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The map label for this gene is ilvA [H]

Identifier: 119946944

GI number: 119946944

Start: 4125614

End: 4127149

Strand: Direct

Name: ilvA [H]

Synonym: Ping_3338

Alternate gene names: 119946944

Gene position: 4125614-4127149 (Clockwise)

Preceding gene: 119946943

Following gene: 119946945

Centisome position: 90.48

GC content: 43.23

Gene sequence:

>1536_bases
ATGACAGAATTATCCGCAGCACAATACTTAAAAAAAATCTTACTTGCTCCTGTTTATGAAGCAGCCATAGAAACACCCTT
ACAACCGTTAACTAAGTTATCAGAGCGCTTTAATAATCAAATTTTATTAAAGCGTGAAGATCAGCAACCCGTGCATTCCT
TTAAATTACGCGGTGCCTATAATAGATTATCGAATTTAACTGACGAGCAAAAAAGCTGCGGTGTGATTGCTGCCTCGGCA
GGTAACCATGCCCAAGGTGTTGCGCTCTCAGCACAACGCATGGGGATGAAAGCAACGATAGTTATGCCCTGCACCACACC
CGAGATAAAAGTCAGTGCAGTGCGGGCATTCGGTGCCGAGGTGGTGTTATTTGGTGATGCTTTTGATGCTGCCAGCAAGC
ACTCTAAAGAACTGGCTGAATTACATAATTACACCTCAATTCCTCCTTTTGATGATCCCGATGTTATTGCCGGACAAGGT
ACTGTTGGCAAAGAGTTATTACAGCAAAATGCCCACCTCGATAAAATTTTTGTCCCCGTCGGTGGCGGTGGATTGATTGC
TGGTATTGCCGTTTATGTTAAACAGCTTTTACCCAATATTAAGGTGATTGGCGTTGAGCCTGACAATGCAGCTTGTTTAA
AAGCCGCGTTGGAGCATGGTAGCCCGATAACCTTAGATAAAGTTGGATTATTTGCCGACGGTGTTGCCGTTAAGACCATT
GGCAGTGAAACATTTCGTTTGTGTCAGCAATATGTTGATGAAGTGATCACCGTTAGCAGTGATGAAATCTGCACCGCAGT
AAAAGATATCTTTGAAGAGACGCGCGCAATTTCGGAGCCTTCCGGGGCATTATCATTGGCAGGTTTAAAAAAATATTGTC
AAGTACACGAAATTAAAAATCAAAACCTTGCCGCCATTTTAAGTGGAGCCAACCTCAACTTCCATTCCCTGCGTTATATC
TCCGAGCGTTGCGAATTAGGTGAGCAGAAAGAGAGCGTGCTGGCTGTCACTATCCCTGAAAAACAGGGCGCTTTTTTAGC
CTTTTGTAATCAGCTCGACGGGCGTGCTATTACCGAGTTTAATTATCGTTTAAATTCGCGTAAAAACGCAAATATTTTTG
TTGGCGTACGCACCCCGCAAGGTGTTGATGAACTTTTAGCGTTGACCGAAAAACTGCACAAATCAGGTTATTCTGTTGCC
GATTTAAGCAATGATGAAATGGCCAAACTGCATGTCCGTTATATGGTTGGTGGCGCACCCGTCAGTGCTATAAAAGAGCG
TTTATACAGTTTTGAATTTCCTGAACAGCCTAATGCGCTGATTAAGTTTTTAAATATGCTTGGCACTCACGCTAATATAA
CGCTATTTCATTACCGCAATCACGGCGCGGCTTATGGACAGGTTCTTGCCGGTTTTGAACTCGACGAAGGGGTTGATGCA
TTCAGTGAACATTTAGATGCACTGGGTTACAACTATAAAGATGAAACAGAGAACCAGGCTTATCGTTTCTTTTTATCCCA
TGCGAATGATCACTAA

Upstream 100 bases:

>100_bases
GAGCATTCATTTTGCAGAAAATCTTCAAGCGGGCTCAGTAACACGCTTAGGTGAGCTATTTGCAAGTAAAGTTGAACATA
AATAAAGGGTTGATAGCGCA

Downstream 100 bases:

>100_bases
GAGTTAGTTGATAATGCTTCCCCTCAGGCGGATTAAAAAGCTGTTTCGTGTTCTGGCACATCGATTAACTTGGCCTACCA
TGTTTCTGCTTGTGCTGGCG

Product: threonine dehydratase, biosynthetic

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MTELSAAQYLKKILLAPVYEAAIETPLQPLTKLSERFNNQILLKREDQQPVHSFKLRGAYNRLSNLTDEQKSCGVIAASA
GNHAQGVALSAQRMGMKATIVMPCTTPEIKVSAVRAFGAEVVLFGDAFDAASKHSKELAELHNYTSIPPFDDPDVIAGQG
TVGKELLQQNAHLDKIFVPVGGGGLIAGIAVYVKQLLPNIKVIGVEPDNAACLKAALEHGSPITLDKVGLFADGVAVKTI
GSETFRLCQQYVDEVITVSSDEICTAVKDIFEETRAISEPSGALSLAGLKKYCQVHEIKNQNLAAILSGANLNFHSLRYI
SERCELGEQKESVLAVTIPEKQGAFLAFCNQLDGRAITEFNYRLNSRKNANIFVGVRTPQGVDELLALTEKLHKSGYSVA
DLSNDEMAKLHVRYMVGGAPVSAIKERLYSFEFPEQPNALIKFLNMLGTHANITLFHYRNHGAAYGQVLAGFELDEGVDA
FSEHLDALGYNYKDETENQAYRFFLSHANDH

Sequences:

>Translated_511_residues
MTELSAAQYLKKILLAPVYEAAIETPLQPLTKLSERFNNQILLKREDQQPVHSFKLRGAYNRLSNLTDEQKSCGVIAASA
GNHAQGVALSAQRMGMKATIVMPCTTPEIKVSAVRAFGAEVVLFGDAFDAASKHSKELAELHNYTSIPPFDDPDVIAGQG
TVGKELLQQNAHLDKIFVPVGGGGLIAGIAVYVKQLLPNIKVIGVEPDNAACLKAALEHGSPITLDKVGLFADGVAVKTI
GSETFRLCQQYVDEVITVSSDEICTAVKDIFEETRAISEPSGALSLAGLKKYCQVHEIKNQNLAAILSGANLNFHSLRYI
SERCELGEQKESVLAVTIPEKQGAFLAFCNQLDGRAITEFNYRLNSRKNANIFVGVRTPQGVDELLALTEKLHKSGYSVA
DLSNDEMAKLHVRYMVGGAPVSAIKERLYSFEFPEQPNALIKFLNMLGTHANITLFHYRNHGAAYGQVLAGFELDEGVDA
FSEHLDALGYNYKDETENQAYRFFLSHANDH
>Mature_510_residues
TELSAAQYLKKILLAPVYEAAIETPLQPLTKLSERFNNQILLKREDQQPVHSFKLRGAYNRLSNLTDEQKSCGVIAASAG
NHAQGVALSAQRMGMKATIVMPCTTPEIKVSAVRAFGAEVVLFGDAFDAASKHSKELAELHNYTSIPPFDDPDVIAGQGT
VGKELLQQNAHLDKIFVPVGGGGLIAGIAVYVKQLLPNIKVIGVEPDNAACLKAALEHGSPITLDKVGLFADGVAVKTIG
SETFRLCQQYVDEVITVSSDEICTAVKDIFEETRAISEPSGALSLAGLKKYCQVHEIKNQNLAAILSGANLNFHSLRYIS
ERCELGEQKESVLAVTIPEKQGAFLAFCNQLDGRAITEFNYRLNSRKNANIFVGVRTPQGVDELLALTEKLHKSGYSVAD
LSNDEMAKLHVRYMVGGAPVSAIKERLYSFEFPEQPNALIKFLNMLGTHANITLFHYRNHGAAYGQVLAGFELDEGVDAF
SEHLDALGYNYKDETENQAYRFFLSHANDH

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia. Deaminates L-threonine, but also L-serine to a lesser extent [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=297, Percent_Identity=34.3434343434343, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI33469958, Length=322, Percent_Identity=25.4658385093168, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI19923959, Length=324, Percent_Identity=27.1604938271605, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI295821202, Length=144, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI295821200, Length=144, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI4557415, Length=144, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790207, Length=500, Percent_Identity=63.4, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI1789505, Length=289, Percent_Identity=41.522491349481, Blast_Score=198, Evalue=8e-52,
Organism=Escherichia coli, GI1789235, Length=310, Percent_Identity=24.8387096774194, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI2367138, Length=199, Percent_Identity=25.6281407035176, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71991565, Length=325, Percent_Identity=36.9230769230769, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17537387, Length=317, Percent_Identity=35.0157728706625, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17508781, Length=285, Percent_Identity=33.6842105263158, Blast_Score=138, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6320930, Length=516, Percent_Identity=48.8372093023256, Blast_Score=450, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6322631, Length=293, Percent_Identity=39.2491467576792, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319788, Length=267, Percent_Identity=26.5917602996255, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21355833, Length=289, Percent_Identity=34.6020761245675, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24645328, Length=212, Percent_Identity=32.5471698113208, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55844; Mature: 55713

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELSAAQYLKKILLAPVYEAAIETPLQPLTKLSERFNNQILLKREDQQPVHSFKLRGAY
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHH
NRLSNLTDEQKSCGVIAASAGNHAQGVALSAQRMGMKATIVMPCTTPEIKVSAVRAFGAE
HHHHCCCCHHHCCCEEEECCCCCCCCEEEHHHHCCCEEEEEEECCCCCHHHHHHHHCCCE
VVLFGDAFDAASKHSKELAELHNYTSIPPFDDPDVIAGQGTVGKELLQQNAHLDKIFVPV
EEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCHHHHHHHCCCCCCEEEEEE
GGGGLIAGIAVYVKQLLPNIKVIGVEPDNAACLKAALEHGSPITLDKVGLFADGVAVKTI
CCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCEEECCCCEECCEEEEEC
GSETFRLCQQYVDEVITVSSDEICTAVKDIFEETRAISEPSGALSLAGLKKYCQVHEIKN
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCC
QNLAAILSGANLNFHSLRYISERCELGEQKESVLAVTIPEKQGAFLAFCNQLDGRAITEF
CCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEE
NYRLNSRKNANIFVGVRTPQGVDELLALTEKLHKSGYSVADLSNDEMAKLHVRYMVGGAP
EEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHEEEEEEEECCCC
VSAIKERLYSFEFPEQPNALIKFLNMLGTHANITLFHYRNHGAAYGQVLAGFELDEGVDA
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHCCCCCCCHHHH
FSEHLDALGYNYKDETENQAYRFFLSHANDH
HHHHHHHHCCCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TELSAAQYLKKILLAPVYEAAIETPLQPLTKLSERFNNQILLKREDQQPVHSFKLRGAY
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHH
NRLSNLTDEQKSCGVIAASAGNHAQGVALSAQRMGMKATIVMPCTTPEIKVSAVRAFGAE
HHHHCCCCHHHCCCEEEECCCCCCCCEEEHHHHCCCEEEEEEECCCCCHHHHHHHHCCCE
VVLFGDAFDAASKHSKELAELHNYTSIPPFDDPDVIAGQGTVGKELLQQNAHLDKIFVPV
EEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCHHHHHHHCCCCCCEEEEEE
GGGGLIAGIAVYVKQLLPNIKVIGVEPDNAACLKAALEHGSPITLDKVGLFADGVAVKTI
CCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCEEECCCCEECCEEEEEC
GSETFRLCQQYVDEVITVSSDEICTAVKDIFEETRAISEPSGALSLAGLKKYCQVHEIKN
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCC
QNLAAILSGANLNFHSLRYISERCELGEQKESVLAVTIPEKQGAFLAFCNQLDGRAITEF
CCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEE
NYRLNSRKNANIFVGVRTPQGVDELLALTEKLHKSGYSVADLSNDEMAKLHVRYMVGGAP
EEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHEEEEEEEECCCC
VSAIKERLYSFEFPEQPNALIKFLNMLGTHANITLFHYRNHGAAYGQVLAGFELDEGVDA
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHCCCCCCCHHHH
FSEHLDALGYNYKDETENQAYRFFLSHANDH
HHHHHHHHCCCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3315862; 3550695; 1379743; 9278503; 3003115; 2473940; 9562556 [H]