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The map label for this gene is hupA [H]

Identifier: 119946824

GI number: 119946824

Start: 3973164

End: 3973439

Strand: Direct

Name: hupA [H]

Synonym: Ping_3218

Alternate gene names: 119946824

Gene position: 3973164-3973439 (Clockwise)

Preceding gene: 119946823

Following gene: 119946830

Centisome position: 87.14

GC content: 39.86

Gene sequence:

>276_bases
ATGAACAAAACTCAACTTATTACTGATATTGCAGAGAAAGCAGAACTAACAAAAGTTCAAGCTAAAGCGGCTTTAGAACA
GATGATGACTAGCGTAACAGACAGTCTAAAAGATGGTGAGCCAGTACAGTTAATTGGATTTGGTACTTTTAAAGTAAACC
ACCGGGCAGCCCGTACAGGTCGAAATCCACAAACTGGGGCCGATATTCAAATCAAAGCGGCTAATGTACCTGCTTTTGTT
GCCGGTAAATCGCTTAAAGAAGCCGTTAATAAATAA

Upstream 100 bases:

>100_bases
TGACTTTTTTATGACACATTAGCTTAATTGATATTTCCAAGTGACTCGTGAATCGCCATTAAAGCTAATTCTAACACCCT
ATAAAAATGGATATACTAAG

Downstream 100 bases:

>100_bases
TCGACCTGAAAAAAAGCCGATGTGATAAAACATCGGCTTTTTATTCAAGCTTCGAACTACGAGTTTCGAGCTTCCCGCCT
TCGGGGTTTCTAGCCTTTCA

Product: DNA-binding protein HU alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 91; Mature: 91

Protein sequence:

>91_residues
MNKTQLITDIAEKAELTKVQAKAALEQMMTSVTDSLKDGEPVQLIGFGTFKVNHRAARTGRNPQTGADIQIKAANVPAFV
AGKSLKEAVNK

Sequences:

>Translated_91_residues
MNKTQLITDIAEKAELTKVQAKAALEQMMTSVTDSLKDGEPVQLIGFGTFKVNHRAARTGRNPQTGADIQIKAANVPAFV
AGKSLKEAVNK
>Mature_91_residues
MNKTQLITDIAEKAELTKVQAKAALEQMMTSVTDSLKDGEPVQLIGFGTFKVNHRAARTGRNPQTGADIQIKAANVPAFV
AGKSLKEAVNK

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions [H]

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family [H]

Homologues:

Organism=Escherichia coli, GI1790433, Length=89, Percent_Identity=74.1573033707865, Blast_Score=139, Evalue=5e-35,
Organism=Escherichia coli, GI1786644, Length=90, Percent_Identity=61.1111111111111, Blast_Score=112, Evalue=6e-27,
Organism=Escherichia coli, GI1787141, Length=91, Percent_Identity=34.0659340659341, Blast_Score=71, Evalue=2e-14,
Organism=Escherichia coli, GI1788005, Length=89, Percent_Identity=37.0786516853933, Blast_Score=63, Evalue=4e-12,

Paralogues:

None

Copy number: 1380 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992 [H]

Pfam domain/function: PF00216 Bac_DNA_binding [H]

EC number: NA

Molecular weight: Translated: 9752; Mature: 9752

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: PS00045 HISTONE_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTQLITDIAEKAELTKVQAKAALEQMMTSVTDSLKDGEPVQLIGFGTFKVNHRAARTG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECEEEECCHHHHCC
RNPQTGADIQIKAANVPAFVAGKSLKEAVNK
CCCCCCCCEEEEECCCCHHHHCHHHHHHHCC
>Mature Secondary Structure
MNKTQLITDIAEKAELTKVQAKAALEQMMTSVTDSLKDGEPVQLIGFGTFKVNHRAARTG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECEEEECCHHHHCC
RNPQTGADIQIKAANVPAFVAGKSLKEAVNK
CCCCCCCCEEEEECCCCHHHHCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1508695 [H]