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The map label for this gene is gppA [H]

Identifier: 119946799

GI number: 119946799

Start: 3941418

End: 3942344

Strand: Direct

Name: gppA [H]

Synonym: Ping_3192

Alternate gene names: 119946799

Gene position: 3941418-3942344 (Clockwise)

Preceding gene: 119946798

Following gene: 119946800

Centisome position: 86.44

GC content: 37.65

Gene sequence:

>927_bases
ATGACCAACAACCGCTATACCATCATTGACCTTGGATCAAATAGCTTTCATATGCTAACTGTTGAAAGGATCAATAATGG
TTTTAGTGTTTATTCTAAATCAAAACAGAAAGTGCGCCTTGCTGCAGGCTTAGATGAACAATATAACATCAATCAAGAAA
CCATACAGAAAGGCTTAGATTGTTTAACCAACTTCAAAAATGAACTGCGTATTTTACAGCCTGTTAAAGTCCTTATTACC
GCCACGGCAGCATTACGCCTGGCCAACAATAAAGAAGTATTTATAAAGCAAGCAGAAGAAATATTGCAGCGACCCATTAA
TTTAATATCTGGCCTGCAAGAAGCGCGGATAATCTATAAGGGCGTTGCATTTACTGAAAATATTTTGTTCCCTCTGCTGG
TTATTGATATAGGAGGCGCAAGCACCGAATTAATAATAGGCGAGGGTACGACAGTAAAAATTGCTCACAGCTTAGATATG
GGCTGCGTCACTTGGTTAAAAAGATATTTTCCCGATAATCAGCTCAATCAGGAAAATTTCAAAAATGCCATTGAACAGGC
AAAAAAAGTGATACAGCCAGAGGCACAACAATATTTACAGCAAGGCTGGTCACTAACGATGGGCGCTTCAGGCACCATCC
AAGCGGTTCAAGAAATAAACGAAAAACAGAAACTAAGCCCTGAAATCAACTTACAACTTTTATATCAGATCAGAGCATTG
TGCATAAGATGTGGAACAATTGAAAATTTACATATTGATGGCTTAAAATTATCCAGAAAACTAGTCTTTGCGAGTGGACT
TTCAATACTCATCGCACTATTTGAAATATTAGCTATTCCAGCTGTACAATGCTCAAAAGGTGCCTTACGTGAAGGGTTAA
TTAGTATTTTATTCTCAAGCCACACTGAAACTACTCTATCCATATAA

Upstream 100 bases:

>100_bases
AATGCGATGCTCGACTCTTTACCCGTAATGAAGGTAACAAAGTACAAAGCACATCCGAATAGCCGTAAAGATAATTATCA
CCGTACTCATAAGCGATAGA

Downstream 100 bases:

>100_bases
TAATACTCTCAATAACATCATCAAATTTTAAACAATGAGCTGCTCCGGGAAAGACTTACTACAGAAAAATAATTTTGCAT
TTATGCAATGCTTGTAGAGA

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTNNRYTIIDLGSNSFHMLTVERINNGFSVYSKSKQKVRLAAGLDEQYNINQETIQKGLDCLTNFKNELRILQPVKVLIT
ATAALRLANNKEVFIKQAEEILQRPINLISGLQEARIIYKGVAFTENILFPLLVIDIGGASTELIIGEGTTVKIAHSLDM
GCVTWLKRYFPDNQLNQENFKNAIEQAKKVIQPEAQQYLQQGWSLTMGASGTIQAVQEINEKQKLSPEINLQLLYQIRAL
CIRCGTIENLHIDGLKLSRKLVFASGLSILIALFEILAIPAVQCSKGALREGLISILFSSHTETTLSI

Sequences:

>Translated_308_residues
MTNNRYTIIDLGSNSFHMLTVERINNGFSVYSKSKQKVRLAAGLDEQYNINQETIQKGLDCLTNFKNELRILQPVKVLIT
ATAALRLANNKEVFIKQAEEILQRPINLISGLQEARIIYKGVAFTENILFPLLVIDIGGASTELIIGEGTTVKIAHSLDM
GCVTWLKRYFPDNQLNQENFKNAIEQAKKVIQPEAQQYLQQGWSLTMGASGTIQAVQEINEKQKLSPEINLQLLYQIRAL
CIRCGTIENLHIDGLKLSRKLVFASGLSILIALFEILAIPAVQCSKGALREGLISILFSSHTETTLSI
>Mature_307_residues
TNNRYTIIDLGSNSFHMLTVERINNGFSVYSKSKQKVRLAAGLDEQYNINQETIQKGLDCLTNFKNELRILQPVKVLITA
TAALRLANNKEVFIKQAEEILQRPINLISGLQEARIIYKGVAFTENILFPLLVIDIGGASTELIIGEGTTVKIAHSLDMG
CVTWLKRYFPDNQLNQENFKNAIEQAKKVIQPEAQQYLQQGWSLTMGASGTIQAVQEINEKQKLSPEINLQLLYQIRALC
IRCGTIENLHIDGLKLSRKLVFASGLSILIALFEILAIPAVQCSKGALREGLISILFSSHTETTLSI

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=293, Percent_Identity=48.122866894198, Blast_Score=273, Evalue=9e-75,
Organism=Escherichia coli, GI1788848, Length=294, Percent_Identity=39.4557823129252, Blast_Score=206, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 34345; Mature: 34214

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNNRYTIIDLGSNSFHMLTVERINNGFSVYSKSKQKVRLAAGLDEQYNINQETIQKGLD
CCCCCEEEEEECCCCEEEEEEEHHCCCHHHHCCCHHHEEEEECCCCCCCCCHHHHHHHHH
CLTNFKNELRILQPVKVLITATAALRLANNKEVFIKQAEEILQRPINLISGLQEARIIYK
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
GVAFTENILFPLLVIDIGGASTELIIGEGTTVKIAHSLDMGCVTWLKRYFPDNQLNQENF
HHHHHHHHHHEEEEEEECCCCEEEEEECCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHH
KNAIEQAKKVIQPEAQQYLQQGWSLTMGASGTIQAVQEINEKQKLSPEINLQLLYQIRAL
HHHHHHHHHHHCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
CIRCGTIENLHIDGLKLSRKLVFASGLSILIALFEILAIPAVQCSKGALREGLISILFSS
HHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHCC
HTETTLSI
CCCEEECC
>Mature Secondary Structure 
TNNRYTIIDLGSNSFHMLTVERINNGFSVYSKSKQKVRLAAGLDEQYNINQETIQKGLD
CCCCEEEEEECCCCEEEEEEEHHCCCHHHHCCCHHHEEEEECCCCCCCCCHHHHHHHHH
CLTNFKNELRILQPVKVLITATAALRLANNKEVFIKQAEEILQRPINLISGLQEARIIYK
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
GVAFTENILFPLLVIDIGGASTELIIGEGTTVKIAHSLDMGCVTWLKRYFPDNQLNQENF
HHHHHHHHHHEEEEEEECCCCEEEEEECCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHH
KNAIEQAKKVIQPEAQQYLQQGWSLTMGASGTIQAVQEINEKQKLSPEINLQLLYQIRAL
HHHHHHHHHHHCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
CIRCGTIENLHIDGLKLSRKLVFASGLSILIALFEILAIPAVQCSKGALREGLISILFSS
HHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHCC
HTETTLSI
CCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA