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The map label for this gene is ccmE

Identifier: 119946641

GI number: 119946641

Start: 3720275

End: 3720742

Strand: Reverse

Name: ccmE

Synonym: Ping_3020

Alternate gene names: 119946641

Gene position: 3720742-3720275 (Counterclockwise)

Preceding gene: 119946642

Following gene: 119946640

Centisome position: 81.6

GC content: 41.88

Gene sequence:

>468_bases
ATGAATCCGAGACGTAAAAAGCGTTTGTTAATCACCTCCTTATTGGCGGTTGCCCTCTCACTGGCAGTAGGGTTAGTTCT
TTTTGCTTTACAGCAAAATATCGATCTTTTTTATACACCGACAGAAATCATTGAAGGTAAAAAAGAAACCGGTATAAAAC
CCGAAGTCGGGCAACGCTTACGCATTGGCGGCATGGTCGTACAGGGATCAGTAAAACGGAATCCAGAGAGTTTAAAAGTA
AGCTTTGATTTGGTGGATAACGGTGGTGGTATTGTGACTGTCTTTTTTGATGGTATTTTGCCGGATTTATTCCGTGAGGG
GCAAGGTATTGTTGCTCAGGGTAATTTACTGAATGCCACAGAAATTAACGCTTCTGAAGTGCTTGCTAAACATGACGAAG
AGTATATGCCCCCGGAAGTTTCTGAGGCACTGGTTGGCATGGATAATTTCAAAGCCAATAACAAATAA

Upstream 100 bases:

>100_bases
TCAATACCCTAACAAAAAGAAAAAAAATATTAAAAACTGTCAATCAGCGTATCGCACGTGAAGAGCGAATAAAGAAAGCA
AAAAACAGGAAAGGTACATT

Downstream 100 bases:

>100_bases
CTATAAGGAAAAGACATTTCATGTTACCTGAAATTGGTCAAGTTGTGCTGGCAATAGCCTGCATGTTTTCATTATTACAA
GTCGTTTATCCGCTCTATGG

Product: CcmE/CycJ protein

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MNPRRKKRLLITSLLAVALSLAVGLVLFALQQNIDLFYTPTEIIEGKKETGIKPEVGQRLRIGGMVVQGSVKRNPESLKV
SFDLVDNGGGIVTVFFDGILPDLFREGQGIVAQGNLLNATEINASEVLAKHDEEYMPPEVSEALVGMDNFKANNK

Sequences:

>Translated_155_residues
MNPRRKKRLLITSLLAVALSLAVGLVLFALQQNIDLFYTPTEIIEGKKETGIKPEVGQRLRIGGMVVQGSVKRNPESLKV
SFDLVDNGGGIVTVFFDGILPDLFREGQGIVAQGNLLNATEINASEVLAKHDEEYMPPEVSEALVGMDNFKANNK
>Mature_155_residues
MNPRRKKRLLITSLLAVALSLAVGLVLFALQQNIDLFYTPTEIIEGKKETGIKPEVGQRLRIGGMVVQGSVKRNPESLKV
SFDLVDNGGGIVTVFFDGILPDLFREGQGIVAQGNLLNATEINASEVLAKHDEEYMPPEVSEALVGMDNFKANNK

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=144, Percent_Identity=61.1111111111111, Blast_Score=176, Evalue=7e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_PSYIN (A1SZ07)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_944321.1
- ProteinModelPortal:   A1SZ07
- SMR:   A1SZ07
- STRING:   A1SZ07
- GeneID:   4623804
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_3020
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- PhylomeDB:   A1SZ07
- BioCyc:   PING357804:PING_3020-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 16908; Mature: 16908

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: BINDING 131-131

Signals:

None

Transmembrane regions:

HASH(0x198305a8)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPRRKKRLLITSLLAVALSLAVGLVLFALQQNIDLFYTPTEIIEGKKETGIKPEVGQRL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHCCCHHCCCCCCCCCEE
RIGGMVVQGSVKRNPESLKVSFDLVDNGGGIVTVFFDGILPDLFREGQGIVAQGNLLNAT
EECCEEEECCCCCCCCEEEEEEEEEECCCCEEEEEEHHHHHHHHHCCCCEEEECCCCCCC
EINASEVLAKHDEEYMPPEVSEALVGMDNFKANNK
CCCHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCH
>Mature Secondary Structure
MNPRRKKRLLITSLLAVALSLAVGLVLFALQQNIDLFYTPTEIIEGKKETGIKPEVGQRL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHCCCHHCCCCCCCCCEE
RIGGMVVQGSVKRNPESLKVSFDLVDNGGGIVTVFFDGILPDLFREGQGIVAQGNLLNAT
EECCEEEECCCCCCCCEEEEEEEEEECCCCEEEEEEHHHHHHHHHCCCCEEEECCCCCCC
EINASEVLAKHDEEYMPPEVSEALVGMDNFKANNK
CCCHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA