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The map label for this gene is pdhA [H]

Identifier: 119947203

GI number: 119947203

Start: 4415577

End: 4416566

Strand: Direct

Name: pdhA [H]

Synonym: Ping_3601

Alternate gene names: 119947203

Gene position: 4415577-4416566 (Clockwise)

Preceding gene: 119947202

Following gene: 119947204

Centisome position: 96.84

GC content: 45.86

Gene sequence:

>990_bases
ATGAGCAGTAACAAATTACATGTTAATCGTATTCATTTACATTTTTTACTTAAGCAGATGATTCGAATTCGTCGCTTCGA
AGAGCGTTGCGTGACCCTTTATAATGAAGAAAAAATTCGCGGATTTTTACACTTATATAATGGAGAGGAGGCCATTGCCG
TTGGCGTAATGCAGGCATTAACGGCAGAAGATGCCGTACTGGCAACTTATCGCGAACACGGCCATGCGCTGGCAAGAGGT
CTGAGCATGGATTCCGTGATGGCGGAGATGTTTGGCAAAGCCAGTGGTTGTAGCGGTGGACGAGGCGGGTCGATGCACCT
GTTTGATAGCAGTCAGCGCTTTTATGGCGGTAGTGCCATTGTTGCTGGCGCGCTACCTATTGCCGTTGGGATCGCATTAG
CGGATAAAATGTTACAGCGCCAGGCTGTTACCTGCTGTTTTTTTGGTGACGGAGCAGTCGCCGAGGGAGAGTTTCACGAG
AGCCTGAATCTTGCCAAATTGTGGCAACTGCCCATCTTATTTATCTGTGAAAACAATCTTTATGCCATGGGCACAGCGCT
GGAAATTGAACATTCCAATCAGAAAATTCATTTAAAAGCAGCAAGTTATGGCTTAGCTGCACAAGTGATAGATGGTATGA
ATGTTATTGATGTTGAAGCCGCGGCAAAACTTGCCTGCAGCGCAATACGCAATGGTGCCGGGCCACATTTTATCGAATGC
CAGACCTATCGTTTTCGTGGGCACTCTATGTTTGATACCCAGCTTTATCGTAATAATGACGAAGTTGAGCAGTGGAAGAA
AAAAGGACCACTGATCCAATTAACCCAGTGGTTAAAAGACAATCATCAAATAGAACCCGAAGAGCTGCAAGCCATTGAAT
TAGCGGTGGAGAAAGAGATTGATGCGGCAGTGTGCAGCGCAGATGCGGCTGATATCGAGCCCGTCGAAAATTTGTTAAAG
CATGTATATACAGAGGTGTCCAATGGATAA

Upstream 100 bases:

>100_bases
CGTTTATTAAAAGCGCGCGAACTCGGATTGCCGGAAGGTGATATTTCCACTCTTGAAAGTGATGAAGCCTAACTGATAAG
TTTGCTTAGGAGGTAACGGT

Downstream 100 bases:

>100_bases
AATCACCTTCAGAGAGGCATTTAAGGAAGCGATAGCTGAAGCATTAAATAATGATGCCAGGGTCTTTTTAATCGGCGAAG
ATGTGGGTCGATATGGGGGT

Product: pyruvate dehydrogenase (acetyl-transferring)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MSSNKLHVNRIHLHFLLKQMIRIRRFEERCVTLYNEEKIRGFLHLYNGEEAIAVGVMQALTAEDAVLATYREHGHALARG
LSMDSVMAEMFGKASGCSGGRGGSMHLFDSSQRFYGGSAIVAGALPIAVGIALADKMLQRQAVTCCFFGDGAVAEGEFHE
SLNLAKLWQLPILFICENNLYAMGTALEIEHSNQKIHLKAASYGLAAQVIDGMNVIDVEAAAKLACSAIRNGAGPHFIEC
QTYRFRGHSMFDTQLYRNNDEVEQWKKKGPLIQLTQWLKDNHQIEPEELQAIELAVEKEIDAAVCSADAADIEPVENLLK
HVYTEVSNG

Sequences:

>Translated_329_residues
MSSNKLHVNRIHLHFLLKQMIRIRRFEERCVTLYNEEKIRGFLHLYNGEEAIAVGVMQALTAEDAVLATYREHGHALARG
LSMDSVMAEMFGKASGCSGGRGGSMHLFDSSQRFYGGSAIVAGALPIAVGIALADKMLQRQAVTCCFFGDGAVAEGEFHE
SLNLAKLWQLPILFICENNLYAMGTALEIEHSNQKIHLKAASYGLAAQVIDGMNVIDVEAAAKLACSAIRNGAGPHFIEC
QTYRFRGHSMFDTQLYRNNDEVEQWKKKGPLIQLTQWLKDNHQIEPEELQAIELAVEKEIDAAVCSADAADIEPVENLLK
HVYTEVSNG
>Mature_328_residues
SSNKLHVNRIHLHFLLKQMIRIRRFEERCVTLYNEEKIRGFLHLYNGEEAIAVGVMQALTAEDAVLATYREHGHALARGL
SMDSVMAEMFGKASGCSGGRGGSMHLFDSSQRFYGGSAIVAGALPIAVGIALADKMLQRQAVTCCFFGDGAVAEGEFHES
LNLAKLWQLPILFICENNLYAMGTALEIEHSNQKIHLKAASYGLAAQVIDGMNVIDVEAAAKLACSAIRNGAGPHFIECQ
TYRFRGHSMFDTQLYRNNDEVEQWKKKGPLIQLTQWLKDNHQIEPEELQAIELAVEKEIDAAVCSADAADIEPVENLLKH
VYTEVSNG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=314, Percent_Identity=39.8089171974522, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI291084742, Length=309, Percent_Identity=37.5404530744337, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4505685, Length=309, Percent_Identity=37.5404530744337, Blast_Score=205, Evalue=4e-53,
Organism=Homo sapiens, GI291084744, Length=316, Percent_Identity=36.7088607594937, Blast_Score=198, Evalue=5e-51,
Organism=Homo sapiens, GI291084757, Length=309, Percent_Identity=33.9805825242718, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI11386135, Length=329, Percent_Identity=29.7872340425532, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI258645172, Length=283, Percent_Identity=32.1554770318021, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17536047, Length=323, Percent_Identity=37.1517027863777, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI32564172, Length=323, Percent_Identity=37.1517027863777, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI86563357, Length=283, Percent_Identity=31.8021201413428, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI86563355, Length=283, Percent_Identity=31.8021201413428, Blast_Score=135, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6321026, Length=313, Percent_Identity=39.6166134185303, Blast_Score=221, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24639748, Length=318, Percent_Identity=37.1069182389937, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24639744, Length=308, Percent_Identity=37.6623376623377, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI28571106, Length=308, Percent_Identity=37.6623376623377, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24639740, Length=308, Percent_Identity=37.6623376623377, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24639746, Length=307, Percent_Identity=37.4592833876222, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI21355903, Length=261, Percent_Identity=28.3524904214559, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36380; Mature: 36249

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNKLHVNRIHLHFLLKQMIRIRRFEERCVTLYNEEKIRGFLHLYNGEEAIAVGVMQAL
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCCHHHHHHHHHHH
TAEDAVLATYREHGHALARGLSMDSVMAEMFGKASGCSGGRGGSMHLFDSSQRFYGGSAI
HHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCH
VAGALPIAVGIALADKMLQRQAVTCCFFGDGAVAEGEFHESLNLAKLWQLPILFICENNL
HHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEECCCHHHCCCHHHHHCCCEEEEECCCE
YAMGTALEIEHSNQKIHLKAASYGLAAQVIDGMNVIDVEAAAKLACSAIRNGAGPHFIEC
EEEEEEEEEEECCCEEEEEECCCCHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCEEEE
QTYRFRGHSMFDTQLYRNNDEVEQWKKKGPLIQLTQWLKDNHQIEPEELQAIELAVEKEI
EEEEECCCCEEHHHHHCCCCHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
DAAVCSADAADIEPVENLLKHVYTEVSNG
HHHHHCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSNKLHVNRIHLHFLLKQMIRIRRFEERCVTLYNEEKIRGFLHLYNGEEAIAVGVMQAL
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCCHHHHHHHHHHH
TAEDAVLATYREHGHALARGLSMDSVMAEMFGKASGCSGGRGGSMHLFDSSQRFYGGSAI
HHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCH
VAGALPIAVGIALADKMLQRQAVTCCFFGDGAVAEGEFHESLNLAKLWQLPILFICENNL
HHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEECCCHHHCCCHHHHHCCCEEEEECCCE
YAMGTALEIEHSNQKIHLKAASYGLAAQVIDGMNVIDVEAAAKLACSAIRNGAGPHFIEC
EEEEEEEEEEECCCEEEEEECCCCHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCEEEE
QTYRFRGHSMFDTQLYRNNDEVEQWKKKGPLIQLTQWLKDNHQIEPEELQAIELAVEKEI
EEEEECCCCEEHHHHHCCCCHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
DAAVCSADAADIEPVENLLKHVYTEVSNG
HHHHHCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]