWTEHFDIKLLTKADKVAELLPKDTVNWAYLGEHLDVAEVLGFTSRNPDAVMSYLHYHRTTK
TEYELECMRRANQIAVQGHLAAKNAFYNGASEFEIQQHYLSAVGQSENEVPYGNIIALNQNAAILHYTALEHQSPAKRLS
FLIDAGASYFGYASDITRTYAFEKNRFDELIAAMNKAQLELIDMMRPGVRYPDLHLATHAKVAQMLLDFDLATGDAQGLV
DQGITSAFFPHGLGHMLGLQVHDVGGFSHDERGTHIAAPEAHPFLRCTRILAPNQVLTMEPGLYIIDTLLNELKQDSRGL
QINWQTVDELRPFGGIRIEDNVIVHQDRNENMTRELGLAD
>Mature_440_residues
MDQLAHHYRAHIAELNRRVAEILSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWLPVLDNPNCWLVVNGRDKPQL
IFYRPVDFWHKVSDVPDMFWTEHFDIKLLTKADKVAELLPKDTVNWAYLGEHLDVAEVLGFTSRNPDAVMSYLHYHRTTK
TEYELECMRRANQIAVQGHLAAKNAFYNGASEFEIQQHYLSAVGQSENEVPYGNIIALNQNAAILHYTALEHQSPAKRLS
FLIDAGASYFGYASDITRTYAFEKNRFDELIAAMNKAQLELIDMMRPGVRYPDLHLATHAKVAQMLLDFDLATGDAQGLV
DQGITSAFFPHGLGHMLGLQVHDVGGFSHDERGTHIAAPEAHPFLRCTRILAPNQVLTMEPGLYIIDTLLNELKQDSRGL
QINWQTVDELRPFGGIRIEDNVIVHQDRNENMTRELGLAD

Specific function: Splits dipeptides with a prolyl residue in the C- terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=450, Percent_Identity=29.3333333333333, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI260593665, Length=289, Percent_Identity=33.9100346020761, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI260593663, Length=446, Percent_Identity=27.5784753363229, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1790282, Length=443, Percent_Identity=50.3386004514673, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1789275, Length=286, Percent_Identity=31.1188811188811, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1788728, Length=292, Percent_Identity=27.0547945205479, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17508215, Length=448, Percent_Identity=28.3482142857143, Blast_Score=151, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6321118, Length=287, Percent_Identity=32.404181184669, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320922, Length=284, Percent_Identity=26.4084507042254, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21357079, Length=455, Percent_Identity=25.2747252747253, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI19920384, Length=304, Percent_Identity=27.9605263157895, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR001131
- InterPro:   IPR022846 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 49997; Mature: 49997

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQLAHHYRAHIAELNRRVAEILSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEHHCCCCCCCCCCCCEEEE
PVLDNPNCWLVVNGRDKPQLIFYRPVDFWHKVSDVPDMFWTEHFDIKLLTKADKVAELLP
EEECCCCEEEEECCCCCCCEEEECCHHHHHHHCCCCHHHHCCCCCEEEEECHHHHHHHCC
KDTVNWAYLGEHLDVAEVLGFTSRNPDAVMSYLHYHRTTKTEYELECMRRANQIAVQGHL
CCCCCCEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEH
AAKNAFYNGASEFEIQQHYLSAVGQSENEVPYGNIIALNQNAAILHYTALEHQSPAKRLS
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEECCCCCHHHHHH
FLIDAGASYFGYASDITRTYAFEKNRFDELIAAMNKAQLELIDMMRPGVRYPDLHLATHA
HHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
KVAQMLLDFDLATGDAQGLVDQGITSAFFPHGLGHMLGLQVHDVGGFSHDERGTHIAAPE
HHHHHHHHHHCCCCCCHHHHHHCCHHHHHHCCHHHHHCEEEEECCCCCCCCCCCEEECCC
AHPFLRCTRILAPNQVLTMEPGLYIIDTLLNELKQDSRGLQINWQTVDELRPFGGIRIED
CCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCEEEEC
NVIVHQDRNENMTRELGLAD
CEEEECCCCCCCHHHCCCCC
>Mature Secondary Structure
MDQLAHHYRAHIAELNRRVAEILSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEHHCCCCCCCCCCCCEEEE
PVLDNPNCWLVVNGRDKPQLIFYRPVDFWHKVSDVPDMFWTEHFDIKLLTKADKVAELLP
EEECCCCEEEEECCCCCCCEEEECCHHHHHHHCCCCHHHHCCCCCEEEEECHHHHHHHCC
KDTVNWAYLGEHLDVAEVLGFTSRNPDAVMSYLHYHRTTKTEYELECMRRANQIAVQGHL
CCCCCCEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEH
AAKNAFYNGASEFEIQQHYLSAVGQSENEVPYGNIIALNQNAAILHYTALEHQSPAKRLS
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEECCCCCHHHHHH
FLIDAGASYFGYASDITRTYAFEKNRFDELIAAMNKAQLELIDMMRPGVRYPDLHLATHA
HHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
KVAQMLLDFDLATGDAQGLVDQGITSAFFPHGLGHMLGLQVHDVGGFSHDERGTHIAAPE
HHHHHHHHHHCCCCCCHHHHHHCCHHHHHHCCHHHHHCEEEEECCCCCCCCCCCEEECCC
AHPFLRCTRILAPNQVLTMEPGLYIIDTLLNELKQDSRGLQINWQTVDELRPFGGIRIED
CCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCEEEEC
NVIVHQDRNENMTRELGLAD
CEEEECCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA